2Q93A

E. coli methionine aminopeptidase mn-form with inhibitor b21
Total Genus 83
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
83
sequence length
263
structure length
263
Chain Sequence
AISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGRGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISHDE
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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molecule tags Hydrolase
molecule keywords Methionine aminopeptidase
publication title Structural analysis of inhibition of E. coli methionine aminopeptidase: implication of loop flexibility in selective inhibition of bacterial enzymes.
pubmed doi rcsb
source organism Escherichia coli
total genus 83
structure length 263
sequence length 263
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2007-06-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 2q93A00
2Q95A 4FLIA 4RGZ1 1XGSA 3PKEA 2BHAA 2Q93A 3TB5A 1C27A 3BIQA 5JI6A 3MATA 2GZ5A 2BWUA 2GG2A 3FMRA 3D27A 1XNZA 2IW2A 2GU4A 3Q6DA 4ZWUA 1XGNA 1B6AA 2GU6A 3BITA 1QZYA 5CDVA 1WN1A 4FLKA 2V3XA 2BWWA 2Q96A 4U6EA 4IDYA 2EVOA 3FMQA 2DFIA 4Z7MA 2ADUA 5CDEA 5CE6A 3L7GA 1B59A 4A6VA 5E5BA 2V6CA 2GG5A 1MATA 1WL6A 1YVMA 2OAZA 2P98A 3L24A 4EGEA 4IKTA 5D6EA 1XGOA 2BWVA 2BHCA 2BWXA 2P99A 4FKCA 2G6PA 2BB7A 2BWSA 1C23A 4S2RP 5D6FA 2EA4A 4QR8A 1KQ0A 4IKRA 4U6WA 3CB5A 1YW8A 2EA2A 2GU5A 2GGCA 4U73A 4HXXA 5FCHA 2GG0A 4MATA 4PNCA 1XGMA 1C24A 4U69A 3TAVA 2OKNA 5CLSA 1C21A 3IU9A 1W7VA 1R58A 1C22A 1BOAA 5CNXA 4IPAA 1WBQA 4S00A 1O0XA 2BWYA 4U6CA 2GG9A 2P9AA 3MX6A 1QXYA 1M35A 3IG4A 3PKDA 4U1BA 4PV4A 4U76A 3S6BA 3PKCA 4A6WA 2V3ZA 3FM3A 4IECA 3RORA 4S01A 2GTXA 5FCFA 2GG8A 1JAWA 4JUQA 4U71A 1WLRA 1YW9A 2Q92A 4S2TP 1KQ9A 1N51A 2NQ7A 2B3HA 4FLJA 3IU8A 4IKSA 1WKMA 1QXZA 2BHBA 5CIKA 5JFRA 4ZWPA 3RVAA 4RZYA 4ZWOA 1A16A 4FO7A 1WL9A 2BHDA 4U6ZA 1PV9A 2GG7A 2ZSGA 4FLLA 2V3YA 2Q8KA 2GGBA 3PKBA 3MR1A 3CTZA 5CDLA 4IF7A 2B3LA 3BIPA 4KM3A 4U6JA 2EVCA 3PKAA 4U70A 2BH3A 1R5GA 1Y1NA 2GU7A 2EVMA 2BN7A 2B3KA 2Q94A 1WY2A 4U75A 4IU6A 1KP0A 1QXWA 1R5HA 2HOWA 5JHUA 1BN5A 2NQ6A 3IU7A 2GA2A 1YW7A 3CB6A 2MATA 4IKUA 4OOKA 4B28A 4RZZA 4R60A 1W2MA 2GG3A 4FO8A 1YJ3A 2BWTA 4ZNGA 4FUKA 1CHMA
