4U6JA

Hsmetap in complex with methionine
Total Genus 102
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
102
sequence length
304
structure length
304
Chain Sequence
YRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLFHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARPHFMS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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molecule tags Hydrolase
molecule keywords Methionine aminopeptidase 1
publication title Identification of the Molecular Basis of Inhibitor Selectivity between the Human and Streptococcal Type I Methionine Aminopeptidases
pubmed doi rcsb
source organism Homo sapiens
total genus 102
structure length 304
sequence length 304
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2014-07-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4u6jA00
4FO8A 5FCFA 5CDLA 5FCHA 2GTXA 2GU6A 4IKRA 2IW2A 3BITA 2HOWA 4S01A 3TB5A 5CDVA 4ZWUA 4U6JA 4A6VA 4U6ZA 1Y1NA 1M35A 4FUKA 1PV9A 1WL9A 2OKNA 3PKAA 3PKEA 4ZWOA 4S2TP 2BWYA 4QR8A 2P9AA 3CB5A 1WLRA 4JUQA 2OAZA 3S6BA 3RORA 4S2RP 1XGSA 2MATA 4ZNGA 5CNXA 4RGZ1 1C22A 2BWSA 4U73A 5CIKA 2V3YA 1C23A 2BH3A 3FM3A 1B59A 1YJ3A 1WN1A 2V3XA 4IDYA 5CE6A 1KQ9A 2BHCA 5CLSA 2GU7A 1YVMA 1JAWA 3MATA 4U71A 2GU4A 1MATA 2G6PA 3BIPA 4U70A 4FLLA 4EGEA 5JHUA 1BOAA 1N51A 2B3KA 2Q96A 2GG7A 3BIQA 1KP0A 2B3LA 3FMRA 4KM3A 1QXWA 4IF7A 2Q95A 2BWTA 4U1BA 1XNZA 2P99A 4IKSA 4IKUA 2GZ5A 2GG2A 4A6WA 5E5BA 1O0XA 3FMQA 4R60A 4IPAA 4U6CA 4OOKA 5D6FA 2Q94A 2V6CA 5JI6A 3TAVA 3IU7A 2EA4A 1W2MA 5JFRA 1CHMA 1YW8A 2GGBA 2BWUA 2V3ZA 2BB7A 3IG4A 4U75A 1QXYA 1YW7A 2DFIA 4U76A 2ZSGA 2GA2A 1C21A 4B28A 2BWWA 2Q92A 1A16A 2BN7A 3MX6A 3IU9A 2BHDA 4S00A 3CB6A 3PKCA 1XGOA 2Q8KA 3MR1A 2GGCA 4IKTA 4ZWPA 1R5GA 3PKDA 4U6WA 3D27A 1XGNA 2EA2A 1C27A 4RZYA 4MATA 1YW9A 1BN5A 3Q6DA 4HXXA 3IU8A 5CDEA 4FKCA 2NQ7A 2GG0A 2B3HA 4U69A 1KQ0A 4IU6A 1C24A 2ADUA 1B6AA 1WY2A 4FLIA 4IECA 2P98A 2EVMA 2BWVA 2NQ6A 1WL6A 4PV4A 2BHBA 2GG3A 4RZZA 5D6EA 2GG5A 2BHAA 2GU5A 3RVAA 2GG8A 3CTZA 2EVCA 1WKMA 1WBQA 4FO7A 1R5HA 4U6EA 1QZYA 2GG9A 4Z7MA 2EVOA 4FLJA 1W7VA 4FLKA 3PKBA 1R58A 2Q93A 3L7GA 1XGMA 4PNCA 3L24A 2BWXA 1QXZA
