4P24A

Pore forming toxin
Total Genus 49
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
49
sequence length
293
structure length
292
Chain Sequence
ADSDINIKTGTTDIGSTTVKTGDLVTYDKENGMHKKVFYSFIDDKNHNKKLLVIRTKGTIAGQYRVYSEEGANKSGLAWPSAFKVQLQLPDNEVAQISDYYPRNSIDTKEYMSTLTYGFNGNVTGDDTGKIGGLIGANVSIGHTLKYVQPDFKTILESPTDKKVGWKVIFNNMVNQNAGPYDRDSWNPVYGNQLFMKTANGSMKAAENFLDPNKASSLLSSGFSPDFATVITMDRKASKQQTNIDVIYERVRDDYQLHWTSTNWKGTNTKDKWTDRSSERYKIDWEKEEMTN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural basis for pore-forming mechanism of staphylococcal alpha-hemolysin.
pubmed doi rcsb
molecule keywords Alpha-hemolysin
molecule tags Toxin
source organism Staphylococcus aureus subsp. aureus mu50
total genus 49
structure length 292
sequence length 293
chains with identical sequence B, C, D, E, F, G
ec nomenclature
pdb deposition date 2014-03-01

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF07968 Leukocidin Leukocidin/Hemolysin toxin family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.70.240.10 Mainly Beta Distorted Sandwich Leukocidin-like Leukocidin/porin MspA 4p24A00
4TW1A 4IZLA 3ROHA 4TW1B 4IDJA 4IYAA 4I0NA 4U6VA 5K59C 4IYCA 2QK7A 4J0OA 3M4DA 5K59A 3ANZA 2QK7B 3M2LA 3M3RA 1T5RA 4P1YA 3O44A 4P1YB 4P24A 4IYTA 3M4EA 4H56A 2YGTA 4Q7GA 4P1XA 1LKFA 3B07A 3LKFA 4P1XB 1PVLA 3B07B 4YHDA 7AHLA 2LKFA
chains in the Genus database with same CATH superfamily
4TW1A 4IZLA 3ROHA 4TW1B 4IDJA 4IYAA 4I0NA 4U6VA 5K59C 4IYCA 2QK7A 4J0OA 3M4DA 5K59A 3ANZA 2QK7B 3M2LA 3M3RA 1T5RA 4P1YA 3O44A 4P1YB 4P24A 4IYTA 3M4EA 4H56A 2YGTA 4Q7GA 1XEZA 4P1XA 1LKFA 3B07A 3LKFA 4P1XB 1PVLA 3B07B 4YHDA 7AHLA 2LKFA
chains in the Genus database with same CATH topology
4TW1A 4IZLA 3ROHA 4TW1B 4IDJA 4IYAA 4I0NA 4U6VA 5K59C 4IYCA 2QK7A 4J0OA 3M4DA 5K59A 3ANZA 2QK7B 3M2LA 3M3RA 1T5RA 4P1YA 3O44A 4P1YB 4P24A 4IYTA 3M4EA 4H56A 2YGTA 4Q7GA 4P1XA 1LKFA 3B07A 3LKFA 4P1XB 1PVLA 3B07B 4YHDA 7AHLA 2LKFA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4TW1 A;  4IZL A;  3ROH A;  4TW1 B;  4IDJ A;  4IYA A;  4I0N A;  4U6V A;  5K59 C;  4IYC A;  2QK7 A;  4J0O A;  3M4D A;  5K59 A;  3ANZ A;  2QK7 B;  3M2L A;  3M3R A;  1T5R A;  4P1Y A;  3O44 A;  4P1Y B;  4P24 A;  4IYT A;  3M4E A;  4H56 A;  2YGT A;  4Q7G A;  4P1X A;  1LKF A;  3B07 A;  3LKF A;  4P1X B;  1PVL A;  3B07 B;  4YHD A;  7AHL A;  2LKF A; 
#chains in the Genus database with same CATH topology
 4TW1 A;  4IZL A;  3ROH A;  4TW1 B;  4IDJ A;  4IYA A;  4I0N A;  4U6V A;  5K59 C;  4IYC A;  2QK7 A;  4J0O A;  3M4D A;  5K59 A;  3ANZ A;  2QK7 B;  3M2L A;  3M3R A;  1T5R A;  4P1Y A;  3O44 A;  4P1Y B;  4P24 A;  4IYT A;  3M4E A;  4H56 A;  2YGT A;  4Q7G A;  1XEZ A;  4P1X A;  1LKF A;  3B07 A;  3LKF A;  4P1X B;  1PVL A;  3B07 B;  4YHD A;  7AHL A;  2LKF A; 
#chains in the Genus database with same CATH homology
 4TW1 A;  4IZL A;  3ROH A;  4TW1 B;  4IDJ A;  4IYA A;  4I0N A;  4U6V A;  5K59 C;  4IYC A;  2QK7 A;  4J0O A;  3M4D A;  5K59 A;  3ANZ A;  2QK7 B;  3M2L A;  3M3R A;  1T5R A;  4P1Y A;  3O44 A;  4P1Y B;  4P24 A;  4IYT A;  3M4E A;  4H56 A;  2YGT A;  4Q7G A;  4P1X A;  1LKF A;  3B07 A;  3LKF A;  4P1X B;  1PVL A;  3B07 B;  4YHD A;  7AHL A;  2LKF A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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