4FLKA

Human metap1 with bengamide analog y10, in mn form
Total Genus 98
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
98
sequence length
304
structure length
304
Chain Sequence
YRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLFHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARPHFMS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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molecule tags Hydrolase/hydrolase inhibitor
molecule keywords Methionine aminopeptidase 1
publication title Structural analysis of bengamide derivatives as inhibitors of methionine aminopeptidases.
pubmed doi rcsb
source organism Homo sapiens
total genus 98
structure length 304
sequence length 304
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2012-06-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4flkA00
2GU5A 2GGBA 4FLLA 1XGNA 1QXZA 2BHCA 3BIQA 2V3ZA 4Z7MA 3FM3A 5CDEA 3Q6DA 4JUQA 1YVMA 4FLJA 4S2TP 1M35A 2OKNA 4U71A 1R5GA 3D27A 1WKMA 1C27A 2BWYA 2GG7A 2V3YA 2GU4A 2BB7A 4RZYA 1WL9A 4U70A 1CHMA 1QXWA 4FUKA 1WLRA 3IU7A 5E5BA 4ZWPA 3TB5A 1WN1A 1WL6A 2GG3A 4RGZ1 3L24A 1XNZA 2Q92A 4FLKA 3S6BA 4IPAA 2EA4A 2NQ6A 2EVOA 1QZYA 1KQ9A 4FLIA 4S01A 4ZWUA 3BIPA 2BWWA 1BN5A 3CB5A 4HXXA 2EVCA 4IKTA 1WY2A 1Y1NA 2BWUA 2GU7A 4A6WA 5JFRA 4PV4A 5CLSA 2GGCA 2OAZA 2V6CA 3BITA 4R60A 2GA2A 1MATA 2GG9A 2BWTA 3L7GA 2GG0A 4FO8A 4S00A 5CE6A 4FKCA 3PKBA 4FO7A 1B6AA 2BWVA 4A6VA 4U1BA 5CIKA 1KQ0A 1KP0A 2NQ7A 5CDVA 4U6WA 2BWXA 2V3XA 1WBQA 4IECA 2IW2A 1R5HA 3RORA 1XGOA 3TAVA 2GG8A 4IDYA 4EGEA 4RZZA 2Q93A 1XGSA 4U75A 1JAWA 3PKCA 1BOAA 2GTXA 3MR1A 1C22A 3PKEA 5CDLA 3IG4A 3IU9A 1QXYA 4U6CA 1YW8A 4OOKA 2BH3A 1YW9A 2Q8KA 2ADUA 2GZ5A 3IU8A 4IKUA 4IF7A 4ZWOA 2B3LA 2Q95A 2P99A 3MX6A 1YJ3A 2GU6A 5D6FA 1PV9A 5CNXA 2Q94A 4KM3A 2Q96A 2BWSA 2EVMA 2BHBA 5JI6A 1C24A 4IKRA 1N51A 3RVAA 1YW7A 1A16A 4U73A 4PNCA 4MATA 2EA2A 4U6ZA 2HOWA 4U6JA 5FCHA 1XGMA 2DFIA 4IU6A 1W2MA 2B3HA 3PKDA 2GG2A 3CB6A 1O0XA 2BHDA 4ZNGA 1C21A 2BHAA 2BN7A 4QR8A 2B3KA 5FCFA 2ZSGA 4IKSA 4U76A 2GG5A 2P98A 1R58A 3MATA 4U6EA 4B28A 5JHUA 1W7VA 3PKAA 3CTZA 2P9AA 3FMRA 4S2RP 5D6EA 2G6PA 1B59A 3FMQA 1C23A 2MATA 4U69A
chains in the Genus database with same CATH superfamily
