2GZ5A

Human type 1 methionine aminopeptidase in complex with ovalicin at 1.1 ang
Total Genus 99
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
99
sequence length
304
structure length
304
Chain Sequence
YRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLFHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARPHFMS
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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molecule tags Hydrolase
molecule keywords Methionine aminopeptidase 1
publication title Structure of the angiogenesis inhibitor ovalicin bound to its noncognate target, human Type 1 methionine aminopeptidase.
pubmed doi rcsb
source organism Homo sapiens
total genus 99
structure length 304
sequence length 304
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2006-05-10

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 2gz5A00
2BHDA 2BWTA 4U6CA 2GTXA 4IKSA 2GGBA 3FM3A 1PV9A 1KP0A 3MATA 4U75A 2GU7A 2BWYA 5CNXA 4RGZ1 4U69A 2BH3A 2BHBA 1YW8A 2GZ5A 4ZNGA 4R60A 5D6EA 3TAVA 4A6WA 2P9AA 4FUKA 3CB6A 4ZWPA 2ZSGA 3MX6A 1R5GA 2MATA 2NQ7A 1N51A 4IPAA 2EVOA 4MATA 5CIKA 4S00A 1XGMA 4FLLA 3Q6DA 1C23A 2GGCA 4IU6A 4IKRA 2EA2A 2B3KA 4B28A 4ZWOA 1XGOA 5FCFA 2GG7A 1YJ3A 1BN5A 3PKAA 3PKBA 1KQ9A 2G6PA 3CB5A 4PNCA 1W7VA 3L24A 2NQ6A 4U1BA 1QZYA 2Q93A 1M35A 5CDVA 1C22A 2GU6A 4FO8A 1XNZA 1CHMA 1WLRA 2BWSA 2GG8A 3IU8A 5JFRA 3MR1A 2OKNA 2V6CA 4S01A 2BWXA 3FMRA 3FMQA 1B59A 4FLJA 2GG9A 2V3XA 4OOKA 4EGEA 3PKDA 2BWWA 2Q96A 3CTZA 2HOWA 4IKTA 1R58A 2GG3A 1WKMA 1WN1A 1XGNA 1B6AA 1KQ0A 1WBQA 3PKEA 4IKUA 5JI6A 2GG2A 2Q92A 2P99A 1WL9A 2EVCA 3IU9A 1R5HA 5E5BA 4U73A 4U70A 1O0XA 1W2MA 3RVAA 3BITA 2BN7A 2IW2A 2OAZA 2Q94A 5CLSA 2EA4A 3RORA 2Q95A 5JHUA 4Z7MA 2GA2A 2DFIA 5CDEA 4U6WA 4KM3A 4A6VA 5CE6A 1WY2A 4U6JA 4U71A 2GU5A 1QXZA 3TB5A 4HXXA 2V3YA 4FO7A 2Q8KA 1WL6A 3IU7A 1C24A 3BIQA 4QR8A 4S2RP 2EVMA 1A16A 1BOAA 5CDLA 3S6BA 4FLIA 4U76A 1YW9A 5FCHA 2GG5A 2B3HA 2BB7A 2BHCA 2GU4A 2B3LA 1QXWA 2BHAA 1C27A 2BWVA 4FLKA 4PV4A 3IG4A 1C21A 4S2TP 4IECA 3BIPA 4RZYA 1XGSA 4IDYA 5D6FA 1JAWA 1Y1NA 3D27A 4RZZA 4ZWUA 4JUQA 2GG0A 4U6ZA 2P98A 2V3ZA 3PKCA 4IF7A 4U6EA 2BWUA 1QXYA 1YW7A 2ADUA 1MATA 3L7GA 4FKCA 1YVMA
