2P99A

E. coli methionine aminopeptidase monometalated with inhibitor ye6
Total Genus 85
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
85
sequence length
261
structure length
261
Chain Sequence
AISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGRGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISH
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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molecule tags Hydrolase
molecule keywords Methionine aminopeptidase
publication title Inhibition of Monometalated Methionine Aminopeptidase: Inhibitor Discovery and Crystallographic Analysis.
pubmed doi rcsb
source organism Escherichia coli
total genus 85
structure length 261
sequence length 261
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2007-03-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 2p99A00
4A6VA 4U6ZA 2GU4A 2Q92A 2OAZA 2BWXA 4IPAA 4IKUA 1C22A 2BHAA 5JHUA 2GG7A 4U6CA 1N51A 1R5GA 3MR1A 2Q93A 2GG0A 4MATA 2ZSGA 1MATA 2BWVA 4IU6A 3PKEA 4U76A 5CLSA 4ZWOA 3RORA 1YJ3A 1C21A 4IF7A 1YW8A 2Q94A 4ZWPA 3L24A 1QZYA 2EVCA 2GU6A 5E5BA 2NQ7A 1W2MA 1YW9A 3TAVA 3BITA 4U6EA 4FLJA 2GA2A 2P99A 2P9AA 2GG3A 1XGSA 3BIQA 1QXWA 2EVMA 2BWTA 2GGCA 2GG5A 3S6BA 3CTZA 3FM3A 2B3KA 3IU8A 5CIKA 2BB7A 4IKRA 4S01A 3BIPA 3Q6DA 3TB5A 4FLLA 2B3HA 2EVOA 1XGNA 4U6JA 3FMRA 1XGOA 4IDYA 5CNXA 2V3XA 4HXXA 1KP0A 1WLRA 4IKSA 3CB5A 2BWSA 2OKNA 4PNCA 4JUQA 3IU7A 2V6CA 3IU9A 1CHMA 4U69A 1M35A 1R5HA 2HOWA 2DFIA 3FMQA 2BHBA 4U6WA 4FLIA 5D6EA 5JFRA 3PKBA 4PV4A 2BWYA 2BWWA 4S00A 4FKCA 3MATA 4U71A 2BWUA 5CDVA 1JAWA 1KQ9A 1QXYA 4RGZ1 3D27A 2V3YA 4U75A 4IKTA 2GU7A 5FCHA 1R58A 4FO7A 4IECA 4RZZA 1B6AA 2BHDA 2G6PA 3IG4A 4FLKA 1WL6A 5D6FA 1O0XA 1BOAA 4FUKA 2BHCA 3CB6A 1C24A 2ADUA 1YW7A 4U70A 3MX6A 1BN5A 4A6WA 5CDEA 2IW2A 4S2RP 4U73A 5FCFA 1Y1NA 4ZNGA 2Q96A 2GGBA 2GG9A 1WY2A 4S2TP 2BN7A 1C27A 3PKAA 1PV9A 1WN1A 3PKDA 4RZYA 1XNZA 2GTXA 2P98A 2GG8A 4B28A 2GU5A 1YVMA 4U1BA 4KM3A 1B59A 2BH3A 4ZWUA 4Z7MA 1C23A 2GG2A 3L7GA 5CE6A 1QXZA 2EA4A 2MATA 1W7VA 3RVAA 1WKMA 1KQ0A 1A16A 3PKCA 4QR8A 2B3LA 2Q95A 2EA2A 1XGMA 1WBQA 4EGEA 5JI6A 5CDLA 4R60A 2NQ6A 2Q8KA 2GZ5A 2V3ZA 4FO8A 1WL9A 4OOKA