chains in the Genus database with same CATH superfamily
2Q95A 4FLIA 4RGZ1 1XGSA 3PKEA 2BHAA 2Q93A 3TB5A 1C27A 3BIQA 5JI6A 3MATA 2GZ5A 2BWUA 2GG2A 3FMRA 3D27A 1XNZA 2IW2A 2GU4A 3Q6DA 4ZWUA 1XGNA 1B6AA 2GU6A 3BITA 1QZYA 5CDVA 1WN1A 4FLKA 2V3XA 2BWWA 2Q96A 4U6EA 4IDYA 2EVOA 3FMQA 2DFIA 4Z7MA 2ADUA 5CDEA 5CE6A 3L7GA 1B59A 4A6VA 5E5BA 2V6CA 2GG5A 1MATA 1WL6A 1YVMA 2OAZA 2P98A 3L24A 4EGEA 4IKTA 5D6EA 1XGOA 2BWVA 2BHCA 2BWXA 2P99A 4FKCA 2G6PA 2BB7A 2BWSA 1C23A 4S2RP 5D6FA 2EA4A 4QR8A 1KQ0A 4IKRA 4U6WA 3CB5A 1YW8A 2EA2A 2GU5A 2GGCA 4U73A 4HXXA 5FCHA 2GG0A 4MATA 4PNCA 1XGMA 1C24A 4U69A 3TAVA 2OKNA 5CLSA 1C21A 3IU9A 1W7VA 1R58A 1C22A 1BOAA 5CNXA 4IPAA 1WBQA 4S00A 1O0XA 2BWYA 4U6CA 2GG9A 2P9AA 3MX6A 1QXYA 1M35A 3IG4A 3PKDA 4U1BA 4PV4A 4U76A 3S6BA 3PKCA 4A6WA 2V3ZA 3FM3A 4IECA 3RORA 4S01A 2GTXA 5FCFA 2GG8A 1JAWA 4JUQA 4U71A 1WLRA 1YW9A 2Q92A 4S2TP 1KQ9A 1N51A 2NQ7A 2B3HA 4FLJA 3IU8A 4IKSA 1WKMA 1QXZA 2BHBA 5CIKA 5JFRA 4ZWPA 3RVAA 4RZYA 4ZWOA 1A16A 4FO7A 1WL9A 2BHDA 4U6ZA 1PV9A 2GG7A 2ZSGA 4FLLA 2V3YA 2Q8KA 2GGBA 3PKBA 3MR1A 3CTZA 5CDLA 4IF7A 2B3LA 3BIPA 4KM3A 4U6JA 2EVCA 3PKAA 4U70A 2BH3A 1R5GA 1Y1NA 2GU7A 2EVMA 2BN7A 2B3KA 2Q94A 1WY2A 4U75A 4IU6A 1KP0A 1QXWA 1R5HA 2HOWA 5JHUA 1BN5A 2NQ6A 3IU7A 2GA2A 1YW7A 3CB6A 2MATA 4IKUA 4OOKA 4B28A 4RZZA 4R60A 1W2MA 2GG3A 4FO8A 1YJ3A 2BWTA 4ZNGA 4FUKA 1CHMA
chains in the Genus database with same CATH topology
2Q95A 4FLIA 4RGZ1 1XGSA 3PKEA 2BHAA 2Q93A 3TB5A 1C27A 3BIQA 5JI6A 3MATA 2GZ5A 2BWUA 2GG2A 3FMRA 3D27A 1XNZA 2IW2A 2GU4A 3Q6DA 4ZWUA 1XGNA 1B6AA 2GU6A 3BITA 1QZYA 5CDVA 1WN1A 4FLKA 2V3XA 2BWWA 2Q96A 4U6EA 4IDYA 2EVOA 3FMQA 2DFIA 4Z7MA 2ADUA 5CDEA 5CE6A 3L7GA 1B59A 4A6VA 5E5BA 2V6CA 2GG5A 1MATA 1WL6A 1YVMA 2OAZA 2P98A 3L24A 4EGEA 4IKTA 5D6EA 1XGOA 2BWVA 2BHCA 2BWXA 2P99A 4FKCA 2G6PA 2BB7A 2BWSA 1C23A 4S2RP 5D6FA 2EA4A 4QR8A 1KQ0A 4IKRA 4U6WA 3CB5A 1YW8A 2EA2A 2GU5A 2GGCA 4U73A 4HXXA 5FCHA 2GG0A 4MATA 4PNCA 1XGMA 1C24A 4U69A 3TAVA 2OKNA 5CLSA 1C21A 3IU9A 1W7VA 1R58A 1C22A 1BOAA 5CNXA 4IPAA 1WBQA 4S00A 1O0XA 2BWYA 4U6CA 2GG9A 2P9AA 3MX6A 1QXYA 1M35A 3IG4A 3PKDA 4U1BA 4PV4A 4U76A 3S6BA 3PKCA 4A6WA 2V3ZA 3FM3A 4IECA 3RORA 4S01A 2GTXA 5FCFA 2GG8A 1JAWA 