4U73A

Hsmetap(f309m) in complex with (amino(phenyl)methyl)phosphonic acid
Total Genus 99
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
99
sequence length
304
structure length
304
Chain Sequence
YRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLMHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARPHFMS
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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molecule tags Hydrolase
molecule keywords Methionine aminopeptidase 1
publication title Identification of the Molecular Basis of Inhibitor Selectivity between the Human and Streptococcal Type I Methionine Aminopeptidases
pubmed doi rcsb
source organism Homo sapiens
total genus 99
structure length 304
sequence length 304
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2014-07-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4u73A00
2BB7A 2V3XA 1B6AA 1WKMA 1Y1NA 4A6VA 2EA4A 1XGMA 3FM3A 2GG3A 5D6FA 4S01A 1QZYA 3MX6A 3FMQA 4FLJA 3D27A 1WL6A 1XGSA 5JI6A 1R5HA 1WL9A 2GG0A 2NQ6A 1YVMA 4U6JA 3L24A 2GG8A 4U69A 4HXXA 2GU5A 2G6PA 3MATA 3TAVA 5FCHA 2B3KA 3PKDA 4B28A 3Q6DA 4EGEA 2BHCA 1C21A 1WLRA 2BN7A 2EVOA 1W7VA 1N51A 2BWUA 1WY2A 3CB5A 4FKCA 1XGOA 1KQ9A 2BWYA 5CIKA 2GGBA 3S6BA 3MR1A 4ZWOA 1KQ0A 4S2RP 2GG7A 4S00A 4U6WA 4IKTA 2P98A 1A16A 2BWXA 5JFRA 3BIQA 3RORA 3BIPA 4IKRA 2BWSA 3IU7A 4IDYA 4FLKA 1WN1A 4S2TP 3IG4A 2EA2A 2GU6A 4ZNGA 5CDLA 3FMRA 5CLSA 4OOKA 2GZ5A 4JUQA 1PV9A 1YW7A 2MATA 1O0XA 2V3ZA 1R5GA 3IU8A 5JHUA 4U1BA 2GU7A 4KM3A 1CHMA 2BHBA 5CE6A 4R60A 1MATA 2NQ7A 2HOWA 2GG9A 4FLLA 3CTZA 2OKNA 4IKUA 3CB6A 2DFIA 4U70A 4ZWPA 2GG2A 1M35A 2ADUA 2GTXA 3PKBA 2Q8KA 4Z7MA 1YW8A 1YW9A 2BHDA 4IPAA 1BOAA 2EVMA 2BWVA 4U6EA 4U6CA 2P99A 3RVAA 5CDVA 1C24A 5FCFA 2B3LA 5CNXA 2Q94A 5CDEA 4PNCA 1R58A 4FUKA 5D6EA 2EVCA 3TB5A 2Q92A 2Q93A 2GA2A 4FLIA 2V3YA 4RZYA 1KP0A 1BN5A 2V6CA 4U75A 1WBQA 1YJ3A 1XGNA 2Q95A 4QR8A 3L7GA 4IF7A 1QXZA 1QXYA 3BITA 4FO7A 4U71A 1XNZA 4U73A 4ZWUA 1B59A 1JAWA 2Q96A 4IKSA 1W2MA 2GG5A 3PKEA 4U6ZA 4PV4A 2GGCA 2P9AA 2BWTA 2ZSGA 3PKCA 4IU6A 2BHAA 1C27A 2IW2A 4RGZ1 1C22A 2GU4A 2BWWA 1QXWA 3IU9A 2BH3A 2OAZA 4IECA 4RZZA 3PKAA 1C23A 4A6WA 4FO8A 5E5BA 4MATA 2B3HA 4U76A
