2Q94A

E. coli methionine aminopeptidase mn-form with inhibitor a04
Total Genus 85
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
85
sequence length
262
structure length
262
Chain Sequence
AISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGRGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISHD
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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molecule tags Hydrolase
molecule keywords Methionine aminopeptidase
publication title Structural analysis of inhibition of E. coli methionine aminopeptidase: implication of loop flexibility in selective inhibition of bacterial enzymes.
pubmed doi rcsb
source organism Escherichia coli
total genus 85
structure length 262
sequence length 262
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2007-06-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 2q94A00
4IECA 4MATA 3TB5A 3PKBA 4OOKA 4IKUA 2OAZA 4Z7MA 1R5HA 2BWWA 1YVMA 2BHCA 2GG5A 2P98A 1C23A 1WLRA 1C22A 3PKCA 4IKTA 5JI6A 2BN7A 2EVCA 2HOWA 4IF7A 1YW8A 2GU7A 4FO8A 2Q8KA 1R58A 1JAWA 4PNCA 2GA2A 4ZWPA 5CDLA 4RZYA 1YJ3A 4HXXA 4FLLA 1BOAA 1B6AA 3PKAA 1BN5A 2EVMA 2EA2A 4RGZ1 2BWXA 3D27A 2ADUA 2Q94A 1KQ9A 2Q92A 1QXWA 4S00A 4EGEA 1QXYA 3BIPA 2V6CA 1N51A 2GG8A 4ZWOA 1XGSA 4ZWUA 4FLIA 3MX6A 1WBQA 2B3LA 3FM3A 4U6EA 4IDYA 2GU5A 1CHMA 1YW9A 5E5BA 1QZYA 2GZ5A 1B59A 3PKDA 4QR8A 2GG3A 5D6EA 3CB5A 1QXZA 1YW7A 4ZNGA 4U6ZA 2B3HA 3MR1A 1WKMA 4U75A 4FUKA 1W2MA 4S2TP 4U6JA 5D6FA 2BWTA 2GG2A 1A16A 2V3XA 3RVAA 2P9AA 4S2RP 5FCHA 1C27A 1XNZA 2BHBA 5CDVA 2B3KA 1W7VA 1O0XA 5CDEA 3L24A 5JHUA 1KP0A 3PKEA 1KQ0A 4U69A 2BH3A 4RZZA 2V3ZA 2BWSA 1Y1NA 2Q96A 2MATA 2EA4A 3FMRA 4PV4A 4U6WA 2NQ6A 2P99A 2OKNA 1XGOA 2BWVA 1C24A 2GTXA 2GU4A 4FKCA 5FCFA 3TAVA 3IG4A 5CIKA 4U73A 2GGBA 3MATA 2Q95A 2GG7A 4KM3A 4S01A 1R5GA 5CNXA 5CLSA 4IKRA 1XGMA 2GG9A 1WL6A 2ZSGA 3BIQA 3IU8A 4FLKA 3BITA 3IU9A 3S6BA 1M35A 2DFIA 2BHDA 4U1BA 4R60A 3RORA 1C21A 2Q93A 1XGNA 2GGCA 2NQ7A 2GG0A 4IKSA 3CB6A 4U76A 4FLJA 2BHAA 4IPAA 2BWYA 3Q6DA 2V3YA 4JUQA 4A6WA 2G6PA 3IU7A 2BWUA 4FO7A 5CE6A 2EVOA 2GU6A 4B28A 1PV9A 1MATA 2IW2A 5JFRA 2BB7A 4U71A 3L7GA 4A6VA 4IU6A 4U70A 1WY2A 4U6CA 3FMQA 1WL9A 3CTZA 1WN1A