chains in the Genus database with same CATH superfamily
2BHDA 2BWTA 4U6CA 2GTXA 4IKSA 2GGBA 3FM3A 1PV9A 1KP0A 3MATA 4U75A 2GU7A 2BWYA 5CNXA 4RGZ1 4U69A 2BH3A 2BHBA 1YW8A 2GZ5A 4ZNGA 4R60A 5D6EA 3TAVA 4A6WA 2P9AA 4FUKA 3CB6A 4ZWPA 2ZSGA 3MX6A 1R5GA 2MATA 2NQ7A 1N51A 4IPAA 2EVOA 4MATA 5CIKA 4S00A 1XGMA 4FLLA 3Q6DA 1C23A 2GGCA 4IU6A 4IKRA 2EA2A 2B3KA 4B28A 4ZWOA 1XGOA 5FCFA 2GG7A 1YJ3A 1BN5A 3PKAA 3PKBA 1KQ9A 2G6PA 3CB5A 4PNCA 1W7VA 3L24A 2NQ6A 4U1BA 1QZYA 2Q93A 1M35A 5CDVA 1C22A 2GU6A 4FO8A 1XNZA 1CHMA 1WLRA 2BWSA 2GG8A 3IU8A 5JFRA 3MR1A 2OKNA 2V6CA 4S01A 2BWXA 3FMRA 3FMQA 1B59A 4FLJA 2GG9A 2V3XA 4OOKA 4EGEA 3PKDA 2BWWA 2Q96A 3CTZA 2HOWA 4IKTA 1R58A 2GG3A 1WKMA 1WN1A 1XGNA 1B6AA 1KQ0A 1WBQA 3PKEA 4IKUA 5JI6A 2GG2A 2Q92A 2P99A 1WL9A 2EVCA 3IU9A 1R5HA 5E5BA 4U73A 4U70A 1O0XA 1W2MA 3RVAA 3BITA 2BN7A 2IW2A 2OAZA 2Q94A 5CLSA 2EA4A 3RORA 2Q95A 5JHUA 4Z7MA 2GA2A 2DFIA 5CDEA 4U6WA 4KM3A 4A6VA 5CE6A 1WY2A 4U6JA 4U71A 2GU5A 1QXZA 3TB5A 4HXXA 2V3YA 4FO7A 2Q8KA 1WL6A 3IU7A 1C24A 3BIQA 4QR8A 4S2RP 2EVMA 1A16A 1BOAA 5CDLA 3S6BA 4FLIA 4U76A 1YW9A 5FCHA 2GG5A 2B3HA 2BB7A 2BHCA 2GU4A 2B3LA 1QXWA 2BHAA 1C27A 2BWVA 4FLKA 4PV4A 3IG4A 1C21A 4S2TP 4IECA 3BIPA 4RZYA 1XGSA 4IDYA 5D6FA 1JAWA 1Y1NA 3D27A 4RZZA 4ZWUA 4JUQA 2GG0A 4U6ZA 2P98A 2V3ZA 3PKCA 4IF7A 4U6EA 2BWUA 1QXYA 1YW7A 2ADUA 1MATA 3L7GA 4FKCA 1YVMA
chains in the Genus database with same CATH topology
2BHDA 2BWTA 4U6CA 2GTXA 4IKSA 2GGBA 3FM3A 1PV9A 1KP0A 3MATA 4U75A 2GU7A 2BWYA 5CNXA 4RGZ1 4U69A 2BH3A 2BHBA 1YW8A 2GZ5A 4ZNGA 4R60A 5D6EA 3TAVA 4A6WA 2P9AA 4FUKA 3CB6A 4ZWPA 2ZSGA 3MX6A 1R5GA 2MATA 2NQ7A 1N51A 4IPAA 2EVOA 4MATA 5CIKA 4S00A 1XGMA 4FLLA 3Q6DA 1C23A 2GGCA 4IU6A 4IKRA 2EA2A 2B3KA 4B28A 4ZWOA 1XGOA 5FCFA 2GG7A 1YJ3A 1BN5A 3PKAA 3PKBA 1KQ9A 2G6PA 3CB5A 4PNCA 1W7VA 3L24A 2NQ6A 4U1BA 1QZYA 2Q93A 1M35A 5CDVA 1C22A 2GU6A 4FO8A 1XNZA 1CHMA 1WLRA 2BWSA 2GG8A 3IU8A 5JFRA 3MR1A 2OKNA 2V6CA 4S01A 2BWXA 3FMRA 3FMQA 1B59A 4FLJA 2GG9A 2V3XA 4OOKA 4EGEA 3PKDA 2BWWA 2Q96A 3CTZA 2HOWA 4IKTA 1R58A 2GG3A 1WKMA 1WN1A 1XGNA 1B6AA 1KQ0A 1WBQA 3PKEA 4IKUA 5JI6A 2GG2A 2Q92A 2P99A 1WL9A 2EVCA 3IU9A 1R5HA 5E5BA 4U73A 4U70A 1O0XA 1W2MA 3RVAA 3BITA 2BN7A 2IW2A 2OAZA 2Q94A 