chains in the Genus database with same CATH superfamily
2BB7A 2V3XA 1B6AA 1WKMA 1Y1NA 4A6VA 2EA4A 1XGMA 3FM3A 2GG3A 5D6FA 4S01A 1QZYA 3MX6A 3FMQA 4FLJA 3D27A 1WL6A 1XGSA 5JI6A 1R5HA 1WL9A 2GG0A 2NQ6A 1YVMA 4U6JA 3L24A 2GG8A 4U69A 4HXXA 2GU5A 2G6PA 3MATA 3TAVA 5FCHA 2B3KA 3PKDA 4B28A 3Q6DA 4EGEA 2BHCA 1C21A 1WLRA 2BN7A 2EVOA 1W7VA 1N51A 2BWUA 1WY2A 3CB5A 4FKCA 1XGOA 1KQ9A 2BWYA 5CIKA 2GGBA 3S6BA 3MR1A 4ZWOA 1KQ0A 4S2RP 2GG7A 4S00A 4U6WA 4IKTA 2P98A 1A16A 2BWXA 5JFRA 3BIQA 3RORA 3BIPA 4IKRA 2BWSA 3IU7A 4IDYA 4FLKA 1WN1A 4S2TP 3IG4A 2EA2A 2GU6A 4ZNGA 5CDLA 3FMRA 5CLSA 4OOKA 2GZ5A 4JUQA 1PV9A 1YW7A 2MATA 1O0XA 2V3ZA 1R5GA 3IU8A 5JHUA 4U1BA 2GU7A 4KM3A 1CHMA 2BHBA 5CE6A 4R60A 1MATA 2NQ7A 2HOWA 2GG9A 4FLLA 3CTZA 2OKNA 4IKUA 3CB6A 2DFIA 4U70A 4ZWPA 2GG2A 1M35A 2ADUA 2GTXA 3PKBA 2Q8KA 4Z7MA 1YW8A 1YW9A 2BHDA 4IPAA 1BOAA 2EVMA 2BWVA 4U6EA 4U6CA 2P99A 3RVAA 5CDVA 1C24A 5FCFA 2B3LA 5CNXA 2Q94A 5CDEA 4PNCA 1R58A 4FUKA 5D6EA 2EVCA 3TB5A 2Q92A 2Q93A 2GA2A 4FLIA 2V3YA 4RZYA 1KP0A 1BN5A 2V6CA 4U75A 1WBQA 1YJ3A 1XGNA 2Q95A 4QR8A 3L7GA 4IF7A 1QXZA 1QXYA 3BITA 4FO7A 4U71A 1XNZA 4U73A 4ZWUA 1B59A 1JAWA 2Q96A 4IKSA 1W2MA 2GG5A 3PKEA 4U6ZA 4PV4A 2GGCA 2P9AA 2BWTA 2ZSGA 3PKCA 4IU6A 2BHAA 1C27A 2IW2A 4RGZ1 1C22A 2GU4A 2BWWA 1QXWA 3IU9A 2BH3A 2OAZA 4IECA 4RZZA 3PKAA 1C23A 4A6WA 4FO8A 5E5BA 4MATA 2B3HA 4U76A
chains in the Genus database with same CATH topology
2BB7A 2V3XA 1B6AA 1WKMA 1Y1NA 4A6VA 2EA4A 1XGMA 3FM3A 2GG3A 5D6FA 4S01A 1QZYA 3MX6A 3FMQA 4FLJA 3D27A 1WL6A 1XGSA 5JI6A 1R5HA 1WL9A 2GG0A 2NQ6A 1YVMA 4U6JA 3L24A 2GG8A 4U69A 4HXXA 2GU5A 2G6PA 3MATA 3TAVA 5FCHA 2B3KA 3PKDA 4B28A 3Q6DA 4EGEA 2BHCA 1C21A 1WLRA 2BN7A 2EVOA 1W7VA 1N51A 2BWUA 1WY2A 3CB5A 4FKCA 1XGOA 1KQ9A 2BWYA 5CIKA 2GGBA 3S6BA 3MR1A 4ZWOA 1KQ0A 4S2RP 2GG7A 4S00A 4U6WA 4IKTA 2P98A 1A16A 2BWXA 5JFRA 3BIQA 3RORA 3BIPA 4IKRA 2BWSA 3IU7A 4IDYA 4FLKA 1WN1A 4S2TP 3IG4A 2EA2A 2GU6A 4ZNGA 5CDLA 3FMRA 5CLSA 4OOKA 2GZ5A 4JUQA 1PV9A 1YW7A 2MATA 1O0XA 2V3ZA 1R5GA 3IU8A 5JHUA 4U1BA 2GU7A 4KM3A 1CHMA 2BHBA 5CE6A 4R60A 1MATA 2NQ7A 2HOWA 2GG9A 4FLLA 3CTZA 2OKNA 4IKUA 3CB6A 2DFIA 4U70A 4ZWPA 2GG2A 1M35A 2ADUA 2GTXA 3PKBA 2Q8KA 4Z7MA 1YW8A 1YW9A 2BHDA 4IPAA 1BOAA 