4FLJA

Human metap1 with bengamide analog y08, in mn form
Total Genus 99
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
99
sequence length
304
structure length
304
Chain Sequence
YRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLFHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARPHFMS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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molecule tags Hydrolase/hydrolase inhibitor
molecule keywords Methionine aminopeptidase 1
publication title Structural analysis of bengamide derivatives as inhibitors of methionine aminopeptidases.
pubmed doi rcsb
source organism Homo sapiens
total genus 99
structure length 304
sequence length 304
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2012-06-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4fljA00
2GGCA 3RORA 1CHMA 1PV9A 2NQ7A 2G6PA 2GZ5A 3IU9A 3CB5A 1O0XA 3FM3A 1YW7A 4S01A 2B3HA 4ZWOA 2EA2A 3L24A 3PKCA 2V3XA 2BWVA 3L7GA 2DFIA 4U6CA 2GG8A 2HOWA 1XGMA 4MATA 4U75A 2P99A 2BHBA 2Q93A 2Q8KA 4FLIA 3BIPA 2MATA 4HXXA 1KQ0A 4IKUA 4RZYA 4U6WA 1KQ9A 1KP0A 1M35A 4S2RP 4KM3A 1C21A 4U70A 2V3YA 2BH3A 1WY2A 2OKNA 3MATA 5CNXA 1C23A 3D27A 4RZZA 4U6ZA 2GG2A 3FMRA 2ADUA 4A6VA 1R5GA 2V6CA 2ZSGA 5CIKA 3Q6DA 1WBQA 3IU8A 1JAWA 5JI6A 2Q92A 2BWTA 2Q95A 5JFRA 4IKTA 1WLRA 2GGBA 2V3ZA 1A16A 1MATA 4IECA 4U1BA 1WKMA 4FO7A 2B3KA 1YW8A 2NQ6A 2BWXA 2OAZA 3RVAA 3CB6A 2GA2A 4IDYA 4PNCA 2IW2A 5FCHA 4QR8A 2GU5A 4ZWPA 2B3LA 2BN7A 4FLLA 1BN5A 1QXZA 2EVCA 2GG9A 4U71A 5FCFA 2GU7A 4PV4A 4FO8A 4IF7A 2BWWA 2GG5A 3FMQA 2BHCA 3TB5A 4S00A 1N51A 1QXYA 3PKBA 4A6WA 2BWSA 3IU7A 1YW9A 4ZWUA 1XGSA 3BITA 3MX6A 4FUKA 3S6BA 1C24A 4IKSA 5D6EA 2GG0A 4U69A 2GG7A 2Q94A 4Z7MA 1YVMA 1R5HA 2Q96A 5CDLA 4EGEA 2EVOA 2GG3A 1WL9A 1QZYA 2GTXA 4U6JA 2BWYA 2BHAA 4IPAA 3PKDA 2BB7A 1QXWA 3PKEA 5E5BA 5CDVA 1C27A 1W7VA 3IG4A 2GU4A 4RGZ1 4U73A 1YJ3A 5CLSA 5CDEA 1WL6A 4FLKA 4B28A 4U6EA 2BWUA 3CTZA 1XGNA 1XNZA 2GU6A 5JHUA 1B6AA 4S2TP 4FKCA 1W2MA 4ZNGA 1XGOA 3TAVA 4FLJA 2P98A 4U76A 4R60A 4IKRA 5CE6A 1B59A 1R58A 3MR1A 1C22A 1WN1A 1BOAA 2EVMA 2P9AA 4JUQA 4OOKA 4IU6A 5D6FA 2EA4A 3PKAA 1Y1NA 3BIQA 2BHDA
chains in the Genus database with same CATH superfamily