chains in the Genus database with same CATH superfamily
4A6VA 4U6ZA 2GU4A 2Q92A 2OAZA 2BWXA 4IPAA 4IKUA 1C22A 2BHAA 5JHUA 2GG7A 4U6CA 1N51A 1R5GA 3MR1A 2Q93A 2GG0A 4MATA 2ZSGA 1MATA 2BWVA 4IU6A 3PKEA 4U76A 5CLSA 4ZWOA 3RORA 1YJ3A 1C21A 4IF7A 1YW8A 2Q94A 4ZWPA 3L24A 1QZYA 2EVCA 2GU6A 5E5BA 2NQ7A 1W2MA 1YW9A 3TAVA 3BITA 4U6EA 4FLJA 2GA2A 2P99A 2P9AA 2GG3A 1XGSA 3BIQA 1QXWA 2EVMA 2BWTA 2GGCA 2GG5A 3S6BA 3CTZA 3FM3A 2B3KA 3IU8A 5CIKA 2BB7A 4IKRA 4S01A 3BIPA 3Q6DA 3TB5A 4FLLA 2B3HA 2EVOA 1XGNA 4U6JA 3FMRA 1XGOA 4IDYA 5CNXA 2V3XA 4HXXA 1KP0A 1WLRA 4IKSA 3CB5A 2BWSA 2OKNA 4PNCA 4JUQA 3IU7A 2V6CA 3IU9A 1CHMA 4U69A 1M35A 1R5HA 2HOWA 2DFIA 3FMQA 2BHBA 4U6WA 4FLIA 5D6EA 5JFRA 3PKBA 4PV4A 2BWYA 2BWWA 4S00A 4FKCA 3MATA 4U71A 2BWUA 5CDVA 1JAWA 1KQ9A 1QXYA 4RGZ1 3D27A 2V3YA 4U75A 4IKTA 2GU7A 5FCHA 1R58A 4FO7A 4IECA 4RZZA 1B6AA 2BHDA 2G6PA 3IG4A 4FLKA 1WL6A 5D6FA 1O0XA 1BOAA 4FUKA 2BHCA 3CB6A 1C24A 2ADUA 1YW7A 4U70A 3MX6A 1BN5A 4A6WA 5CDEA 2IW2A 4S2RP 4U73A 5FCFA 1Y1NA 4ZNGA 2Q96A 2GGBA 2GG9A 1WY2A 4S2TP 2BN7A 1C27A 3PKAA 1PV9A 1WN1A 3PKDA 4RZYA 1XNZA 2GTXA 2P98A 2GG8A 4B28A 2GU5A 1YVMA 4U1BA 4KM3A 1B59A 2BH3A 4ZWUA 4Z7MA 1C23A 2GG2A 3L7GA 5CE6A 1QXZA 2EA4A 2MATA 1W7VA 3RVAA 1WKMA 1KQ0A 1A16A 3PKCA 4QR8A 2B3LA 2Q95A 2EA2A 1XGMA 1WBQA 4EGEA 5JI6A 5CDLA 4R60A 2NQ6A 2Q8KA 2GZ5A 2V3ZA 4FO8A 1WL9A 4OOKA
chains in the Genus database with same CATH topology
4A6VA 4U6ZA 2GU4A 2Q92A 2OAZA 2BWXA 4IPAA 4IKUA 1C22A 2BHAA 5JHUA 2GG7A 4U6CA 1N51A 1R5GA 3MR1A 2Q93A 2GG0A 4MATA 2ZSGA 1MATA 2BWVA 4IU6A 3PKEA 4U76A 5CLSA 4ZWOA 3RORA 1YJ3A 1C21A 4IF7A 1YW8A 2Q94A 4ZWPA 3L24A 1QZYA 2EVCA 2GU6A 5E5BA 2NQ7A 1W2MA 1YW9A 3TAVA 3BITA 4U6EA 4FLJA 2GA2A 2P99A 2P9AA 2GG3A 1XGSA 3BIQA 1QXWA 2EVMA 2BWTA 2GGCA 2GG5A 3S6BA 3CTZA 3FM3A 2B3KA 3IU8A 5CIKA 2BB7A 4IKRA 4S01A 3BIPA 3Q6DA 3TB5A 4FLLA 2B3HA 2EVOA 1XGNA 4U6JA 3FMRA 1XGOA 4IDYA 5CNXA 2V3XA 4HXXA 1KP0A 1WLRA 4IKSA 3CB5A 2BWSA 2OKNA 4PNCA 4JUQA 3IU7A 2V6CA 3IU9A 1CHMA 4U69A 1M35A 1R5HA 2HOWA 2DFIA 3FMQA 2BHBA 4U6WA 4FLIA 5D6EA 5JFRA 3PKBA 4PV4A 2BWYA 2BWWA 4S00A 4FKCA 3MATA 4U71A 2BWUA 5CDVA 1JAWA 1KQ9A 1QXYA 4RGZ1 3D27A 2V3YA 4U75A 4IKTA 2GU7A 5FCHA 1R58A 4FO7A 4IECA 4RZZA 1B6AA 2BHDA 2G6PA 