chains in the Genus database with same CATH superfamily
4IECA 4MATA 3TB5A 3PKBA 4OOKA 4IKUA 2OAZA 4Z7MA 1R5HA 2BWWA 1YVMA 2BHCA 2GG5A 2P98A 1C23A 1WLRA 1C22A 3PKCA 4IKTA 5JI6A 2BN7A 2EVCA 2HOWA 4IF7A 1YW8A 2GU7A 4FO8A 2Q8KA 1R58A 1JAWA 4PNCA 2GA2A 4ZWPA 5CDLA 4RZYA 1YJ3A 4HXXA 4FLLA 1BOAA 1B6AA 3PKAA 1BN5A 2EVMA 2EA2A 4RGZ1 2BWXA 3D27A 2ADUA 2Q94A 1KQ9A 2Q92A 1QXWA 4S00A 4EGEA 1QXYA 3BIPA 2V6CA 1N51A 2GG8A 4ZWOA 1XGSA 4ZWUA 4FLIA 3MX6A 1WBQA 2B3LA 3FM3A 4U6EA 4IDYA 2GU5A 1CHMA 1YW9A 5E5BA 1QZYA 2GZ5A 1B59A 3PKDA 4QR8A 2GG3A 5D6EA 3CB5A 1QXZA 1YW7A 4ZNGA 4U6ZA 2B3HA 3MR1A 1WKMA 4U75A 4FUKA 1W2MA 4S2TP 4U6JA 5D6FA 2BWTA 2GG2A 1A16A 2V3XA 3RVAA 2P9AA 4S2RP 5FCHA 1C27A 1XNZA 2BHBA 5CDVA 2B3KA 1W7VA 1O0XA 5CDEA 3L24A 5JHUA 1KP0A 3PKEA 1KQ0A 4U69A 2BH3A 4RZZA 2V3ZA 2BWSA 1Y1NA 2Q96A 2MATA 2EA4A 3FMRA 4PV4A 4U6WA 2NQ6A 2P99A 2OKNA 1XGOA 2BWVA 1C24A 2GTXA 2GU4A 4FKCA 5FCFA 3TAVA 3IG4A 5CIKA 4U73A 2GGBA 3MATA 2Q95A 2GG7A 4KM3A 4S01A 1R5GA 5CNXA 5CLSA 4IKRA 1XGMA 2GG9A 1WL6A 2ZSGA 3BIQA 3IU8A 4FLKA 3BITA 3IU9A 3S6BA 1M35A 2DFIA 2BHDA 4U1BA 4R60A 3RORA 1C21A 2Q93A 1XGNA 2GGCA 2NQ7A 2GG0A 4IKSA 3CB6A 4U76A 4FLJA 2BHAA 4IPAA 2BWYA 3Q6DA 2V3YA 4JUQA 4A6WA 2G6PA 3IU7A 2BWUA 4FO7A 5CE6A 2EVOA 2GU6A 4B28A 1PV9A 1MATA 2IW2A 5JFRA 2BB7A 4U71A 3L7GA 4A6VA 4IU6A 4U70A 1WY2A 4U6CA 3FMQA 1WL9A 3CTZA 1WN1A
chains in the Genus database with same CATH topology
4IECA 4MATA 3TB5A 3PKBA 4OOKA 4IKUA 2OAZA 4Z7MA 1R5HA 2BWWA 1YVMA 2BHCA 2GG5A 2P98A 1C23A 1WLRA 1C22A 3PKCA 4IKTA 5JI6A 2BN7A 2EVCA 2HOWA 4IF7A 1YW8A 2GU7A 4FO8A 2Q8KA 1R58A 1JAWA 4PNCA 2GA2A 4ZWPA 5CDLA 4RZYA 1YJ3A 4HXXA 4FLLA 1BOAA 1B6AA 3PKAA 1BN5A 2EVMA 2EA2A 4RGZ1 2BWXA 3D27A 2ADUA 2Q94A 1KQ9A 2Q92A 1QXWA 4S00A 4EGEA 1QXYA 3BIPA 2V6CA 1N51A 2GG8A 4ZWOA 1XGSA 4ZWUA 4FLIA 3MX6A 1WBQA 2B3LA 3FM3A 4U6EA 4IDYA 2GU5A 1CHMA 1YW9A 5E5BA 1QZYA 2GZ5A 1B59A 3PKDA 4QR8A 2GG3A 5D6EA 3CB5A 1QXZA 1YW7A 4ZNGA 4U6ZA 2B3HA 3MR1A 1WKMA 4U75A 4FUKA 1W2MA 4S2TP 4U6JA 5D6FA 2BWTA 2GG2A 1A16A 2V3XA 3RVAA 2P9AA 4S2RP 5FCHA 1C27A 1XNZA 2BHBA 5CDVA 2B3KA 1W7VA 1O0XA 5CDEA 3L24A 5JHUA 1KP0A 3PKEA 1KQ0A 4U69A 2BH3A 4RZZA 2V3ZA 2BWSA 1Y1NA 2Q96A 2MATA 2EA4A 3FMRA 4PV4A 4U6WA 