4U71A

Hsmetap(f309m) in complex with 1- amino(cyclohexyl)methy)phosphonic acid
Total Genus 99
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
99
sequence length
304
structure length
304
Chain Sequence
YRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLMHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARPHFMS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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molecule tags Hydrolase
molecule keywords Methionine aminopeptidase 1
publication title Identification of the Molecular Basis of Inhibitor Selectivity between the Human and Streptococcal Type I Methionine Aminopeptidases
pubmed doi rcsb
source organism Homo sapiens
total genus 99
structure length 304
sequence length 304
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2014-07-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4u71A00
2G6PA 4KM3A 1O0XA 1YW8A 4U70A 1BN5A 2Q8KA 2EVOA 4FO7A 2P98A 2BWUA 4FKCA 4Z7MA 2MATA 2BWXA 2NQ6A 1WKMA 2BHBA 4FLJA 5JHUA 1WL6A 5FCHA 1A16A 4PNCA 4U1BA 4QR8A 1YW7A 4U69A 5CNXA 3TAVA 5D6EA 2V3YA 3IU8A 3MR1A 3PKBA 2GG2A 2GG5A 2Q95A 4FLKA 5JFRA 3RORA 2GGBA 4ZNGA 1B6AA 3BIPA 3FMQA 4U6JA 1YJ3A 4IECA 4S00A 4PV4A 2GU6A 4RZZA 1QXZA 4OOKA 2BH3A 4FO8A 4IKSA 3S6BA 2GG9A 2GG8A 4IU6A 4U6WA 3CB5A 3BITA 3PKCA 4IF7A 2Q93A 3PKAA 1XGOA 1M35A 1W2MA 4S01A 4ZWOA 3PKEA 5CDLA 1Y1NA 5CDVA 4U76A 3PKDA 1QXYA 3TB5A 2GG0A 4IDYA 2BHCA 1KQ0A 2DFIA 2GTXA 3IU7A 4HXXA 2B3KA 4R60A 2V6CA 4U73A 4IPAA 2GU5A 2BWWA 2Q94A 1C21A 4A6VA 2Q92A 1WLRA 3D27A 4ZWUA 1YW9A 2BN7A 3CB6A 2NQ7A 2GU4A 3L24A 2B3HA 3CTZA 1PV9A 1XGNA 2Q96A 4U6ZA 2P99A 2V3XA 2P9AA 2GZ5A 3IG4A 5JI6A 5CDEA 2ADUA 1YVMA 5E5BA 4A6WA 4EGEA 3FMRA 1N51A 4B28A 1WBQA 3BIQA 4IKTA 1C24A 2GA2A 1B59A 2V3ZA 4RZYA 2BB7A 2EVMA 2GG3A 4S2TP 5CIKA 2EA2A 4S2RP 2EVCA 1JAWA 1R5HA 1XNZA 2BWSA 1XGSA 1BOAA 4JUQA 2GGCA 3Q6DA 2ZSGA 2HOWA 1QZYA 3MATA 2IW2A 3FM3A 4RGZ1 4IKRA 3IU9A 4FLLA 4U6EA 5FCFA 1KQ9A 5D6FA 5CE6A 4U71A 1WY2A 2EA4A 2GU7A 1R5GA 1WN1A 2OKNA 1KP0A 3MX6A 2BHDA 1C23A 5CLSA 2OAZA 2BWTA 4FUKA 4MATA 4ZWPA 1QXWA 4FLIA 3RVAA 4IKUA 2B3LA 2BWVA 2BWYA 1CHMA 1MATA 4U6CA 1XGMA 1C22A 1R58A 3L7GA 1W7VA 1WL9A 2BHAA 1C27A 4U75A 2GG7A