chains in the Genus database with same CATH superfamily
4FO8A 5FCFA 5CDLA 5FCHA 2GTXA 2GU6A 4IKRA 2IW2A 3BITA 2HOWA 4S01A 3TB5A 5CDVA 4ZWUA 4U6JA 4A6VA 4U6ZA 1Y1NA 1M35A 4FUKA 1PV9A 1WL9A 2OKNA 3PKAA 3PKEA 4ZWOA 4S2TP 2BWYA 4QR8A 2P9AA 3CB5A 1WLRA 4JUQA 2OAZA 3S6BA 3RORA 4S2RP 1XGSA 2MATA 4ZNGA 5CNXA 4RGZ1 1C22A 2BWSA 4U73A 5CIKA 2V3YA 1C23A 2BH3A 3FM3A 1B59A 1YJ3A 1WN1A 2V3XA 4IDYA 5CE6A 1KQ9A 2BHCA 5CLSA 2GU7A 1YVMA 1JAWA 3MATA 4U71A 2GU4A 1MATA 2G6PA 3BIPA 4U70A 4FLLA 4EGEA 5JHUA 1BOAA 1N51A 2B3KA 2Q96A 2GG7A 3BIQA 1KP0A 2B3LA 3FMRA 4KM3A 1QXWA 4IF7A 2Q95A 2BWTA 4U1BA 1XNZA 2P99A 4IKSA 4IKUA 2GZ5A 2GG2A 4A6WA 5E5BA 1O0XA 3FMQA 4R60A 4IPAA 4U6CA 4OOKA 5D6FA 2Q94A 2V6CA 5JI6A 3TAVA 3IU7A 2EA4A 1W2MA 5JFRA 1CHMA 1YW8A 2GGBA 2BWUA 2V3ZA 2BB7A 3IG4A 4U75A 1QXYA 1YW7A 2DFIA 4U76A 2ZSGA 2GA2A 1C21A 4B28A 2BWWA 2Q92A 1A16A 2BN7A 3MX6A 3IU9A 2BHDA 4S00A 3CB6A 3PKCA 1XGOA 2Q8KA 3MR1A 2GGCA 4IKTA 4ZWPA 1R5GA 3PKDA 4U6WA 3D27A 1XGNA 2EA2A 1C27A 4RZYA 4MATA 1YW9A 1BN5A 3Q6DA 4HXXA 3IU8A 5CDEA 4FKCA 2NQ7A 2GG0A 2B3HA 4U69A 1KQ0A 4IU6A 1C24A 2ADUA 1B6AA 1WY2A 4FLIA 4IECA 2P98A 2EVMA 2BWVA 2NQ6A 1WL6A 4PV4A 2BHBA 2GG3A 4RZZA 5D6EA 2GG5A 2BHAA 2GU5A 3RVAA 2GG8A 3CTZA 2EVCA 1WKMA 1WBQA 4FO7A 1R5HA 4U6EA 1QZYA 2GG9A 4Z7MA 2EVOA 4FLJA 1W7VA 4FLKA 3PKBA 1R58A 2Q93A 3L7GA 1XGMA 4PNCA 3L24A 2BWXA 1QXZA
chains in the Genus database with same CATH topology
4FO8A 5FCFA 5CDLA 5FCHA 2GTXA 2GU6A 4IKRA 2IW2A 3BITA 2HOWA 4S01A 3TB5A 5CDVA 4ZWUA 4U6JA 4A6VA 4U6ZA 1Y1NA 1M35A 4FUKA 1PV9A 1WL9A 2OKNA 3PKAA 3PKEA 4ZWOA 4S2TP 2BWYA 4QR8A 2P9AA 3CB5A 1WLRA 4JUQA 2OAZA 3S6BA 3RORA 4S2RP 1XGSA 2MATA 4ZNGA 5CNXA 4RGZ1 1C22A 2BWSA 4U73A 5CIKA 2V3YA 1C23A 2BH3A 3FM3A 1B59A 1YJ3A 1WN1A 2V3XA 4IDYA 5CE6A 1KQ9A 2BHCA 5CLSA 2GU7A 1YVMA 1JAWA 3MATA 4U71A 2GU4A 1MATA 2G6PA 3BIPA 4U70A 4FLLA 4EGEA 5JHUA 1BOAA 1N51A 2B3KA 2Q96A 2GG7A 3BIQA 1KP0A 2B3LA 3FMRA 4KM3A 1QXWA 4IF7A 2Q95A 2BWTA 4U1BA 1XNZA 2P99A 4IKSA 4IKUA 2GZ5A 2GG2A 4A6WA 5E5BA 1O0XA 3FMQA 4R60A 4IPAA 4U6CA 4OOKA 5D6FA 2Q94A 2V6CA 5JI6A 3TAVA 3IU7A 2EA4A 1W2MA 5JFRA 1CHMA 1YW8A 2GGBA 2BWUA 2V3ZA 2BB7A 3IG4A 4U75A 1QXYA 1YW7A 2DFIA 4U76A 2ZSGA 2GA2A 1C21A 4B28A 2BWWA 2Q92A 1A16A 2BN7A 3MX6A 