2GGCA 3RORA 1CHMA 1PV9A 2NQ7A 2G6PA 2GZ5A 3IU9A 3CB5A 1O0XA 3FM3A 1YW7A 4S01A 2B3HA 4ZWOA 2EA2A 3L24A 3PKCA 2V3XA 2BWVA 3L7GA 2DFIA 4U6CA 2GG8A 2HOWA 1XGMA 4MATA 4U75A 2P99A 2BHBA 2Q93A 2Q8KA 4FLIA 3BIPA 2MATA 4HXXA 1KQ0A 4IKUA 4RZYA 4U6WA 1KQ9A 1KP0A 1M35A 4S2RP 4KM3A 1C21A 4U70A 2V3YA 2BH3A 1WY2A 2OKNA 3MATA 5CNXA 1C23A 3D27A 4RZZA 4U6ZA 2GG2A 3FMRA 2ADUA 4A6VA 1R5GA 2V6CA 2ZSGA 5CIKA 3Q6DA 1WBQA 3IU8A 1JAWA 5JI6A 2Q92A 2BWTA 2Q95A 5JFRA 4IKTA 1WLRA 2GGBA 2V3ZA 1A16A 1MATA 4IECA 4U1BA 1WKMA 4FO7A 2B3KA 1YW8A 2NQ6A 2BWXA 2OAZA 3RVAA 3CB6A 2GA2A 4IDYA 4PNCA 2IW2A 5FCHA 4QR8A 2GU5A 4ZWPA 2B3LA 2BN7A 4FLLA 1BN5A 1QXZA 2EVCA 2GG9A 4U71A 5FCFA 2GU7A 4PV4A 4FO8A 4IF7A 2BWWA 2GG5A 3FMQA 2BHCA 3TB5A 4S00A 1N51A 1QXYA 3PKBA 4A6WA 2BWSA 3IU7A 1YW9A 4ZWUA 1XGSA 3BITA 3MX6A 4FUKA 3S6BA 1C24A 4IKSA 5D6EA 2GG0A 4U69A 2GG7A 2Q94A 4Z7MA 1YVMA 1R5HA 2Q96A 5CDLA 4EGEA 2EVOA 2GG3A 1WL9A 1QZYA 2GTXA 4U6JA 2BWYA 2BHAA 4IPAA 3PKDA 2BB7A 1QXWA 3PKEA 5E5BA 5CDVA 1C27A 1W7VA 3IG4A 2GU4A 4RGZ1 4U73A 1YJ3A 5CLSA 5CDEA 1WL6A 4FLKA 4B28A 4U6EA 2BWUA 3CTZA 1XGNA 1XNZA 2GU6A 5JHUA 1B6AA 4S2TP 4FKCA 1W2MA 4ZNGA 1XGOA 3TAVA 4FLJA 2P98A 4U76A 4R60A 4IKRA 5CE6A 1B59A 1R58A 3MR1A 1C22A 1WN1A 1BOAA 2EVMA 2P9AA 4JUQA 4OOKA 4IU6A 5D6FA 2EA4A 3PKAA 1Y1NA 3BIQA 2BHDA
chains in the Genus database with same CATH topology
2GGCA 3RORA 1CHMA 1PV9A 2NQ7A 2G6PA 2GZ5A 3IU9A 3CB5A 1O0XA 3FM3A 1YW7A 4S01A 2B3HA 4ZWOA 2EA2A 3L24A 3PKCA 2V3XA 2BWVA 3L7GA 2DFIA 4U6CA 2GG8A 2HOWA 1XGMA 4MATA 4U75A 2P99A 2BHBA 2Q93A 2Q8KA 4FLIA 3BIPA 2MATA 4HXXA 1KQ0A 4IKUA 4RZYA 4U6WA 1KQ9A 1KP0A 1M35A 4S2RP 4KM3A 1C21A 4U70A 2V3YA 2BH3A 1WY2A 2OKNA 3MATA 5CNXA 1C23A 3D27A 4RZZA 4U6ZA 2GG2A 3FMRA 2ADUA 4A6VA 1R5GA 2V6CA 2ZSGA 5CIKA 3Q6DA 1WBQA 3IU8A 1JAWA 5JI6A 2Q92A 2BWTA 2Q95A 5JFRA 4IKTA 1WLRA 2GGBA 2V3ZA 1A16A 1MATA 4IECA 4U1BA 1WKMA 4FO7A 2B3KA 1YW8A 2NQ6A 2BWXA 2OAZA 3RVAA 3CB6A 2GA2A 4IDYA 4PNCA 2IW2A 5FCHA 4QR8A 2GU5A 4ZWPA 2B3LA 2BN7A 4FLLA 1BN5A 1QXZA 2EVCA 2GG9A 4U71A 5FCFA 2GU7A 4PV4A 4FO8A 4IF7A 2BWWA 2GG5A 3FMQA 2BHCA 3TB5A 4S00A 1N51A 1QXYA 3PKBA 4A6WA 2BWSA 3IU7A 1YW9A 4ZWUA 1XGSA 3BITA 3MX6A 4FUKA 3S6BA 1C24A 