chains in the Genus database with same CATH superfamily
2G6PA 4KM3A 1O0XA 1YW8A 4U70A 1BN5A 2Q8KA 2EVOA 4FO7A 2P98A 2BWUA 4FKCA 4Z7MA 2MATA 2BWXA 2NQ6A 1WKMA 2BHBA 4FLJA 5JHUA 1WL6A 5FCHA 1A16A 4PNCA 4U1BA 4QR8A 1YW7A 4U69A 5CNXA 3TAVA 5D6EA 2V3YA 3IU8A 3MR1A 3PKBA 2GG2A 2GG5A 2Q95A 4FLKA 5JFRA 3RORA 2GGBA 4ZNGA 1B6AA 3BIPA 3FMQA 4U6JA 1YJ3A 4IECA 4S00A 4PV4A 2GU6A 4RZZA 1QXZA 4OOKA 2BH3A 4FO8A 4IKSA 3S6BA 2GG9A 2GG8A 4IU6A 4U6WA 3CB5A 3BITA 3PKCA 4IF7A 2Q93A 3PKAA 1XGOA 1M35A 1W2MA 4S01A 4ZWOA 3PKEA 5CDLA 1Y1NA 5CDVA 4U76A 3PKDA 1QXYA 3TB5A 2GG0A 4IDYA 2BHCA 1KQ0A 2DFIA 2GTXA 3IU7A 4HXXA 2B3KA 4R60A 2V6CA 4U73A 4IPAA 2GU5A 2BWWA 2Q94A 1C21A 4A6VA 2Q92A 1WLRA 3D27A 4ZWUA 1YW9A 2BN7A 3CB6A 2NQ7A 2GU4A 3L24A 2B3HA 3CTZA 1PV9A 1XGNA 2Q96A 4U6ZA 2P99A 2V3XA 2P9AA 2GZ5A 3IG4A 5JI6A 5CDEA 2ADUA 1YVMA 5E5BA 4A6WA 4EGEA 3FMRA 1N51A 4B28A 1WBQA 3BIQA 4IKTA 1C24A 2GA2A 1B59A 2V3ZA 4RZYA 2BB7A 2EVMA 2GG3A 4S2TP 5CIKA 2EA2A 4S2RP 2EVCA 1JAWA 1R5HA 1XNZA 2BWSA 1XGSA 1BOAA 4JUQA 2GGCA 3Q6DA 2ZSGA 2HOWA 1QZYA 3MATA 2IW2A 3FM3A 4RGZ1 4IKRA 3IU9A 4FLLA 4U6EA 5FCFA 1KQ9A 5D6FA 5CE6A 4U71A 1WY2A 2EA4A 2GU7A 1R5GA 1WN1A 2OKNA 1KP0A 3MX6A 2BHDA 1C23A 5CLSA 2OAZA 2BWTA 4FUKA 4MATA 4ZWPA 1QXWA 4FLIA 3RVAA 4IKUA 2B3LA 2BWVA 2BWYA 1CHMA 1MATA 4U6CA 1XGMA 1C22A 1R58A 3L7GA 1W7VA 1WL9A 2BHAA 1C27A 4U75A 2GG7A
chains in the Genus database with same CATH topology
2G6PA 4KM3A 1O0XA 1YW8A 4U70A 1BN5A 2Q8KA 2EVOA 4FO7A 2P98A 2BWUA 4FKCA 4Z7MA 2MATA 2BWXA 2NQ6A 1WKMA 2BHBA 4FLJA 5JHUA 1WL6A 5FCHA 1A16A 4PNCA 4U1BA 4QR8A 1YW7A 4U69A 5CNXA 3TAVA 5D6EA 2V3YA 3IU8A 3MR1A 3PKBA 2GG2A 2GG5A 2Q95A 4FLKA 5JFRA 3RORA 2GGBA 4ZNGA 1B6AA 3BIPA 3FMQA 4U6JA 1YJ3A 4IECA 4S00A 4PV4A 2GU6A 4RZZA 1QXZA 4OOKA 2BH3A 4FO8A 4IKSA 3S6BA 2GG9A 2GG8A 4IU6A 4U6WA 3CB5A 3BITA 3PKCA 4IF7A 2Q93A 3PKAA 1XGOA 1M35A 1W2MA 4S01A 4ZWOA 3PKEA 5CDLA 1Y1NA 5CDVA 4U76A 3PKDA 1QXYA 3TB5A 2GG0A 4IDYA 2BHCA 1KQ0A 2DFIA 2GTXA 3IU7A 4HXXA 2B3KA 4R60A 2V6CA 4U73A 4IPAA 2GU5A 2BWWA 2Q94A 1C21A 4A6VA 2Q92A 1WLRA 3D27A 4ZWUA 1YW9A 2BN7A 3CB6A 2NQ7A 2GU4A 3L24A 2B3HA 3CTZA 1PV9A 1XGNA 2Q96A 4U6ZA 2P99A 2V3XA 2P9AA 2GZ5A 3IG4A 5JI6A 5CDEA 2ADUA 1YVMA 5E5BA 4A6WA 