4U75A

Hsmetap (f309m) in complex with methionine
Total Genus 102
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
102
sequence length
304
structure length
304
Chain Sequence
YRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLMHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARPHFMS
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
molecule tags Hydrolase
molecule keywords Methionine aminopeptidase 1
publication title Identification of the Molecular Basis of Inhibitor Selectivity between the Human and Streptococcal Type I Methionine Aminopeptidases
pubmed doi rcsb
source organism Homo sapiens
total genus 102
structure length 304
sequence length 304
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2014-07-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4u75A00
4IPAA 4FKCA 1A16A 1B6AA 2GG3A 2OKNA 1C23A 3MX6A 1C24A 4R60A 2ZSGA 4U75A 5CDLA 3BITA 2ADUA 2GU7A 4ZWUA 4IDYA 3RVAA 2Q96A 4U6WA 3D27A 4S00A 3MR1A 2BHCA 1R5GA 4A6WA 2BWTA 4RZZA 3S6BA 5JHUA 1C22A 2V3XA 4FO8A 2P9AA 5FCHA 2GG9A 4IKUA 2BWSA 4U6EA 1R58A 2BN7A 4JUQA 2BH3A 1YW8A 1XGOA 2GG8A 2GG0A 4ZWPA 1QZYA 3Q6DA 4OOKA 2GU4A 4IF7A 4IKTA 3CB5A 3RORA 2BHAA 1R5HA 5D6FA 2BB7A 5CLSA 2BWUA 3IU9A 2EA2A 4KM3A 2GG7A 2Q93A 1KP0A 4PV4A 2NQ7A 1CHMA 2GZ5A 4FO7A 4IKSA 4U76A 3CB6A 4U73A 1N51A 1O0XA 4S2RP 4IECA 1MATA 4RZYA 1XGMA 1BOAA 1XNZA 4FLKA 2GA2A 4A6VA 5D6EA 4U6ZA 1JAWA 3TB5A 2EVMA 4U1BA 3BIQA 2GGCA 5CNXA 3FM3A 1WBQA 1WKMA 3PKEA 4RGZ1 3IU8A 2EA4A 2Q95A 3BIPA 1BN5A 4HXXA 2BWYA 1YVMA 5CIKA 1QXWA 2GU6A 1WN1A 2V6CA 2G6PA 1B59A 1WY2A 3FMRA 2Q8KA 5CDVA 1QXZA 4FLIA 1WLRA 1M35A 4MATA 4U6CA 5CDEA 1XGNA 1KQ9A 1Y1NA 3IG4A 5JFRA 4Z7MA 1WL9A 5JI6A 2GTXA 2BWWA 2BHDA 1C21A 2P99A 3FMQA 3PKAA 2P98A 4FLLA 3CTZA 4FUKA 3MATA 4IU6A 5E5BA 1KQ0A 5FCFA 1XGSA 2BHBA 2V3ZA 1QXYA 4FLJA 3PKDA 3TAVA 2GG2A 2Q94A 2B3LA 4B28A 2OAZA 1W7VA 2B3HA 1YW7A 4S2TP 2GGBA 2MATA 3PKBA 2GU5A 2NQ6A 2BWXA 1YW9A 2DFIA 2B3KA 4U70A 4U71A 4ZWOA 3PKCA 2HOWA 5CE6A 4U6JA 1WL6A 2V3YA 1YJ3A 4PNCA 1C27A 4EGEA 3IU7A 1W2MA 4QR8A 4ZNGA 3L24A 4S01A 1PV9A 2EVOA 2Q92A 2IW2A 2GG5A 2EVCA 3L7GA 4U69A 4IKRA 2BWVA
chains in the Genus database with same CATH superfamily