4IKSA 5D6EA 2GG0A 4U69A 2GG7A 2Q94A 4Z7MA 1YVMA 1R5HA 2Q96A 5CDLA 4EGEA 2EVOA 2GG3A 1WL9A 1QZYA 2GTXA 4U6JA 2BWYA 2BHAA 4IPAA 3PKDA 2BB7A 1QXWA 3PKEA 5E5BA 5CDVA 1C27A 1W7VA 3IG4A 2GU4A 4RGZ1 4U73A 1YJ3A 5CLSA 5CDEA 1WL6A 4FLKA 4B28A 4U6EA 2BWUA 3CTZA 1XGNA 1XNZA 2GU6A 5JHUA 1B6AA 4S2TP 4FKCA 1W2MA 4ZNGA 1XGOA 3TAVA 4FLJA 2P98A 4U76A 4R60A 4IKRA 5CE6A 1B59A 1R58A 3MR1A 1C22A 1WN1A 1BOAA 2EVMA 2P9AA 4JUQA 4OOKA 4IU6A 5D6FA 2EA4A 3PKAA 1Y1NA 3BIQA 2BHDA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 2GGC A;  3ROR A;  1CHM A;  1PV9 A;  2NQ7 A;  2G6P A;  2GZ5 A;  3IU9 A;  3CB5 A;  1O0X A;  3FM3 A;  1YW7 A;  4S01 A;  2B3H A;  4ZWO A;  2EA2 A;  3L24 A;  3PKC A;  2V3X A;  2BWV A;  3L7G A;  2DFI A;  4U6C A;  2GG8 A;  2HOW A;  1XGM A;  4MAT A;  4U75 A;  2P99 A;  2BHB A;  2Q93 A;  2Q8K A;  4FLI A;  3BIP A;  2MAT A;  4HXX A;  1KQ0 A;  4IKU A;  4RZY A;  4U6W A;  1KQ9 A;  1KP0 A;  1M35 A;  4S2R P;  4KM3 A;  1C21 A;  4U70 A;  2V3Y A;  2BH3 A;  1WY2 A;  2OKN A;  3MAT A;  5CNX A;  1C23 A;  3D27 A;  4RZZ A;  4U6Z A;  2GG2 A;  3FMR A;  2ADU A;  4A6V A;  1R5G A;  2V6C A;  2ZSG A;  5CIK A;  3Q6D A;  1WBQ A;  3IU8 A;  1JAW A;  5JI6 A;  2Q92 A;  2BWT A;  2Q95 A;  5JFR A;  4IKT A;  1WLR A;  2GGB A;  2V3Z A;  1A16 A;  1MAT A;  4IEC A;  4U1B A;  1WKM A;  4FO7 A;  2B3K A;  1YW8 A;  2NQ6 A;  2BWX A;  2OAZ A;  3RVA A;  3CB6 A;  2GA2 A;  4IDY A;  4PNC A;  2IW2 A;  5FCH A;  4QR8 A;  2GU5 A;  4ZWP A;  2B3L A;  2BN7 A;  4FLL A;  1BN5 A;  1QXZ A;  2EVC A;  2GG9 A;  4U71 A;  5FCF A;  2GU7 A;  4PV4 A;  4FO8 A;  4IF7 A;  2BWW A;  2GG5 A;  3FMQ A;  2BHC A;  3TB5 A;  4S00 A;  1N51 A;  1QXY A;  3PKB A;  4A6W A;  2BWS A;  3IU7 A;  1YW9 A;  4ZWU A;  1XGS A;  3BIT A;  3MX6 A;  4FUK A;  3S6B A;  1C24 A;  4IKS A;  5D6E A;  2GG0 A;  4U69 A;  2GG7 A;  2Q94 A;  4Z7M A;  1YVM A;  1R5H A;  2Q96 A;  5CDL A;  4EGE A;  2EVO A;  2GG3 A;  1WL9 A;  1QZY A;  2GTX A;  4U6J A;  2BWY A;  2BHA A;  4IPA A;  3PKD A;  2BB7 A;  1QXW A;  3PKE A;  5E5B A;  5CDV A;  1C27 A;  1W7V A;  3IG4 A;  2GU4 A;  4RGZ 1;  4U73 A;  1YJ3 A;  5CLS A;  5CDE A;  1WL6 A;  4FLK A;  4B28 A;  4U6E A;  2BWU A;  3CTZ A;  1XGN A;  1XNZ A;  2GU6 A;  5JHU A;  1B6A A;  4S2T P;  4FKC A;  1W2M A;  4ZNG A;  1XGO A;  3TAV A;  4FLJ A;  2P98 A;  4U76 A;  4R60 A;  4IKR A;  5CE6 A;  1B59 A;  1R58 A;  3MR1 A;  1C22 A;  1WN1 A;  1BOA A;  2EVM A;  2P9A A;  4JUQ A;  4OOK A;  4IU6 A;  5D6F A;  2EA4 A;  3PKA A;  1Y1N A;  3BIQ A;  2BHD A; 