2EVMA 2BWVA 4U6EA 4U6CA 2P99A 3RVAA 5CDVA 1C24A 5FCFA 2B3LA 5CNXA 2Q94A 5CDEA 4PNCA 1R58A 4FUKA 5D6EA 2EVCA 3TB5A 2Q92A 2Q93A 2GA2A 4FLIA 2V3YA 4RZYA 1KP0A 1BN5A 2V6CA 4U75A 1WBQA 1YJ3A 1XGNA 2Q95A 4QR8A 3L7GA 4IF7A 1QXZA 1QXYA 3BITA 4FO7A 4U71A 1XNZA 4U73A 4ZWUA 1B59A 1JAWA 2Q96A 4IKSA 1W2MA 2GG5A 3PKEA 4U6ZA 4PV4A 2GGCA 2P9AA 2BWTA 2ZSGA 3PKCA 4IU6A 2BHAA 1C27A 2IW2A 4RGZ1 1C22A 2GU4A 2BWWA 1QXWA 3IU9A 2BH3A 2OAZA 4IECA 4RZZA 3PKAA 1C23A 4A6WA 4FO8A 5E5BA 4MATA 2B3HA 4U76A
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 2BB7 A;  2V3X A;  1B6A A;  1WKM A;  1Y1N A;  4A6V A;  2EA4 A;  1XGM A;  3FM3 A;  2GG3 A;  5D6F A;  4S01 A;  1QZY A;  3MX6 A;  3FMQ A;  4FLJ A;  3D27 A;  1WL6 A;  1XGS A;  5JI6 A;  1R5H A;  1WL9 A;  2GG0 A;  2NQ6 A;  1YVM A;  4U6J A;  3L24 A;  2GG8 A;  4U69 A;  4HXX A;  2GU5 A;  2G6P A;  3MAT A;  3TAV A;  5FCH A;  2B3K A;  3PKD A;  4B28 A;  3Q6D A;  4EGE A;  2BHC A;  1C21 A;  1WLR A;  2BN7 A;  2EVO A;  1W7V A;  1N51 A;  2BWU A;  1WY2 A;  3CB5 A;  4FKC A;  1XGO A;  1KQ9 A;  2BWY A;  5CIK A;  2GGB A;  3S6B A;  3MR1 A;  4ZWO A;  1KQ0 A;  4S2R P;  2GG7 A;  4S00 A;  4U6W A;  4IKT A;  2P98 A;  1A16 A;  2BWX A;  5JFR A;  3BIQ A;  3ROR A;  3BIP A;  4IKR A;  2BWS A;  3IU7 A;  4IDY A;  4FLK A;  1WN1 A;  4S2T P;  3IG4 A;  2EA2 A;  2GU6 A;  4ZNG A;  5CDL A;  3FMR A;  5CLS A;  4OOK A;  2GZ5 A;  4JUQ A;  1PV9 A;  1YW7 A;  2MAT A;  1O0X A;  2V3Z A;  1R5G A;  3IU8 A;  5JHU A;  4U1B A;  2GU7 A;  4KM3 A;  1CHM A;  2BHB A;  5CE6 A;  4R60 A;  1MAT A;  2NQ7 A;  2HOW A;  2GG9 A;  4FLL A;  3CTZ A;  2OKN A;  4IKU A;  3CB6 A;  2DFI A;  4U70 A;  4ZWP A;  2GG2 A;  1M35 A;  2ADU A;  2GTX A;  3PKB A;  2Q8K A;  4Z7M A;  1YW8 A;  1YW9 A;  2BHD A;  4IPA A;  1BOA A;  2EVM A;  2BWV A;  4U6E A;  4U6C A;  2P99 A;  3RVA A;  5CDV A;  1C24 A;  5FCF A;  2B3L A;  5CNX A;  2Q94 A;  5CDE A;  4PNC A;  1R58 A;  4FUK A;  5D6E A;  2EVC A;  3TB5 A;  2Q92 A;  2Q93 A;  2GA2 A;  4FLI A;  2V3Y A;  4RZY A;  1KP0 A;  1BN5 A;  2V6C A;  4U75 A;  1WBQ A;  1YJ3 A;  1XGN A;  2Q95 A;  4QR8 A;  3L7G A;  4IF7 A;  1QXZ A;  1QXY A;  3BIT A;  4FO7 A;  4U71 A;  1XNZ A;  4U73 A;  4ZWU A;  1B59 A;  1JAW A;  2Q96 A;  4IKS A;  1W2M A;  2GG5 A;  3PKE A;  4U6Z A;  4PV4 A;  2GGC A;  2P9A A;  2BWT A;  2ZSG A;  3PKC A;  4IU6 A;  2BHA A;  1C27 A;  2IW2 A;  4RGZ 1;  1C22 A;  2GU4 A;  2BWW A;  1QXW A;  3IU9 A;  2BH3 A;  2OAZ A;  4IEC A;  4RZZ A;  3PKA A;  1C23 A;  4A6W A;  4FO8 A;  5E5B A;  4MAT A;  2B3H A;  4U76 A; 