3IG4A 4FLKA 1WL6A 5D6FA 1O0XA 1BOAA 4FUKA 2BHCA 3CB6A 1C24A 2ADUA 1YW7A 4U70A 3MX6A 1BN5A 4A6WA 5CDEA 2IW2A 4S2RP 4U73A 5FCFA 1Y1NA 4ZNGA 2Q96A 2GGBA 2GG9A 1WY2A 4S2TP 2BN7A 1C27A 3PKAA 1PV9A 1WN1A 3PKDA 4RZYA 1XNZA 2GTXA 2P98A 2GG8A 4B28A 2GU5A 1YVMA 4U1BA 4KM3A 1B59A 2BH3A 4ZWUA 4Z7MA 1C23A 2GG2A 3L7GA 5CE6A 1QXZA 2EA4A 2MATA 1W7VA 3RVAA 1WKMA 1KQ0A 1A16A 3PKCA 4QR8A 2B3LA 2Q95A 2EA2A 1XGMA 1WBQA 4EGEA 5JI6A 5CDLA 4R60A 2NQ6A 2Q8KA 2GZ5A 2V3ZA 4FO8A 1WL9A 4OOKA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 4A6V A;  4U6Z A;  2GU4 A;  2Q92 A;  2OAZ A;  2BWX A;  4IPA A;  4IKU A;  1C22 A;  2BHA A;  5JHU A;  2GG7 A;  4U6C A;  1N51 A;  1R5G A;  3MR1 A;  2Q93 A;  2GG0 A;  4MAT A;  2ZSG A;  1MAT A;  2BWV A;  4IU6 A;  3PKE A;  4U76 A;  5CLS A;  4ZWO A;  3ROR A;  1YJ3 A;  1C21 A;  4IF7 A;  1YW8 A;  2Q94 A;  4ZWP A;  3L24 A;  1QZY A;  2EVC A;  2GU6 A;  5E5B A;  2NQ7 A;  1W2M A;  1YW9 A;  3TAV A;  3BIT A;  4U6E A;  4FLJ A;  2GA2 A;  2P99 A;  2P9A A;  2GG3 A;  1XGS A;  3BIQ A;  1QXW A;  2EVM A;  2BWT A;  2GGC A;  2GG5 A;  3S6B A;  3CTZ A;  3FM3 A;  2B3K A;  3IU8 A;  5CIK A;  2BB7 A;  4IKR A;  4S01 A;  3BIP A;  3Q6D A;  3TB5 A;  4FLL A;  2B3H A;  2EVO A;  1XGN A;  4U6J A;  3FMR A;  1XGO A;  4IDY A;  5CNX A;  2V3X A;  4HXX A;  1KP0 A;  1WLR A;  4IKS A;  3CB5 A;  2BWS A;  2OKN A;  4PNC A;  4JUQ A;  3IU7 A;  2V6C A;  3IU9 A;  1CHM A;  4U69 A;  1M35 A;  1R5H A;  2HOW A;  2DFI A;  3FMQ A;  2BHB A;  4U6W A;  4FLI A;  5D6E A;  5JFR A;  3PKB A;  4PV4 A;  2BWY A;  2BWW A;  4S00 A;  4FKC A;  3MAT A;  4U71 A;  2BWU A;  5CDV A;  1JAW A;  1KQ9 A;  1QXY A;  4RGZ 1;  3D27 A;  2V3Y A;  4U75 A;  4IKT A;  2GU7 A;  5FCH A;  1R58 A;  4FO7 A;  4IEC A;  4RZZ A;  1B6A A;  2BHD A;  2G6P A;  3IG4 A;  4FLK A;  1WL6 A;  5D6F A;  1O0X A;  1BOA A;  4FUK A;  2BHC A;  3CB6 A;  1C24 A;  2ADU A;  1YW7 A;  4U70 A;  3MX6 A;  1BN5 A;  4A6W A;  5CDE A;  2IW2 A;  4S2R P;  4U73 A;  5FCF A;  1Y1N A;  4ZNG A;  2Q96 A;  2GGB A;  2GG9 A;  1WY2 A;  4S2T P;  2BN7 A;  1C27 A;  3PKA A;  1PV9 A;  1WN1 A;  3PKD A;  4RZY A;  1XNZ A;  2GTX A;  2P98 A;  2GG8 A;  4B28 A;  2GU5 A;  1YVM A;  4U1B A;  4KM3 A;  1B59 A;  2BH3 A;  4ZWU A;  4Z7M A;  1C23 A;  2GG2 A;  3L7G A;  5CE6 A;  1QXZ A;  2EA4 A;  2MAT A;  1W7V A;  3RVA A;  1WKM A;  1KQ0 A;  1A16 A;  3PKC A;  4QR8 A;  2B3L A;  2Q95 A;  2EA2 A;  1XGM A;  1WBQ A;  4EGE A;  5JI6 A;  5CDL A;  4R60 A;  2NQ6 A;  2Q8K A;  2GZ5 A;  2V3Z A;  4FO8 A;  1WL9 A;  4OOK A; 
