2GU6A

E. coli methionine aminopeptidase in complex with nlep, 1: 2, di-metalated
Total Genus 92
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
92
sequence length
261
structure length
261
Chain Sequence
SIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGRGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISHDE
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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molecule tags Hydrolase
molecule keywords Methionine aminopeptidase
publication title Structural basis of catalysis by monometalated methionine aminopeptidase.
pubmed doi rcsb
source organism Escherichia coli
total genus 92
structure length 261
sequence length 261
chains with identical sequence B
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2006-04-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 2gu6A00
1QXYA 2BWVA 2GTXA 1YW8A 1CHMA 4S01A 4S2RP 4U6JA 4RGZ1 4FLJA 2DFIA 3L24A 1WKMA 2BHCA 2BWSA 3FMRA 2BHBA 2EVCA 2HOWA 4U71A 3L7GA 4U6CA 1YW9A 5JFRA 1MATA 4U6WA 1R5HA 2EVOA 4IKSA 1C22A 2GGBA 3D27A 1XNZA 1C24A 1BN5A 1R5GA 1QZYA 2NQ7A 2V3XA 4A6VA 4S00A 2B3HA 4FLIA 2GZ5A 3IU7A 3S6BA 2MATA 4PNCA 2Q95A 4IU6A 2GG8A 1XGNA 1KP0A 3CB6A 2Q96A 1XGSA 2P9AA 2ZSGA 2BH3A 4IKTA 4ZWPA 3IU9A 1QXWA 1WLRA 1O0XA 4FO7A 3BIPA 2OAZA 5CDLA 5E5BA 4A6WA 4Z7MA 4HXXA 4FO8A 5FCFA 2V6CA 3IG4A 4JUQA 4ZWUA 2Q94A 2NQ6A 4IKRA 1YJ3A 2BB7A 2EA2A 3PKDA 4EGEA 4U70A 1C23A 3RVAA 2P99A 5D6EA 4IPAA 3RORA 1XGMA 2B3KA 2BHDA 1WBQA 3MATA 1N51A 2GU7A 4MATA 2EA4A 2V3ZA 4FLKA 4IKUA 4RZZA 5JI6A 2BWUA 3FM3A 2Q93A 2V3YA 5CIKA 1WN1A 4QR8A 3MR1A 3PKAA 3TAVA 4IECA 4IF7A 2EVMA 2GG0A 1Y1NA 5CNXA 2GG3A 1B6AA 4S2TP 1YVMA 3IU8A 2GA2A 2GG2A 2ADUA 4ZNGA 4U73A 4ZWOA 2GG5A 4U1BA 3PKCA 4RZYA 2B3LA 4U6ZA 5CE6A 1KQ0A 2BN7A 1JAWA 5JHUA 2GG9A 2BWXA 1W2MA 3Q6DA 4PV4A 1A16A 3TB5A 1PV9A 4FUKA 3FMQA 4IDYA 2Q92A 3BIQA 3CB5A 2BWTA 3BITA 4U75A 4R60A 4KM3A 5CDVA 2GG7A 2GU6A 4OOKA 3CTZA 4B28A 1QXZA 1R58A 3PKBA 1WL9A 2P98A 1BOAA 4U76A 5FCHA 1C27A 1YW7A 2IW2A 5D6FA 3PKEA 2BWYA 2BWWA 1C21A 1KQ9A 2GU4A 2BHAA 2GU5A 1W7VA 1B59A 1WL6A 1M35A 1XGOA 2GGCA 4U69A 5CDEA 2OKNA 3MX6A 2Q8KA 4FLLA 2G6PA 1WY2A 5CLSA 4FKCA 4U6EA