2GU5A 2GGBA 4FLLA 1XGNA 1QXZA 2BHCA 3BIQA 2V3ZA 4Z7MA 3FM3A 5CDEA 3Q6DA 4JUQA 1YVMA 4FLJA 4S2TP 1M35A 2OKNA 4U71A 1R5GA 3D27A 1WKMA 1C27A 2BWYA 2GG7A 2V3YA 2GU4A 2BB7A 4RZYA 1WL9A 4U70A 1CHMA 1QXWA 4FUKA 1WLRA 3IU7A 5E5BA 4ZWPA 3TB5A 1WN1A 1WL6A 2GG3A 4RGZ1 3L24A 1XNZA 2Q92A 4FLKA 3S6BA 4IPAA 2EA4A 2NQ6A 2EVOA 1QZYA 1KQ9A 4FLIA 4S01A 4ZWUA 3BIPA 2BWWA 1BN5A 3CB5A 4HXXA 2EVCA 4IKTA 1WY2A 1Y1NA 2BWUA 2GU7A 4A6WA 5JFRA 4PV4A 5CLSA 2GGCA 2OAZA 2V6CA 3BITA 4R60A 2GA2A 1MATA 2GG9A 2BWTA 3L7GA 2GG0A 4FO8A 4S00A 5CE6A 4FKCA 3PKBA 4FO7A 1B6AA 2BWVA 4A6VA 4U1BA 5CIKA 1KQ0A 1KP0A 2NQ7A 5CDVA 4U6WA 2BWXA 2V3XA 1WBQA 4IECA 2IW2A 1R5HA 3RORA 1XGOA 3TAVA 2GG8A 4IDYA 4EGEA 4RZZA 2Q93A 1XGSA 4U75A 1JAWA 3PKCA 1BOAA 2GTXA 3MR1A 1C22A 3PKEA 5CDLA 3IG4A 3IU9A 1QXYA 4U6CA 1YW8A 4OOKA 2BH3A 1YW9A 2Q8KA 2ADUA 2GZ5A 3IU8A 4IKUA 4IF7A 4ZWOA 2B3LA 2Q95A 2P99A 3MX6A 1YJ3A 2GU6A 5D6FA 1PV9A 5CNXA 2Q94A 4KM3A 2Q96A 2BWSA 2EVMA 2BHBA 5JI6A 1C24A 4IKRA 1N51A 3RVAA 1YW7A 1A16A 4U73A 4PNCA 4MATA 2EA2A 4U6ZA 2HOWA 4U6JA 5FCHA 1XGMA 2DFIA 4IU6A 1W2MA 2B3HA 3PKDA 2GG2A 3CB6A 1O0XA 2BHDA 4ZNGA 1C21A 2BHAA 2BN7A 4QR8A 2B3KA 5FCFA 2ZSGA 4IKSA 4U76A 2GG5A 2P98A 1R58A 3MATA 4U6EA 4B28A 5JHUA 1W7VA 3PKAA 3CTZA 2P9AA 3FMRA 4S2RP 5D6EA 2G6PA 1B59A 3FMQA 1C23A 2MATA 4U69A
chains in the Genus database with same CATH topology
2GU5A 2GGBA 4FLLA 1XGNA 1QXZA 2BHCA 3BIQA 2V3ZA 4Z7MA 3FM3A 5CDEA 3Q6DA 4JUQA 1YVMA 4FLJA 4S2TP 1M35A 2OKNA 4U71A 1R5GA 3D27A 1WKMA 1C27A 2BWYA 2GG7A 2V3YA 2GU4A 2BB7A 4RZYA 1WL9A 4U70A 1CHMA 1QXWA 4FUKA 1WLRA 3IU7A 5E5BA 4ZWPA 3TB5A 1WN1A 1WL6A 2GG3A 4RGZ1 3L24A 1XNZA 2Q92A 4FLKA 3S6BA 4IPAA 2EA4A 2NQ6A 2EVOA 1QZYA 1KQ9A 4FLIA 4S01A 4ZWUA 3BIPA 2BWWA 1BN5A 3CB5A 4HXXA 2EVCA 4IKTA 1WY2A 1Y1NA 2BWUA 2GU7A 4A6WA 5JFRA 4PV4A 5CLSA 2GGCA 2OAZA 2V6CA 3BITA 4R60A 2GA2A 1MATA 2GG9A 2BWTA 3L7GA 2GG0A 4FO8A 4S00A 5CE6A 4FKCA 3PKBA 4FO7A 1B6AA 2BWVA 4A6VA 4U1BA 5CIKA 1KQ0A 1KP0A 2NQ7A 5CDVA 4U6WA 2BWXA 2V3XA 1WBQA 4IECA 2IW2A 1R5HA 3RORA 1XGOA 3TAVA 2GG8A 4IDYA 4EGEA 4RZZA 2Q93A 1XGSA 4U75A 1JAWA 3PKCA 1BOAA 2GTXA 3MR1A 1C22A 3PKEA 5CDLA 3IG4A 3IU9A 1QXYA 4U6CA 1YW8A 4OOKA 2BH3A 1YW9A 2Q8KA 