|
18
|
99
|
4ejkA |
Hiv protease (pr) dimer in closed form with pepstatin in active site and fragment 1f1-n in the outside/top of flap |
|
94
|
391
|
4dv9A |
Crystal structure of bace1 with its inhibitor |
|
16
|
99
|
4e43A |
Hiv protease (pr) dimer with acetate in exo site and peptide in active site |
|
16
|
99
|
4dqgA |
Crystal structure of apo(g16c/l38c) hiv-1 protease |
|
106
|
390
|
4djvA |
Structure of bace bound to 2-imino-5-(3'-methoxy-[1,1'-biphenyl]-3-yl)-3-methyl-5-phenylimidazolidin-4-one |
|
19
|
99
|
4dfgA |
Crystal structure of wild-type hiv-1 protease with cyclopentyltetrahydro- furanyl urethanes as p2-ligand, grl-0249a |
|
99
|
388
|
4d8cA |
Crystal structure of human beta secretase in complex with nvp-bxd552, derived from a co-crystallization experiment |
|
18
|
99
|
4djrA |
Crystal structure of wild-type hiv-1 protease in complex with mkp97 |
|
100
|
391
|
4di2A |
Crystal structure of bace1 in complex with hydroxyethylamine inhibitor 37 |
|
95
|
388
|
4d83A |
Crystal structure of human beta secretase in complex with nvp-bur436, derived from a co-crystallization experiment |
|
105
|
390
|
4djuA |
Structure of bace bound to 2-imino-3-methyl-5,5-diphenylimidazolidin-4-one |
|
104
|
390
|
4djyA |
Structure of bace bound to (r)-5-cyclopropyl-2-imino-3-methyl-5-(3-(5-(prop-1-yn-1-yl)pyridin-3-yl)phenyl)imidazolidin-4-one |
|
90
|
387
|
4dh6A |
Structure of bace-1 (beta-secretase) in complex with (2r)-n-((2s,3r)-1-(benzo[d][1,3]dioxol-5-yl)-3-hydroxy-4-((s)-6'-neopentyl-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridine]-4'-ylamino)butan-2-yl)-2-methoxypropanamide |
|
18
|
99
|
4djpA |
Crystal structure of wild-type hiv-1 protease in complex with mkp73 |
|
18
|
99
|
4djqA |
Crystal structure of wild-type hiv-1 protease in complex with mkp86 |
|
15
|
99
|
4cpsA |
Macrocyclic transition-state mimicking hiv-1 protease inhibitors encompassing a tertiary alcohol |
|
104
|
390
|
4djxA |
Structure of bace bound to 5-(3-(5-chloropyridin-3-yl)phenyl)-5-cyclopropyl-2-imino-3-methylimidazolidin-4-one |
|
101
|
389
|
4d85A |
Crystal structure of human beta secretase in complex with nvp-bvi151 |
|
16
|
99
|
4cpxA |
Macrocyclic transition-state mimicking hiv-1 protease inhibitors encompassing a tertiary alcohol |
|
19
|
99
|
4djoA |
Crystal structure of wild-type hiv-1 protease in complex with mkp56 |
|
15
|
99
|
4cp7A |
Macrocyclic transition-state mimicking hiv-1 protease inhibitors encompassing a tertiary alcohol |
|
101
|
388
|
4d89A |
Crystal structure of human beta secretase in complex with nvp-bxd552, derived from a soaking experiment |
|
15
|
99
|
4cpqA |
Macrocyclic transition-state mimicking hiv-1 protease inhibitors encompassing a tertiary alcohol |
|
99
|
388
|
4d88A |
Crystal structure of human beta secretase in complex with nvp-bxq490 |
|
104
|
390
|
4djwA |
Structure of bace bound to 2-imino-3-methyl-5-phenyl-5-(3-(pyridin-3-yl)phenyl)imidazolidin-4-one |
|
16
|
99
|
4cprA |
Macrocyclic transition-state mimicking hiv-1 protease inhibitors encompassing a tertiary alcohol |
|
16
|
99
|
4cpuA |
Macrocyclic transition-state mimicking hiv-1 protease inhibitors encompassing a tertiary alcohol |
|
15
|
99
|
4cpwA |
Macrocyclic transition-state mimicking hiv-1 protease inhibitors encompassing a tertiary alcohol |
|
83
|
323
|
4cmsA |
X-ray analyses of aspartic proteinases iv. structure and refinement at 2.2 angstroms resolution of bovine chymosin |
|
15
|
99
|
4cptA |
Macrocyclic transition-state mimicking hiv-1 protease inhibitors encompassing a tertiary alcohol |
|
84
|
327
|
4ckuA |
Three dimensional structure of plasmepsin ii in complex with hydroxyethylamine-based inhibitor |
|
16
|
99
|
4coeA |
Macrocyclic transition-state mimicking hiv-1 protease inhibitors encompassing a tertiary alcohol |
|
87
|
323
|
4aucA |
Bovine chymosin in complex with pepstatin a |
|
104
|
388
|
4b1dA |
New aminoimidazoles as bace-1 inhibitors: from rational design to ab- lowering in brain |
|
104
|
388
|
4azyA |
Design and synthesis of bace1 inhibitors with in vivo brain reduction of beta-amyloid peptides (compound 10) |
|
102
|
388
|
4b77A |
Aminoimidazoles as bace-1 inhibitors: from de novo design to ab- lowering in brain |
|
102
|
390
|
4bfdA |
Crystal structure of bace-1 in complex with chemical ligand |
|
101
|
375
|
4b1cA |
New aminoimidazoles as bace-1 inhibitors: from rational design to ab- lowering in brain |
|
99
|
384
|
4b0qA |
Lead generation of bace1 inhibitors by coupling non-amidine new warheads to a known binding scaffold |
|
102
|
388
|
4b00A |
Design and synthesis of bace1 inhibitors with in vivo brain reduction of beta-amyloid peptides (compound (r)-41) |
|
94
|
384
|
4belA |
Bace2 xaperone complex |
|
103
|
388
|
4b72A |
Aminoimidazoles as bace-1 inhibitors: from de novo design to ab- lowering in brain |
|
99
|
383
|
4bfbA |
Bace2 xaperone complex |
|
102
|
389
|
4b05A |
Preclinical characterization of azd3839, a novel clinical candidate bace1 inhibitor for the treatment of alzheimer disease |
|
102
|
384
|
4b78A |
Aminoimidazoles as bace-1 inhibitors: from de novo design to ab- lowering in brain |
|
100
|
385
|
4b70A |
Aminoimidazoles as bace-1 inhibitors: from de novo design to ab- lowering in brain |
|
95
|
390
|
4bekA |
Crystal structure of bace-1 in complex with chemical ligand |
|
101
|
388
|
4b1eA |
New aminoimidazoles as bace-1 inhibitors: from rational design to ab- lowering in brain |
|
16
|
99
|
3zpuA |
Design and synthesis of p1-p3 macrocyclic tertiary alcohol comprising hiv-1 protease inhibitors |
|
102
|
388
|
4acuA |
Aminoimidazoles as bace-1 inhibitors. x-ray crystal structure of beta secretase complexed with compound 14 |