4IPAA 4FKCA 1A16A 1B6AA 2GG3A 2OKNA 1C23A 3MX6A 1C24A 4R60A 2ZSGA 4U75A 5CDLA 3BITA 2ADUA 2GU7A 4ZWUA 4IDYA 3RVAA 2Q96A 4U6WA 3D27A 4S00A 3MR1A 2BHCA 1R5GA 4A6WA 2BWTA 4RZZA 3S6BA 5JHUA 1C22A 2V3XA 4FO8A 2P9AA 5FCHA 2GG9A 4IKUA 2BWSA 4U6EA 1R58A 2BN7A 4JUQA 2BH3A 1YW8A 1XGOA 2GG8A 2GG0A 4ZWPA 1QZYA 3Q6DA 4OOKA 2GU4A 4IF7A 4IKTA 3CB5A 3RORA 2BHAA 1R5HA 5D6FA 2BB7A 5CLSA 2BWUA 3IU9A 2EA2A 4KM3A 2GG7A 2Q93A 1KP0A 4PV4A 2NQ7A 1CHMA 2GZ5A 4FO7A 4IKSA 4U76A 3CB6A 4U73A 1N51A 1O0XA 4S2RP 4IECA 1MATA 4RZYA 1XGMA 1BOAA 1XNZA 4FLKA 2GA2A 4A6VA 5D6EA 4U6ZA 1JAWA 3TB5A 2EVMA 4U1BA 3BIQA 2GGCA 5CNXA 3FM3A 1WBQA 1WKMA 3PKEA 4RGZ1 3IU8A 2EA4A 2Q95A 3BIPA 1BN5A 4HXXA 2BWYA 1YVMA 5CIKA 1QXWA 2GU6A 1WN1A 2V6CA 2G6PA 1B59A 1WY2A 3FMRA 2Q8KA 5CDVA 1QXZA 4FLIA 1WLRA 1M35A 4MATA 4U6CA 5CDEA 1XGNA 1KQ9A 1Y1NA 3IG4A 5JFRA 4Z7MA 1WL9A 5JI6A 2GTXA 2BWWA 2BHDA 1C21A 2P99A 3FMQA 3PKAA 2P98A 4FLLA 3CTZA 4FUKA 3MATA 4IU6A 5E5BA 1KQ0A 5FCFA 1XGSA 2BHBA 2V3ZA 1QXYA 4FLJA 3PKDA 3TAVA 2GG2A 2Q94A 2B3LA 4B28A 2OAZA 1W7VA 2B3HA 1YW7A 4S2TP 2GGBA 2MATA 3PKBA 2GU5A 2NQ6A 2BWXA 1YW9A 2DFIA 2B3KA 4U70A 4U71A 4ZWOA 3PKCA 2HOWA 5CE6A 4U6JA 1WL6A 2V3YA 1YJ3A 4PNCA 1C27A 4EGEA 3IU7A 1W2MA 4QR8A 4ZNGA 3L24A 4S01A 1PV9A 2EVOA 2Q92A 2IW2A 2GG5A 2EVCA 3L7GA 4U69A 4IKRA 2BWVA
chains in the Genus database with same CATH topology
4IPAA 4FKCA 1A16A 1B6AA 2GG3A 2OKNA 1C23A 3MX6A 1C24A 4R60A 2ZSGA 4U75A 5CDLA 3BITA 2ADUA 2GU7A 4ZWUA 4IDYA 3RVAA 2Q96A 4U6WA 3D27A 4S00A 3MR1A 2BHCA 1R5GA 4A6WA 2BWTA 4RZZA 3S6BA 5JHUA 1C22A 2V3XA 4FO8A 2P9AA 5FCHA 2GG9A 4IKUA 2BWSA 4U6EA 1R58A 2BN7A 4JUQA 2BH3A 1YW8A 1XGOA 2GG8A 2GG0A 4ZWPA 1QZYA 3Q6DA 4OOKA 2GU4A 4IF7A 4IKTA 3CB5A 3RORA 2BHAA 1R5HA 5D6FA 2BB7A 5CLSA 2BWUA 3IU9A 2EA2A 4KM3A 2GG7A 2Q93A 1KP0A 4PV4A 2NQ7A 1CHMA 2GZ5A 4FO7A 4IKSA 4U76A 3CB6A 4U73A 1N51A 1O0XA 4S2RP 4IECA 1MATA 4RZYA 1XGMA 1BOAA 1XNZA 4FLKA 2GA2A 4A6VA 5D6EA 4U6ZA 1JAWA 3TB5A 2EVMA 4U1BA 3BIQA 2GGCA 5CNXA 3FM3A 1WBQA 1WKMA 3PKEA 4RGZ1 3IU8A 2EA4A 2Q95A 3BIPA 1BN5A 4HXXA 2BWYA 1YVMA 5CIKA 1QXWA 2GU6A 1WN1A 2V6CA 2G6PA 1B59A 1WY2A 3FMRA 2Q8KA 5CDVA 1QXZA 4FLIA 1WLRA 1M35A 4MATA 4U6CA 5CDEA 1XGNA 1KQ9A 1Y1NA 