3S5EA

Crystal structure of human frataxin variant w155r, one of the friedreich's ataxia point mutations
Total Genus 32
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
32
sequence length
121
structure length
121
Chain Sequence
GSLDETTYERLAEETLDSLAEFFEDLADKPYTFEDYDVSFGSGVLTVKLGGDLGTYVINKQTPNKQIRLSSPSSGPKRYDWTGKNWVYSHDGVSLHELLAAELTKALKTKLDLSSLAYSGK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Friedreich's Ataxia Variants I154F and W155R Diminish Frataxin-Based Activation of the Iron-Sulfur Cluster Assembly Complex.
pubmed doi rcsb
molecule keywords Frataxin, mitochondrial
molecule tags Unknown function
source organism Homo sapiens
total genus 32
structure length 121
sequence length 121
ec nomenclature ec 1.16.3.1: Ferroxidase.
pdb deposition date 2011-05-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01491 Frataxin_Cyay Frataxin-like domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.920.10 Alpha Beta 2-Layer Sandwich Metal Transport, Frataxin; Chain A Frataxin/CyaY 3s5eA00
3S4MA 1LY7A 3T3LA 3T3TA 4HS5A 3OEQA 3T3JA 3T3KA 4EC2A 3S5EA 4LK8A 2P1XA 3S5DA 4JPDA 1SOYA 3OERA 3S5FA 4LP1A 1EKGA 2EFFA 3T3XA 2GA5A 2FQLA 1EW4A
chains in the Genus database with same CATH superfamily
3SSCA 3IAM7 1LY7A 3S4MA 3T3LA 3T3TA 4HS5A 3OEQA 1D2MA 4P78C 3T3JA 3T3KA 3IAS7 4EC2A 3S5EA 4C26A 4LK8A 2P1XA 3GD9A 3S5DA 3SSEA 3GD0A 4JPDA 1SOYA 3SSDA 4HEA7 3OERA 2FUG7 1WHZA 3S5FA 3IMOA 3I9V7 1V5RA 4LP1A 1EKGA 2EFFA 3A5PA 3T3XA 2GA5A 2FQLA 1EW4A
chains in the Genus database with same CATH topology
3S4MA 1LY7A 3T3LA 3T3TA 4HS5A 3OEQA 3T3JA 3T3KA 4EC2A 3S5EA 4LK8A 2P1XA 3S5DA 4JPDA 1SOYA 3OERA 3S5FA 4LP1A 1EKGA 2EFFA 3T3XA 2GA5A 2FQLA 1EW4A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3S4M A;  1LY7 A;  3T3L A;  3T3T A;  4HS5 A;  3OEQ A;  3T3J A;  3T3K A;  4EC2 A;  3S5E A;  4LK8 A;  2P1X A;  3S5D A;  4JPD A;  1SOY A;  3OER A;  3S5F A;  4LP1 A;  1EKG A;  2EFF A;  3T3X A;  2GA5 A;  2FQL A;  1EW4 A; 
#chains in the Genus database with same CATH topology
 3SSC A;  3IAM 7;  1LY7 A;  3S4M A;  3T3L A;  3T3T A;  4HS5 A;  3OEQ A;  1D2M A;  4P78 C;  3T3J A;  3T3K A;  3IAS 7;  4EC2 A;  3S5E A;  4C26 A;  4LK8 A;  2P1X A;  3GD9 A;  3S5D A;  3SSE A;  3GD0 A;  4JPD A;  1SOY A;  3SSD A;  4HEA 7;  3OER A;  2FUG 7;  1WHZ A;  3S5F A;  3IMO A;  3I9V 7;  1V5R A;  4LP1 A;  1EKG A;  2EFF A;  3A5P A;  3T3X A;  2GA5 A;  2FQL A;  1EW4 A; 
#chains in the Genus database with same CATH homology
 3S4M A;  1LY7 A;  3T3L A;  3T3T A;  4HS5 A;  3OEQ A;  3T3J A;  3T3K A;  4EC2 A;  3S5E A;  4LK8 A;  2P1X A;  3S5D A;  4JPD A;  1SOY A;  3OER A;  3S5F A;  4LP1 A;  1EKG A;  2EFF A;  3T3X A;  2GA5 A;  2FQL A;  1EW4 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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