#chains in the Genus database with same CATH topology
 2BB7 A;  2V3X A;  1B6A A;  1WKM A;  1Y1N A;  4A6V A;  2EA4 A;  1XGM A;  3FM3 A;  2GG3 A;  5D6F A;  4S01 A;  1QZY A;  3MX6 A;  3FMQ A;  4FLJ A;  3D27 A;  1WL6 A;  1XGS A;  5JI6 A;  1R5H A;  1WL9 A;  2GG0 A;  2NQ6 A;  1YVM A;  4U6J A;  3L24 A;  2GG8 A;  4U69 A;  4HXX A;  2GU5 A;  2G6P A;  3MAT A;  3TAV A;  5FCH A;  2B3K A;  3PKD A;  4B28 A;  3Q6D A;  4EGE A;  2BHC A;  1C21 A;  1WLR A;  2BN7 A;  2EVO A;  1W7V A;  1N51 A;  2BWU A;  1WY2 A;  3CB5 A;  4FKC A;  1XGO A;  1KQ9 A;  2BWY A;  5CIK A;  2GGB A;  3S6B A;  3MR1 A;  4ZWO A;  1KQ0 A;  4S2R P;  2GG7 A;  4S00 A;  4U6W A;  4IKT A;  2P98 A;  1A16 A;  2BWX A;  5JFR A;  3BIQ A;  3ROR A;  3BIP A;  4IKR A;  2BWS A;  3IU7 A;  4IDY A;  4FLK A;  1WN1 A;  4S2T P;  3IG4 A;  2EA2 A;  2GU6 A;  4ZNG A;  5CDL A;  3FMR A;  5CLS A;  4OOK A;  2GZ5 A;  4JUQ A;  1PV9 A;  1YW7 A;  2MAT A;  1O0X A;  2V3Z A;  1R5G A;  3IU8 A;  5JHU A;  4U1B A;  2GU7 A;  4KM3 A;  1CHM A;  2BHB A;  5CE6 A;  4R60 A;  1MAT A;  2NQ7 A;  2HOW A;  2GG9 A;  4FLL A;  3CTZ A;  2OKN A;  4IKU A;  3CB6 A;  2DFI A;  4U70 A;  4ZWP A;  2GG2 A;  1M35 A;  2ADU A;  2GTX A;  3PKB A;  2Q8K A;  4Z7M A;  1YW8 A;  1YW9 A;  2BHD A;  4IPA A;  1BOA A;  2EVM A;  2BWV A;  4U6E A;  4U6C A;  2P99 A;  3RVA A;  5CDV A;  1C24 A;  5FCF A;  2B3L A;  5CNX A;  2Q94 A;  5CDE A;  4PNC A;  1R58 A;  4FUK A;  5D6E A;  2EVC A;  3TB5 A;  2Q92 A;  2Q93 A;  2GA2 A;  4FLI A;  2V3Y A;  4RZY A;  1KP0 A;  1BN5 A;  2V6C A;  4U75 A;  1WBQ A;  1YJ3 A;  1XGN A;  2Q95 A;  4QR8 A;  3L7G A;  4IF7 A;  1QXZ A;  1QXY A;  3BIT A;  4FO7 A;  4U71 A;  1XNZ A;  4U73 A;  4ZWU A;  1B59 A;  1JAW A;  2Q96 A;  4IKS A;  1W2M A;  2GG5 A;  3PKE A;  4U6Z A;  4PV4 A;  2GGC A;  2P9A A;  2BWT A;  2ZSG A;  3PKC A;  4IU6 A;  2BHA A;  1C27 A;  2IW2 A;  4RGZ 1;  1C22 A;  2GU4 A;  2BWW A;  1QXW A;  3IU9 A;  2BH3 A;  2OAZ A;  4IEC A;  4RZZ A;  3PKA A;  1C23 A;  4A6W A;  4FO8 A;  5E5B A;  4MAT A;  2B3H A;  4U76 A; 