3IG4A 5JFRA 4Z7MA 1WL9A 5JI6A 2GTXA 2BWWA 2BHDA 1C21A 2P99A 3FMQA 3PKAA 2P98A 4FLLA 3CTZA 4FUKA 3MATA 4IU6A 5E5BA 1KQ0A 5FCFA 1XGSA 2BHBA 2V3ZA 1QXYA 4FLJA 3PKDA 3TAVA 2GG2A 2Q94A 2B3LA 4B28A 2OAZA 1W7VA 2B3HA 1YW7A 4S2TP 2GGBA 2MATA 3PKBA 2GU5A 2NQ6A 2BWXA 1YW9A 2DFIA 2B3KA 4U70A 4U71A 4ZWOA 3PKCA 2HOWA 5CE6A 4U6JA 1WL6A 2V3YA 1YJ3A 4PNCA 1C27A 4EGEA 3IU7A 1W2MA 4QR8A 4ZNGA 3L24A 4S01A 1PV9A 2EVOA 2Q92A 2IW2A 2GG5A 2EVCA 3L7GA 4U69A 4IKRA 2BWVA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 4IPA A;  4FKC A;  1A16 A;  1B6A A;  2GG3 A;  2OKN A;  1C23 A;  3MX6 A;  1C24 A;  4R60 A;  2ZSG A;  4U75 A;  5CDL A;  3BIT A;  2ADU A;  2GU7 A;  4ZWU A;  4IDY A;  3RVA A;  2Q96 A;  4U6W A;  3D27 A;  4S00 A;  3MR1 A;  2BHC A;  1R5G A;  4A6W A;  2BWT A;  4RZZ A;  3S6B A;  5JHU A;  1C22 A;  2V3X A;  4FO8 A;  2P9A A;  5FCH A;  2GG9 A;  4IKU A;  2BWS A;  4U6E A;  1R58 A;  2BN7 A;  4JUQ A;  2BH3 A;  1YW8 A;  1XGO A;  2GG8 A;  2GG0 A;  4ZWP A;  1QZY A;  3Q6D A;  4OOK A;  2GU4 A;  4IF7 A;  4IKT A;  3CB5 A;  3ROR A;  2BHA A;  1R5H A;  5D6F A;  2BB7 A;  5CLS A;  2BWU A;  3IU9 A;  2EA2 A;  4KM3 A;  2GG7 A;  2Q93 A;  1KP0 A;  4PV4 A;  2NQ7 A;  1CHM A;  2GZ5 A;  4FO7 A;  4IKS A;  4U76 A;  3CB6 A;  4U73 A;  1N51 A;  1O0X A;  4S2R P;  4IEC A;  1MAT A;  4RZY A;  1XGM A;  1BOA A;  1XNZ A;  4FLK A;  2GA2 A;  4A6V A;  5D6E A;  4U6Z A;  1JAW A;  3TB5 A;  2EVM A;  4U1B A;  3BIQ A;  2GGC A;  5CNX A;  3FM3 A;  1WBQ A;  1WKM A;  3PKE A;  4RGZ 1;  3IU8 A;  2EA4 A;  2Q95 A;  3BIP A;  1BN5 A;  4HXX A;  2BWY A;  1YVM A;  5CIK A;  1QXW A;  2GU6 A;  1WN1 A;  2V6C A;  2G6P A;  1B59 A;  1WY2 A;  3FMR A;  2Q8K A;  5CDV A;  1QXZ A;  4FLI A;  1WLR A;  1M35 A;  4MAT A;  4U6C A;  5CDE A;  1XGN A;  1KQ9 A;  1Y1N A;  3IG4 A;  5JFR A;  4Z7M A;  1WL9 A;  5JI6 A;  2GTX A;  2BWW A;  2BHD A;  1C21 A;  2P99 A;  3FMQ A;  3PKA A;  2P98 A;  4FLL A;  3CTZ A;  4FUK A;  3MAT A;  4IU6 A;  5E5B A;  1KQ0 A;  5FCF A;  1XGS A;  2BHB A;  2V3Z A;  1QXY A;  4FLJ A;  3PKD A;  3TAV A;  2GG2 A;  2Q94 A;  2B3L A;  4B28 A;  2OAZ A;  1W7V A;  2B3H A;  1YW7 A;  4S2T P;  2GGB A;  2MAT A;  3PKB A;  2GU5 A;  2NQ6 A;  2BWX A;  1YW9 A;  2DFI A;  2B3K A;  4U70 A;  4U71 A;  4ZWO A;  3PKC A;  2HOW A;  5CE6 A;  4U6J A;  1WL6 A;  2V3Y A;  1YJ3 A;  4PNC A;  1C27 A;  4EGE A;  3IU7 A;  1W2M A;  4QR8 A;  4ZNG A;  3L24 A;  4S01 A;  1PV9 A;  2EVO A;  2Q92 A;  2IW2 A;  2GG5 A;  2EVC A;  3L7G A;  4U69 A;  4IKR A;  2BWV A; 