4EGEA 3FMRA 1N51A 4B28A 1WBQA 3BIQA 4IKTA 1C24A 2GA2A 1B59A 2V3ZA 4RZYA 2BB7A 2EVMA 2GG3A 4S2TP 5CIKA 2EA2A 4S2RP 2EVCA 1JAWA 1R5HA 1XNZA 2BWSA 1XGSA 1BOAA 4JUQA 2GGCA 3Q6DA 2ZSGA 2HOWA 1QZYA 3MATA 2IW2A 3FM3A 4RGZ1 4IKRA 3IU9A 4FLLA 4U6EA 5FCFA 1KQ9A 5D6FA 5CE6A 4U71A 1WY2A 2EA4A 2GU7A 1R5GA 1WN1A 2OKNA 1KP0A 3MX6A 2BHDA 1C23A 5CLSA 2OAZA 2BWTA 4FUKA 4MATA 4ZWPA 1QXWA 4FLIA 3RVAA 4IKUA 2B3LA 2BWVA 2BWYA 1CHMA 1MATA 4U6CA 1XGMA 1C22A 1R58A 3L7GA 1W7VA 1WL9A 2BHAA 1C27A 4U75A 2GG7A
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 2G6P A;  4KM3 A;  1O0X A;  1YW8 A;  4U70 A;  1BN5 A;  2Q8K A;  2EVO A;  4FO7 A;  2P98 A;  2BWU A;  4FKC A;  4Z7M A;  2MAT A;  2BWX A;  2NQ6 A;  1WKM A;  2BHB A;  4FLJ A;  5JHU A;  1WL6 A;  5FCH A;  1A16 A;  4PNC A;  4U1B A;  4QR8 A;  1YW7 A;  4U69 A;  5CNX A;  3TAV A;  5D6E A;  2V3Y A;  3IU8 A;  3MR1 A;  3PKB A;  2GG2 A;  2GG5 A;  2Q95 A;  4FLK A;  5JFR A;  3ROR A;  2GGB A;  4ZNG A;  1B6A A;  3BIP A;  3FMQ A;  4U6J A;  1YJ3 A;  4IEC A;  4S00 A;  4PV4 A;  2GU6 A;  4RZZ A;  1QXZ A;  4OOK A;  2BH3 A;  4FO8 A;  4IKS A;  3S6B A;  2GG9 A;  2GG8 A;  4IU6 A;  4U6W A;  3CB5 A;  3BIT A;  3PKC A;  4IF7 A;  2Q93 A;  3PKA A;  1XGO A;  1M35 A;  1W2M A;  4S01 A;  4ZWO A;  3PKE A;  5CDL A;  1Y1N A;  5CDV A;  4U76 A;  3PKD A;  1QXY A;  3TB5 A;  2GG0 A;  4IDY A;  2BHC A;  1KQ0 A;  2DFI A;  2GTX A;  3IU7 A;  4HXX A;  2B3K A;  4R60 A;  2V6C A;  4U73 A;  4IPA A;  2GU5 A;  2BWW A;  2Q94 A;  1C21 A;  4A6V A;  2Q92 A;  1WLR A;  3D27 A;  4ZWU A;  1YW9 A;  2BN7 A;  3CB6 A;  2NQ7 A;  2GU4 A;  3L24 A;  2B3H A;  3CTZ A;  1PV9 A;  1XGN A;  2Q96 A;  4U6Z A;  2P99 A;  2V3X A;  2P9A A;  2GZ5 A;  3IG4 A;  5JI6 A;  5CDE A;  2ADU A;  1YVM A;  5E5B A;  4A6W A;  4EGE A;  3FMR A;  1N51 A;  4B28 A;  1WBQ A;  3BIQ A;  4IKT A;  1C24 A;  2GA2 A;  1B59 A;  2V3Z A;  4RZY A;  2BB7 A;  2EVM A;  2GG3 A;  4S2T P;  5CIK A;  2EA2 A;  4S2R P;  2EVC A;  1JAW A;  1R5H A;  1XNZ A;  2BWS A;  1XGS A;  1BOA A;  4JUQ A;  2GGC A;  3Q6D A;  2ZSG A;  2HOW A;  1QZY A;  3MAT A;  2IW2 A;  3FM3 A;  4RGZ 1;  4IKR A;  3IU9 A;  4FLL A;  4U6E A;  5FCF A;  1KQ9 A;  5D6F A;  5CE6 A;  4U71 A;  1WY2 A;  2EA4 A;  2GU7 A;  1R5G A;  1WN1 A;  2OKN A;  1KP0 A;  3MX6 A;  2BHD A;  1C23 A;  5CLS A;  2OAZ A;  2BWT A;  4FUK A;  4MAT A;  4ZWP A;  1QXW A;  4FLI A;  3RVA A;  4IKU A;  2B3L A;  2BWV A;  2BWY A;  1CHM A;  1MAT A;  4U6C A;  1XGM A;  1C22 A;  1R58 A;  3L7G A;  1W7V A;  1WL9 A;  2BHA A;  1C27 A;  4U75 A;  2GG7 A; 