#chains in the Genus database with same CATH topology
 4A6V A;  4U6Z A;  2GU4 A;  2Q92 A;  2OAZ A;  2BWX A;  4IPA A;  4IKU A;  1C22 A;  2BHA A;  5JHU A;  2GG7 A;  4U6C A;  1N51 A;  1R5G A;  3MR1 A;  2Q93 A;  2GG0 A;  4MAT A;  2ZSG A;  1MAT A;  2BWV A;  4IU6 A;  3PKE A;  4U76 A;  5CLS A;  4ZWO A;  3ROR A;  1YJ3 A;  1C21 A;  4IF7 A;  1YW8 A;  2Q94 A;  4ZWP A;  3L24 A;  1QZY A;  2EVC A;  2GU6 A;  5E5B A;  2NQ7 A;  1W2M A;  1YW9 A;  3TAV A;  3BIT A;  4U6E A;  4FLJ A;  2GA2 A;  2P99 A;  2P9A A;  2GG3 A;  1XGS A;  3BIQ A;  1QXW A;  2EVM A;  2BWT A;  2GGC A;  2GG5 A;  3S6B A;  3CTZ A;  3FM3 A;  2B3K A;  3IU8 A;  5CIK A;  2BB7 A;  4IKR A;  4S01 A;  3BIP A;  3Q6D A;  3TB5 A;  4FLL A;  2B3H A;  2EVO A;  1XGN A;  4U6J A;  3FMR A;  1XGO A;  4IDY A;  5CNX A;  2V3X A;  4HXX A;  1KP0 A;  1WLR A;  4IKS A;  3CB5 A;  2BWS A;  2OKN A;  4PNC A;  4JUQ A;  3IU7 A;  2V6C A;  3IU9 A;  1CHM A;  4U69 A;  1M35 A;  1R5H A;  2HOW A;  2DFI A;  3FMQ A;  2BHB A;  4U6W A;  4FLI A;  5D6E A;  5JFR A;  3PKB A;  4PV4 A;  2BWY A;  2BWW A;  4S00 A;  4FKC A;  3MAT A;  4U71 A;  2BWU A;  5CDV A;  1JAW A;  1KQ9 A;  1QXY A;  4RGZ 1;  3D27 A;  2V3Y A;  4U75 A;  4IKT A;  2GU7 A;  5FCH A;  1R58 A;  4FO7 A;  4IEC A;  4RZZ A;  1B6A A;  2BHD A;  2G6P A;  3IG4 A;  4FLK A;  1WL6 A;  5D6F A;  1O0X A;  1BOA A;  4FUK A;  2BHC A;  3CB6 A;  1C24 A;  2ADU A;  1YW7 A;  4U70 A;  3MX6 A;  1BN5 A;  4A6W A;  5CDE A;  2IW2 A;  4S2R P;  4U73 A;  5FCF A;  1Y1N A;  4ZNG A;  2Q96 A;  2GGB A;  2GG9 A;  1WY2 A;  4S2T P;  2BN7 A;  1C27 A;  3PKA A;  1PV9 A;  1WN1 A;  3PKD A;  4RZY A;  1XNZ A;  2GTX A;  2P98 A;  2GG8 A;  4B28 A;  2GU5 A;  1YVM A;  4U1B A;  4KM3 A;  1B59 A;  2BH3 A;  4ZWU A;  4Z7M A;  1C23 A;  2GG2 A;  3L7G A;  5CE6 A;  1QXZ A;  2EA4 A;  2MAT A;  1W7V A;  3RVA A;  1WKM A;  1KQ0 A;  1A16 A;  3PKC A;  4QR8 A;  2B3L A;  2Q95 A;  2EA2 A;  1XGM A;  1WBQ A;  4EGE A;  5JI6 A;  5CDL A;  4R60 A;  2NQ6 A;  2Q8K A;  2GZ5 A;  2V3Z A;  4FO8 A;  1WL9 A;  4OOK A; 