3IU9A 2BHDA 4S00A 3CB6A 3PKCA 1XGOA 2Q8KA 3MR1A 2GGCA 4IKTA 4ZWPA 1R5GA 3PKDA 4U6WA 3D27A 1XGNA 2EA2A 1C27A 4RZYA 4MATA 1YW9A 1BN5A 3Q6DA 4HXXA 3IU8A 5CDEA 4FKCA 2NQ7A 2GG0A 2B3HA 4U69A 1KQ0A 4IU6A 1C24A 2ADUA 1B6AA 1WY2A 4FLIA 4IECA 2P98A 2EVMA 2BWVA 2NQ6A 1WL6A 4PV4A 2BHBA 2GG3A 4RZZA 5D6EA 2GG5A 2BHAA 2GU5A 3RVAA 2GG8A 3CTZA 2EVCA 1WKMA 1WBQA 4FO7A 1R5HA 4U6EA 1QZYA 2GG9A 4Z7MA 2EVOA 4FLJA 1W7VA 4FLKA 3PKBA 1R58A 2Q93A 3L7GA 1XGMA 4PNCA 3L24A 2BWXA 1QXZA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 4FO8 A;  5FCF A;  5CDL A;  5FCH A;  2GTX A;  2GU6 A;  4IKR A;  2IW2 A;  3BIT A;  2HOW A;  4S01 A;  3TB5 A;  5CDV A;  4ZWU A;  4U6J A;  4A6V A;  4U6Z A;  1Y1N A;  1M35 A;  4FUK A;  1PV9 A;  1WL9 A;  2OKN A;  3PKA A;  3PKE A;  4ZWO A;  4S2T P;  2BWY A;  4QR8 A;  2P9A A;  3CB5 A;  1WLR A;  4JUQ A;  2OAZ A;  3S6B A;  3ROR A;  4S2R P;  1XGS A;  2MAT A;  4ZNG A;  5CNX A;  4RGZ 1;  1C22 A;  2BWS A;  4U73 A;  5CIK A;  2V3Y A;  1C23 A;  2BH3 A;  3FM3 A;  1B59 A;  1YJ3 A;  1WN1 A;  2V3X A;  4IDY A;  5CE6 A;  1KQ9 A;  2BHC A;  5CLS A;  2GU7 A;  1YVM A;  1JAW A;  3MAT A;  4U71 A;  2GU4 A;  1MAT A;  2G6P A;  3BIP A;  4U70 A;  4FLL A;  4EGE A;  5JHU A;  1BOA A;  1N51 A;  2B3K A;  2Q96 A;  2GG7 A;  3BIQ A;  1KP0 A;  2B3L A;  3FMR A;  4KM3 A;  1QXW A;  4IF7 A;  2Q95 A;  2BWT A;  4U1B A;  1XNZ A;  2P99 A;  4IKS A;  4IKU A;  2GZ5 A;  2GG2 A;  4A6W A;  5E5B A;  1O0X A;  3FMQ A;  4R60 A;  4IPA A;  4U6C A;  4OOK A;  5D6F A;  2Q94 A;  2V6C A;  5JI6 A;  3TAV A;  3IU7 A;  2EA4 A;  1W2M A;  5JFR A;  1CHM A;  1YW8 A;  2GGB A;  2BWU A;  2V3Z A;  2BB7 A;  3IG4 A;  4U75 A;  1QXY A;  1YW7 A;  2DFI A;  4U76 A;  2ZSG A;  2GA2 A;  1C21 A;  4B28 A;  2BWW A;  2Q92 A;  1A16 A;  2BN7 A;  3MX6 A;  3IU9 A;  2BHD A;  4S00 A;  3CB6 A;  3PKC A;  1XGO A;  2Q8K A;  3MR1 A;  2GGC A;  4IKT A;  4ZWP A;  1R5G A;  3PKD A;  4U6W A;  3D27 A;  1XGN A;  2EA2 A;  1C27 A;  4RZY A;  4MAT A;  1YW9 A;  1BN5 A;  3Q6D A;  4HXX A;  3IU8 A;  5CDE A;  4FKC A;  2NQ7 A;  2GG0 A;  2B3H A;  4U69 A;  1KQ0 A;  4IU6 A;  1C24 A;  2ADU A;  1B6A A;  1WY2 A;  4FLI A;  4IEC A;  2P98 A;  2EVM A;  2BWV A;  2NQ6 A;  1WL6 A;  4PV4 A;  2BHB A;  2GG3 A;  4RZZ A;  5D6E A;  2GG5 A;  2BHA A;  2GU5 A;  3RVA A;  2GG8 A;  3CTZ A;  2EVC A;  1WKM A;  1WBQ A;  4FO7 A;  1R5H A;  4U6E A;  1QZY A;  2GG9 A;  4Z7M A;  2EVO A;  4FLJ A;  1W7V A;  4FLK A;  3PKB A;  1R58 A;  2Q93 A;  3L7G A;  1XGM A;  4PNC A;  3L24 A;  2BWX A;  1QXZ A; 