2NQ6A 2P99A 2OKNA 1XGOA 2BWVA 1C24A 2GTXA 2GU4A 4FKCA 5FCFA 3TAVA 3IG4A 5CIKA 4U73A 2GGBA 3MATA 2Q95A 2GG7A 4KM3A 4S01A 1R5GA 5CNXA 5CLSA 4IKRA 1XGMA 2GG9A 1WL6A 2ZSGA 3BIQA 3IU8A 4FLKA 3BITA 3IU9A 3S6BA 1M35A 2DFIA 2BHDA 4U1BA 4R60A 3RORA 1C21A 2Q93A 1XGNA 2GGCA 2NQ7A 2GG0A 4IKSA 3CB6A 4U76A 4FLJA 2BHAA 4IPAA 2BWYA 3Q6DA 2V3YA 4JUQA 4A6WA 2G6PA 3IU7A 2BWUA 4FO7A 5CE6A 2EVOA 2GU6A 4B28A 1PV9A 1MATA 2IW2A 5JFRA 2BB7A 4U71A 3L7GA 4A6VA 4IU6A 4U70A 1WY2A 4U6CA 3FMQA 1WL9A 3CTZA 1WN1A
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 4IEC A;  4MAT A;  3TB5 A;  3PKB A;  4OOK A;  4IKU A;  2OAZ A;  4Z7M A;  1R5H A;  2BWW A;  1YVM A;  2BHC A;  2GG5 A;  2P98 A;  1C23 A;  1WLR A;  1C22 A;  3PKC A;  4IKT A;  5JI6 A;  2BN7 A;  2EVC A;  2HOW A;  4IF7 A;  1YW8 A;  2GU7 A;  4FO8 A;  2Q8K A;  1R58 A;  1JAW A;  4PNC A;  2GA2 A;  4ZWP A;  5CDL A;  4RZY A;  1YJ3 A;  4HXX A;  4FLL A;  1BOA A;  1B6A A;  3PKA A;  1BN5 A;  2EVM A;  2EA2 A;  4RGZ 1;  2BWX A;  3D27 A;  2ADU A;  2Q94 A;  1KQ9 A;  2Q92 A;  1QXW A;  4S00 A;  4EGE A;  1QXY A;  3BIP A;  2V6C A;  1N51 A;  2GG8 A;  4ZWO A;  1XGS A;  4ZWU A;  4FLI A;  3MX6 A;  1WBQ A;  2B3L A;  3FM3 A;  4U6E A;  4IDY A;  2GU5 A;  1CHM A;  1YW9 A;  5E5B A;  1QZY A;  2GZ5 A;  1B59 A;  3PKD A;  4QR8 A;  2GG3 A;  5D6E A;  3CB5 A;  1QXZ A;  1YW7 A;  4ZNG A;  4U6Z A;  2B3H A;  3MR1 A;  1WKM A;  4U75 A;  4FUK A;  1W2M A;  4S2T P;  4U6J A;  5D6F A;  2BWT A;  2GG2 A;  1A16 A;  2V3X A;  3RVA A;  2P9A A;  4S2R P;  5FCH A;  1C27 A;  1XNZ A;  2BHB A;  5CDV A;  2B3K A;  1W7V A;  1O0X A;  5CDE A;  3L24 A;  5JHU A;  1KP0 A;  3PKE A;  1KQ0 A;  4U69 A;  2BH3 A;  4RZZ A;  2V3Z A;  2BWS A;  1Y1N A;  2Q96 A;  2MAT A;  2EA4 A;  3FMR A;  4PV4 A;  4U6W A;  2NQ6 A;  2P99 A;  2OKN A;  1XGO A;  2BWV A;  1C24 A;  2GTX A;  2GU4 A;  4FKC A;  5FCF A;  3TAV A;  3IG4 A;  5CIK A;  4U73 A;  2GGB A;  3MAT A;  2Q95 A;  2GG7 A;  4KM3 A;  4S01 A;  1R5G A;  5CNX A;  5CLS A;  4IKR A;  1XGM A;  2GG9 A;  1WL6 A;  2ZSG A;  3BIQ A;  3IU8 A;  4FLK A;  3BIT A;  3IU9 A;  3S6B A;  1M35 A;  2DFI A;  2BHD A;  4U1B A;  4R60 A;  3ROR A;  1C21 A;  2Q93 A;  1XGN A;  2GGC A;  2NQ7 A;  2GG0 A;  4IKS A;  3CB6 A;  4U76 A;  4FLJ A;  2BHA A;  4IPA A;  2BWY A;  3Q6D A;  2V3Y A;  4JUQ A;  4A6W A;  2G6P A;  3IU7 A;  2BWU A;  4FO7 A;  5CE6 A;  2EVO A;  2GU6 A;  4B28 A;  1PV9 A;  1MAT A;  2IW2 A;  5JFR A;  2BB7 A;  4U71 A;  3L7G A;  4A6V A;  4IU6 A;  4U70 A;  1WY2 A;  4U6C A;  3FMQ A;  1WL9 A;  3CTZ A;  1WN1 A; 