4JUQA 4U71A 1WLRA 1YW9A 2Q92A 4S2TP 1KQ9A 1N51A 2NQ7A 2B3HA 4FLJA 3IU8A 4IKSA 1WKMA 1QXZA 2BHBA 5CIKA 5JFRA 4ZWPA 3RVAA 4RZYA 4ZWOA 1A16A 4FO7A 1WL9A 2BHDA 4U6ZA 1PV9A 2GG7A 2ZSGA 4FLLA 2V3YA 2Q8KA 2GGBA 3PKBA 3MR1A 3CTZA 5CDLA 4IF7A 2B3LA 3BIPA 4KM3A 4U6JA 2EVCA 3PKAA 4U70A 2BH3A 1R5GA 1Y1NA 2GU7A 2EVMA 2BN7A 2B3KA 2Q94A 1WY2A 4U75A 4IU6A 1KP0A 1QXWA 1R5HA 2HOWA 5JHUA 1BN5A 2NQ6A 3IU7A 2GA2A 1YW7A 3CB6A 2MATA 4IKUA 4OOKA 4B28A 4RZZA 4R60A 1W2MA 2GG3A 4FO8A 1YJ3A 2BWTA 4ZNGA 4FUKA 1CHMA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 2Q95 A;  4FLI A;  4RGZ 1;  1XGS A;  3PKE A;  2BHA A;  2Q93 A;  3TB5 A;  1C27 A;  3BIQ A;  5JI6 A;  3MAT A;  2GZ5 A;  2BWU A;  2GG2 A;  3FMR A;  3D27 A;  1XNZ A;  2IW2 A;  2GU4 A;  3Q6D A;  4ZWU A;  1XGN A;  1B6A A;  2GU6 A;  3BIT A;  1QZY A;  5CDV A;  1WN1 A;  4FLK A;  2V3X A;  2BWW A;  2Q96 A;  4U6E A;  4IDY A;  2EVO A;  3FMQ A;  2DFI A;  4Z7M A;  2ADU A;  5CDE A;  5CE6 A;  3L7G A;  1B59 A;  4A6V A;  5E5B A;  2V6C A;  2GG5 A;  1MAT A;  1WL6 A;  1YVM A;  2OAZ A;  2P98 A;  3L24 A;  4EGE A;  4IKT A;  5D6E A;  1XGO A;  2BWV A;  2BHC A;  2BWX A;  2P99 A;  4FKC A;  2G6P A;  2BB7 A;  2BWS A;  1C23 A;  4S2R P;  5D6F A;  2EA4 A;  4QR8 A;  1KQ0 A;  4IKR A;  4U6W A;  3CB5 A;  1YW8 A;  2EA2 A;  2GU5 A;  2GGC A;  4U73 A;  4HXX A;  5FCH A;  2GG0 A;  4MAT A;  4PNC A;  1XGM A;  1C24 A;  4U69 A;  3TAV A;  2OKN A;  5CLS A;  1C21 A;  3IU9 A;  1W7V A;  1R58 A;  1C22 A;  1BOA A;  5CNX A;  4IPA A;  1WBQ A;  4S00 A;  1O0X A;  2BWY A;  4U6C A;  2GG9 A;  2P9A A;  3MX6 A;  1QXY A;  1M35 A;  3IG4 A;  3PKD A;  4U1B A;  4PV4 A;  4U76 A;  3S6B A;  3PKC A;  4A6W A;  2V3Z A;  3FM3 A;  4IEC A;  3ROR A;  4S01 A;  2GTX A;  5FCF A;  2GG8 A;  1JAW A;  4JUQ A;  4U71 A;  1WLR A;  1YW9 A;  2Q92 A;  4S2T P;  1KQ9 A;  1N51 A;  2NQ7 A;  2B3H A;  4FLJ A;  3IU8 A;  4IKS A;  1WKM A;  1QXZ A;  2BHB A;  5CIK A;  5JFR A;  4ZWP A;  3RVA A;  4RZY A;  4ZWO A;  1A16 A;  4FO7 A;  1WL9 A;  2BHD A;  4U6Z A;  1PV9 A;  2GG7 A;  2ZSG A;  4FLL A;  2V3Y A;  2Q8K A;  2GGB A;  3PKB A;  3MR1 A;  3CTZ A;  5CDL A;  4IF7 A;  2B3L A;  3BIP A;  4KM3 A;  4U6J A;  2EVC A;  3PKA A;  4U70 A;  2BH3 A;  1R5G A;  1Y1N A;  2GU7 A;  2EVM A;  2BN7 A;  2B3K A;  2Q94 A;  1WY2 A;  4U75 A;  4IU6 A;  1KP0 A;  1QXW A;  1R5H A;  2HOW A;  5JHU A;  1BN5 A;  2NQ6 A;  3IU7 A;  2GA2 A;  1YW7 A;  3CB6 A;  2MAT A;  4IKU A;  4OOK A;  4B28 A;  4RZZ A;  4R60 A;  1W2M A;  2GG3 A;  4FO8 A;  1YJ3 A;  2BWT A;  4ZNG A;  4FUK A;  1CHM A; 
