4FLJA

Human metap1 with bengamide analog y08, in mn form
Total Genus 99
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
99
sequence length
304
structure length
304
Chain Sequence
YRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLFHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARPHFMS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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molecule tags Hydrolase/hydrolase inhibitor
molecule keywords Methionine aminopeptidase 1
publication title Structural analysis of bengamide derivatives as inhibitors of methionine aminopeptidases.
pubmed doi rcsb
source organism Homo sapiens
total genus 99
structure length 304
sequence length 304
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2012-06-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4fljA00
2BHCA 1N51A 1W2MA 2GGCA 2EVMA 2Q94A 4B28A 1KP0A 1WY2A 2V3XA 5D6FA 2BHBA 1BN5A 1WBQA 1WN1A 4QR8A 2BHDA 1YW9A 2GG7A 2Q96A 4RZYA 4FO7A 4JUQA 2V3YA 1XGOA 4ZNGA 1C23A 2G6PA 4IKUA 2Q93A 4IU6A 2GG0A 4FKCA 4HXXA 4A6WA 1CHMA 2BWUA 4FLJA 4IKRA 5CLSA 2NQ6A 3BITA 4A6VA 2P98A 3MR1A 1YW7A 2GU7A 3PKCA 4RGZ1 4S01A 4IKSA 3FMRA 2EVOA 2OAZA 4IECA 2EA4A 2GG5A 1MATA 3MX6A 2GGBA 4U6WA 4FLIA 1C27A 3CB5A 4OOKA 2B3HA 3TAVA 1JAWA 3D27A 1KQ0A 1B59A 2GG8A 3IU7A 2GU6A 2OKNA 4KM3A 2B3KA 2GU5A 4IDYA 1QXZA 2BN7A 4FUKA 3L24A 3BIQA 4S00A 1Y1NA 5CDVA 4IKTA 2Q8KA 5E5BA 5CDEA 5JI6A 2BWTA 1C24A 5CNXA 1C21A 4U69A 1B6AA 4U6JA 1QXWA 1R5GA 3PKBA 2Q92A 2V3ZA 2B3LA 1KQ9A 3PKDA 4Z7MA 5D6EA 4ZWUA 4FLLA 2HOWA 4FO8A 1QXYA 1R58A 1XGSA 1W7VA 2GG9A 2GG3A 2IW2A 5CE6A 2BWSA 3FMQA 1WLRA 5CIKA 5FCHA 1C22A 2BH3A 1XGNA 1YVMA 4MATA 3RVAA 1XNZA 2BWYA 4U71A 4S2TP 1XGMA 2EVCA 5FCFA 1BOAA 4U1BA 1WL9A 4U76A 4R60A 1R5HA 2GA2A 3Q6DA 4EGEA 3CB6A 4U73A 1WL6A 5JHUA 3IG4A 2MATA 3IU9A 3PKEA 4U70A 1YW8A 2ZSGA 2BWWA 4ZWPA 2DFIA 4U75A 3L7GA 1YJ3A 2GG2A 2GTXA 2Q95A 2EA2A 3IU8A 4U6EA 2GU4A 2P99A 4RZZA 4PNCA 4S2RP 1PV9A 2V6CA 1WKMA 2BB7A 3TB5A 1QZYA 1A16A 4IPAA 2GZ5A 1O0XA 2P9AA 5CDLA 2NQ7A 3FM3A 4U6ZA 2ADUA 3BIPA 3MATA 4IF7A 5JFRA 4ZWOA 3PKAA 3RORA 3S6BA 4PV4A 1M35A 4U6CA 4FLKA 2BWVA 2BHAA 3CTZA 2BWXA
chains in the Genus database with same CATH superfamily
