2GG8A

Novel bacterial methionine aminopeptidase inhibitors
Total Genus 88
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
88
sequence length
263
structure length
263
Chain Sequence
AISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGRGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISHDE
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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molecule tags Hydrolase
molecule keywords Methionine aminopeptidase
publication title Serendipitous discovery of novel bacterial methionine aminopeptidase inhibitors.
pubmed doi rcsb
source organism Escherichia coli k12
total genus 88
structure length 263
sequence length 263
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2006-03-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 2gg8A00
2EA2A 4U6JA 1C22A 4OOKA 1YW9A 1R58A 3L7GA 4S01A 4FO8A 2Q96A 2Q92A 2BHAA 3MX6A 1O0XA 1YVMA 2GGCA 2BWWA 2V3XA 4QR8A 2P98A 1B59A 1C21A 2GTXA 4PV4A 4FLKA 1A16A 2NQ7A 3IU8A 4FO7A 4U70A 1XNZA 2Q94A 2P9AA 2ZSGA 5D6EA 2GZ5A 4FKCA 5CDVA 4IECA 4FLLA 3IU9A 3BIPA 1WY2A 1WKMA 2BWYA 2B3KA 2GU7A 2OKNA 3TAVA 1XGMA 4FLJA 1QXWA 4KM3A 1KQ0A 4RZZA 3BIQA 2EVCA 1KQ9A 2Q95A 2G6PA 3MATA 4ZWUA 3PKCA 1C24A 1Y1NA 2ADUA 3D27A 1WN1A 4U76A 5CLSA 1BN5A 1WLRA 4IF7A 3PKDA 4RGZ1 2BWTA 2Q93A 2BWUA 4U75A 1N51A 2HOWA 4IDYA 2BWXA 1M35A 3IU7A 4Z7MA 1JAWA 4U6EA 3TB5A 5FCFA 1R5HA 2EA4A 1XGOA 4U69A 4FLIA 1WBQA 2GA2A 3RVAA 3RORA 1QZYA 1XGNA 2B3HA 2V3ZA 5JI6A 2BWSA 4U6WA 2GU4A 3IG4A 1W7VA 1R5GA 4HXXA 2OAZA 3CB6A 1C27A 2NQ6A 4IU6A 1PV9A 2BHCA 3PKBA 4FUKA 1CHMA 1MATA 1WL6A 4B28A 4EGEA 2V6CA 1KP0A 1YW8A 1YW7A 2MATA 4IKSA 2GGBA 1B6AA 5E5BA 1W2MA 3L24A 4RZYA 3CB5A 3PKAA 4U73A 1QXZA 1BOAA 1C23A 1YJ3A 4ZWPA 5JFRA 4IKUA 5CDLA 1XGSA 5FCHA 4IPAA 2Q8KA 4ZWOA 2B3LA 2GG0A 4ZNGA 4IKRA 2BB7A 2GU6A 5CIKA 2P99A 2BH3A 3Q6DA 3FMQA 3PKEA 5CDEA 1QXYA 2V3YA 4MATA 3MR1A 2EVMA 4S00A 2GG3A 2GG8A 5JHUA 4U71A 4S2TP 5D6FA 2BWVA 2GU5A 4S2RP 4IKTA 4R60A 2EVOA 3FM3A 4JUQA 4U1BA 4U6CA 2BHDA 3FMRA 2GG7A 3S6BA 2GG2A 4A6VA 5CNXA 2GG9A 4PNCA 2BN7A 2IW2A 2GG5A 4A6WA 3BITA 2DFIA 2BHBA 3CTZA 4U6ZA 5CE6A 1WL9A
chains in the Genus database with same CATH superfamily