#chains in the Genus database with same CATH topology
 2G6P A;  4KM3 A;  1O0X A;  1YW8 A;  4U70 A;  1BN5 A;  2Q8K A;  2EVO A;  4FO7 A;  2P98 A;  2BWU A;  4FKC A;  4Z7M A;  2MAT A;  2BWX A;  2NQ6 A;  1WKM A;  2BHB A;  4FLJ A;  5JHU A;  1WL6 A;  5FCH A;  1A16 A;  4PNC A;  4U1B A;  4QR8 A;  1YW7 A;  4U69 A;  5CNX A;  3TAV A;  5D6E A;  2V3Y A;  3IU8 A;  3MR1 A;  3PKB A;  2GG2 A;  2GG5 A;  2Q95 A;  4FLK A;  5JFR A;  3ROR A;  2GGB A;  4ZNG A;  1B6A A;  3BIP A;  3FMQ A;  4U6J A;  1YJ3 A;  4IEC A;  4S00 A;  4PV4 A;  2GU6 A;  4RZZ A;  1QXZ A;  4OOK A;  2BH3 A;  4FO8 A;  4IKS A;  3S6B A;  2GG9 A;  2GG8 A;  4IU6 A;  4U6W A;  3CB5 A;  3BIT A;  3PKC A;  4IF7 A;  2Q93 A;  3PKA A;  1XGO A;  1M35 A;  1W2M A;  4S01 A;  4ZWO A;  3PKE A;  5CDL A;  1Y1N A;  5CDV A;  4U76 A;  3PKD A;  1QXY A;  3TB5 A;  2GG0 A;  4IDY A;  2BHC A;  1KQ0 A;  2DFI A;  2GTX A;  3IU7 A;  4HXX A;  2B3K A;  4R60 A;  2V6C A;  4U73 A;  4IPA A;  2GU5 A;  2BWW A;  2Q94 A;  1C21 A;  4A6V A;  2Q92 A;  1WLR A;  3D27 A;  4ZWU A;  1YW9 A;  2BN7 A;  3CB6 A;  2NQ7 A;  2GU4 A;  3L24 A;  2B3H A;  3CTZ A;  1PV9 A;  1XGN A;  2Q96 A;  4U6Z A;  2P99 A;  2V3X A;  2P9A A;  2GZ5 A;  3IG4 A;  5JI6 A;  5CDE A;  2ADU A;  1YVM A;  5E5B A;  4A6W A;  4EGE A;  3FMR A;  1N51 A;  4B28 A;  1WBQ A;  3BIQ A;  4IKT A;  1C24 A;  2GA2 A;  1B59 A;  2V3Z A;  4RZY A;  2BB7 A;  2EVM A;  2GG3 A;  4S2T P;  5CIK A;  2EA2 A;  4S2R P;  2EVC A;  1JAW A;  1R5H A;  1XNZ A;  2BWS A;  1XGS A;  1BOA A;  4JUQ A;  2GGC A;  3Q6D A;  2ZSG A;  2HOW A;  1QZY A;  3MAT A;  2IW2 A;  3FM3 A;  4RGZ 1;  4IKR A;  3IU9 A;  4FLL A;  4U6E A;  5FCF A;  1KQ9 A;  5D6F A;  5CE6 A;  4U71 A;  1WY2 A;  2EA4 A;  2GU7 A;  1R5G A;  1WN1 A;  2OKN A;  1KP0 A;  3MX6 A;  2BHD A;  1C23 A;  5CLS A;  2OAZ A;  2BWT A;  4FUK A;  4MAT A;  4ZWP A;  1QXW A;  4FLI A;  3RVA A;  4IKU A;  2B3L A;  2BWV A;  2BWY A;  1CHM A;  1MAT A;  4U6C A;  1XGM A;  1C22 A;  1R58 A;  3L7G A;  1W7V A;  1WL9 A;  2BHA A;  1C27 A;  4U75 A;  2GG7 A; 
