|
18
|
99
|
3sa3A |
Crystal structure of wild-type hiv-1 protease in complex with ag23 |
|
17
|
99
|
5kqzA |
Protease e35d-cap2 |
|
18
|
99
|
5jfuA |
Hiv-1 wild type protease with grl-007-14a (a adamantane p1-ligand with bis-thf in p2 and benzylamine in p1') |
|
18
|
99
|
5jfpA |
Hiv-1 wild type protease with grl-097-13a (a adamantane p1-ligand with bis-thf in p2 and isobutylamine in p1') |
|
18
|
99
|
5ivtA |
Crystal structure of hiv protease complexed with [(1s)-1-[(s)-(4-chlorophenyl)-(3,5-difluorophenyl)methyl]-2-[[5-fluoro-4-[2-[(2r,5s)-5-(2,2,2-trifluoroethylcarbamoyloxymethyl)morpholin-4-ium-2-yl]ethyl]pyridin-1-ium-3-yl]amino]-2-oxo-ethyl]ammonium |
|
16
|
99
|
5ivqA |
Crystal structure of hiv protease complexed with methyl n-[(1s)-1-benzhydryl-2-(3-morpholin-4-ium-2-ylpropylamino)-2-oxo-ethyl]carbamate |
|
18
|
99
|
5ivrA |
Crystal structure of hiv protease complexed with methyl n-[(1s)-1-[[2-[(3s)-3-[(4-aminophenyl)methylamino]-4-hydroxy-butyl]phenyl]carbamoyl]-2,2-diphenyl-ethyl]carbamate |
|
20
|
99
|
6cdlA |
Hiv-1 wild type protease with grl-03214a, 6-5-5-ring fused umbrella-like tetrahydropyranofuran as the p2-ligand, a cyclopropylaminobenzothiazole as the p2'-ligand and 3,5-difluorophenylmethyl as the p1-ligand |
|
19
|
99
|
6cdjA |
Hiv-1 wild type protease with grl-03314a, 6-5-5-ring fused umbrella-like tetrahydropyranofuran as the p2-ligand, a cyclopropylaminobenzothiazole as the p2'-ligand and 3,5-difluorophenylmethyl as the p1-ligand |
|
19
|
99
|
6bz2A |
Crystal structure of wild-type hiv-1 protease with a novel hiv-1 inhibitor grl-14213a of 6-5-5-ring fused crown-like tetrahydropyranofuran as the p2-ligand, a cyclopropylaminobenzothiazole as the p2'-ligand and 3,5-difluorophenylmethyl as the p1-ligand |
|
19
|
99
|
6braA |
Hiv-1 protease (d25n, inactive) in complex with phage display optimized substrate sgiflets |
|
0
|
8
|
6braS |
Hiv-1 protease (d25n, inactive) in complex with phage display optimized substrate sgiflets |
|
19
|
99
|
6b4nA |
A hydroxymethyl functionality at the 4-position of the 2-phenyloxazole moiety of hiv-1 protease inhibitors involving the p2' ligands |
|
19
|
103
|
5yrsB |
X-ray snapshot of hiv-1 protease in action: observation of tetrahedral intermediate and its sihb with catalytic aspartate |
|
18
|
99
|
5yrsA |
X-ray snapshot of hiv-1 protease in action: observation of tetrahedral intermediate and its sihb with catalytic aspartate |
|
105
|
282
|
5z6oA |
Crystal structure of penicillium cyclopium protease |
|
17
|
99
|
5vj3A |
Hiv protease (pr) in open form with mg2+ in active site and hive-9 in eye site |
|
17
|
99
|
5b18A |
Crystal structure of a darunavir resistant hiv-1 protease |
|
18
|
99
|
5bs4A |
Hiv-1 wild type protease with grl-047-11a (a methylamine bis-tetrahydrofuran p2-ligand, 4-amino sulfonamide derivative) |
|
18
|
99
|
5bryA |
Hiv-1 wild type protease with grl-011-11a (a methylamine bis-tetrahydrofuran p2-ligand, sulfonamide isostere derivate) |
|
18
|
99
|
4zlsA |
Hiv-1 wild type protease with grl-096-13a (a boc-derivative p2-ligand, 3,-5-dimethylbiphenyl p1-ligand) |
|
18
|
99
|
4zipA |
Hiv-1 wild type protease with grl-0648a (a isophthalamide-derived p2-ligand) |
|
20
|
99
|
4z50A |
Crystal structure of multidrug resistant hiv-1 protease clinical isolate pr20d25n with tucked flap |