chains in the Genus database with same CATH superfamily
1QXYA 2BWVA 2GTXA 1YW8A 1CHMA 4S01A 4S2RP 4U6JA 4RGZ1 4FLJA 2DFIA 3L24A 1WKMA 2BHCA 2BWSA 3FMRA 2BHBA 2EVCA 2HOWA 4U71A 3L7GA 4U6CA 1YW9A 5JFRA 1MATA 4U6WA 1R5HA 2EVOA 4IKSA 1C22A 2GGBA 3D27A 1XNZA 1C24A 1BN5A 1R5GA 1QZYA 2NQ7A 2V3XA 4A6VA 4S00A 2B3HA 4FLIA 2GZ5A 3IU7A 3S6BA 2MATA 4PNCA 2Q95A 4IU6A 2GG8A 1XGNA 1KP0A 3CB6A 2Q96A 1XGSA 2P9AA 2ZSGA 2BH3A 4IKTA 4ZWPA 3IU9A 1QXWA 1WLRA 1O0XA 4FO7A 3BIPA 2OAZA 5CDLA 5E5BA 4A6WA 4Z7MA 4HXXA 4FO8A 5FCFA 2V6CA 3IG4A 4JUQA 4ZWUA 2Q94A 2NQ6A 4IKRA 1YJ3A 2BB7A 2EA2A 3PKDA 4EGEA 4U70A 1C23A 3RVAA 2P99A 5D6EA 4IPAA 3RORA 1XGMA 2B3KA 2BHDA 1WBQA 3MATA 1N51A 2GU7A 4MATA 2EA4A 2V3ZA 4FLKA 4IKUA 4RZZA 5JI6A 2BWUA 3FM3A 2Q93A 2V3YA 5CIKA 1WN1A 4QR8A 3MR1A 3PKAA 3TAVA 4IECA 4IF7A 2EVMA 2GG0A 1Y1NA 5CNXA 2GG3A 1B6AA 4S2TP 1YVMA 3IU8A 2GA2A 2GG2A 2ADUA 4ZNGA 4U73A 4ZWOA 2GG5A 4U1BA 3PKCA 4RZYA 2B3LA 4U6ZA 5CE6A 1KQ0A 2BN7A 1JAWA 5JHUA 2GG9A 2BWXA 1W2MA 3Q6DA 4PV4A 1A16A 3TB5A 1PV9A 4FUKA 3FMQA 4IDYA 2Q92A 3BIQA 3CB5A 2BWTA 3BITA 4U75A 4R60A 4KM3A 5CDVA 2GG7A 2GU6A 4OOKA 3CTZA 4B28A 1QXZA 1R58A 3PKBA 1WL9A 2P98A 1BOAA 4U76A 5FCHA 1C27A 1YW7A 2IW2A 5D6FA 3PKEA 2BWYA 2BWWA 1C21A 1KQ9A 2GU4A 2BHAA 2GU5A 1W7VA 1B59A 1WL6A 1M35A 1XGOA 2GGCA 4U69A 5CDEA 2OKNA 3MX6A 2Q8KA 4FLLA 2G6PA 1WY2A 5CLSA 4FKCA 4U6EA
chains in the Genus database with same CATH topology
1QXYA 2BWVA 2GTXA 1YW8A 1CHMA 4S01A 4S2RP 4U6JA 4RGZ1 4FLJA 2DFIA 3L24A 1WKMA 2BHCA 2BWSA 3FMRA 2BHBA 2EVCA 2HOWA 4U71A 3L7GA 4U6CA 1YW9A 5JFRA 1MATA 4U6WA 1R5HA 2EVOA 4IKSA 1C22A 2GGBA 3D27A 1XNZA 1C24A 1BN5A 1R5GA 1QZYA 2NQ7A 2V3XA 4A6VA 4S00A 2B3HA 4FLIA 2GZ5A 3IU7A 3S6BA 2MATA 4PNCA 2Q95A 4IU6A 2GG8A 1XGNA 1KP0A 3CB6A 2Q96A 1XGSA 2P9AA 2ZSGA 2BH3A 4IKTA 4ZWPA 3IU9A 1QXWA 1WLRA 1O0XA 4FO7A 3BIPA 2OAZA 5CDLA 5E5BA 4A6WA 4Z7MA 4HXXA 4FO8A 5FCFA 2V6CA 3IG4A 4JUQA 4ZWUA 2Q94A 2NQ6A 4IKRA 1YJ3A 2BB7A 2EA2A 3PKDA 4EGEA 4U70A 1C23A 3RVAA 2P99A 5D6EA 4IPAA 3RORA 1XGMA 2B3KA 2BHDA 1WBQA 3MATA 1N51A 2GU7A 4MATA 2EA4A 2V3ZA 4FLKA 4IKUA 4RZZA 5JI6A 2BWUA 3FM3A 2Q93A 2V3YA 5CIKA 1WN1A 4QR8A 3MR1A 3PKAA 3TAVA 4IECA 4IF7A 2EVMA 2GG0A 1Y1NA 5CNXA 2GG3A 1B6AA 4S2TP 1YVMA 3IU8A 