#chains in the Genus database with same CATH topology
 2GGC A;  3ROR A;  1CHM A;  1PV9 A;  2NQ7 A;  2G6P A;  2GZ5 A;  3IU9 A;  3CB5 A;  1O0X A;  3FM3 A;  1YW7 A;  4S01 A;  2B3H A;  4ZWO A;  2EA2 A;  3L24 A;  3PKC A;  2V3X A;  2BWV A;  3L7G A;  2DFI A;  4U6C A;  2GG8 A;  2HOW A;  1XGM A;  4MAT A;  4U75 A;  2P99 A;  2BHB A;  2Q93 A;  2Q8K A;  4FLI A;  3BIP A;  2MAT A;  4HXX A;  1KQ0 A;  4IKU A;  4RZY A;  4U6W A;  1KQ9 A;  1KP0 A;  1M35 A;  4S2R P;  4KM3 A;  1C21 A;  4U70 A;  2V3Y A;  2BH3 A;  1WY2 A;  2OKN A;  3MAT A;  5CNX A;  1C23 A;  3D27 A;  4RZZ A;  4U6Z A;  2GG2 A;  3FMR A;  2ADU A;  4A6V A;  1R5G A;  2V6C A;  2ZSG A;  5CIK A;  3Q6D A;  1WBQ A;  3IU8 A;  1JAW A;  5JI6 A;  2Q92 A;  2BWT A;  2Q95 A;  5JFR A;  4IKT A;  1WLR A;  2GGB A;  2V3Z A;  1A16 A;  1MAT A;  4IEC A;  4U1B A;  1WKM A;  4FO7 A;  2B3K A;  1YW8 A;  2NQ6 A;  2BWX A;  2OAZ A;  3RVA A;  3CB6 A;  2GA2 A;  4IDY A;  4PNC A;  2IW2 A;  5FCH A;  4QR8 A;  2GU5 A;  4ZWP A;  2B3L A;  2BN7 A;  4FLL A;  1BN5 A;  1QXZ A;  2EVC A;  2GG9 A;  4U71 A;  5FCF A;  2GU7 A;  4PV4 A;  4FO8 A;  4IF7 A;  2BWW A;  2GG5 A;  3FMQ A;  2BHC A;  3TB5 A;  4S00 A;  1N51 A;  1QXY A;  3PKB A;  4A6W A;  2BWS A;  3IU7 A;  1YW9 A;  4ZWU A;  1XGS A;  3BIT A;  3MX6 A;  4FUK A;  3S6B A;  1C24 A;  4IKS A;  5D6E A;  2GG0 A;  4U69 A;  2GG7 A;  2Q94 A;  4Z7M A;  1YVM A;  1R5H A;  2Q96 A;  5CDL A;  4EGE A;  2EVO A;  2GG3 A;  1WL9 A;  1QZY A;  2GTX A;  4U6J A;  2BWY A;  2BHA A;  4IPA A;  3PKD A;  2BB7 A;  1QXW A;  3PKE A;  5E5B A;  5CDV A;  1C27 A;  1W7V A;  3IG4 A;  2GU4 A;  4RGZ 1;  4U73 A;  1YJ3 A;  5CLS A;  5CDE A;  1WL6 A;  4FLK A;  4B28 A;  4U6E A;  2BWU A;  3CTZ A;  1XGN A;  1XNZ A;  2GU6 A;  5JHU A;  1B6A A;  4S2T P;  4FKC A;  1W2M A;  4ZNG A;  1XGO A;  3TAV A;  4FLJ A;  2P98 A;  4U76 A;  4R60 A;  4IKR A;  5CE6 A;  1B59 A;  1R58 A;  3MR1 A;  1C22 A;  1WN1 A;  1BOA A;  2EVM A;  2P9A A;  4JUQ A;  4OOK A;  4IU6 A;  5D6F A;  2EA4 A;  3PKA A;  1Y1N A;  3BIQ A;  2BHD A; 