2ADUA 2GZ5A 3IU8A 4IKUA 4IF7A 4ZWOA 2B3LA 2Q95A 2P99A 3MX6A 1YJ3A 2GU6A 5D6FA 1PV9A 5CNXA 2Q94A 4KM3A 2Q96A 2BWSA 2EVMA 2BHBA 5JI6A 1C24A 4IKRA 1N51A 3RVAA 1YW7A 1A16A 4U73A 4PNCA 4MATA 2EA2A 4U6ZA 2HOWA 4U6JA 5FCHA 1XGMA 2DFIA 4IU6A 1W2MA 2B3HA 3PKDA 2GG2A 3CB6A 1O0XA 2BHDA 4ZNGA 1C21A 2BHAA 2BN7A 4QR8A 2B3KA 5FCFA 2ZSGA 4IKSA 4U76A 2GG5A 2P98A 1R58A 3MATA 4U6EA 4B28A 5JHUA 1W7VA 3PKAA 3CTZA 2P9AA 3FMRA 4S2RP 5D6EA 2G6PA 1B59A 3FMQA 1C23A 2MATA 4U69A
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 2GU5 A;  2GGB A;  4FLL A;  1XGN A;  1QXZ A;  2BHC A;  3BIQ A;  2V3Z A;  4Z7M A;  3FM3 A;  5CDE A;  3Q6D A;  4JUQ A;  1YVM A;  4FLJ A;  4S2T P;  1M35 A;  2OKN A;  4U71 A;  1R5G A;  3D27 A;  1WKM A;  1C27 A;  2BWY A;  2GG7 A;  2V3Y A;  2GU4 A;  2BB7 A;  4RZY A;  1WL9 A;  4U70 A;  1CHM A;  1QXW A;  4FUK A;  1WLR A;  3IU7 A;  5E5B A;  4ZWP A;  3TB5 A;  1WN1 A;  1WL6 A;  2GG3 A;  4RGZ 1;  3L24 A;  1XNZ A;  2Q92 A;  4FLK A;  3S6B A;  4IPA A;  2EA4 A;  2NQ6 A;  2EVO A;  1QZY A;  1KQ9 A;  4FLI A;  4S01 A;  4ZWU A;  3BIP A;  2BWW A;  1BN5 A;  3CB5 A;  4HXX A;  2EVC A;  4IKT A;  1WY2 A;  1Y1N A;  2BWU A;  2GU7 A;  4A6W A;  5JFR A;  4PV4 A;  5CLS A;  2GGC A;  2OAZ A;  2V6C A;  3BIT A;  4R60 A;  2GA2 A;  1MAT A;  2GG9 A;  2BWT A;  3L7G A;  2GG0 A;  4FO8 A;  4S00 A;  5CE6 A;  4FKC A;  3PKB A;  4FO7 A;  1B6A A;  2BWV A;  4A6V A;  4U1B A;  5CIK A;  1KQ0 A;  1KP0 A;  2NQ7 A;  5CDV A;  4U6W A;  2BWX A;  2V3X A;  1WBQ A;  4IEC A;  2IW2 A;  1R5H A;  3ROR A;  1XGO A;  3TAV A;  2GG8 A;  4IDY A;  4EGE A;  4RZZ A;  2Q93 A;  1XGS A;  4U75 A;  1JAW A;  3PKC A;  1BOA A;  2GTX A;  3MR1 A;  1C22 A;  3PKE A;  5CDL A;  3IG4 A;  3IU9 A;  1QXY A;  4U6C A;  1YW8 A;  4OOK A;  2BH3 A;  1YW9 A;  2Q8K A;  2ADU A;  2GZ5 A;  3IU8 A;  4IKU A;  4IF7 A;  4ZWO A;  2B3L A;  2Q95 A;  2P99 A;  3MX6 A;  1YJ3 A;  2GU6 A;  5D6F A;  1PV9 A;  5CNX A;  2Q94 A;  4KM3 A;  2Q96 A;  2BWS A;  2EVM A;  2BHB A;  5JI6 A;  1C24 A;  4IKR A;  1N51 A;  3RVA A;  1YW7 A;  1A16 A;  4U73 A;  4PNC A;  4MAT A;  2EA2 A;  4U6Z A;  2HOW A;  4U6J A;  5FCH A;  1XGM A;  2DFI A;  4IU6 A;  1W2M A;  2B3H A;  3PKD A;  2GG2 A;  3CB6 A;  1O0X A;  2BHD A;  4ZNG A;  1C21 A;  2BHA A;  2BN7 A;  4QR8 A;  2B3K A;  5FCF A;  2ZSG A;  4IKS A;  4U76 A;  2GG5 A;  2P98 A;  1R58 A;  3MAT A;  4U6E A;  4B28 A;  5JHU A;  1W7V A;  3PKA A;  3CTZ A;  2P9A A;  3FMR A;  4S2R P;  5D6E A;  2G6P A;  1B59 A;  3FMQ A;  1C23 A;  2MAT A;  4U69 A; 