#chains in the Genus database with same CATH topology
 2Q95 A;  4FLI A;  4RGZ 1;  1XGS A;  3PKE A;  2BHA A;  2Q93 A;  3TB5 A;  1C27 A;  3BIQ A;  5JI6 A;  3MAT A;  2GZ5 A;  2BWU A;  2GG2 A;  3FMR A;  3D27 A;  1XNZ A;  2IW2 A;  2GU4 A;  3Q6D A;  4ZWU A;  1XGN A;  1B6A A;  2GU6 A;  3BIT A;  1QZY A;  5CDV A;  1WN1 A;  4FLK A;  2V3X A;  2BWW A;  2Q96 A;  4U6E A;  4IDY A;  2EVO A;  3FMQ A;  2DFI A;  4Z7M A;  2ADU A;  5CDE A;  5CE6 A;  3L7G A;  1B59 A;  4A6V A;  5E5B A;  2V6C A;  2GG5 A;  1MAT A;  1WL6 A;  1YVM A;  2OAZ A;  2P98 A;  3L24 A;  4EGE A;  4IKT A;  5D6E A;  1XGO A;  2BWV A;  2BHC A;  2BWX A;  2P99 A;  4FKC A;  2G6P A;  2BB7 A;  2BWS A;  1C23 A;  4S2R P;  5D6F A;  2EA4 A;  4QR8 A;  1KQ0 A;  4IKR A;  4U6W A;  3CB5 A;  1YW8 A;  2EA2 A;  2GU5 A;  2GGC A;  4U73 A;  4HXX A;  5FCH A;  2GG0 A;  4MAT A;  4PNC A;  1XGM A;  1C24 A;  4U69 A;  3TAV A;  2OKN A;  5CLS A;  1C21 A;  3IU9 A;  1W7V A;  1R58 A;  1C22 A;  1BOA A;  5CNX A;  4IPA A;  1WBQ A;  4S00 A;  1O0X A;  2BWY A;  4U6C A;  2GG9 A;  2P9A A;  3MX6 A;  1QXY A;  1M35 A;  3IG4 A;  3PKD A;  4U1B A;  4PV4 A;  4U76 A;  3S6B A;  3PKC A;  4A6W A;  2V3Z A;  3FM3 A;  4IEC A;  3ROR A;  4S01 A;  2GTX A;  5FCF A;  2GG8 A;  1JAW A;  4JUQ A;  4U71 A;  1WLR A;  1YW9 A;  2Q92 A;  4S2T P;  1KQ9 A;  1N51 A;  2NQ7 A;  2B3H A;  4FLJ A;  3IU8 A;  4IKS A;  1WKM A;  1QXZ A;  2BHB A;  5CIK A;  5JFR A;  4ZWP A;  3RVA A;  4RZY A;  4ZWO A;  1A16 A;  4FO7 A;  1WL9 A;  2BHD A;  4U6Z A;  1PV9 A;  2GG7 A;  2ZSG A;  4FLL A;  2V3Y A;  2Q8K A;  2GGB A;  3PKB A;  3MR1 A;  3CTZ A;  5CDL A;  4IF7 A;  2B3L A;  3BIP A;  4KM3 A;  4U6J A;  2EVC A;  3PKA A;  4U70 A;  2BH3 A;  1R5G A;  1Y1N A;  2GU7 A;  2EVM A;  2BN7 A;  2B3K A;  2Q94 A;  1WY2 A;  4U75 A;  4IU6 A;  1KP0 A;  1QXW A;  1R5H A;  2HOW A;  5JHU A;  1BN5 A;  2NQ6 A;  3IU7 A;  2GA2 A;  1YW7 A;  3CB6 A;  2MAT A;  4IKU A;  4OOK A;  4B28 A;  4RZZ A;  4R60 A;  1W2M A;  2GG3 A;  4FO8 A;  1YJ3 A;  2BWT A;  4ZNG A;  4FUK A;  1CHM A; 