#chains in the Genus database with same CATH topology
 4FO8 A;  5FCF A;  5CDL A;  5FCH A;  2GTX A;  2GU6 A;  4IKR A;  2IW2 A;  3BIT A;  2HOW A;  4S01 A;  3TB5 A;  5CDV A;  4ZWU A;  4U6J A;  4A6V A;  4U6Z A;  1Y1N A;  1M35 A;  4FUK A;  1PV9 A;  1WL9 A;  2OKN A;  3PKA A;  3PKE A;  4ZWO A;  4S2T P;  2BWY A;  4QR8 A;  2P9A A;  3CB5 A;  1WLR A;  4JUQ A;  2OAZ A;  3S6B A;  3ROR A;  4S2R P;  1XGS A;  2MAT A;  4ZNG A;  5CNX A;  4RGZ 1;  1C22 A;  2BWS A;  4U73 A;  5CIK A;  2V3Y A;  1C23 A;  2BH3 A;  3FM3 A;  1B59 A;  1YJ3 A;  1WN1 A;  2V3X A;  4IDY A;  5CE6 A;  1KQ9 A;  2BHC A;  5CLS A;  2GU7 A;  1YVM A;  1JAW A;  3MAT A;  4U71 A;  2GU4 A;  1MAT A;  2G6P A;  3BIP A;  4U70 A;  4FLL A;  4EGE A;  5JHU A;  1BOA A;  1N51 A;  2B3K A;  2Q96 A;  2GG7 A;  3BIQ A;  1KP0 A;  2B3L A;  3FMR A;  4KM3 A;  1QXW A;  4IF7 A;  2Q95 A;  2BWT A;  4U1B A;  1XNZ A;  2P99 A;  4IKS A;  4IKU A;  2GZ5 A;  2GG2 A;  4A6W A;  5E5B A;  1O0X A;  3FMQ A;  4R60 A;  4IPA A;  4U6C A;  4OOK A;  5D6F A;  2Q94 A;  2V6C A;  5JI6 A;  3TAV A;  3IU7 A;  2EA4 A;  1W2M A;  5JFR A;  1CHM A;  1YW8 A;  2GGB A;  2BWU A;  2V3Z A;  2BB7 A;  3IG4 A;  4U75 A;  1QXY A;  1YW7 A;  2DFI A;  4U76 A;  2ZSG A;  2GA2 A;  1C21 A;  4B28 A;  2BWW A;  2Q92 A;  1A16 A;  2BN7 A;  3MX6 A;  3IU9 A;  2BHD A;  4S00 A;  3CB6 A;  3PKC A;  1XGO A;  2Q8K A;  3MR1 A;  2GGC A;  4IKT A;  4ZWP A;  1R5G A;  3PKD A;  4U6W A;  3D27 A;  1XGN A;  2EA2 A;  1C27 A;  4RZY A;  4MAT A;  1YW9 A;  1BN5 A;  3Q6D A;  4HXX A;  3IU8 A;  5CDE A;  4FKC A;  2NQ7 A;  2GG0 A;  2B3H A;  4U69 A;  1KQ0 A;  4IU6 A;  1C24 A;  2ADU A;  1B6A A;  1WY2 A;  4FLI A;  4IEC A;  2P98 A;  2EVM A;  2BWV A;  2NQ6 A;  1WL6 A;  4PV4 A;  2BHB A;  2GG3 A;  4RZZ A;  5D6E A;  2GG5 A;  2BHA A;  2GU5 A;  3RVA A;  2GG8 A;  3CTZ A;  2EVC A;  1WKM A;  1WBQ A;  4FO7 A;  1R5H A;  4U6E A;  1QZY A;  2GG9 A;  4Z7M A;  2EVO A;  4FLJ A;  1W7V A;  4FLK A;  3PKB A;  1R58 A;  2Q93 A;  3L7G A;  1XGM A;  4PNC A;  3L24 A;  2BWX A;  1QXZ A; 