#chains in the Genus database with same CATH topology
 2GU5 A;  2GGB A;  4FLL A;  1XGN A;  1QXZ A;  2BHC A;  3BIQ A;  2V3Z A;  4Z7M A;  3FM3 A;  5CDE A;  3Q6D A;  4JUQ A;  1YVM A;  4FLJ A;  4S2T P;  1M35 A;  2OKN A;  4U71 A;  1R5G A;  3D27 A;  1WKM A;  1C27 A;  2BWY A;  2GG7 A;  2V3Y A;  2GU4 A;  2BB7 A;  4RZY A;  1WL9 A;  4U70 A;  1CHM A;  1QXW A;  4FUK A;  1WLR A;  3IU7 A;  5E5B A;  4ZWP A;  3TB5 A;  1WN1 A;  1WL6 A;  2GG3 A;  4RGZ 1;  3L24 A;  1XNZ A;  2Q92 A;  4FLK A;  3S6B A;  4IPA A;  2EA4 A;  2NQ6 A;  2EVO A;  1QZY A;  1KQ9 A;  4FLI A;  4S01 A;  4ZWU A;  3BIP A;  2BWW A;  1BN5 A;  3CB5 A;  4HXX A;  2EVC A;  4IKT A;  1WY2 A;  1Y1N A;  2BWU A;  2GU7 A;  4A6W A;  5JFR A;  4PV4 A;  5CLS A;  2GGC A;  2OAZ A;  2V6C A;  3BIT A;  4R60 A;  2GA2 A;  1MAT A;  2GG9 A;  2BWT A;  3L7G A;  2GG0 A;  4FO8 A;  4S00 A;  5CE6 A;  4FKC A;  3PKB A;  4FO7 A;  1B6A A;  2BWV A;  4A6V A;  4U1B A;  5CIK A;  1KQ0 A;  1KP0 A;  2NQ7 A;  5CDV A;  4U6W A;  2BWX A;  2V3X A;  1WBQ A;  4IEC A;  2IW2 A;  1R5H A;  3ROR A;  1XGO A;  3TAV A;  2GG8 A;  4IDY A;  4EGE A;  4RZZ A;  2Q93 A;  1XGS A;  4U75 A;  1JAW A;  3PKC A;  1BOA A;  2GTX A;  3MR1 A;  1C22 A;  3PKE A;  5CDL A;  3IG4 A;  3IU9 A;  1QXY A;  4U6C A;  1YW8 A;  4OOK A;  2BH3 A;  1YW9 A;  2Q8K A;  2ADU A;  2GZ5 A;  3IU8 A;  4IKU A;  4IF7 A;  4ZWO A;  2B3L A;  2Q95 A;  2P99 A;  3MX6 A;  1YJ3 A;  2GU6 A;  5D6F A;  1PV9 A;  5CNX A;  2Q94 A;  4KM3 A;  2Q96 A;  2BWS A;  2EVM A;  2BHB A;  5JI6 A;  1C24 A;  4IKR A;  1N51 A;  3RVA A;  1YW7 A;  1A16 A;  4U73 A;  4PNC A;  4MAT A;  2EA2 A;  4U6Z A;  2HOW A;  4U6J A;  5FCH A;  1XGM A;  2DFI A;  4IU6 A;  1W2M A;  2B3H A;  3PKD A;  2GG2 A;  3CB6 A;  1O0X A;  2BHD A;  4ZNG A;  1C21 A;  2BHA A;  2BN7 A;  4QR8 A;  2B3K A;  5FCF A;  2ZSG A;  4IKS A;  4U76 A;  2GG5 A;  2P98 A;  1R58 A;  3MAT A;  4U6E A;  4B28 A;  5JHU A;  1W7V A;  3PKA A;  3CTZ A;  2P9A A;  3FMR A;  4S2R P;  5D6E A;  2G6P A;  1B59 A;  3FMQ A;  1C23 A;  2MAT A;  4U69 A; 
