3T3JA

1.70 a structure of friedreich's ataxia frataxin variant n146k
Total Genus 36
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
36
sequence length
123
structure length
123
Chain Sequence
HPGSLDETTYERLAEETLDSLAEFFEDLADKPYTFEDYDVSFGSGVLTVKLGGDLGTYVIKKQTPNKQIWLSSPSSGPKRYDWTGKNWVYSHDGVSLHELLAAELTKALKTKLDLSSLAYSGK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure-Function Analysis of Friedreich's Ataxia Mutants Reveals Determinants of Frataxin Binding and Activation of the Fe-S Assembly Complex.
pubmed doi rcsb
molecule tags Oxidoreductase
source organism Homo sapiens
molecule keywords Frataxin, mitochondrial
total genus 36
structure length 123
sequence length 123
ec nomenclature ec 1.16.3.1: Ferroxidase.
pdb deposition date 2011-07-25

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01491 Frataxin_Cyay Frataxin-like domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.920.10 Alpha Beta 2-Layer Sandwich Metal Transport, Frataxin; Chain A Frataxin/CyaY 3t3jA00
2FQLA 1EW4A 1EKGA 4JPDA 3OERA 3S5DA 1LY7A 4LP1A 3OEQA 3S5FA 3S5EA 2EFFA 2GA5A 4LK8A 4HS5A 1SOYA 3T3TA 3S4MA 3T3XA 4EC2A 2P1XA 3T3KA 3T3JA 3T3LA
chains in the Genus database with same CATH superfamily
2FUG7 1V5RA 3IAS7 2FQLA 1EW4A 1EKGA 3I9V7 4JPDA 3A5PA 3GD9A 3OERA 3S5DA 1LY7A 4LP1A 1D2MA 3OEQA 3S5FA 3S5EA 1WHZA 3SSCA 2EFFA 3IMOA 4HEA7 3SSDA 2GA5A 4LK8A 3IAM7 4C26A 4HS5A 4P78C 1SOYA 3T3TA 3SSEA 3S4MA 3T3XA 3GD0A 4EC2A 2P1XA 3T3KA 3T3JA 3T3LA
chains in the Genus database with same CATH topology
2FQLA 1EW4A 1EKGA 4JPDA 3OERA 3S5DA 1LY7A 4LP1A 3OEQA 3S5FA 3S5EA 2EFFA 2GA5A 4LK8A 4HS5A 1SOYA 3T3TA 3S4MA 3T3XA 4EC2A 2P1XA 3T3KA 3T3JA 3T3LA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2FQL A;  1EW4 A;  1EKG A;  4JPD A;  3OER A;  3S5D A;  1LY7 A;  4LP1 A;  3OEQ A;  3S5F A;  3S5E A;  2EFF A;  2GA5 A;  4LK8 A;  4HS5 A;  1SOY A;  3T3T A;  3S4M A;  3T3X A;  4EC2 A;  2P1X A;  3T3K A;  3T3J A;  3T3L A; 
#chains in the Genus database with same CATH topology
 2FUG 7;  1V5R A;  3IAS 7;  2FQL A;  1EW4 A;  1EKG A;  3I9V 7;  4JPD A;  3A5P A;  3GD9 A;  3OER A;  3S5D A;  1LY7 A;  4LP1 A;  1D2M A;  3OEQ A;  3S5F A;  3S5E A;  1WHZ A;  3SSC A;  2EFF A;  3IMO A;  4HEA 7;  3SSD A;  2GA5 A;  4LK8 A;  3IAM 7;  4C26 A;  4HS5 A;  4P78 C;  1SOY A;  3T3T A;  3SSE A;  3S4M A;  3T3X A;  3GD0 A;  4EC2 A;  2P1X A;  3T3K A;  3T3J A;  3T3L A; 
#chains in the Genus database with same CATH homology
 2FQL A;  1EW4 A;  1EKG A;  4JPD A;  3OER A;  3S5D A;  1LY7 A;  4LP1 A;  3OEQ A;  3S5F A;  3S5E A;  2EFF A;  2GA5 A;  4LK8 A;  4HS5 A;  1SOY A;  3T3T A;  3S4M A;  3T3X A;  4EC2 A;  2P1X A;  3T3K A;  3T3J A;  3T3L A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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