|
15
|
99
|
4z4xA |
Crystal structure of multidrug resistant hiv-1 protease clinical isolate pr20d25n with open flap |
|
19
|
99
|
4qjaA |
Crystal structure of inactive hiv-1 protease in complex with p1-p6 substrate variant (p453l) |
|
0
|
10
|
4qjaP |
Crystal structure of inactive hiv-1 protease in complex with p1-p6 substrate variant (p453l) |
|
18
|
99
|
4f76A |
Crystal structure of the active hiv-1 protease in complex with the products of p1-p6 substrate |
|
18
|
99
|
4f75A |
Crystal structure of active hiv-1 protease in complex with the n terminal product of the substrate rh-in |
|
19
|
99
|
4f73A |
Crystal structure of active hiv-1 protease in complex with the n terminal product of ca-p2 cleavage site |
|
18
|
99
|
4f74A |
Crystal structure of active hiv-1 protease in complex with the n terminal product of the substrate ma-ca. |
|
18
|
99
|
4ejlA |
Apo hiv protease (pr) dimer in closed form with fragment 1f1-n in the outside/top of flap |
|
17
|
99
|
4ej8A |
Apo hiv protease (pr) dimer in closed form with fragment 1f1 in the outside/top of flap |
|
19
|
99
|
4ejdA |
Hiv protease (pr) dimer in closed form with pepstatin in active site and fragment 1f1 in the outside/top of flap |
|
18
|
99
|
4ejkA |
Hiv protease (pr) dimer in closed form with pepstatin in active site and fragment 1f1-n in the outside/top of flap |
|
16
|
99
|
4e43A |
Hiv protease (pr) dimer with acetate in exo site and peptide in active site |
|
16
|
99
|
4cpxA |
Macrocyclic transition-state mimicking hiv-1 protease inhibitors encompassing a tertiary alcohol |
|
15
|
99
|
4cpsA |
Macrocyclic transition-state mimicking hiv-1 protease inhibitors encompassing a tertiary alcohol |
|
19
|
99
|
4dfgA |
Crystal structure of wild-type hiv-1 protease with cyclopentyltetrahydro- furanyl urethanes as p2-ligand, grl-0249a |
|
15
|
99
|
4cpqA |
Macrocyclic transition-state mimicking hiv-1 protease inhibitors encompassing a tertiary alcohol |
|
15
|
99
|
4cp7A |
Macrocyclic transition-state mimicking hiv-1 protease inhibitors encompassing a tertiary alcohol |
|
16
|
99
|
4cpuA |
Macrocyclic transition-state mimicking hiv-1 protease inhibitors encompassing a tertiary alcohol |
|
16
|
99
|
4cprA |
Macrocyclic transition-state mimicking hiv-1 protease inhibitors encompassing a tertiary alcohol |
|
16
|
99
|
4coeA |
Macrocyclic transition-state mimicking hiv-1 protease inhibitors encompassing a tertiary alcohol |
|
15
|
99
|
4cptA |
Macrocyclic transition-state mimicking hiv-1 protease inhibitors encompassing a tertiary alcohol |
|
15
|
99
|
4cpwA |
Macrocyclic transition-state mimicking hiv-1 protease inhibitors encompassing a tertiary alcohol |
|
15
|
99
|
4a4qA |
Stereoselective synthesis, x-ray analysis, and biological evaluation of a new class of lactam based hiv-1 protease inhibitors |
|
16
|
99
|
3zptA |
Design and synthesis of p1-p3 macrocyclic tertiary alcohol comprising hiv-1 protease inhibitors |
|
16
|
99
|
3zpuA |
Design and synthesis of p1-p3 macrocyclic tertiary alcohol comprising hiv-1 protease inhibitors |
|
16
|
99
|
3zpsA |
Design and synthesis of p1-p3 macrocyclic tertiary alcohol comprising hiv-1 protease inhibitors |
|
18
|
116
|
3wsjA |
Htlv-1 protease in complex with the hiv-1 protease inhibitor indinavir |