2EA2A 4U6JA 1C22A 4OOKA 1YW9A 1R58A 3L7GA 4S01A 4FO8A 2Q96A 2Q92A 2BHAA 3MX6A 1O0XA 1YVMA 2GGCA 2BWWA 2V3XA 4QR8A 2P98A 1B59A 1C21A 2GTXA 4PV4A 4FLKA 1A16A 2NQ7A 3IU8A 4FO7A 4U70A 1XNZA 2Q94A 2P9AA 2ZSGA 5D6EA 2GZ5A 4FKCA 5CDVA 4IECA 4FLLA 3IU9A 3BIPA 1WY2A 1WKMA 2BWYA 2B3KA 2GU7A 2OKNA 3TAVA 1XGMA 4FLJA 1QXWA 4KM3A 1KQ0A 4RZZA 3BIQA 2EVCA 1KQ9A 2Q95A 2G6PA 3MATA 4ZWUA 3PKCA 1C24A 1Y1NA 2ADUA 3D27A 1WN1A 4U76A 5CLSA 1BN5A 1WLRA 4IF7A 3PKDA 4RGZ1 2BWTA 2Q93A 2BWUA 4U75A 1N51A 2HOWA 4IDYA 2BWXA 1M35A 3IU7A 4Z7MA 1JAWA 4U6EA 3TB5A 5FCFA 1R5HA 2EA4A 1XGOA 4U69A 4FLIA 1WBQA 2GA2A 3RVAA 3RORA 1QZYA 1XGNA 2B3HA 2V3ZA 5JI6A 2BWSA 4U6WA 2GU4A 3IG4A 1W7VA 1R5GA 4HXXA 2OAZA 3CB6A 1C27A 2NQ6A 4IU6A 1PV9A 2BHCA 3PKBA 4FUKA 1CHMA 1MATA 1WL6A 4B28A 4EGEA 2V6CA 1KP0A 1YW8A 1YW7A 2MATA 4IKSA 2GGBA 1B6AA 5E5BA 1W2MA 3L24A 4RZYA 3CB5A 3PKAA 4U73A 1QXZA 1BOAA 1C23A 1YJ3A 4ZWPA 5JFRA 4IKUA 5CDLA 1XGSA 5FCHA 4IPAA 2Q8KA 4ZWOA 2B3LA 2GG0A 4ZNGA 4IKRA 2BB7A 2GU6A 5CIKA 2P99A 2BH3A 3Q6DA 3FMQA 3PKEA 5CDEA 1QXYA 2V3YA 4MATA 3MR1A 2EVMA 4S00A 2GG3A 2GG8A 5JHUA 4U71A 4S2TP 5D6FA 2BWVA 2GU5A 4S2RP 4IKTA 4R60A 2EVOA 3FM3A 4JUQA 4U1BA 4U6CA 2BHDA 3FMRA 2GG7A 3S6BA 2GG2A 4A6VA 5CNXA 2GG9A 4PNCA 2BN7A 2IW2A 2GG5A 4A6WA 3BITA 2DFIA 2BHBA 3CTZA 4U6ZA 5CE6A 1WL9A
chains in the Genus database with same CATH topology
2EA2A 4U6JA 1C22A 4OOKA 1YW9A 1R58A 3L7GA 4S01A 4FO8A 2Q96A 2Q92A 2BHAA 3MX6A 1O0XA 1YVMA 2GGCA 2BWWA 2V3XA 4QR8A 2P98A 1B59A 1C21A 2GTXA 4PV4A 4FLKA 1A16A 2NQ7A 3IU8A 4FO7A 4U70A 1XNZA 2Q94A 2P9AA 2ZSGA 5D6EA 2GZ5A 4FKCA 5CDVA 4IECA 4FLLA 3IU9A 3BIPA 1WY2A 1WKMA 2BWYA 2B3KA 2GU7A 2OKNA 3TAVA 1XGMA 4FLJA 1QXWA 4KM3A 1KQ0A 4RZZA 3BIQA 2EVCA 1KQ9A 2Q95A 2G6PA 3MATA 4ZWUA 3PKCA 1C24A 1Y1NA 2ADUA 3D27A 1WN1A 4U76A 5CLSA 1BN5A 1WLRA 4IF7A 3PKDA 4RGZ1 2BWTA 2Q93A 2BWUA 4U75A 1N51A 2HOWA 4IDYA 2BWXA 1M35A 3IU7A 4Z7MA 1JAWA 4U6EA 3TB5A 5FCFA 1R5HA 2EA4A 1XGOA 4U69A 4FLIA 1WBQA 2GA2A 3RVAA 3RORA 1QZYA 1XGNA 2B3HA 2V3ZA 5JI6A 2BWSA 4U6WA 2GU4A 3IG4A 1W7VA 1R5GA 4HXXA 2OAZA 3CB6A 1C27A 2NQ6A 4IU6A 1PV9A 2BHCA 3PKBA 4FUKA 1CHMA 1MATA 1WL6A 4B28A 4EGEA 2V6CA 1KP0A 1YW8A 1YW7A 2MATA 4IKSA 2GGBA 1B6AA 5E5BA 