4U6VA

Mechanisms of neutralization of a human anti-alpha toxin antibody
Total Genus 68
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
68
sequence length
282
structure length
272
Chain Sequence
TDIGSNTTVKTGDLVTYDKENGMHKKVFYSFIDDKNHNKKLLVIRTKGTIAGQYRVYSEEGANKSGLAWPSAFKVQLQLPDNEVAQISDYYPRNSIDTKEYMSTLTYGFNGNVTGGANVSIGHTLKYVQPDFKTILESPTDKKVGWKVIFNNMVNQNWGPYDRDSWNPVYGNQLFMKTRNGSMKAADNFLDPNKASSLLSSGFSPDFATVITMDRKASKQQTNIDVIYERVRDDYQLHWTSTNWKGTNTKDKWIDRSSERYKIDWEKEEMTN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Mechanisms of Neutralization of a Human Anti-alpha-toxin Antibody.
pubmed doi rcsb
molecule keywords Fab, antigen binding fragment, heavy chain
molecule tags Immune system
source organism Homo sapiens
total genus 68
structure length 272
sequence length 282
chains with identical sequence B
ec nomenclature
pdb deposition date 2014-07-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF07968 Leukocidin Leukocidin/Hemolysin toxin family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.70.240.10 Mainly Beta Distorted Sandwich Leukocidin-like Leukocidin/porin MspA 4u6vA00
4TW1B 3ROHA 4I0NA 3LKFA 3B07B 2QK7B 4Q7GA 4U6VA 3ANZA 4H56A 3O44A 4IDJA 4TW1A 1LKFA 3M3RA 5K59C 4IZLA 1T5RA 3M2LA 3B07A 4P1YB 2QK7A 4P1XB 2YGTA 4P24A 4IYCA 3M4DA 4IYAA 4J0OA 1PVLA 5K59A 4YHDA 7AHLA 3M4EA 4IYTA 4P1YA 4P1XA 2LKFA
chains in the Genus database with same CATH superfamily
4TW1B 3ROHA 1XEZA 4I0NA 3LKFA 3B07B 2QK7B 4Q7GA 4U6VA 3ANZA 4H56A 3O44A 4IDJA 4TW1A 1LKFA 3M3RA 5K59C 4IZLA 1T5RA 3M2LA 3B07A 4P1YB 2QK7A 4P1XB 2YGTA 4P24A 4IYCA 3M4DA 4IYAA 4J0OA 1PVLA 5K59A 4YHDA 7AHLA 3M4EA 4IYTA 4P1YA 4P1XA 2LKFA
chains in the Genus database with same CATH topology
4TW1B 3ROHA 4I0NA 3LKFA 3B07B 2QK7B 4Q7GA 4U6VA 3ANZA 4H56A 3O44A 4IDJA 4TW1A 1LKFA 3M3RA 5K59C 4IZLA 1T5RA 3M2LA 3B07A 4P1YB 2QK7A 4P1XB 2YGTA 4P24A 4IYCA 3M4DA 4IYAA 4J0OA 1PVLA 5K59A 4YHDA 7AHLA 3M4EA 4IYTA 4P1YA 4P1XA 2LKFA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4TW1 B;  3ROH A;  4I0N A;  3LKF A;  3B07 B;  2QK7 B;  4Q7G A;  4U6V A;  3ANZ A;  4H56 A;  3O44 A;  4IDJ A;  4TW1 A;  1LKF A;  3M3R A;  5K59 C;  4IZL A;  1T5R A;  3M2L A;  3B07 A;  4P1Y B;  2QK7 A;  4P1X B;  2YGT A;  4P24 A;  4IYC A;  3M4D A;  4IYA A;  4J0O A;  1PVL A;  5K59 A;  4YHD A;  7AHL A;  3M4E A;  4IYT A;  4P1Y A;  4P1X A;  2LKF A; 
#chains in the Genus database with same CATH topology
 4TW1 B;  3ROH A;  1XEZ A;  4I0N A;  3LKF A;  3B07 B;  2QK7 B;  4Q7G A;  4U6V A;  3ANZ A;  4H56 A;  3O44 A;  4IDJ A;  4TW1 A;  1LKF A;  3M3R A;  5K59 C;  4IZL A;  1T5R A;  3M2L A;  3B07 A;  4P1Y B;  2QK7 A;  4P1X B;  2YGT A;  4P24 A;  4IYC A;  3M4D A;  4IYA A;  4J0O A;  1PVL A;  5K59 A;  4YHD A;  7AHL A;  3M4E A;  4IYT A;  4P1Y A;  4P1X A;  2LKF A; 
#chains in the Genus database with same CATH homology
 4TW1 B;  3ROH A;  4I0N A;  3LKF A;  3B07 B;  2QK7 B;  4Q7G A;  4U6V A;  3ANZ A;  4H56 A;  3O44 A;  4IDJ A;  4TW1 A;  1LKF A;  3M3R A;  5K59 C;  4IZL A;  1T5R A;  3M2L A;  3B07 A;  4P1Y B;  2QK7 A;  4P1X B;  2YGT A;  4P24 A;  4IYC A;  3M4D A;  4IYA A;  4J0O A;  1PVL A;  5K59 A;  4YHD A;  7AHL A;  3M4E A;  4IYT A;  4P1Y A;  4P1X A;  2LKF A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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