#chains in the Genus database with same CATH topology
 4IPA A;  4FKC A;  1A16 A;  1B6A A;  2GG3 A;  2OKN A;  1C23 A;  3MX6 A;  1C24 A;  4R60 A;  2ZSG A;  4U75 A;  5CDL A;  3BIT A;  2ADU A;  2GU7 A;  4ZWU A;  4IDY A;  3RVA A;  2Q96 A;  4U6W A;  3D27 A;  4S00 A;  3MR1 A;  2BHC A;  1R5G A;  4A6W A;  2BWT A;  4RZZ A;  3S6B A;  5JHU A;  1C22 A;  2V3X A;  4FO8 A;  2P9A A;  5FCH A;  2GG9 A;  4IKU A;  2BWS A;  4U6E A;  1R58 A;  2BN7 A;  4JUQ A;  2BH3 A;  1YW8 A;  1XGO A;  2GG8 A;  2GG0 A;  4ZWP A;  1QZY A;  3Q6D A;  4OOK A;  2GU4 A;  4IF7 A;  4IKT A;  3CB5 A;  3ROR A;  2BHA A;  1R5H A;  5D6F A;  2BB7 A;  5CLS A;  2BWU A;  3IU9 A;  2EA2 A;  4KM3 A;  2GG7 A;  2Q93 A;  1KP0 A;  4PV4 A;  2NQ7 A;  1CHM A;  2GZ5 A;  4FO7 A;  4IKS A;  4U76 A;  3CB6 A;  4U73 A;  1N51 A;  1O0X A;  4S2R P;  4IEC A;  1MAT A;  4RZY A;  1XGM A;  1BOA A;  1XNZ A;  4FLK A;  2GA2 A;  4A6V A;  5D6E A;  4U6Z A;  1JAW A;  3TB5 A;  2EVM A;  4U1B A;  3BIQ A;  2GGC A;  5CNX A;  3FM3 A;  1WBQ A;  1WKM A;  3PKE A;  4RGZ 1;  3IU8 A;  2EA4 A;  2Q95 A;  3BIP A;  1BN5 A;  4HXX A;  2BWY A;  1YVM A;  5CIK A;  1QXW A;  2GU6 A;  1WN1 A;  2V6C A;  2G6P A;  1B59 A;  1WY2 A;  3FMR A;  2Q8K A;  5CDV A;  1QXZ A;  4FLI A;  1WLR A;  1M35 A;  4MAT A;  4U6C A;  5CDE A;  1XGN A;  1KQ9 A;  1Y1N A;  3IG4 A;  5JFR A;  4Z7M A;  1WL9 A;  5JI6 A;  2GTX A;  2BWW A;  2BHD A;  1C21 A;  2P99 A;  3FMQ A;  3PKA A;  2P98 A;  4FLL A;  3CTZ A;  4FUK A;  3MAT A;  4IU6 A;  5E5B A;  1KQ0 A;  5FCF A;  1XGS A;  2BHB A;  2V3Z A;  1QXY A;  4FLJ A;  3PKD A;  3TAV A;  2GG2 A;  2Q94 A;  2B3L A;  4B28 A;  2OAZ A;  1W7V A;  2B3H A;  1YW7 A;  4S2T P;  2GGB A;  2MAT A;  3PKB A;  2GU5 A;  2NQ6 A;  2BWX A;  1YW9 A;  2DFI A;  2B3K A;  4U70 A;  4U71 A;  4ZWO A;  3PKC A;  2HOW A;  5CE6 A;  4U6J A;  1WL6 A;  2V3Y A;  1YJ3 A;  4PNC A;  1C27 A;  4EGE A;  3IU7 A;  1W2M A;  4QR8 A;  4ZNG A;  3L24 A;  4S01 A;  1PV9 A;  2EVO A;  2Q92 A;  2IW2 A;  2GG5 A;  2EVC A;  3L7G A;  4U69 A;  4IKR A;  2BWV A; 
