2MUBA

Solution structure of the analgesic sea anemone peptide apetx2
Total Genus 2
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
2
sequence length
42
structure length
42
Chain Sequence
GTACSCGNSKGIYWFYRPSCPTDRGYTGSCRYFLGTCCTPAD
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Understanding the Molecular Basis of Toxin Promiscuity: The Analgesic Sea Anemone Peptide APETx2 Interacts with Acid-Sensing Ion Channel 3 and hERG Channels via Overlapping Pharmacophores.
pubmed doi rcsb
molecule keywords Toxin APETx2
molecule tags Toxin
total genus 2
structure length 42
sequence length 42
ec nomenclature
pdb deposition date 2014-09-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF07936 Defensin_4 Potassium-channel blocking toxin
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.20.20.10 Mainly Beta Single Sheet Anthopleurin-A Anthopleurin-A 2mubA00
2H9XA 3LMSB 1ZLHB 2K2XA 2MUBA 1WQKA 2JTOA 1B8WA 1AHLA 1WXNA 1APFA 2SH1A 2BDSA 1ZUEA 1H5OA 4GV5A 1Z99A 1ZLIB 1SH1A 1D6BA 1BDSA 1ZUFA 1ATXA 2MN3A 3D4UB 2RNGA 1SHIA
chains in the Genus database with same CATH superfamily
2H9XA 3MYVA 2QSFA 2HJEA 3LMSB 1ZLHB 2IKEA 2K2XA 2MUBA 2XXLA 1EL6A 1WQKA 2JTOA 2DLAA 4YIRA 1B8WA 2HJ9C 1WXNA 1APFA 1AHLA 2SH1A 2BDSA 1ZUEA 1H5OA 3IF4A 3MCXA 4GV5A 1Z99A 3C38A 1ZLIB 3C30A 2JR3A 1SH1A 1D6BA 1BDSA 2B9KA 1ZUFA 2IKDA 3KEZA 2QSGA 1ATXA 1GKUB 2MN3A 1ZHHB 3D4UB 2RNGA 1SHIA 2QSHA 1GL9B
chains in the Genus database with same CATH topology
2H9XA 3MYVA 2QSFA 2HJEA 3LMSB 1ZLHB 2IKEA 2K2XA 2MUBA 2XXLA 1WQKA 2JTOA 2DLAA 4YIRA 1B8WA 2HJ9C 1WXNA 1APFA 1AHLA 2SH1A 2BDSA 1ZUEA 1H5OA 3MCXA 4GV5A 1Z99A 3C38A 1ZLIB 3C30A 2JR3A 1SH1A 1D6BA 1BDSA 2B9KA 1ZUFA 2IKDA 3KEZA 2QSGA 1ATXA 2MN3A 1ZHHB 3D4UB 2RNGA 1SHIA 2QSHA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2H9X A;  3LMS B;  1ZLH B;  2K2X A;  2MUB A;  1WQK A;  2JTO A;  1B8W A;  1AHL A;  1WXN A;  1APF A;  2SH1 A;  2BDS A;  1ZUE A;  1H5O A;  4GV5 A;  1Z99 A;  1ZLI B;  1SH1 A;  1D6B A;  1BDS A;  1ZUF A;  1ATX A;  2MN3 A;  3D4U B;  2RNG A;  1SHI A; 
#chains in the Genus database with same CATH topology
 2H9X A;  3MYV A;  2QSF A;  2HJE A;  3LMS B;  1ZLH B;  2IKE A;  2K2X A;  2MUB A;  2XXL A;  1EL6 A;  1WQK A;  2JTO A;  2DLA A;  4YIR A;  1B8W A;  2HJ9 C;  1WXN A;  1APF A;  1AHL A;  2SH1 A;  2BDS A;  1ZUE A;  1H5O A;  3IF4 A;  3MCX A;  4GV5 A;  1Z99 A;  3C38 A;  1ZLI B;  3C30 A;  2JR3 A;  1SH1 A;  1D6B A;  1BDS A;  2B9K A;  1ZUF A;  2IKD A;  3KEZ A;  2QSG A;  1ATX A;  1GKU B;  2MN3 A;  1ZHH B;  3D4U B;  2RNG A;  1SHI A;  2QSH A;  1GL9 B; 
#chains in the Genus database with same CATH homology
 2H9X A;  3MYV A;  2QSF A;  2HJE A;  3LMS B;  1ZLH B;  2IKE A;  2K2X A;  2MUB A;  2XXL A;  1WQK A;  2JTO A;  2DLA A;  4YIR A;  1B8W A;  2HJ9 C;  1WXN A;  1APF A;  1AHL A;  2SH1 A;  2BDS A;  1ZUE A;  1H5O A;  3MCX A;  4GV5 A;  1Z99 A;  3C38 A;  1ZLI B;  3C30 A;  2JR3 A;  1SH1 A;  1D6B A;  1BDS A;  2B9K A;  1ZUF A;  2IKD A;  3KEZ A;  2QSG A;  1ATX A;  2MN3 A;  1ZHH B;  3D4U B;  2RNG A;  1SHI A;  2QSH A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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