2GA2A 2GG2A 2ADUA 4ZNGA 4U73A 4ZWOA 2GG5A 4U1BA 3PKCA 4RZYA 2B3LA 4U6ZA 5CE6A 1KQ0A 2BN7A 1JAWA 5JHUA 2GG9A 2BWXA 1W2MA 3Q6DA 4PV4A 1A16A 3TB5A 1PV9A 4FUKA 3FMQA 4IDYA 2Q92A 3BIQA 3CB5A 2BWTA 3BITA 4U75A 4R60A 4KM3A 5CDVA 2GG7A 2GU6A 4OOKA 3CTZA 4B28A 1QXZA 1R58A 3PKBA 1WL9A 2P98A 1BOAA 4U76A 5FCHA 1C27A 1YW7A 2IW2A 5D6FA 3PKEA 2BWYA 2BWWA 1C21A 1KQ9A 2GU4A 2BHAA 2GU5A 1W7VA 1B59A 1WL6A 1M35A 1XGOA 2GGCA 4U69A 5CDEA 2OKNA 3MX6A 2Q8KA 4FLLA 2G6PA 1WY2A 5CLSA 4FKCA 4U6EA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 1QXY A;  2BWV A;  2GTX A;  1YW8 A;  1CHM A;  4S01 A;  4S2R P;  4U6J A;  4RGZ 1;  4FLJ A;  2DFI A;  3L24 A;  1WKM A;  2BHC A;  2BWS A;  3FMR A;  2BHB A;  2EVC A;  2HOW A;  4U71 A;  3L7G A;  4U6C A;  1YW9 A;  5JFR A;  1MAT A;  4U6W A;  1R5H A;  2EVO A;  4IKS A;  1C22 A;  2GGB A;  3D27 A;  1XNZ A;  1C24 A;  1BN5 A;  1R5G A;  1QZY A;  2NQ7 A;  2V3X A;  4A6V A;  4S00 A;  2B3H A;  4FLI A;  2GZ5 A;  3IU7 A;  3S6B A;  2MAT A;  4PNC A;  2Q95 A;  4IU6 A;  2GG8 A;  1XGN A;  1KP0 A;  3CB6 A;  2Q96 A;  1XGS A;  2P9A A;  2ZSG A;  2BH3 A;  4IKT A;  4ZWP A;  3IU9 A;  1QXW A;  1WLR A;  1O0X A;  4FO7 A;  3BIP A;  2OAZ A;  5CDL A;  5E5B A;  4A6W A;  4Z7M A;  4HXX A;  4FO8 A;  5FCF A;  2V6C A;  3IG4 A;  4JUQ A;  4ZWU A;  2Q94 A;  2NQ6 A;  4IKR A;  1YJ3 A;  2BB7 A;  2EA2 A;  3PKD A;  4EGE A;  4U70 A;  1C23 A;  3RVA A;  2P99 A;  5D6E A;  4IPA A;  3ROR A;  1XGM A;  2B3K A;  2BHD A;  1WBQ A;  3MAT A;  1N51 A;  2GU7 A;  4MAT A;  2EA4 A;  2V3Z A;  4FLK A;  4IKU A;  4RZZ A;  5JI6 A;  2BWU A;  3FM3 A;  2Q93 A;  2V3Y A;  5CIK A;  1WN1 A;  4QR8 A;  3MR1 A;  3PKA A;  3TAV A;  4IEC A;  4IF7 A;  2EVM A;  2GG0 A;  1Y1N A;  5CNX A;  2GG3 A;  1B6A A;  4S2T P;  1YVM A;  3IU8 A;  2GA2 A;  2GG2 A;  2ADU A;  4ZNG A;  4U73 A;  4ZWO A;  2GG5 A;  4U1B A;  3PKC A;  4RZY A;  2B3L A;  4U6Z A;  5CE6 A;  1KQ0 A;  2BN7 A;  1JAW A;  5JHU A;  2GG9 A;  2BWX A;  1W2M A;  3Q6D A;  4PV4 A;  1A16 A;  3TB5 A;  1PV9 A;  4FUK A;  3FMQ A;  4IDY A;  2Q92 A;  3BIQ A;  3CB5 A;  2BWT A;  3BIT A;  4U75 A;  4R60 A;  4KM3 A;  5CDV A;  2GG7 A;  2GU6 A;  4OOK A;  3CTZ A;  4B28 A;  1QXZ A;  1R58 A;  3PKB A;  1WL9 A;  2P98 A;  1BOA A;  4U76 A;  5FCH A;  1C27 A;  1YW7 A;  2IW2 A;  5D6F A;  3PKE A;  2BWY A;  2BWW A;  1C21 A;  1KQ9 A;  2GU4 A;  2BHA A;  2GU5 A;  1W7V A;  1B59 A;  1WL6 A;  1M35 A;  1XGO A;  2GGC A;  4U69 A;  5CDE A;  2OKN A;  3MX6 A;  2Q8K A;  4FLL A;  2G6P A;  1WY2 A;  5CLS A;  4FKC A;  4U6E A; 