#chains in the Genus database with same CATH topology
 4IEC A;  4MAT A;  3TB5 A;  3PKB A;  4OOK A;  4IKU A;  2OAZ A;  4Z7M A;  1R5H A;  2BWW A;  1YVM A;  2BHC A;  2GG5 A;  2P98 A;  1C23 A;  1WLR A;  1C22 A;  3PKC A;  4IKT A;  5JI6 A;  2BN7 A;  2EVC A;  2HOW A;  4IF7 A;  1YW8 A;  2GU7 A;  4FO8 A;  2Q8K A;  1R58 A;  1JAW A;  4PNC A;  2GA2 A;  4ZWP A;  5CDL A;  4RZY A;  1YJ3 A;  4HXX A;  4FLL A;  1BOA A;  1B6A A;  3PKA A;  1BN5 A;  2EVM A;  2EA2 A;  4RGZ 1;  2BWX A;  3D27 A;  2ADU A;  2Q94 A;  1KQ9 A;  2Q92 A;  1QXW A;  4S00 A;  4EGE A;  1QXY A;  3BIP A;  2V6C A;  1N51 A;  2GG8 A;  4ZWO A;  1XGS A;  4ZWU A;  4FLI A;  3MX6 A;  1WBQ A;  2B3L A;  3FM3 A;  4U6E A;  4IDY A;  2GU5 A;  1CHM A;  1YW9 A;  5E5B A;  1QZY A;  2GZ5 A;  1B59 A;  3PKD A;  4QR8 A;  2GG3 A;  5D6E A;  3CB5 A;  1QXZ A;  1YW7 A;  4ZNG A;  4U6Z A;  2B3H A;  3MR1 A;  1WKM A;  4U75 A;  4FUK A;  1W2M A;  4S2T P;  4U6J A;  5D6F A;  2BWT A;  2GG2 A;  1A16 A;  2V3X A;  3RVA A;  2P9A A;  4S2R P;  5FCH A;  1C27 A;  1XNZ A;  2BHB A;  5CDV A;  2B3K A;  1W7V A;  1O0X A;  5CDE A;  3L24 A;  5JHU A;  1KP0 A;  3PKE A;  1KQ0 A;  4U69 A;  2BH3 A;  4RZZ A;  2V3Z A;  2BWS A;  1Y1N A;  2Q96 A;  2MAT A;  2EA4 A;  3FMR A;  4PV4 A;  4U6W A;  2NQ6 A;  2P99 A;  2OKN A;  1XGO A;  2BWV A;  1C24 A;  2GTX A;  2GU4 A;  4FKC A;  5FCF A;  3TAV A;  3IG4 A;  5CIK A;  4U73 A;  2GGB A;  3MAT A;  2Q95 A;  2GG7 A;  4KM3 A;  4S01 A;  1R5G A;  5CNX A;  5CLS A;  4IKR A;  1XGM A;  2GG9 A;  1WL6 A;  2ZSG A;  3BIQ A;  3IU8 A;  4FLK A;  3BIT A;  3IU9 A;  3S6B A;  1M35 A;  2DFI A;  2BHD A;  4U1B A;  4R60 A;  3ROR A;  1C21 A;  2Q93 A;  1XGN A;  2GGC A;  2NQ7 A;  2GG0 A;  4IKS A;  3CB6 A;  4U76 A;  4FLJ A;  2BHA A;  4IPA A;  2BWY A;  3Q6D A;  2V3Y A;  4JUQ A;  4A6W A;  2G6P A;  3IU7 A;  2BWU A;  4FO7 A;  5CE6 A;  2EVO A;  2GU6 A;  4B28 A;  1PV9 A;  1MAT A;  2IW2 A;  5JFR A;  2BB7 A;  4U71 A;  3L7G A;  4A6V A;  4IU6 A;  4U70 A;  1WY2 A;  4U6C A;  3FMQ A;  1WL9 A;  3CTZ A;  1WN1 A; 