#chains in the Genus database with same CATH homology
 2GGC A;  3ROR A;  1CHM A;  1PV9 A;  2NQ7 A;  2G6P A;  2GZ5 A;  3IU9 A;  3CB5 A;  1O0X A;  3FM3 A;  1YW7 A;  4S01 A;  2B3H A;  4ZWO A;  2EA2 A;  3L24 A;  3PKC A;  2V3X A;  2BWV A;  3L7G A;  2DFI A;  4U6C A;  2GG8 A;  2HOW A;  1XGM A;  4MAT A;  4U75 A;  2P99 A;  2BHB A;  2Q93 A;  2Q8K A;  4FLI A;  3BIP A;  2MAT A;  4HXX A;  1KQ0 A;  4IKU A;  4RZY A;  4U6W A;  1KQ9 A;  1KP0 A;  1M35 A;  4S2R P;  4KM3 A;  1C21 A;  4U70 A;  2V3Y A;  2BH3 A;  1WY2 A;  2OKN A;  3MAT A;  5CNX A;  1C23 A;  3D27 A;  4RZZ A;  4U6Z A;  2GG2 A;  3FMR A;  2ADU A;  4A6V A;  1R5G A;  2V6C A;  2ZSG A;  5CIK A;  3Q6D A;  1WBQ A;  3IU8 A;  1JAW A;  5JI6 A;  2Q92 A;  2BWT A;  2Q95 A;  5JFR A;  4IKT A;  1WLR A;  2GGB A;  2V3Z A;  1A16 A;  1MAT A;  4IEC A;  4U1B A;  1WKM A;  4FO7 A;  2B3K A;  1YW8 A;  2NQ6 A;  2BWX A;  2OAZ A;  3RVA A;  3CB6 A;  2GA2 A;  4IDY A;  4PNC A;  2IW2 A;  5FCH A;  4QR8 A;  2GU5 A;  4ZWP A;  2B3L A;  2BN7 A;  4FLL A;  1BN5 A;  1QXZ A;  2EVC A;  2GG9 A;  4U71 A;  5FCF A;  2GU7 A;  4PV4 A;  4FO8 A;  4IF7 A;  2BWW A;  2GG5 A;  3FMQ A;  2BHC A;  3TB5 A;  4S00 A;  1N51 A;  1QXY A;  3PKB A;  4A6W A;  2BWS A;  3IU7 A;  1YW9 A;  4ZWU A;  1XGS A;  3BIT A;  3MX6 A;  4FUK A;  3S6B A;  1C24 A;  4IKS A;  5D6E A;  2GG0 A;  4U69 A;  2GG7 A;  2Q94 A;  4Z7M A;  1YVM A;  1R5H A;  2Q96 A;  5CDL A;  4EGE A;  2EVO A;  2GG3 A;  1WL9 A;  1QZY A;  2GTX A;  4U6J A;  2BWY A;  2BHA A;  4IPA A;  3PKD A;  2BB7 A;  1QXW A;  3PKE A;  5E5B A;  5CDV A;  1C27 A;  1W7V A;  3IG4 A;  2GU4 A;  4RGZ 1;  4U73 A;  1YJ3 A;  5CLS A;  5CDE A;  1WL6 A;  4FLK A;  4B28 A;  4U6E A;  2BWU A;  3CTZ A;  1XGN A;  1XNZ A;  2GU6 A;  5JHU A;  1B6A A;  4S2T P;  4FKC A;  1W2M A;  4ZNG A;  1XGO A;  3TAV A;  4FLJ A;  2P98 A;  4U76 A;  4R60 A;  4IKR A;  5CE6 A;  1B59 A;  1R58 A;  3MR1 A;  1C22 A;  1WN1 A;  1BOA A;  2EVM A;  2P9A A;  4JUQ A;  4OOK A;  4IU6 A;  5D6F A;  2EA4 A;  3PKA A;  1Y1N A;  3BIQ A;  2BHD A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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