3S5EA

Crystal structure of human frataxin variant w155r, one of the friedreich's ataxia point mutations
Total Genus 32
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
32
sequence length
121
structure length
121
Chain Sequence
GSLDETTYERLAEETLDSLAEFFEDLADKPYTFEDYDVSFGSGVLTVKLGGDLGTYVINKQTPNKQIRLSSPSSGPKRYDWTGKNWVYSHDGVSLHELLAAELTKALKTKLDLSSLAYSGK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Friedreich's Ataxia Variants I154F and W155R Diminish Frataxin-Based Activation of the Iron-Sulfur Cluster Assembly Complex.
pubmed doi rcsb
molecule tags Unknown function
source organism Homo sapiens
molecule keywords Frataxin, mitochondrial
total genus 32
structure length 121
sequence length 121
ec nomenclature ec 1.16.3.1: Ferroxidase.
pdb deposition date 2011-05-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01491 Frataxin_Cyay Frataxin-like domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.920.10 Alpha Beta 2-Layer Sandwich Metal Transport, Frataxin; Chain A Frataxin/CyaY 3s5eA00
1SOYA 3T3TA 1EW4A 4HS5A 2FQLA 3T3JA 3S5DA 2P1XA 2EFFA 4JPDA 1LY7A 3T3LA 3S5EA 3S5FA 3T3XA 3OERA 1EKGA 3OEQA 3S4MA 3T3KA 4LK8A 4EC2A 2GA5A 4LP1A
chains in the Genus database with same CATH superfamily
2FUG7 1SOYA 3IMOA 3T3TA 1EW4A 4HS5A 3SSCA 2FQLA 3T3JA 1D2MA 4C26A 3S5DA 2P1XA 3IAM7 3GD0A 2EFFA 4P78C 4JPDA 1V5RA 1LY7A 1WHZA 3T3LA 3SSDA 3S5EA 3I9V7 3S5FA 3GD9A 3T3XA 3SSEA 3OERA 1EKGA 3OEQA 4HEA7 3S4MA 3IAS7 3T3KA 3A5PA 4LK8A 4EC2A 2GA5A 4LP1A
chains in the Genus database with same CATH topology
1SOYA 3T3TA 1EW4A 4HS5A 2FQLA 3T3JA 3S5DA 2P1XA 2EFFA 4JPDA 1LY7A 3T3LA 3S5EA 3S5FA 3T3XA 3OERA 1EKGA 3OEQA 3S4MA 3T3KA 4LK8A 4EC2A 2GA5A 4LP1A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1SOY A;  3T3T A;  1EW4 A;  4HS5 A;  2FQL A;  3T3J A;  3S5D A;  2P1X A;  2EFF A;  4JPD A;  1LY7 A;  3T3L A;  3S5E A;  3S5F A;  3T3X A;  3OER A;  1EKG A;  3OEQ A;  3S4M A;  3T3K A;  4LK8 A;  4EC2 A;  2GA5 A;  4LP1 A; 
#chains in the Genus database with same CATH topology
 2FUG 7;  1SOY A;  3IMO A;  3T3T A;  1EW4 A;  4HS5 A;  3SSC A;  2FQL A;  3T3J A;  1D2M A;  4C26 A;  3S5D A;  2P1X A;  3IAM 7;  3GD0 A;  2EFF A;  4P78 C;  4JPD A;  1V5R A;  1LY7 A;  1WHZ A;  3T3L A;  3SSD A;  3S5E A;  3I9V 7;  3S5F A;  3GD9 A;  3T3X A;  3SSE A;  3OER A;  1EKG A;  3OEQ A;  4HEA 7;  3S4M A;  3IAS 7;  3T3K A;  3A5P A;  4LK8 A;  4EC2 A;  2GA5 A;  4LP1 A; 
#chains in the Genus database with same CATH homology
 1SOY A;  3T3T A;  1EW4 A;  4HS5 A;  2FQL A;  3T3J A;  3S5D A;  2P1X A;  2EFF A;  4JPD A;  1LY7 A;  3T3L A;  3S5E A;  3S5F A;  3T3X A;  3OER A;  1EKG A;  3OEQ A;  3S4M A;  3T3K A;  4LK8 A;  4EC2 A;  2GA5 A;  4LP1 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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