1W2MA 3L24A 4RZYA 3CB5A 3PKAA 4U73A 1QXZA 1BOAA 1C23A 1YJ3A 4ZWPA 5JFRA 4IKUA 5CDLA 1XGSA 5FCHA 4IPAA 2Q8KA 4ZWOA 2B3LA 2GG0A 4ZNGA 4IKRA 2BB7A 2GU6A 5CIKA 2P99A 2BH3A 3Q6DA 3FMQA 3PKEA 5CDEA 1QXYA 2V3YA 4MATA 3MR1A 2EVMA 4S00A 2GG3A 2GG8A 5JHUA 4U71A 4S2TP 5D6FA 2BWVA 2GU5A 4S2RP 4IKTA 4R60A 2EVOA 3FM3A 4JUQA 4U1BA 4U6CA 2BHDA 3FMRA 2GG7A 3S6BA 2GG2A 4A6VA 5CNXA 2GG9A 4PNCA 2BN7A 2IW2A 2GG5A 4A6WA 3BITA 2DFIA 2BHBA 3CTZA 4U6ZA 5CE6A 1WL9A
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 2EA2 A;  4U6J A;  1C22 A;  4OOK A;  1YW9 A;  1R58 A;  3L7G A;  4S01 A;  4FO8 A;  2Q96 A;  2Q92 A;  2BHA A;  3MX6 A;  1O0X A;  1YVM A;  2GGC A;  2BWW A;  2V3X A;  4QR8 A;  2P98 A;  1B59 A;  1C21 A;  2GTX A;  4PV4 A;  4FLK A;  1A16 A;  2NQ7 A;  3IU8 A;  4FO7 A;  4U70 A;  1XNZ A;  2Q94 A;  2P9A A;  2ZSG A;  5D6E A;  2GZ5 A;  4FKC A;  5CDV A;  4IEC A;  4FLL A;  3IU9 A;  3BIP A;  1WY2 A;  1WKM A;  2BWY A;  2B3K A;  2GU7 A;  2OKN A;  3TAV A;  1XGM A;  4FLJ A;  1QXW A;  4KM3 A;  1KQ0 A;  4RZZ A;  3BIQ A;  2EVC A;  1KQ9 A;  2Q95 A;  2G6P A;  3MAT A;  4ZWU A;  3PKC A;  1C24 A;  1Y1N A;  2ADU A;  3D27 A;  1WN1 A;  4U76 A;  5CLS A;  1BN5 A;  1WLR A;  4IF7 A;  3PKD A;  4RGZ 1;  2BWT A;  2Q93 A;  2BWU A;  4U75 A;  1N51 A;  2HOW A;  4IDY A;  2BWX A;  1M35 A;  3IU7 A;  4Z7M A;  1JAW A;  4U6E A;  3TB5 A;  5FCF A;  1R5H A;  2EA4 A;  1XGO A;  4U69 A;  4FLI A;  1WBQ A;  2GA2 A;  3RVA A;  3ROR A;  1QZY A;  1XGN A;  2B3H A;  2V3Z A;  5JI6 A;  2BWS A;  4U6W A;  2GU4 A;  3IG4 A;  1W7V A;  1R5G A;  4HXX A;  2OAZ A;  3CB6 A;  1C27 A;  2NQ6 A;  4IU6 A;  1PV9 A;  2BHC A;  3PKB A;  4FUK A;  1CHM A;  1MAT A;  1WL6 A;  4B28 A;  4EGE A;  2V6C A;  1KP0 A;  1YW8 A;  1YW7 A;  2MAT A;  4IKS A;  2GGB A;  1B6A A;  5E5B A;  1W2M A;  3L24 A;  4RZY A;  3CB5 A;  3PKA A;  4U73 A;  1QXZ A;  1BOA A;  1C23 A;  1YJ3 A;  4ZWP A;  5JFR A;  4IKU A;  5CDL A;  1XGS A;  5FCH A;  4IPA A;  2Q8K A;  4ZWO A;  2B3L A;  2GG0 A;  4ZNG A;  4IKR A;  2BB7 A;  2GU6 A;  5CIK A;  2P99 A;  2BH3 A;  3Q6D A;  3FMQ A;  3PKE A;  5CDE A;  1QXY A;  2V3Y A;  4MAT A;  3MR1 A;  2EVM A;  4S00 A;  2GG3 A;  2GG8 A;  5JHU A;  4U71 A;  4S2T P;  5D6F A;  2BWV A;  2GU5 A;  4S2R P;  4IKT A;  4R60 A;  2EVO A;  3FM3 A;  4JUQ A;  4U1B A;  4U6C A;  2BHD A;  3FMR A;  2GG7 A;  3S6B A;  2GG2 A;  4A6V A;  5CNX A;  2GG9 A;  4PNC A;  2BN7 A;  2IW2 A;  2GG5 A;  4A6W A;  3BIT A;  2DFI A;  2BHB A;  3CTZ A;  4U6Z A;  5CE6 A;  1WL9 A; 
