2MUBA

Solution structure of the analgesic sea anemone peptide apetx2
Total Genus 2
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
2
sequence length
42
structure length
42
Chain Sequence
GTACSCGNSKGIYWFYRPSCPTDRGYTGSCRYFLGTCCTPAD
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
publication title Understanding the Molecular Basis of Toxin Promiscuity: The Analgesic Sea Anemone Peptide APETx2 Interacts with Acid-Sensing Ion Channel 3 and hERG Channels via Overlapping Pharmacophores.
pubmed doi rcsb
molecule tags Toxin
molecule keywords Toxin APETx2
total genus 2
structure length 42
sequence length 42
ec nomenclature
pdb deposition date 2014-09-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF07936 Defensin_4 Potassium-channel blocking toxin
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.20.20.10 Mainly Beta Single Sheet Anthopleurin-A Anthopleurin-A 2mubA00
1SHIA 1Z99A 3LMSB 2MN3A 2SH1A 1ZLIB 1ZUFA 1SH1A 3D4UB 1WXNA 1AHLA 1ZLHB 1D6BA 2BDSA 1WQKA 2RNGA 2H9XA 1BDSA 1ATXA 1APFA 1H5OA 2JTOA 1ZUEA 2K2XA 1B8WA 2MUBA 4GV5A
chains in the Genus database with same CATH superfamily
2JR3A 1SHIA 1Z99A 3LMSB 2HJ9C 2MN3A 2SH1A 1ZLIB 3MCXA 1ZHHB 1ZUFA 2HJEA 1SH1A 3D4UB 1EL6A 1WXNA 1GKUB 1AHLA 1ZLHB 3C30A 1D6BA 2BDSA 2IKEA 2DLAA 2B9KA 3C38A 2IKDA 1WQKA 2XXLA 2RNGA 4YIRA 2QSGA 3KEZA 2H9XA 1BDSA 1ATXA 1GL9B 1APFA 1H5OA 2QSHA 3IF4A 2JTOA 1ZUEA 2K2XA 1B8WA 3MYVA 2QSFA 2MUBA 4GV5A
chains in the Genus database with same CATH topology
2JR3A 1SHIA 1Z99A 3LMSB 2HJ9C 2MN3A 2SH1A 1ZLIB 3MCXA 1ZHHB 1ZUFA 2HJEA 1SH1A 3D4UB 1WXNA 1AHLA 1ZLHB 3C30A 1D6BA 2BDSA 2IKEA 2DLAA 2B9KA 3C38A 2IKDA 1WQKA 2XXLA 2RNGA 4YIRA 2QSGA 3KEZA 2H9XA 1BDSA 1ATXA 1APFA 1H5OA 2QSHA 2JTOA 1ZUEA 2K2XA 1B8WA 3MYVA 2QSFA 2MUBA 4GV5A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1SHI A;  1Z99 A;  3LMS B;  2MN3 A;  2SH1 A;  1ZLI B;  1ZUF A;  1SH1 A;  3D4U B;  1WXN A;  1AHL A;  1ZLH B;  1D6B A;  2BDS A;  1WQK A;  2RNG A;  2H9X A;  1BDS A;  1ATX A;  1APF A;  1H5O A;  2JTO A;  1ZUE A;  2K2X A;  1B8W A;  2MUB A;  4GV5 A; 
#chains in the Genus database with same CATH topology
 2JR3 A;  1SHI A;  1Z99 A;  3LMS B;  2HJ9 C;  2MN3 A;  2SH1 A;  1ZLI B;  3MCX A;  1ZHH B;  1ZUF A;  2HJE A;  1SH1 A;  3D4U B;  1EL6 A;  1WXN A;  1GKU B;  1AHL A;  1ZLH B;  3C30 A;  1D6B A;  2BDS A;  2IKE A;  2DLA A;  2B9K A;  3C38 A;  2IKD A;  1WQK A;  2XXL A;  2RNG A;  4YIR A;  2QSG A;  3KEZ A;  2H9X A;  1BDS A;  1ATX A;  1GL9 B;  1APF A;  1H5O A;  2QSH A;  3IF4 A;  2JTO A;  1ZUE A;  2K2X A;  1B8W A;  3MYV A;  2QSF A;  2MUB A;  4GV5 A; 
#chains in the Genus database with same CATH homology
 2JR3 A;  1SHI A;  1Z99 A;  3LMS B;  2HJ9 C;  2MN3 A;  2SH1 A;  1ZLI B;  3MCX A;  1ZHH B;  1ZUF A;  2HJE A;  1SH1 A;  3D4U B;  1WXN A;  1AHL A;  1ZLH B;  3C30 A;  1D6B A;  2BDS A;  2IKE A;  2DLA A;  2B9K A;  3C38 A;  2IKD A;  1WQK A;  2XXL A;  2RNG A;  4YIR A;  2QSG A;  3KEZ A;  2H9X A;  1BDS A;  1ATX A;  1APF A;  1H5O A;  2QSH A;  2JTO A;  1ZUE A;  2K2X A;  1B8W A;  3MYV A;  2QSF A;  2MUB A;  4GV5 A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...