4YHDA

Staphylococcal alpha-hemolysin h35a mutant monomer
Total Genus 64
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
64
sequence length
290
structure length
281
Chain Sequence
INIKTGTTDIGSNTTVKTGDLVTYDKENGMAKKVFYSFIDDKNHNKKLLVIRTKGTIAGQYRVYSEEGANKSGLAWPSAFKVQLQLPDNEVAQISDYYPRNSIDTKEYMSTLTYGFNGNVTGDDANVSIGHTLKYVQPDFKTILESPTDKKVGWKVIFNNMVNQNWGPYDRDSWNPVYGNQLFMKTRNGSMKAAENFLDPNKASSLLSSGFSPDFATVITMDRKASKQQTNIDVIYERVRDDYQLHWTSTNWKGTNTKDKWTDRSSERYKIDWEKEEMTNL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural basis for pore-forming mechanism of staphylococcal alpha-hemolysin
pubmed doi rcsb
molecule tags Toxin
source organism Staphylococcus aureus
molecule keywords Alpha-hemolysin
total genus 64
structure length 281
sequence length 290
chains with identical sequence B, C, D, E, G
ec nomenclature
pdb deposition date 2015-02-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF07968 Leukocidin Leukocidin/Hemolysin toxin family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.70.240.10 Mainly Beta Distorted Sandwich Leukocidin-like Leukocidin/porin MspA 4yhdA00
4P1XB 3M3RA 4H56A 3ANZA 4IDJA 4P24A 5K59C 3B07A 4P1YB 4IYAA 2QK7B 4U6VA 4IYTA 2LKFA 3O44A 4P1XA 4TW1B 3ROHA 4YHDA 3M2LA 1LKFA 5K59A 4IZLA 2YGTA 2QK7A 4I0NA 4P1YA 4Q7GA 4TW1A 4J0OA 1PVLA 7AHLA 3B07B 3M4EA 3M4DA 1T5RA 4IYCA 3LKFA
chains in the Genus database with same CATH superfamily
4P1XB 3M3RA 4H56A 3ANZA 4IDJA 4P24A 5K59C 3B07A 4P1YB 4IYAA 2QK7B 4U6VA 4IYTA 2LKFA 3O44A 4P1XA 4TW1B 3ROHA 4YHDA 3M2LA 1LKFA 5K59A 4IZLA 2YGTA 2QK7A 4I0NA 4P1YA 1XEZA 4Q7GA 4TW1A 4J0OA 1PVLA 7AHLA 3B07B 3M4EA 3M4DA 1T5RA 4IYCA 3LKFA
chains in the Genus database with same CATH topology
4P1XB 3M3RA 4H56A 3ANZA 4IDJA 4P24A 5K59C 3B07A 4P1YB 4IYAA 2QK7B 4U6VA 4IYTA 2LKFA 3O44A 4P1XA 4TW1B 3ROHA 4YHDA 3M2LA 1LKFA 5K59A 4IZLA 2YGTA 2QK7A 4I0NA 4P1YA 4Q7GA 4TW1A 4J0OA 1PVLA 7AHLA 3B07B 3M4EA 3M4DA 1T5RA 4IYCA 3LKFA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4P1X B;  3M3R A;  4H56 A;  3ANZ A;  4IDJ A;  4P24 A;  5K59 C;  3B07 A;  4P1Y B;  4IYA A;  2QK7 B;  4U6V A;  4IYT A;  2LKF A;  3O44 A;  4P1X A;  4TW1 B;  3ROH A;  4YHD A;  3M2L A;  1LKF A;  5K59 A;  4IZL A;  2YGT A;  2QK7 A;  4I0N A;  4P1Y A;  4Q7G A;  4TW1 A;  4J0O A;  1PVL A;  7AHL A;  3B07 B;  3M4E A;  3M4D A;  1T5R A;  4IYC A;  3LKF A; 
#chains in the Genus database with same CATH topology
 4P1X B;  3M3R A;  4H56 A;  3ANZ A;  4IDJ A;  4P24 A;  5K59 C;  3B07 A;  4P1Y B;  4IYA A;  2QK7 B;  4U6V A;  4IYT A;  2LKF A;  3O44 A;  4P1X A;  4TW1 B;  3ROH A;  4YHD A;  3M2L A;  1LKF A;  5K59 A;  4IZL A;  2YGT A;  2QK7 A;  4I0N A;  4P1Y A;  1XEZ A;  4Q7G A;  4TW1 A;  4J0O A;  1PVL A;  7AHL A;  3B07 B;  3M4E A;  3M4D A;  1T5R A;  4IYC A;  3LKF A; 
#chains in the Genus database with same CATH homology
 4P1X B;  3M3R A;  4H56 A;  3ANZ A;  4IDJ A;  4P24 A;  5K59 C;  3B07 A;  4P1Y B;  4IYA A;  2QK7 B;  4U6V A;  4IYT A;  2LKF A;  3O44 A;  4P1X A;  4TW1 B;  3ROH A;  4YHD A;  3M2L A;  1LKF A;  5K59 A;  4IZL A;  2YGT A;  2QK7 A;  4I0N A;  4P1Y A;  4Q7G A;  4TW1 A;  4J0O A;  1PVL A;  7AHL A;  3B07 B;  3M4E A;  3M4D A;  1T5R A;  4IYC A;  3LKF A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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