#chains in the Genus database with same CATH topology
 2EA2 A;  4U6J A;  1C22 A;  4OOK A;  1YW9 A;  1R58 A;  3L7G A;  4S01 A;  4FO8 A;  2Q96 A;  2Q92 A;  2BHA A;  3MX6 A;  1O0X A;  1YVM A;  2GGC A;  2BWW A;  2V3X A;  4QR8 A;  2P98 A;  1B59 A;  1C21 A;  2GTX A;  4PV4 A;  4FLK A;  1A16 A;  2NQ7 A;  3IU8 A;  4FO7 A;  4U70 A;  1XNZ A;  2Q94 A;  2P9A A;  2ZSG A;  5D6E A;  2GZ5 A;  4FKC A;  5CDV A;  4IEC A;  4FLL A;  3IU9 A;  3BIP A;  1WY2 A;  1WKM A;  2BWY A;  2B3K A;  2GU7 A;  2OKN A;  3TAV A;  1XGM A;  4FLJ A;  1QXW A;  4KM3 A;  1KQ0 A;  4RZZ A;  3BIQ A;  2EVC A;  1KQ9 A;  2Q95 A;  2G6P A;  3MAT A;  4ZWU A;  3PKC A;  1C24 A;  1Y1N A;  2ADU A;  3D27 A;  1WN1 A;  4U76 A;  5CLS A;  1BN5 A;  1WLR A;  4IF7 A;  3PKD A;  4RGZ 1;  2BWT A;  2Q93 A;  2BWU A;  4U75 A;  1N51 A;  2HOW A;  4IDY A;  2BWX A;  1M35 A;  3IU7 A;  4Z7M A;  1JAW A;  4U6E A;  3TB5 A;  5FCF A;  1R5H A;  2EA4 A;  1XGO A;  4U69 A;  4FLI A;  1WBQ A;  2GA2 A;  3RVA A;  3ROR A;  1QZY A;  1XGN A;  2B3H A;  2V3Z A;  5JI6 A;  2BWS A;  4U6W A;  2GU4 A;  3IG4 A;  1W7V A;  1R5G A;  4HXX A;  2OAZ A;  3CB6 A;  1C27 A;  2NQ6 A;  4IU6 A;  1PV9 A;  2BHC A;  3PKB A;  4FUK A;  1CHM A;  1MAT A;  1WL6 A;  4B28 A;  4EGE A;  2V6C A;  1KP0 A;  1YW8 A;  1YW7 A;  2MAT A;  4IKS A;  2GGB A;  1B6A A;  5E5B A;  1W2M A;  3L24 A;  4RZY A;  3CB5 A;  3PKA A;  4U73 A;  1QXZ A;  1BOA A;  1C23 A;  1YJ3 A;  4ZWP A;  5JFR A;  4IKU A;  5CDL A;  1XGS A;  5FCH A;  4IPA A;  2Q8K A;  4ZWO A;  2B3L A;  2GG0 A;  4ZNG A;  4IKR A;  2BB7 A;  2GU6 A;  5CIK A;  2P99 A;  2BH3 A;  3Q6D A;  3FMQ A;  3PKE A;  5CDE A;  1QXY A;  2V3Y A;  4MAT A;  3MR1 A;  2EVM A;  4S00 A;  2GG3 A;  2GG8 A;  5JHU A;  4U71 A;  4S2T P;  5D6F A;  2BWV A;  2GU5 A;  4S2R P;  4IKT A;  4R60 A;  2EVO A;  3FM3 A;  4JUQ A;  4U1B A;  4U6C A;  2BHD A;  3FMR A;  2GG7 A;  3S6B A;  2GG2 A;  4A6V A;  5CNX A;  2GG9 A;  4PNC A;  2BN7 A;  2IW2 A;  2GG5 A;  4A6W A;  3BIT A;  2DFI A;  2BHB A;  3CTZ A;  4U6Z A;  5CE6 A;  1WL9 A; 
