4P24A

Pore forming toxin
Total Genus 49
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
49
sequence length
293
structure length
292
Chain Sequence
ADSDINIKTGTTDIGSTTVKTGDLVTYDKENGMHKKVFYSFIDDKNHNKKLLVIRTKGTIAGQYRVYSEEGANKSGLAWPSAFKVQLQLPDNEVAQISDYYPRNSIDTKEYMSTLTYGFNGNVTGDDTGKIGGLIGANVSIGHTLKYVQPDFKTILESPTDKKVGWKVIFNNMVNQNAGPYDRDSWNPVYGNQLFMKTANGSMKAAENFLDPNKASSLLSSGFSPDFATVITMDRKASKQQTNIDVIYERVRDDYQLHWTSTNWKGTNTKDKWTDRSSERYKIDWEKEEMTN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural basis for pore-forming mechanism of staphylococcal alpha-hemolysin.
pubmed doi rcsb
molecule tags Toxin
source organism Staphylococcus aureus subsp. aureus mu50
molecule keywords Alpha-hemolysin
total genus 49
structure length 292
sequence length 293
chains with identical sequence B, C, D, E, F, G
ec nomenclature
pdb deposition date 2014-03-01

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF07968 Leukocidin Leukocidin/Hemolysin toxin family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.70.240.10 Mainly Beta Distorted Sandwich Leukocidin-like Leukocidin/porin MspA 4p24A00
4U6VA 1T5RA 5K59A 2QK7A 1LKFA 2YGTA 4P1XA 4P24A 3M4DA 4YHDA 3ROHA 4IDJA 4IYAA 4TW1B 5K59C 3M4EA 4P1YB 3ANZA 3O44A 3LKFA 4I0NA 4IYTA 7AHLA 4TW1A 4H56A 4IZLA 4P1YA 3B07B 3M2LA 2QK7B 4Q7GA 1PVLA 4J0OA 3M3RA 2LKFA 4IYCA 4P1XB 3B07A
chains in the Genus database with same CATH superfamily
4U6VA 1T5RA 5K59A 2QK7A 1LKFA 2YGTA 1XEZA 4P1XA 4P24A 3M4DA 4YHDA 3ROHA 4IDJA 4IYAA 4TW1B 5K59C 3M4EA 4P1YB 3ANZA 3O44A 3LKFA 4I0NA 4IYTA 7AHLA 4TW1A 4H56A 4IZLA 4P1YA 3B07B 3M2LA 2QK7B 4Q7GA 1PVLA 4J0OA 3M3RA 2LKFA 4IYCA 4P1XB 3B07A
chains in the Genus database with same CATH topology
4U6VA 1T5RA 5K59A 2QK7A 1LKFA 2YGTA 4P1XA 4P24A 3M4DA 4YHDA 3ROHA 4IDJA 4IYAA 4TW1B 5K59C 3M4EA 4P1YB 3ANZA 3O44A 3LKFA 4I0NA 4IYTA 7AHLA 4TW1A 4H56A 4IZLA 4P1YA 3B07B 3M2LA 2QK7B 4Q7GA 1PVLA 4J0OA 3M3RA 2LKFA 4IYCA 4P1XB 3B07A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4U6V A;  1T5R A;  5K59 A;  2QK7 A;  1LKF A;  2YGT A;  4P1X A;  4P24 A;  3M4D A;  4YHD A;  3ROH A;  4IDJ A;  4IYA A;  4TW1 B;  5K59 C;  3M4E A;  4P1Y B;  3ANZ A;  3O44 A;  3LKF A;  4I0N A;  4IYT A;  7AHL A;  4TW1 A;  4H56 A;  4IZL A;  4P1Y A;  3B07 B;  3M2L A;  2QK7 B;  4Q7G A;  1PVL A;  4J0O A;  3M3R A;  2LKF A;  4IYC A;  4P1X B;  3B07 A; 
#chains in the Genus database with same CATH topology
 4U6V A;  1T5R A;  5K59 A;  2QK7 A;  1LKF A;  2YGT A;  1XEZ A;  4P1X A;  4P24 A;  3M4D A;  4YHD A;  3ROH A;  4IDJ A;  4IYA A;  4TW1 B;  5K59 C;  3M4E A;  4P1Y B;  3ANZ A;  3O44 A;  3LKF A;  4I0N A;  4IYT A;  7AHL A;  4TW1 A;  4H56 A;  4IZL A;  4P1Y A;  3B07 B;  3M2L A;  2QK7 B;  4Q7G A;  1PVL A;  4J0O A;  3M3R A;  2LKF A;  4IYC A;  4P1X B;  3B07 A; 
#chains in the Genus database with same CATH homology
 4U6V A;  1T5R A;  5K59 A;  2QK7 A;  1LKF A;  2YGT A;  4P1X A;  4P24 A;  3M4D A;  4YHD A;  3ROH A;  4IDJ A;  4IYA A;  4TW1 B;  5K59 C;  3M4E A;  4P1Y B;  3ANZ A;  3O44 A;  3LKF A;  4I0N A;  4IYT A;  7AHL A;  4TW1 A;  4H56 A;  4IZL A;  4P1Y A;  3B07 B;  3M2L A;  2QK7 B;  4Q7G A;  1PVL A;  4J0O A;  3M3R A;  2LKF A;  4IYC A;  4P1X B;  3B07 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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