2BHCA 1N51A 1W2MA 2GGCA 2EVMA 2Q94A 4B28A 1KP0A 1WY2A 2V3XA 5D6FA 2BHBA 1BN5A 1WBQA 1WN1A 4QR8A 2BHDA 1YW9A 2GG7A 2Q96A 4RZYA 4FO7A 4JUQA 2V3YA 1XGOA 4ZNGA 1C23A 2G6PA 4IKUA 2Q93A 4IU6A 2GG0A 4FKCA 4HXXA 4A6WA 1CHMA 2BWUA 4FLJA 4IKRA 5CLSA 2NQ6A 3BITA 4A6VA 2P98A 3MR1A 1YW7A 2GU7A 3PKCA 4RGZ1 4S01A 4IKSA 3FMRA 2EVOA 2OAZA 4IECA 2EA4A 2GG5A 1MATA 3MX6A 2GGBA 4U6WA 4FLIA 1C27A 3CB5A 4OOKA 2B3HA 3TAVA 1JAWA 3D27A 1KQ0A 1B59A 2GG8A 3IU7A 2GU6A 2OKNA 4KM3A 2B3KA 2GU5A 4IDYA 1QXZA 2BN7A 4FUKA 3L24A 3BIQA 4S00A 1Y1NA 5CDVA 4IKTA 2Q8KA 5E5BA 5CDEA 5JI6A 2BWTA 1C24A 5CNXA 1C21A 4U69A 1B6AA 4U6JA 1QXWA 1R5GA 3PKBA 2Q92A 2V3ZA 2B3LA 1KQ9A 3PKDA 4Z7MA 5D6EA 4ZWUA 4FLLA 2HOWA 4FO8A 1QXYA 1R58A 1XGSA 1W7VA 2GG9A 2GG3A 2IW2A 5CE6A 2BWSA 3FMQA 1WLRA 5CIKA 5FCHA 1C22A 2BH3A 1XGNA 1YVMA 4MATA 3RVAA 1XNZA 2BWYA 4U71A 4S2TP 1XGMA 2EVCA 5FCFA 1BOAA 4U1BA 1WL9A 4U76A 4R60A 1R5HA 2GA2A 3Q6DA 4EGEA 3CB6A 4U73A 1WL6A 5JHUA 3IG4A 2MATA 3IU9A 3PKEA 4U70A 1YW8A 2ZSGA 2BWWA 4ZWPA 2DFIA 4U75A 3L7GA 1YJ3A 2GG2A 2GTXA 2Q95A 2EA2A 3IU8A 4U6EA 2GU4A 2P99A 4RZZA 4PNCA 4S2RP 1PV9A 2V6CA 1WKMA 2BB7A 3TB5A 1QZYA 1A16A 4IPAA 2GZ5A 1O0XA 2P9AA 5CDLA 2NQ7A 3FM3A 4U6ZA 2ADUA 3BIPA 3MATA 4IF7A 5JFRA 4ZWOA 3PKAA 3RORA 3S6BA 4PV4A 1M35A 4U6CA 4FLKA 2BWVA 2BHAA 3CTZA 2BWXA
chains in the Genus database with same CATH topology
2BHCA 1N51A 1W2MA 2GGCA 2EVMA 2Q94A 4B28A 1KP0A 1WY2A 2V3XA 5D6FA 2BHBA 1BN5A 1WBQA 1WN1A 4QR8A 2BHDA 1YW9A 2GG7A 2Q96A 4RZYA 4FO7A 4JUQA 2V3YA 1XGOA 4ZNGA 1C23A 2G6PA 4IKUA 2Q93A 4IU6A 2GG0A 4FKCA 4HXXA 4A6WA 1CHMA 2BWUA 4FLJA 4IKRA 5CLSA 2NQ6A 3BITA 4A6VA 2P98A 3MR1A 1YW7A 2GU7A 3PKCA 4RGZ1 4S01A 4IKSA 3FMRA 2EVOA 2OAZA 4IECA 2EA4A 2GG5A 1MATA 3MX6A 2GGBA 4U6WA 4FLIA 1C27A 3CB5A 4OOKA 2B3HA 3TAVA 1JAWA 3D27A 1KQ0A 1B59A 2GG8A 3IU7A 2GU6A 2OKNA 4KM3A 2B3KA 2GU5A 4IDYA 1QXZA 2BN7A 4FUKA 3L24A 3BIQA 4S00A 1Y1NA 5CDVA 4IKTA 2Q8KA 5E5BA 5CDEA 5JI6A 2BWTA 1C24A 5CNXA 1C21A 4U69A 1B6AA 4U6JA 1QXWA 1R5GA 3PKBA 2Q92A 2V3ZA 2B3LA 1KQ9A 3PKDA 4Z7MA 5D6EA 4ZWUA 4FLLA 2HOWA 4FO8A 1QXYA 1R58A 1XGSA 1W7VA 2GG9A 2GG3A 2IW2A 5CE6A 2BWSA 3FMQA 1WLRA 5CIKA 5FCHA 1C22A 2BH3A 1XGNA 1YVMA 4MATA 3RVAA 