#chains in the Genus database with same CATH homology
 2EA2 A;  4U6J A;  1C22 A;  4OOK A;  1YW9 A;  1R58 A;  3L7G A;  4S01 A;  4FO8 A;  2Q96 A;  2Q92 A;  2BHA A;  3MX6 A;  1O0X A;  1YVM A;  2GGC A;  2BWW A;  2V3X A;  4QR8 A;  2P98 A;  1B59 A;  1C21 A;  2GTX A;  4PV4 A;  4FLK A;  1A16 A;  2NQ7 A;  3IU8 A;  4FO7 A;  4U70 A;  1XNZ A;  2Q94 A;  2P9A A;  2ZSG A;  5D6E A;  2GZ5 A;  4FKC A;  5CDV A;  4IEC A;  4FLL A;  3IU9 A;  3BIP A;  1WY2 A;  1WKM A;  2BWY A;  2B3K A;  2GU7 A;  2OKN A;  3TAV A;  1XGM A;  4FLJ A;  1QXW A;  4KM3 A;  1KQ0 A;  4RZZ A;  3BIQ A;  2EVC A;  1KQ9 A;  2Q95 A;  2G6P A;  3MAT A;  4ZWU A;  3PKC A;  1C24 A;  1Y1N A;  2ADU A;  3D27 A;  1WN1 A;  4U76 A;  5CLS A;  1BN5 A;  1WLR A;  4IF7 A;  3PKD A;  4RGZ 1;  2BWT A;  2Q93 A;  2BWU A;  4U75 A;  1N51 A;  2HOW A;  4IDY A;  2BWX A;  1M35 A;  3IU7 A;  4Z7M A;  1JAW A;  4U6E A;  3TB5 A;  5FCF A;  1R5H A;  2EA4 A;  1XGO A;  4U69 A;  4FLI A;  1WBQ A;  2GA2 A;  3RVA A;  3ROR A;  1QZY A;  1XGN A;  2B3H A;  2V3Z A;  5JI6 A;  2BWS A;  4U6W A;  2GU4 A;  3IG4 A;  1W7V A;  1R5G A;  4HXX A;  2OAZ A;  3CB6 A;  1C27 A;  2NQ6 A;  4IU6 A;  1PV9 A;  2BHC A;  3PKB A;  4FUK A;  1CHM A;  1MAT A;  1WL6 A;  4B28 A;  4EGE A;  2V6C A;  1KP0 A;  1YW8 A;  1YW7 A;  2MAT A;  4IKS A;  2GGB A;  1B6A A;  5E5B A;  1W2M A;  3L24 A;  4RZY A;  3CB5 A;  3PKA A;  4U73 A;  1QXZ A;  1BOA A;  1C23 A;  1YJ3 A;  4ZWP A;  5JFR A;  4IKU A;  5CDL A;  1XGS A;  5FCH A;  4IPA A;  2Q8K A;  4ZWO A;  2B3L A;  2GG0 A;  4ZNG A;  4IKR A;  2BB7 A;  2GU6 A;  5CIK A;  2P99 A;  2BH3 A;  3Q6D A;  3FMQ A;  3PKE A;  5CDE A;  1QXY A;  2V3Y A;  4MAT A;  3MR1 A;  2EVM A;  4S00 A;  2GG3 A;  2GG8 A;  5JHU A;  4U71 A;  4S2T P;  5D6F A;  2BWV A;  2GU5 A;  4S2R P;  4IKT A;  4R60 A;  2EVO A;  3FM3 A;  4JUQ A;  4U1B A;  4U6C A;  2BHD A;  3FMR A;  2GG7 A;  3S6B A;  2GG2 A;  4A6V A;  5CNX A;  2GG9 A;  4PNC A;  2BN7 A;  2IW2 A;  2GG5 A;  4A6W A;  3BIT A;  2DFI A;  2BHB A;  3CTZ A;  4U6Z A;  5CE6 A;  1WL9 A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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