#chains in the Genus database with same CATH topology
 1QXY A;  2BWV A;  2GTX A;  1YW8 A;  1CHM A;  4S01 A;  4S2R P;  4U6J A;  4RGZ 1;  4FLJ A;  2DFI A;  3L24 A;  1WKM A;  2BHC A;  2BWS A;  3FMR A;  2BHB A;  2EVC A;  2HOW A;  4U71 A;  3L7G A;  4U6C A;  1YW9 A;  5JFR A;  1MAT A;  4U6W A;  1R5H A;  2EVO A;  4IKS A;  1C22 A;  2GGB A;  3D27 A;  1XNZ A;  1C24 A;  1BN5 A;  1R5G A;  1QZY A;  2NQ7 A;  2V3X A;  4A6V A;  4S00 A;  2B3H A;  4FLI A;  2GZ5 A;  3IU7 A;  3S6B A;  2MAT A;  4PNC A;  2Q95 A;  4IU6 A;  2GG8 A;  1XGN A;  1KP0 A;  3CB6 A;  2Q96 A;  1XGS A;  2P9A A;  2ZSG A;  2BH3 A;  4IKT A;  4ZWP A;  3IU9 A;  1QXW A;  1WLR A;  1O0X A;  4FO7 A;  3BIP A;  2OAZ A;  5CDL A;  5E5B A;  4A6W A;  4Z7M A;  4HXX A;  4FO8 A;  5FCF A;  2V6C A;  3IG4 A;  4JUQ A;  4ZWU A;  2Q94 A;  2NQ6 A;  4IKR A;  1YJ3 A;  2BB7 A;  2EA2 A;  3PKD A;  4EGE A;  4U70 A;  1C23 A;  3RVA A;  2P99 A;  5D6E A;  4IPA A;  3ROR A;  1XGM A;  2B3K A;  2BHD A;  1WBQ A;  3MAT A;  1N51 A;  2GU7 A;  4MAT A;  2EA4 A;  2V3Z A;  4FLK A;  4IKU A;  4RZZ A;  5JI6 A;  2BWU A;  3FM3 A;  2Q93 A;  2V3Y A;  5CIK A;  1WN1 A;  4QR8 A;  3MR1 A;  3PKA A;  3TAV A;  4IEC A;  4IF7 A;  2EVM A;  2GG0 A;  1Y1N A;  5CNX A;  2GG3 A;  1B6A A;  4S2T P;  1YVM A;  3IU8 A;  2GA2 A;  2GG2 A;  2ADU A;  4ZNG A;  4U73 A;  4ZWO A;  2GG5 A;  4U1B A;  3PKC A;  4RZY A;  2B3L A;  4U6Z A;  5CE6 A;  1KQ0 A;  2BN7 A;  1JAW A;  5JHU A;  2GG9 A;  2BWX A;  1W2M A;  3Q6D A;  4PV4 A;  1A16 A;  3TB5 A;  1PV9 A;  4FUK A;  3FMQ A;  4IDY A;  2Q92 A;  3BIQ A;  3CB5 A;  2BWT A;  3BIT A;  4U75 A;  4R60 A;  4KM3 A;  5CDV A;  2GG7 A;  2GU6 A;  4OOK A;  3CTZ A;  4B28 A;  1QXZ A;  1R58 A;  3PKB A;  1WL9 A;  2P98 A;  1BOA A;  4U76 A;  5FCH A;  1C27 A;  1YW7 A;  2IW2 A;  5D6F A;  3PKE A;  2BWY A;  2BWW A;  1C21 A;  1KQ9 A;  2GU4 A;  2BHA A;  2GU5 A;  1W7V A;  1B59 A;  1WL6 A;  1M35 A;  1XGO A;  2GGC A;  4U69 A;  5CDE A;  2OKN A;  3MX6 A;  2Q8K A;  4FLL A;  2G6P A;  1WY2 A;  5CLS A;  4FKC A;  4U6E A; 