1XNZA 2BWYA 4U71A 4S2TP 1XGMA 2EVCA 5FCFA 1BOAA 4U1BA 1WL9A 4U76A 4R60A 1R5HA 2GA2A 3Q6DA 4EGEA 3CB6A 4U73A 1WL6A 5JHUA 3IG4A 2MATA 3IU9A 3PKEA 4U70A 1YW8A 2ZSGA 2BWWA 4ZWPA 2DFIA 4U75A 3L7GA 1YJ3A 2GG2A 2GTXA 2Q95A 2EA2A 3IU8A 4U6EA 2GU4A 2P99A 4RZZA 4PNCA 4S2RP 1PV9A 2V6CA 1WKMA 2BB7A 3TB5A 1QZYA 1A16A 4IPAA 2GZ5A 1O0XA 2P9AA 5CDLA 2NQ7A 3FM3A 4U6ZA 2ADUA 3BIPA 3MATA 4IF7A 5JFRA 4ZWOA 3PKAA 3RORA 3S6BA 4PV4A 1M35A 4U6CA 4FLKA 2BWVA 2BHAA 3CTZA 2BWXA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 2BHC A;  1N51 A;  1W2M A;  2GGC A;  2EVM A;  2Q94 A;  4B28 A;  1KP0 A;  1WY2 A;  2V3X A;  5D6F A;  2BHB A;  1BN5 A;  1WBQ A;  1WN1 A;  4QR8 A;  2BHD A;  1YW9 A;  2GG7 A;  2Q96 A;  4RZY A;  4FO7 A;  4JUQ A;  2V3Y A;  1XGO A;  4ZNG A;  1C23 A;  2G6P A;  4IKU A;  2Q93 A;  4IU6 A;  2GG0 A;  4FKC A;  4HXX A;  4A6W A;  1CHM A;  2BWU A;  4FLJ A;  4IKR A;  5CLS A;  2NQ6 A;  3BIT A;  4A6V A;  2P98 A;  3MR1 A;  1YW7 A;  2GU7 A;  3PKC A;  4RGZ 1;  4S01 A;  4IKS A;  3FMR A;  2EVO A;  2OAZ A;  4IEC A;  2EA4 A;  2GG5 A;  1MAT A;  3MX6 A;  2GGB A;  4U6W A;  4FLI A;  1C27 A;  3CB5 A;  4OOK A;  2B3H A;  3TAV A;  1JAW A;  3D27 A;  1KQ0 A;  1B59 A;  2GG8 A;  3IU7 A;  2GU6 A;  2OKN A;  4KM3 A;  2B3K A;  2GU5 A;  4IDY A;  1QXZ A;  2BN7 A;  4FUK A;  3L24 A;  3BIQ A;  4S00 A;  1Y1N A;  5CDV A;  4IKT A;  2Q8K A;  5E5B A;  5CDE A;  5JI6 A;  2BWT A;  1C24 A;  5CNX A;  1C21 A;  4U69 A;  1B6A A;  4U6J A;  1QXW A;  1R5G A;  3PKB A;  2Q92 A;  2V3Z A;  2B3L A;  1KQ9 A;  3PKD A;  4Z7M A;  5D6E A;  4ZWU A;  4FLL A;  2HOW A;  4FO8 A;  1QXY A;  1R58 A;  1XGS A;  1W7V A;  2GG9 A;  2GG3 A;  2IW2 A;  5CE6 A;  2BWS A;  3FMQ A;  1WLR A;  5CIK A;  5FCH A;  1C22 A;  2BH3 A;  1XGN A;  1YVM A;  4MAT A;  3RVA A;  1XNZ A;  2BWY A;  4U71 A;  4S2T P;  1XGM A;  2EVC A;  5FCF A;  1BOA A;  4U1B A;  1WL9 A;  4U76 A;  4R60 A;  1R5H A;  2GA2 A;  3Q6D A;  4EGE A;  3CB6 A;  4U73 A;  1WL6 A;  5JHU A;  3IG4 A;  2MAT A;  3IU9 A;  3PKE A;  4U70 A;  1YW8 A;  2ZSG A;  2BWW A;  4ZWP A;  2DFI A;  4U75 A;  3L7G A;  1YJ3 A;  2GG2 A;  2GTX A;  2Q95 A;  2EA2 A;  3IU8 A;  4U6E A;  2GU4 A;  2P99 A;  4RZZ A;  4PNC A;  4S2R P;  1PV9 A;  2V6C A;  1WKM A;  2BB7 A;  3TB5 A;  1QZY A;  1A16 A;  4IPA A;  2GZ5 A;  1O0X A;  2P9A A;  5CDL A;  2NQ7 A;  3FM3 A;  4U6Z A;  2ADU A;  3BIP A;  3MAT A;  4IF7 A;  5JFR A;  4ZWO A;  3PKA A;  3ROR A;  3S6B A;  4PV4 A;  1M35 A;  4U6C A;  4FLK A;  2BWV A;  2BHA A;  3CTZ A;  2BWX A; 
