4YHDA

Staphylococcal alpha-hemolysin h35a mutant monomer
Total Genus 64
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
64
sequence length
290
structure length
281
Chain Sequence
INIKTGTTDIGSNTTVKTGDLVTYDKENGMAKKVFYSFIDDKNHNKKLLVIRTKGTIAGQYRVYSEEGANKSGLAWPSAFKVQLQLPDNEVAQISDYYPRNSIDTKEYMSTLTYGFNGNVTGDDANVSIGHTLKYVQPDFKTILESPTDKKVGWKVIFNNMVNQNWGPYDRDSWNPVYGNQLFMKTRNGSMKAAENFLDPNKASSLLSSGFSPDFATVITMDRKASKQQTNIDVIYERVRDDYQLHWTSTNWKGTNTKDKWTDRSSERYKIDWEKEEMTNL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural basis for pore-forming mechanism of staphylococcal alpha-hemolysin
pubmed doi rcsb
molecule tags Toxin
source organism Staphylococcus aureus
molecule keywords Alpha-hemolysin
total genus 64
structure length 281
sequence length 290
chains with identical sequence B, C, D, E, G
ec nomenclature
pdb deposition date 2015-02-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF07968 Leukocidin Leukocidin/Hemolysin toxin family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.70.240.10 Mainly Beta Distorted Sandwich Leukocidin-like Leukocidin/porin MspA 4yhdA00
4IYTA 3M4DA 4TW1B 4YHDA 4TW1A 4I0NA 2LKFA 1LKFA 5K59A 4H56A 1PVLA 4Q7GA 3ANZA 2YGTA 2QK7B 2QK7A 5K59C 3M4EA 4J0OA 3M2LA 4IZLA 4P1XB 3O44A 4P1XA 4IYCA 4IYAA 3ROHA 4P24A 1T5RA 3B07B 4P1YA 4P1YB 4U6VA 7AHLA 3B07A 4IDJA 3M3RA 3LKFA
chains in the Genus database with same CATH superfamily
4IYTA 3M4DA 4TW1B 4YHDA 4TW1A 4I0NA 2LKFA 1LKFA 5K59A 4H56A 1PVLA 4Q7GA 3ANZA 2YGTA 2QK7B 2QK7A 5K59C 3M4EA 4J0OA 3M2LA 4IZLA 4P1XB 1XEZA 3O44A 4P1XA 4IYCA 4IYAA 3ROHA 4P24A 1T5RA 3B07B 4P1YA 4P1YB 4U6VA 7AHLA 3B07A 4IDJA 3M3RA 3LKFA
chains in the Genus database with same CATH topology
4IYTA 3M4DA 4TW1B 4YHDA 4TW1A 4I0NA 2LKFA 1LKFA 5K59A 4H56A 1PVLA 4Q7GA 3ANZA 2YGTA 2QK7B 2QK7A 5K59C 3M4EA 4J0OA 3M2LA 4IZLA 4P1XB 3O44A 4P1XA 4IYCA 4IYAA 3ROHA 4P24A 1T5RA 3B07B 4P1YA 4P1YB 4U6VA 7AHLA 3B07A 4IDJA 3M3RA 3LKFA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4IYT A;  3M4D A;  4TW1 B;  4YHD A;  4TW1 A;  4I0N A;  2LKF A;  1LKF A;  5K59 A;  4H56 A;  1PVL A;  4Q7G A;  3ANZ A;  2YGT A;  2QK7 B;  2QK7 A;  5K59 C;  3M4E A;  4J0O A;  3M2L A;  4IZL A;  4P1X B;  3O44 A;  4P1X A;  4IYC A;  4IYA A;  3ROH A;  4P24 A;  1T5R A;  3B07 B;  4P1Y A;  4P1Y B;  4U6V A;  7AHL A;  3B07 A;  4IDJ A;  3M3R A;  3LKF A; 
#chains in the Genus database with same CATH topology
 4IYT A;  3M4D A;  4TW1 B;  4YHD A;  4TW1 A;  4I0N A;  2LKF A;  1LKF A;  5K59 A;  4H56 A;  1PVL A;  4Q7G A;  3ANZ A;  2YGT A;  2QK7 B;  2QK7 A;  5K59 C;  3M4E A;  4J0O A;  3M2L A;  4IZL A;  4P1X B;  1XEZ A;  3O44 A;  4P1X A;  4IYC A;  4IYA A;  3ROH A;  4P24 A;  1T5R A;  3B07 B;  4P1Y A;  4P1Y B;  4U6V A;  7AHL A;  3B07 A;  4IDJ A;  3M3R A;  3LKF A; 
#chains in the Genus database with same CATH homology
 4IYT A;  3M4D A;  4TW1 B;  4YHD A;  4TW1 A;  4I0N A;  2LKF A;  1LKF A;  5K59 A;  4H56 A;  1PVL A;  4Q7G A;  3ANZ A;  2YGT A;  2QK7 B;  2QK7 A;  5K59 C;  3M4E A;  4J0O A;  3M2L A;  4IZL A;  4P1X B;  3O44 A;  4P1X A;  4IYC A;  4IYA A;  3ROH A;  4P24 A;  1T5R A;  3B07 B;  4P1Y A;  4P1Y B;  4U6V A;  7AHL A;  3B07 A;  4IDJ A;  3M3R A;  3LKF A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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