#chains in the Genus database with same CATH homology
 2GU5 A;  2GGB A;  4FLL A;  1XGN A;  1QXZ A;  2BHC A;  3BIQ A;  2V3Z A;  4Z7M A;  3FM3 A;  5CDE A;  3Q6D A;  4JUQ A;  1YVM A;  4FLJ A;  4S2T P;  1M35 A;  2OKN A;  4U71 A;  1R5G A;  3D27 A;  1WKM A;  1C27 A;  2BWY A;  2GG7 A;  2V3Y A;  2GU4 A;  2BB7 A;  4RZY A;  1WL9 A;  4U70 A;  1CHM A;  1QXW A;  4FUK A;  1WLR A;  3IU7 A;  5E5B A;  4ZWP A;  3TB5 A;  1WN1 A;  1WL6 A;  2GG3 A;  4RGZ 1;  3L24 A;  1XNZ A;  2Q92 A;  4FLK A;  3S6B A;  4IPA A;  2EA4 A;  2NQ6 A;  2EVO A;  1QZY A;  1KQ9 A;  4FLI A;  4S01 A;  4ZWU A;  3BIP A;  2BWW A;  1BN5 A;  3CB5 A;  4HXX A;  2EVC A;  4IKT A;  1WY2 A;  1Y1N A;  2BWU A;  2GU7 A;  4A6W A;  5JFR A;  4PV4 A;  5CLS A;  2GGC A;  2OAZ A;  2V6C A;  3BIT A;  4R60 A;  2GA2 A;  1MAT A;  2GG9 A;  2BWT A;  3L7G A;  2GG0 A;  4FO8 A;  4S00 A;  5CE6 A;  4FKC A;  3PKB A;  4FO7 A;  1B6A A;  2BWV A;  4A6V A;  4U1B A;  5CIK A;  1KQ0 A;  1KP0 A;  2NQ7 A;  5CDV A;  4U6W A;  2BWX A;  2V3X A;  1WBQ A;  4IEC A;  2IW2 A;  1R5H A;  3ROR A;  1XGO A;  3TAV A;  2GG8 A;  4IDY A;  4EGE A;  4RZZ A;  2Q93 A;  1XGS A;  4U75 A;  1JAW A;  3PKC A;  1BOA A;  2GTX A;  3MR1 A;  1C22 A;  3PKE A;  5CDL A;  3IG4 A;  3IU9 A;  1QXY A;  4U6C A;  1YW8 A;  4OOK A;  2BH3 A;  1YW9 A;  2Q8K A;  2ADU A;  2GZ5 A;  3IU8 A;  4IKU A;  4IF7 A;  4ZWO A;  2B3L A;  2Q95 A;  2P99 A;  3MX6 A;  1YJ3 A;  2GU6 A;  5D6F A;  1PV9 A;  5CNX A;  2Q94 A;  4KM3 A;  2Q96 A;  2BWS A;  2EVM A;  2BHB A;  5JI6 A;  1C24 A;  4IKR A;  1N51 A;  3RVA A;  1YW7 A;  1A16 A;  4U73 A;  4PNC A;  4MAT A;  2EA2 A;  4U6Z A;  2HOW A;  4U6J A;  5FCH A;  1XGM A;  2DFI A;  4IU6 A;  1W2M A;  2B3H A;  3PKD A;  2GG2 A;  3CB6 A;  1O0X A;  2BHD A;  4ZNG A;  1C21 A;  2BHA A;  2BN7 A;  4QR8 A;  2B3K A;  5FCF A;  2ZSG A;  4IKS A;  4U76 A;  2GG5 A;  2P98 A;  1R58 A;  3MAT A;  4U6E A;  4B28 A;  5JHU A;  1W7V A;  3PKA A;  3CTZ A;  2P9A A;  3FMR A;  4S2R P;  5D6E A;  2G6P A;  1B59 A;  3FMQ A;  1C23 A;  2MAT A;  4U69 A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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