#chains in the Genus database with same CATH topology
 2BHC A;  1N51 A;  1W2M A;  2GGC A;  2EVM A;  2Q94 A;  4B28 A;  1KP0 A;  1WY2 A;  2V3X A;  5D6F A;  2BHB A;  1BN5 A;  1WBQ A;  1WN1 A;  4QR8 A;  2BHD A;  1YW9 A;  2GG7 A;  2Q96 A;  4RZY A;  4FO7 A;  4JUQ A;  2V3Y A;  1XGO A;  4ZNG A;  1C23 A;  2G6P A;  4IKU A;  2Q93 A;  4IU6 A;  2GG0 A;  4FKC A;  4HXX A;  4A6W A;  1CHM A;  2BWU A;  4FLJ A;  4IKR A;  5CLS A;  2NQ6 A;  3BIT A;  4A6V A;  2P98 A;  3MR1 A;  1YW7 A;  2GU7 A;  3PKC A;  4RGZ 1;  4S01 A;  4IKS A;  3FMR A;  2EVO A;  2OAZ A;  4IEC A;  2EA4 A;  2GG5 A;  1MAT A;  3MX6 A;  2GGB A;  4U6W A;  4FLI A;  1C27 A;  3CB5 A;  4OOK A;  2B3H A;  3TAV A;  1JAW A;  3D27 A;  1KQ0 A;  1B59 A;  2GG8 A;  3IU7 A;  2GU6 A;  2OKN A;  4KM3 A;  2B3K A;  2GU5 A;  4IDY A;  1QXZ A;  2BN7 A;  4FUK A;  3L24 A;  3BIQ A;  4S00 A;  1Y1N A;  5CDV A;  4IKT A;  2Q8K A;  5E5B A;  5CDE A;  5JI6 A;  2BWT A;  1C24 A;  5CNX A;  1C21 A;  4U69 A;  1B6A A;  4U6J A;  1QXW A;  1R5G A;  3PKB A;  2Q92 A;  2V3Z A;  2B3L A;  1KQ9 A;  3PKD A;  4Z7M A;  5D6E A;  4ZWU A;  4FLL A;  2HOW A;  4FO8 A;  1QXY A;  1R58 A;  1XGS A;  1W7V A;  2GG9 A;  2GG3 A;  2IW2 A;  5CE6 A;  2BWS A;  3FMQ A;  1WLR A;  5CIK A;  5FCH A;  1C22 A;  2BH3 A;  1XGN A;  1YVM A;  4MAT A;  3RVA A;  1XNZ A;  2BWY A;  4U71 A;  4S2T P;  1XGM A;  2EVC A;  5FCF A;  1BOA A;  4U1B A;  1WL9 A;  4U76 A;  4R60 A;  1R5H A;  2GA2 A;  3Q6D A;  4EGE A;  3CB6 A;  4U73 A;  1WL6 A;  5JHU A;  3IG4 A;  2MAT A;  3IU9 A;  3PKE A;  4U70 A;  1YW8 A;  2ZSG A;  2BWW A;  4ZWP A;  2DFI A;  4U75 A;  3L7G A;  1YJ3 A;  2GG2 A;  2GTX A;  2Q95 A;  2EA2 A;  3IU8 A;  4U6E A;  2GU4 A;  2P99 A;  4RZZ A;  4PNC A;  4S2R P;  1PV9 A;  2V6C A;  1WKM A;  2BB7 A;  3TB5 A;  1QZY A;  1A16 A;  4IPA A;  2GZ5 A;  1O0X A;  2P9A A;  5CDL A;  2NQ7 A;  3FM3 A;  4U6Z A;  2ADU A;  3BIP A;  3MAT A;  4IF7 A;  5JFR A;  4ZWO A;  3PKA A;  3ROR A;  3S6B A;  4PV4 A;  1M35 A;  4U6C A;  4FLK A;  2BWV A;  2BHA A;  3CTZ A;  2BWX A; 