#chains in the Genus database with same CATH homology
 2BB7 A;  2V3X A;  1B6A A;  1WKM A;  1Y1N A;  4A6V A;  2EA4 A;  1XGM A;  3FM3 A;  2GG3 A;  5D6F A;  4S01 A;  1QZY A;  3MX6 A;  3FMQ A;  4FLJ A;  3D27 A;  1WL6 A;  1XGS A;  5JI6 A;  1R5H A;  1WL9 A;  2GG0 A;  2NQ6 A;  1YVM A;  4U6J A;  3L24 A;  2GG8 A;  4U69 A;  4HXX A;  2GU5 A;  2G6P A;  3MAT A;  3TAV A;  5FCH A;  2B3K A;  3PKD A;  4B28 A;  3Q6D A;  4EGE A;  2BHC A;  1C21 A;  1WLR A;  2BN7 A;  2EVO A;  1W7V A;  1N51 A;  2BWU A;  1WY2 A;  3CB5 A;  4FKC A;  1XGO A;  1KQ9 A;  2BWY A;  5CIK A;  2GGB A;  3S6B A;  3MR1 A;  4ZWO A;  1KQ0 A;  4S2R P;  2GG7 A;  4S00 A;  4U6W A;  4IKT A;  2P98 A;  1A16 A;  2BWX A;  5JFR A;  3BIQ A;  3ROR A;  3BIP A;  4IKR A;  2BWS A;  3IU7 A;  4IDY A;  4FLK A;  1WN1 A;  4S2T P;  3IG4 A;  2EA2 A;  2GU6 A;  4ZNG A;  5CDL A;  3FMR A;  5CLS A;  4OOK A;  2GZ5 A;  4JUQ A;  1PV9 A;  1YW7 A;  2MAT A;  1O0X A;  2V3Z A;  1R5G A;  3IU8 A;  5JHU A;  4U1B A;  2GU7 A;  4KM3 A;  1CHM A;  2BHB A;  5CE6 A;  4R60 A;  1MAT A;  2NQ7 A;  2HOW A;  2GG9 A;  4FLL A;  3CTZ A;  2OKN A;  4IKU A;  3CB6 A;  2DFI A;  4U70 A;  4ZWP A;  2GG2 A;  1M35 A;  2ADU A;  2GTX A;  3PKB A;  2Q8K A;  4Z7M A;  1YW8 A;  1YW9 A;  2BHD A;  4IPA A;  1BOA A;  2EVM A;  2BWV A;  4U6E A;  4U6C A;  2P99 A;  3RVA A;  5CDV A;  1C24 A;  5FCF A;  2B3L A;  5CNX A;  2Q94 A;  5CDE A;  4PNC A;  1R58 A;  4FUK A;  5D6E A;  2EVC A;  3TB5 A;  2Q92 A;  2Q93 A;  2GA2 A;  4FLI A;  2V3Y A;  4RZY A;  1KP0 A;  1BN5 A;  2V6C A;  4U75 A;  1WBQ A;  1YJ3 A;  1XGN A;  2Q95 A;  4QR8 A;  3L7G A;  4IF7 A;  1QXZ A;  1QXY A;  3BIT A;  4FO7 A;  4U71 A;  1XNZ A;  4U73 A;  4ZWU A;  1B59 A;  1JAW A;  2Q96 A;  4IKS A;  1W2M A;  2GG5 A;  3PKE A;  4U6Z A;  4PV4 A;  2GGC A;  2P9A A;  2BWT A;  2ZSG A;  3PKC A;  4IU6 A;  2BHA A;  1C27 A;  2IW2 A;  4RGZ 1;  1C22 A;  2GU4 A;  2BWW A;  1QXW A;  3IU9 A;  2BH3 A;  2OAZ A;  4IEC A;  4RZZ A;  3PKA A;  1C23 A;  4A6W A;  4FO8 A;  5E5B A;  4MAT A;  2B3H A;  4U76 A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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