#chains in the Genus database with same CATH homology
 4IPA A;  4FKC A;  1A16 A;  1B6A A;  2GG3 A;  2OKN A;  1C23 A;  3MX6 A;  1C24 A;  4R60 A;  2ZSG A;  4U75 A;  5CDL A;  3BIT A;  2ADU A;  2GU7 A;  4ZWU A;  4IDY A;  3RVA A;  2Q96 A;  4U6W A;  3D27 A;  4S00 A;  3MR1 A;  2BHC A;  1R5G A;  4A6W A;  2BWT A;  4RZZ A;  3S6B A;  5JHU A;  1C22 A;  2V3X A;  4FO8 A;  2P9A A;  5FCH A;  2GG9 A;  4IKU A;  2BWS A;  4U6E A;  1R58 A;  2BN7 A;  4JUQ A;  2BH3 A;  1YW8 A;  1XGO A;  2GG8 A;  2GG0 A;  4ZWP A;  1QZY A;  3Q6D A;  4OOK A;  2GU4 A;  4IF7 A;  4IKT A;  3CB5 A;  3ROR A;  2BHA A;  1R5H A;  5D6F A;  2BB7 A;  5CLS A;  2BWU A;  3IU9 A;  2EA2 A;  4KM3 A;  2GG7 A;  2Q93 A;  1KP0 A;  4PV4 A;  2NQ7 A;  1CHM A;  2GZ5 A;  4FO7 A;  4IKS A;  4U76 A;  3CB6 A;  4U73 A;  1N51 A;  1O0X A;  4S2R P;  4IEC A;  1MAT A;  4RZY A;  1XGM A;  1BOA A;  1XNZ A;  4FLK A;  2GA2 A;  4A6V A;  5D6E A;  4U6Z A;  1JAW A;  3TB5 A;  2EVM A;  4U1B A;  3BIQ A;  2GGC A;  5CNX A;  3FM3 A;  1WBQ A;  1WKM A;  3PKE A;  4RGZ 1;  3IU8 A;  2EA4 A;  2Q95 A;  3BIP A;  1BN5 A;  4HXX A;  2BWY A;  1YVM A;  5CIK A;  1QXW A;  2GU6 A;  1WN1 A;  2V6C A;  2G6P A;  1B59 A;  1WY2 A;  3FMR A;  2Q8K A;  5CDV A;  1QXZ A;  4FLI A;  1WLR A;  1M35 A;  4MAT A;  4U6C A;  5CDE A;  1XGN A;  1KQ9 A;  1Y1N A;  3IG4 A;  5JFR A;  4Z7M A;  1WL9 A;  5JI6 A;  2GTX A;  2BWW A;  2BHD A;  1C21 A;  2P99 A;  3FMQ A;  3PKA A;  2P98 A;  4FLL A;  3CTZ A;  4FUK A;  3MAT A;  4IU6 A;  5E5B A;  1KQ0 A;  5FCF A;  1XGS A;  2BHB A;  2V3Z A;  1QXY A;  4FLJ A;  3PKD A;  3TAV A;  2GG2 A;  2Q94 A;  2B3L A;  4B28 A;  2OAZ A;  1W7V A;  2B3H A;  1YW7 A;  4S2T P;  2GGB A;  2MAT A;  3PKB A;  2GU5 A;  2NQ6 A;  2BWX A;  1YW9 A;  2DFI A;  2B3K A;  4U70 A;  4U71 A;  4ZWO A;  3PKC A;  2HOW A;  5CE6 A;  4U6J A;  1WL6 A;  2V3Y A;  1YJ3 A;  4PNC A;  1C27 A;  4EGE A;  3IU7 A;  1W2M A;  4QR8 A;  4ZNG A;  3L24 A;  4S01 A;  1PV9 A;  2EVO A;  2Q92 A;  2IW2 A;  2GG5 A;  2EVC A;  3L7G A;  4U69 A;  4IKR A;  2BWV A;
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...
How to cite