5CLSA 2EA4A 3RORA 2Q95A 5JHUA 4Z7MA 2GA2A 2DFIA 5CDEA 4U6WA 4KM3A 4A6VA 5CE6A 1WY2A 4U6JA 4U71A 2GU5A 1QXZA 3TB5A 4HXXA 2V3YA 4FO7A 2Q8KA 1WL6A 3IU7A 1C24A 3BIQA 4QR8A 4S2RP 2EVMA 1A16A 1BOAA 5CDLA 3S6BA 4FLIA 4U76A 1YW9A 5FCHA 2GG5A 2B3HA 2BB7A 2BHCA 2GU4A 2B3LA 1QXWA 2BHAA 1C27A 2BWVA 4FLKA 4PV4A 3IG4A 1C21A 4S2TP 4IECA 3BIPA 4RZYA 1XGSA 4IDYA 5D6FA 1JAWA 1Y1NA 3D27A 4RZZA 4ZWUA 4JUQA 2GG0A 4U6ZA 2P98A 2V3ZA 3PKCA 4IF7A 4U6EA 2BWUA 1QXYA 1YW7A 2ADUA 1MATA 3L7GA 4FKCA 1YVMA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 2BHD A;  2BWT A;  4U6C A;  2GTX A;  4IKS A;  2GGB A;  3FM3 A;  1PV9 A;  1KP0 A;  3MAT A;  4U75 A;  2GU7 A;  2BWY A;  5CNX A;  4RGZ 1;  4U69 A;  2BH3 A;  2BHB A;  1YW8 A;  2GZ5 A;  4ZNG A;  4R60 A;  5D6E A;  3TAV A;  4A6W A;  2P9A A;  4FUK A;  3CB6 A;  4ZWP A;  2ZSG A;  3MX6 A;  1R5G A;  2MAT A;  2NQ7 A;  1N51 A;  4IPA A;  2EVO A;  4MAT A;  5CIK A;  4S00 A;  1XGM A;  4FLL A;  3Q6D A;  1C23 A;  2GGC A;  4IU6 A;  4IKR A;  2EA2 A;  2B3K A;  4B28 A;  4ZWO A;  1XGO A;  5FCF A;  2GG7 A;  1YJ3 A;  1BN5 A;  3PKA A;  3PKB A;  1KQ9 A;  2G6P A;  3CB5 A;  4PNC A;  1W7V A;  3L24 A;  2NQ6 A;  4U1B A;  1QZY A;  2Q93 A;  1M35 A;  5CDV A;  1C22 A;  2GU6 A;  4FO8 A;  1XNZ A;  1CHM A;  1WLR A;  2BWS A;  2GG8 A;  3IU8 A;  5JFR A;  3MR1 A;  2OKN A;  2V6C A;  4S01 A;  2BWX A;  3FMR A;  3FMQ A;  1B59 A;  4FLJ A;  2GG9 A;  2V3X A;  4OOK A;  4EGE A;  3PKD A;  2BWW A;  2Q96 A;  3CTZ A;  2HOW A;  4IKT A;  1R58 A;  2GG3 A;  1WKM A;  1WN1 A;  1XGN A;  1B6A A;  1KQ0 A;  1WBQ A;  3PKE A;  4IKU A;  5JI6 A;  2GG2 A;  2Q92 A;  2P99 A;  1WL9 A;  2EVC A;  3IU9 A;  1R5H A;  5E5B A;  4U73 A;  4U70 A;  1O0X A;  1W2M A;  3RVA A;  3BIT A;  2BN7 A;  2IW2 A;  2OAZ A;  2Q94 A;  5CLS A;  2EA4 A;  3ROR A;  2Q95 A;  5JHU A;  4Z7M A;  2GA2 A;  2DFI A;  5CDE A;  4U6W A;  4KM3 A;  4A6V A;  5CE6 A;  1WY2 A;  4U6J A;  4U71 A;  2GU5 A;  1QXZ A;  3TB5 A;  4HXX A;  2V3Y A;  4FO7 A;  2Q8K A;  1WL6 A;  3IU7 A;  1C24 A;  3BIQ A;  4QR8 A;  4S2R P;  2EVM A;  1A16 A;  1BOA A;  5CDL A;  3S6B A;  4FLI A;  4U76 A;  1YW9 A;  5FCH A;  2GG5 A;  2B3H A;  2BB7 A;  2BHC A;  2GU4 A;  2B3L A;  1QXW A;  2BHA A;  1C27 A;  2BWV A;  4FLK A;  4PV4 A;  3IG4 A;  1C21 A;  4S2T P;  4IEC A;  3BIP A;  4RZY A;  1XGS A;  4IDY A;  5D6F A;  1JAW A;  1Y1N A;  3D27 A;  4RZZ A;  4ZWU A;  4JUQ A;  2GG0 A;  4U6Z A;  2P98 A;  2V3Z A;  3PKC A;  4IF7 A;  4U6E A;  2BWU A;  1QXY A;  1YW7 A;  2ADU A;  1MAT A;  3L7G A;  4FKC A;  1YVM A; 