#chains in the Genus database with same CATH homology
 4IEC A;  4MAT A;  3TB5 A;  3PKB A;  4OOK A;  4IKU A;  2OAZ A;  4Z7M A;  1R5H A;  2BWW A;  1YVM A;  2BHC A;  2GG5 A;  2P98 A;  1C23 A;  1WLR A;  1C22 A;  3PKC A;  4IKT A;  5JI6 A;  2BN7 A;  2EVC A;  2HOW A;  4IF7 A;  1YW8 A;  2GU7 A;  4FO8 A;  2Q8K A;  1R58 A;  1JAW A;  4PNC A;  2GA2 A;  4ZWP A;  5CDL A;  4RZY A;  1YJ3 A;  4HXX A;  4FLL A;  1BOA A;  1B6A A;  3PKA A;  1BN5 A;  2EVM A;  2EA2 A;  4RGZ 1;  2BWX A;  3D27 A;  2ADU A;  2Q94 A;  1KQ9 A;  2Q92 A;  1QXW A;  4S00 A;  4EGE A;  1QXY A;  3BIP A;  2V6C A;  1N51 A;  2GG8 A;  4ZWO A;  1XGS A;  4ZWU A;  4FLI A;  3MX6 A;  1WBQ A;  2B3L A;  3FM3 A;  4U6E A;  4IDY A;  2GU5 A;  1CHM A;  1YW9 A;  5E5B A;  1QZY A;  2GZ5 A;  1B59 A;  3PKD A;  4QR8 A;  2GG3 A;  5D6E A;  3CB5 A;  1QXZ A;  1YW7 A;  4ZNG A;  4U6Z A;  2B3H A;  3MR1 A;  1WKM A;  4U75 A;  4FUK A;  1W2M A;  4S2T P;  4U6J A;  5D6F A;  2BWT A;  2GG2 A;  1A16 A;  2V3X A;  3RVA A;  2P9A A;  4S2R P;  5FCH A;  1C27 A;  1XNZ A;  2BHB A;  5CDV A;  2B3K A;  1W7V A;  1O0X A;  5CDE A;  3L24 A;  5JHU A;  1KP0 A;  3PKE A;  1KQ0 A;  4U69 A;  2BH3 A;  4RZZ A;  2V3Z A;  2BWS A;  1Y1N A;  2Q96 A;  2MAT A;  2EA4 A;  3FMR A;  4PV4 A;  4U6W A;  2NQ6 A;  2P99 A;  2OKN A;  1XGO A;  2BWV A;  1C24 A;  2GTX A;  2GU4 A;  4FKC A;  5FCF A;  3TAV A;  3IG4 A;  5CIK A;  4U73 A;  2GGB A;  3MAT A;  2Q95 A;  2GG7 A;  4KM3 A;  4S01 A;  1R5G A;  5CNX A;  5CLS A;  4IKR A;  1XGM A;  2GG9 A;  1WL6 A;  2ZSG A;  3BIQ A;  3IU8 A;  4FLK A;  3BIT A;  3IU9 A;  3S6B A;  1M35 A;  2DFI A;  2BHD A;  4U1B A;  4R60 A;  3ROR A;  1C21 A;  2Q93 A;  1XGN A;  2GGC A;  2NQ7 A;  2GG0 A;  4IKS A;  3CB6 A;  4U76 A;  4FLJ A;  2BHA A;  4IPA A;  2BWY A;  3Q6D A;  2V3Y A;  4JUQ A;  4A6W A;  2G6P A;  3IU7 A;  2BWU A;  4FO7 A;  5CE6 A;  2EVO A;  2GU6 A;  4B28 A;  1PV9 A;  1MAT A;  2IW2 A;  5JFR A;  2BB7 A;  4U71 A;  3L7G A;  4A6V A;  4IU6 A;  4U70 A;  1WY2 A;  4U6C A;  3FMQ A;  1WL9 A;  3CTZ A;  1WN1 A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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