#chains in the Genus database with same CATH homology
 4FO8 A;  5FCF A;  5CDL A;  5FCH A;  2GTX A;  2GU6 A;  4IKR A;  2IW2 A;  3BIT A;  2HOW A;  4S01 A;  3TB5 A;  5CDV A;  4ZWU A;  4U6J A;  4A6V A;  4U6Z A;  1Y1N A;  1M35 A;  4FUK A;  1PV9 A;  1WL9 A;  2OKN A;  3PKA A;  3PKE A;  4ZWO A;  4S2T P;  2BWY A;  4QR8 A;  2P9A A;  3CB5 A;  1WLR A;  4JUQ A;  2OAZ A;  3S6B A;  3ROR A;  4S2R P;  1XGS A;  2MAT A;  4ZNG A;  5CNX A;  4RGZ 1;  1C22 A;  2BWS A;  4U73 A;  5CIK A;  2V3Y A;  1C23 A;  2BH3 A;  3FM3 A;  1B59 A;  1YJ3 A;  1WN1 A;  2V3X A;  4IDY A;  5CE6 A;  1KQ9 A;  2BHC A;  5CLS A;  2GU7 A;  1YVM A;  1JAW A;  3MAT A;  4U71 A;  2GU4 A;  1MAT A;  2G6P A;  3BIP A;  4U70 A;  4FLL A;  4EGE A;  5JHU A;  1BOA A;  1N51 A;  2B3K A;  2Q96 A;  2GG7 A;  3BIQ A;  1KP0 A;  2B3L A;  3FMR A;  4KM3 A;  1QXW A;  4IF7 A;  2Q95 A;  2BWT A;  4U1B A;  1XNZ A;  2P99 A;  4IKS A;  4IKU A;  2GZ5 A;  2GG2 A;  4A6W A;  5E5B A;  1O0X A;  3FMQ A;  4R60 A;  4IPA A;  4U6C A;  4OOK A;  5D6F A;  2Q94 A;  2V6C A;  5JI6 A;  3TAV A;  3IU7 A;  2EA4 A;  1W2M A;  5JFR A;  1CHM A;  1YW8 A;  2GGB A;  2BWU A;  2V3Z A;  2BB7 A;  3IG4 A;  4U75 A;  1QXY A;  1YW7 A;  2DFI A;  4U76 A;  2ZSG A;  2GA2 A;  1C21 A;  4B28 A;  2BWW A;  2Q92 A;  1A16 A;  2BN7 A;  3MX6 A;  3IU9 A;  2BHD A;  4S00 A;  3CB6 A;  3PKC A;  1XGO A;  2Q8K A;  3MR1 A;  2GGC A;  4IKT A;  4ZWP A;  1R5G A;  3PKD A;  4U6W A;  3D27 A;  1XGN A;  2EA2 A;  1C27 A;  4RZY A;  4MAT A;  1YW9 A;  1BN5 A;  3Q6D A;  4HXX A;  3IU8 A;  5CDE A;  4FKC A;  2NQ7 A;  2GG0 A;  2B3H A;  4U69 A;  1KQ0 A;  4IU6 A;  1C24 A;  2ADU A;  1B6A A;  1WY2 A;  4FLI A;  4IEC A;  2P98 A;  2EVM A;  2BWV A;  2NQ6 A;  1WL6 A;  4PV4 A;  2BHB A;  2GG3 A;  4RZZ A;  5D6E A;  2GG5 A;  2BHA A;  2GU5 A;  3RVA A;  2GG8 A;  3CTZ A;  2EVC A;  1WKM A;  1WBQ A;  4FO7 A;  1R5H A;  4U6E A;  1QZY A;  2GG9 A;  4Z7M A;  2EVO A;  4FLJ A;  1W7V A;  4FLK A;  3PKB A;  1R58 A;  2Q93 A;  3L7G A;  1XGM A;  4PNC A;  3L24 A;  2BWX A;  1QXZ A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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