#chains in the Genus database with same CATH homology
 2Q95 A;  4FLI A;  4RGZ 1;  1XGS A;  3PKE A;  2BHA A;  2Q93 A;  3TB5 A;  1C27 A;  3BIQ A;  5JI6 A;  3MAT A;  2GZ5 A;  2BWU A;  2GG2 A;  3FMR A;  3D27 A;  1XNZ A;  2IW2 A;  2GU4 A;  3Q6D A;  4ZWU A;  1XGN A;  1B6A A;  2GU6 A;  3BIT A;  1QZY A;  5CDV A;  1WN1 A;  4FLK A;  2V3X A;  2BWW A;  2Q96 A;  4U6E A;  4IDY A;  2EVO A;  3FMQ A;  2DFI A;  4Z7M A;  2ADU A;  5CDE A;  5CE6 A;  3L7G A;  1B59 A;  4A6V A;  5E5B A;  2V6C A;  2GG5 A;  1MAT A;  1WL6 A;  1YVM A;  2OAZ A;  2P98 A;  3L24 A;  4EGE A;  4IKT A;  5D6E A;  1XGO A;  2BWV A;  2BHC A;  2BWX A;  2P99 A;  4FKC A;  2G6P A;  2BB7 A;  2BWS A;  1C23 A;  4S2R P;  5D6F A;  2EA4 A;  4QR8 A;  1KQ0 A;  4IKR A;  4U6W A;  3CB5 A;  1YW8 A;  2EA2 A;  2GU5 A;  2GGC A;  4U73 A;  4HXX A;  5FCH A;  2GG0 A;  4MAT A;  4PNC A;  1XGM A;  1C24 A;  4U69 A;  3TAV A;  2OKN A;  5CLS A;  1C21 A;  3IU9 A;  1W7V A;  1R58 A;  1C22 A;  1BOA A;  5CNX A;  4IPA A;  1WBQ A;  4S00 A;  1O0X A;  2BWY A;  4U6C A;  2GG9 A;  2P9A A;  3MX6 A;  1QXY A;  1M35 A;  3IG4 A;  3PKD A;  4U1B A;  4PV4 A;  4U76 A;  3S6B A;  3PKC A;  4A6W A;  2V3Z A;  3FM3 A;  4IEC A;  3ROR A;  4S01 A;  2GTX A;  5FCF A;  2GG8 A;  1JAW A;  4JUQ A;  4U71 A;  1WLR A;  1YW9 A;  2Q92 A;  4S2T P;  1KQ9 A;  1N51 A;  2NQ7 A;  2B3H A;  4FLJ A;  3IU8 A;  4IKS A;  1WKM A;  1QXZ A;  2BHB A;  5CIK A;  5JFR A;  4ZWP A;  3RVA A;  4RZY A;  4ZWO A;  1A16 A;  4FO7 A;  1WL9 A;  2BHD A;  4U6Z A;  1PV9 A;  2GG7 A;  2ZSG A;  4FLL A;  2V3Y A;  2Q8K A;  2GGB A;  3PKB A;  3MR1 A;  3CTZ A;  5CDL A;  4IF7 A;  2B3L A;  3BIP A;  4KM3 A;  4U6J A;  2EVC A;  3PKA A;  4U70 A;  2BH3 A;  1R5G A;  1Y1N A;  2GU7 A;  2EVM A;  2BN7 A;  2B3K A;  2Q94 A;  1WY2 A;  4U75 A;  4IU6 A;  1KP0 A;  1QXW A;  1R5H A;  2HOW A;  5JHU A;  1BN5 A;  2NQ6 A;  3IU7 A;  2GA2 A;  1YW7 A;  3CB6 A;  2MAT A;  4IKU A;  4OOK A;  4B28 A;  4RZZ A;  4R60 A;  1W2M A;  2GG3 A;  4FO8 A;  1YJ3 A;  2BWT A;  4ZNG A;  4FUK A;  1CHM A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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