#chains in the Genus database with same CATH topology
 2BHD A;  2BWT A;  4U6C A;  2GTX A;  4IKS A;  2GGB A;  3FM3 A;  1PV9 A;  1KP0 A;  3MAT A;  4U75 A;  2GU7 A;  2BWY A;  5CNX A;  4RGZ 1;  4U69 A;  2BH3 A;  2BHB A;  1YW8 A;  2GZ5 A;  4ZNG A;  4R60 A;  5D6E A;  3TAV A;  4A6W A;  2P9A A;  4FUK A;  3CB6 A;  4ZWP A;  2ZSG A;  3MX6 A;  1R5G A;  2MAT A;  2NQ7 A;  1N51 A;  4IPA A;  2EVO A;  4MAT A;  5CIK A;  4S00 A;  1XGM A;  4FLL A;  3Q6D A;  1C23 A;  2GGC A;  4IU6 A;  4IKR A;  2EA2 A;  2B3K A;  4B28 A;  4ZWO A;  1XGO A;  5FCF A;  2GG7 A;  1YJ3 A;  1BN5 A;  3PKA A;  3PKB A;  1KQ9 A;  2G6P A;  3CB5 A;  4PNC A;  1W7V A;  3L24 A;  2NQ6 A;  4U1B A;  1QZY A;  2Q93 A;  1M35 A;  5CDV A;  1C22 A;  2GU6 A;  4FO8 A;  1XNZ A;  1CHM A;  1WLR A;  2BWS A;  2GG8 A;  3IU8 A;  5JFR A;  3MR1 A;  2OKN A;  2V6C A;  4S01 A;  2BWX A;  3FMR A;  3FMQ A;  1B59 A;  4FLJ A;  2GG9 A;  2V3X A;  4OOK A;  4EGE A;  3PKD A;  2BWW A;  2Q96 A;  3CTZ A;  2HOW A;  4IKT A;  1R58 A;  2GG3 A;  1WKM A;  1WN1 A;  1XGN A;  1B6A A;  1KQ0 A;  1WBQ A;  3PKE A;  4IKU A;  5JI6 A;  2GG2 A;  2Q92 A;  2P99 A;  1WL9 A;  2EVC A;  3IU9 A;  1R5H A;  5E5B A;  4U73 A;  4U70 A;  1O0X A;  1W2M A;  3RVA A;  3BIT A;  2BN7 A;  2IW2 A;  2OAZ A;  2Q94 A;  5CLS A;  2EA4 A;  3ROR A;  2Q95 A;  5JHU A;  4Z7M A;  2GA2 A;  2DFI A;  5CDE A;  4U6W A;  4KM3 A;  4A6V A;  5CE6 A;  1WY2 A;  4U6J A;  4U71 A;  2GU5 A;  1QXZ A;  3TB5 A;  4HXX A;  2V3Y A;  4FO7 A;  2Q8K A;  1WL6 A;  3IU7 A;  1C24 A;  3BIQ A;  4QR8 A;  4S2R P;  2EVM A;  1A16 A;  1BOA A;  5CDL A;  3S6B A;  4FLI A;  4U76 A;  1YW9 A;  5FCH A;  2GG5 A;  2B3H A;  2BB7 A;  2BHC A;  2GU4 A;  2B3L A;  1QXW A;  2BHA A;  1C27 A;  2BWV A;  4FLK A;  4PV4 A;  3IG4 A;  1C21 A;  4S2T P;  4IEC A;  3BIP A;  4RZY A;  1XGS A;  4IDY A;  5D6F A;  1JAW A;  1Y1N A;  3D27 A;  4RZZ A;  4ZWU A;  4JUQ A;  2GG0 A;  4U6Z A;  2P98 A;  2V3Z A;  3PKC A;  4IF7 A;  4U6E A;  2BWU A;  1QXY A;  1YW7 A;  2ADU A;  1MAT A;  3L7G A;  4FKC A;  1YVM A; 