#chains in the Genus database with same CATH homology
 4A6V A;  4U6Z A;  2GU4 A;  2Q92 A;  2OAZ A;  2BWX A;  4IPA A;  4IKU A;  1C22 A;  2BHA A;  5JHU A;  2GG7 A;  4U6C A;  1N51 A;  1R5G A;  3MR1 A;  2Q93 A;  2GG0 A;  4MAT A;  2ZSG A;  1MAT A;  2BWV A;  4IU6 A;  3PKE A;  4U76 A;  5CLS A;  4ZWO A;  3ROR A;  1YJ3 A;  1C21 A;  4IF7 A;  1YW8 A;  2Q94 A;  4ZWP A;  3L24 A;  1QZY A;  2EVC A;  2GU6 A;  5E5B A;  2NQ7 A;  1W2M A;  1YW9 A;  3TAV A;  3BIT A;  4U6E A;  4FLJ A;  2GA2 A;  2P99 A;  2P9A A;  2GG3 A;  1XGS A;  3BIQ A;  1QXW A;  2EVM A;  2BWT A;  2GGC A;  2GG5 A;  3S6B A;  3CTZ A;  3FM3 A;  2B3K A;  3IU8 A;  5CIK A;  2BB7 A;  4IKR A;  4S01 A;  3BIP A;  3Q6D A;  3TB5 A;  4FLL A;  2B3H A;  2EVO A;  1XGN A;  4U6J A;  3FMR A;  1XGO A;  4IDY A;  5CNX A;  2V3X A;  4HXX A;  1KP0 A;  1WLR A;  4IKS A;  3CB5 A;  2BWS A;  2OKN A;  4PNC A;  4JUQ A;  3IU7 A;  2V6C A;  3IU9 A;  1CHM A;  4U69 A;  1M35 A;  1R5H A;  2HOW A;  2DFI A;  3FMQ A;  2BHB A;  4U6W A;  4FLI A;  5D6E A;  5JFR A;  3PKB A;  4PV4 A;  2BWY A;  2BWW A;  4S00 A;  4FKC A;  3MAT A;  4U71 A;  2BWU A;  5CDV A;  1JAW A;  1KQ9 A;  1QXY A;  4RGZ 1;  3D27 A;  2V3Y A;  4U75 A;  4IKT A;  2GU7 A;  5FCH A;  1R58 A;  4FO7 A;  4IEC A;  4RZZ A;  1B6A A;  2BHD A;  2G6P A;  3IG4 A;  4FLK A;  1WL6 A;  5D6F A;  1O0X A;  1BOA A;  4FUK A;  2BHC A;  3CB6 A;  1C24 A;  2ADU A;  1YW7 A;  4U70 A;  3MX6 A;  1BN5 A;  4A6W A;  5CDE A;  2IW2 A;  4S2R P;  4U73 A;  5FCF A;  1Y1N A;  4ZNG A;  2Q96 A;  2GGB A;  2GG9 A;  1WY2 A;  4S2T P;  2BN7 A;  1C27 A;  3PKA A;  1PV9 A;  1WN1 A;  3PKD A;  4RZY A;  1XNZ A;  2GTX A;  2P98 A;  2GG8 A;  4B28 A;  2GU5 A;  1YVM A;  4U1B A;  4KM3 A;  1B59 A;  2BH3 A;  4ZWU A;  4Z7M A;  1C23 A;  2GG2 A;  3L7G A;  5CE6 A;  1QXZ A;  2EA4 A;  2MAT A;  1W7V A;  3RVA A;  1WKM A;  1KQ0 A;  1A16 A;  3PKC A;  4QR8 A;  2B3L A;  2Q95 A;  2EA2 A;  1XGM A;  1WBQ A;  4EGE A;  5JI6 A;  5CDL A;  4R60 A;  2NQ6 A;  2Q8K A;  2GZ5 A;  2V3Z A;  4FO8 A;  1WL9 A;  4OOK A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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