#chains in the Genus database with same CATH homology
 2G6P A;  4KM3 A;  1O0X A;  1YW8 A;  4U70 A;  1BN5 A;  2Q8K A;  2EVO A;  4FO7 A;  2P98 A;  2BWU A;  4FKC A;  4Z7M A;  2MAT A;  2BWX A;  2NQ6 A;  1WKM A;  2BHB A;  4FLJ A;  5JHU A;  1WL6 A;  5FCH A;  1A16 A;  4PNC A;  4U1B A;  4QR8 A;  1YW7 A;  4U69 A;  5CNX A;  3TAV A;  5D6E A;  2V3Y A;  3IU8 A;  3MR1 A;  3PKB A;  2GG2 A;  2GG5 A;  2Q95 A;  4FLK A;  5JFR A;  3ROR A;  2GGB A;  4ZNG A;  1B6A A;  3BIP A;  3FMQ A;  4U6J A;  1YJ3 A;  4IEC A;  4S00 A;  4PV4 A;  2GU6 A;  4RZZ A;  1QXZ A;  4OOK A;  2BH3 A;  4FO8 A;  4IKS A;  3S6B A;  2GG9 A;  2GG8 A;  4IU6 A;  4U6W A;  3CB5 A;  3BIT A;  3PKC A;  4IF7 A;  2Q93 A;  3PKA A;  1XGO A;  1M35 A;  1W2M A;  4S01 A;  4ZWO A;  3PKE A;  5CDL A;  1Y1N A;  5CDV A;  4U76 A;  3PKD A;  1QXY A;  3TB5 A;  2GG0 A;  4IDY A;  2BHC A;  1KQ0 A;  2DFI A;  2GTX A;  3IU7 A;  4HXX A;  2B3K A;  4R60 A;  2V6C A;  4U73 A;  4IPA A;  2GU5 A;  2BWW A;  2Q94 A;  1C21 A;  4A6V A;  2Q92 A;  1WLR A;  3D27 A;  4ZWU A;  1YW9 A;  2BN7 A;  3CB6 A;  2NQ7 A;  2GU4 A;  3L24 A;  2B3H A;  3CTZ A;  1PV9 A;  1XGN A;  2Q96 A;  4U6Z A;  2P99 A;  2V3X A;  2P9A A;  2GZ5 A;  3IG4 A;  5JI6 A;  5CDE A;  2ADU A;  1YVM A;  5E5B A;  4A6W A;  4EGE A;  3FMR A;  1N51 A;  4B28 A;  1WBQ A;  3BIQ A;  4IKT A;  1C24 A;  2GA2 A;  1B59 A;  2V3Z A;  4RZY A;  2BB7 A;  2EVM A;  2GG3 A;  4S2T P;  5CIK A;  2EA2 A;  4S2R P;  2EVC A;  1JAW A;  1R5H A;  1XNZ A;  2BWS A;  1XGS A;  1BOA A;  4JUQ A;  2GGC A;  3Q6D A;  2ZSG A;  2HOW A;  1QZY A;  3MAT A;  2IW2 A;  3FM3 A;  4RGZ 1;  4IKR A;  3IU9 A;  4FLL A;  4U6E A;  5FCF A;  1KQ9 A;  5D6F A;  5CE6 A;  4U71 A;  1WY2 A;  2EA4 A;  2GU7 A;  1R5G A;  1WN1 A;  2OKN A;  1KP0 A;  3MX6 A;  2BHD A;  1C23 A;  5CLS A;  2OAZ A;  2BWT A;  4FUK A;  4MAT A;  4ZWP A;  1QXW A;  4FLI A;  3RVA A;  4IKU A;  2B3L A;  2BWV A;  2BWY A;  1CHM A;  1MAT A;  4U6C A;  1XGM A;  1C22 A;  1R58 A;  3L7G A;  1W7V A;  1WL9 A;  2BHA A;  1C27 A;  4U75 A;  2GG7 A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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