#chains in the Genus database with same CATH homology
 2BHD A;  2BWT A;  4U6C A;  2GTX A;  4IKS A;  2GGB A;  3FM3 A;  1PV9 A;  1KP0 A;  3MAT A;  4U75 A;  2GU7 A;  2BWY A;  5CNX A;  4RGZ 1;  4U69 A;  2BH3 A;  2BHB A;  1YW8 A;  2GZ5 A;  4ZNG A;  4R60 A;  5D6E A;  3TAV A;  4A6W A;  2P9A A;  4FUK A;  3CB6 A;  4ZWP A;  2ZSG A;  3MX6 A;  1R5G A;  2MAT A;  2NQ7 A;  1N51 A;  4IPA A;  2EVO A;  4MAT A;  5CIK A;  4S00 A;  1XGM A;  4FLL A;  3Q6D A;  1C23 A;  2GGC A;  4IU6 A;  4IKR A;  2EA2 A;  2B3K A;  4B28 A;  4ZWO A;  1XGO A;  5FCF A;  2GG7 A;  1YJ3 A;  1BN5 A;  3PKA A;  3PKB A;  1KQ9 A;  2G6P A;  3CB5 A;  4PNC A;  1W7V A;  3L24 A;  2NQ6 A;  4U1B A;  1QZY A;  2Q93 A;  1M35 A;  5CDV A;  1C22 A;  2GU6 A;  4FO8 A;  1XNZ A;  1CHM A;  1WLR A;  2BWS A;  2GG8 A;  3IU8 A;  5JFR A;  3MR1 A;  2OKN A;  2V6C A;  4S01 A;  2BWX A;  3FMR A;  3FMQ A;  1B59 A;  4FLJ A;  2GG9 A;  2V3X A;  4OOK A;  4EGE A;  3PKD A;  2BWW A;  2Q96 A;  3CTZ A;  2HOW A;  4IKT A;  1R58 A;  2GG3 A;  1WKM A;  1WN1 A;  1XGN A;  1B6A A;  1KQ0 A;  1WBQ A;  3PKE A;  4IKU A;  5JI6 A;  2GG2 A;  2Q92 A;  2P99 A;  1WL9 A;  2EVC A;  3IU9 A;  1R5H A;  5E5B A;  4U73 A;  4U70 A;  1O0X A;  1W2M A;  3RVA A;  3BIT A;  2BN7 A;  2IW2 A;  2OAZ A;  2Q94 A;  5CLS A;  2EA4 A;  3ROR A;  2Q95 A;  5JHU A;  4Z7M A;  2GA2 A;  2DFI A;  5CDE A;  4U6W A;  4KM3 A;  4A6V A;  5CE6 A;  1WY2 A;  4U6J A;  4U71 A;  2GU5 A;  1QXZ A;  3TB5 A;  4HXX A;  2V3Y A;  4FO7 A;  2Q8K A;  1WL6 A;  3IU7 A;  1C24 A;  3BIQ A;  4QR8 A;  4S2R P;  2EVM A;  1A16 A;  1BOA A;  5CDL A;  3S6B A;  4FLI A;  4U76 A;  1YW9 A;  5FCH A;  2GG5 A;  2B3H A;  2BB7 A;  2BHC A;  2GU4 A;  2B3L A;  1QXW A;  2BHA A;  1C27 A;  2BWV A;  4FLK A;  4PV4 A;  3IG4 A;  1C21 A;  4S2T P;  4IEC A;  3BIP A;  4RZY A;  1XGS A;  4IDY A;  5D6F A;  1JAW A;  1Y1N A;  3D27 A;  4RZZ A;  4ZWU A;  4JUQ A;  2GG0 A;  4U6Z A;  2P98 A;  2V3Z A;  3PKC A;  4IF7 A;  4U6E A;  2BWU A;  1QXY A;  1YW7 A;  2ADU A;  1MAT A;  3L7G A;  4FKC A;  1YVM A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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