#chains in the Genus database with same CATH homology
 2BHC A;  1N51 A;  1W2M A;  2GGC A;  2EVM A;  2Q94 A;  4B28 A;  1KP0 A;  1WY2 A;  2V3X A;  5D6F A;  2BHB A;  1BN5 A;  1WBQ A;  1WN1 A;  4QR8 A;  2BHD A;  1YW9 A;  2GG7 A;  2Q96 A;  4RZY A;  4FO7 A;  4JUQ A;  2V3Y A;  1XGO A;  4ZNG A;  1C23 A;  2G6P A;  4IKU A;  2Q93 A;  4IU6 A;  2GG0 A;  4FKC A;  4HXX A;  4A6W A;  1CHM A;  2BWU A;  4FLJ A;  4IKR A;  5CLS A;  2NQ6 A;  3BIT A;  4A6V A;  2P98 A;  3MR1 A;  1YW7 A;  2GU7 A;  3PKC A;  4RGZ 1;  4S01 A;  4IKS A;  3FMR A;  2EVO A;  2OAZ A;  4IEC A;  2EA4 A;  2GG5 A;  1MAT A;  3MX6 A;  2GGB A;  4U6W A;  4FLI A;  1C27 A;  3CB5 A;  4OOK A;  2B3H A;  3TAV A;  1JAW A;  3D27 A;  1KQ0 A;  1B59 A;  2GG8 A;  3IU7 A;  2GU6 A;  2OKN A;  4KM3 A;  2B3K A;  2GU5 A;  4IDY A;  1QXZ A;  2BN7 A;  4FUK A;  3L24 A;  3BIQ A;  4S00 A;  1Y1N A;  5CDV A;  4IKT A;  2Q8K A;  5E5B A;  5CDE A;  5JI6 A;  2BWT A;  1C24 A;  5CNX A;  1C21 A;  4U69 A;  1B6A A;  4U6J A;  1QXW A;  1R5G A;  3PKB A;  2Q92 A;  2V3Z A;  2B3L A;  1KQ9 A;  3PKD A;  4Z7M A;  5D6E A;  4ZWU A;  4FLL A;  2HOW A;  4FO8 A;  1QXY A;  1R58 A;  1XGS A;  1W7V A;  2GG9 A;  2GG3 A;  2IW2 A;  5CE6 A;  2BWS A;  3FMQ A;  1WLR A;  5CIK A;  5FCH A;  1C22 A;  2BH3 A;  1XGN A;  1YVM A;  4MAT A;  3RVA A;  1XNZ A;  2BWY A;  4U71 A;  4S2T P;  1XGM A;  2EVC A;  5FCF A;  1BOA A;  4U1B A;  1WL9 A;  4U76 A;  4R60 A;  1R5H A;  2GA2 A;  3Q6D A;  4EGE A;  3CB6 A;  4U73 A;  1WL6 A;  5JHU A;  3IG4 A;  2MAT A;  3IU9 A;  3PKE A;  4U70 A;  1YW8 A;  2ZSG A;  2BWW A;  4ZWP A;  2DFI A;  4U75 A;  3L7G A;  1YJ3 A;  2GG2 A;  2GTX A;  2Q95 A;  2EA2 A;  3IU8 A;  4U6E A;  2GU4 A;  2P99 A;  4RZZ A;  4PNC A;  4S2R P;  1PV9 A;  2V6C A;  1WKM A;  2BB7 A;  3TB5 A;  1QZY A;  1A16 A;  4IPA A;  2GZ5 A;  1O0X A;  2P9A A;  5CDL A;  2NQ7 A;  3FM3 A;  4U6Z A;  2ADU A;  3BIP A;  3MAT A;  4IF7 A;  5JFR A;  4ZWO A;  3PKA A;  3ROR A;  3S6B A;  4PV4 A;  1M35 A;  4U6C A;  4FLK A;  2BWV A;  2BHA A;  3CTZ A;  2BWX A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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