#chains in the Genus database with same CATH homology
 1QXY A;  2BWV A;  2GTX A;  1YW8 A;  1CHM A;  4S01 A;  4S2R P;  4U6J A;  4RGZ 1;  4FLJ A;  2DFI A;  3L24 A;  1WKM A;  2BHC A;  2BWS A;  3FMR A;  2BHB A;  2EVC A;  2HOW A;  4U71 A;  3L7G A;  4U6C A;  1YW9 A;  5JFR A;  1MAT A;  4U6W A;  1R5H A;  2EVO A;  4IKS A;  1C22 A;  2GGB A;  3D27 A;  1XNZ A;  1C24 A;  1BN5 A;  1R5G A;  1QZY A;  2NQ7 A;  2V3X A;  4A6V A;  4S00 A;  2B3H A;  4FLI A;  2GZ5 A;  3IU7 A;  3S6B A;  2MAT A;  4PNC A;  2Q95 A;  4IU6 A;  2GG8 A;  1XGN A;  1KP0 A;  3CB6 A;  2Q96 A;  1XGS A;  2P9A A;  2ZSG A;  2BH3 A;  4IKT A;  4ZWP A;  3IU9 A;  1QXW A;  1WLR A;  1O0X A;  4FO7 A;  3BIP A;  2OAZ A;  5CDL A;  5E5B A;  4A6W A;  4Z7M A;  4HXX A;  4FO8 A;  5FCF A;  2V6C A;  3IG4 A;  4JUQ A;  4ZWU A;  2Q94 A;  2NQ6 A;  4IKR A;  1YJ3 A;  2BB7 A;  2EA2 A;  3PKD A;  4EGE A;  4U70 A;  1C23 A;  3RVA A;  2P99 A;  5D6E A;  4IPA A;  3ROR A;  1XGM A;  2B3K A;  2BHD A;  1WBQ A;  3MAT A;  1N51 A;  2GU7 A;  4MAT A;  2EA4 A;  2V3Z A;  4FLK A;  4IKU A;  4RZZ A;  5JI6 A;  2BWU A;  3FM3 A;  2Q93 A;  2V3Y A;  5CIK A;  1WN1 A;  4QR8 A;  3MR1 A;  3PKA A;  3TAV A;  4IEC A;  4IF7 A;  2EVM A;  2GG0 A;  1Y1N A;  5CNX A;  2GG3 A;  1B6A A;  4S2T P;  1YVM A;  3IU8 A;  2GA2 A;  2GG2 A;  2ADU A;  4ZNG A;  4U73 A;  4ZWO A;  2GG5 A;  4U1B A;  3PKC A;  4RZY A;  2B3L A;  4U6Z A;  5CE6 A;  1KQ0 A;  2BN7 A;  1JAW A;  5JHU A;  2GG9 A;  2BWX A;  1W2M A;  3Q6D A;  4PV4 A;  1A16 A;  3TB5 A;  1PV9 A;  4FUK A;  3FMQ A;  4IDY A;  2Q92 A;  3BIQ A;  3CB5 A;  2BWT A;  3BIT A;  4U75 A;  4R60 A;  4KM3 A;  5CDV A;  2GG7 A;  2GU6 A;  4OOK A;  3CTZ A;  4B28 A;  1QXZ A;  1R58 A;  3PKB A;  1WL9 A;  2P98 A;  1BOA A;  4U76 A;  5FCH A;  1C27 A;  1YW7 A;  2IW2 A;  5D6F A;  3PKE A;  2BWY A;  2BWW A;  1C21 A;  1KQ9 A;  2GU4 A;  2BHA A;  2GU5 A;  1W7V A;  1B59 A;  1WL6 A;  1M35 A;  1XGO A;  2GGC A;  4U69 A;  5CDE A;  2OKN A;  3MX6 A;  2Q8K A;  4FLL A;  2G6P A;  1WY2 A;  5CLS A;  4FKC A;  4U6E A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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