1F5XA

Nmr structure of the y174 autoinhibited dbl homology domain
Total Genus 52
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
52
sequence length
208
structure length
208
Chain Sequence
b'MKGDEIYEDLMRLESVPTPPKMTEYDKRCCCLREIQQTEEKYTDTLGSIQQHFMKPLQRFLKPQDMETIFVNIEELFSVHTHFLKELKDALAGPGATTLYQVFIKYKERFLVYGRYCSQVESASKHLDQVATAREDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQDATEKENLRLALDAMRDLAQCVNEVKR'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords RHO-GEF VAV
publication title Structural basis for relief of autoinhibition of the Dbl homology domain of proto-oncogene Vav by tyrosine phosphorylation.
pubmed doi rcsb
source organism Mus musculus
molecule tags Signaling protein
total genus 52
structure length 208
sequence length 208
ec nomenclature
pdb deposition date 2000-06-18

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00621 RhoGEF RhoGEF domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.900.10 Mainly Alpha Up-down Bundle Dbl Homology Domain; Chain A Dbl homology (DH) domain 1f5xA00
1BY1A 3ODXA 3BJIA 5JHHA 3MPXA 5FI1A 1RJ2A 2VRWB 1F5XA 3T06A 2DX1A 1KI1B 1DBHA 1NTYA 2Z0QA 3KSYA 4GOUA 2KR9A 1FOEA 3P6AA 4GZUA 4YONA 1XD4A 3KZ1A 2RGNB 3EO2A 4D0OA 4D0NB 2PZ1A 1X86A 3KY9A 1KZGA 1KZ7A 1LB1A 5JHGA 2NZ8B 1XCGA 3GF9A 3JV3A 3ODOA 4MT7A 2DFKA 3QBVB 5FI0A 4GYVA 1TXDA 3ODWA
chains in the Genus database with same CATH superfamily
1BY1A 3ODXA 3BJIA 5JHHA 3MPXA 5FI1A 1RJ2A 2VRWB 1F5XA 3T06A 2DX1A 1KI1B 1DBHA 1NTYA 2Z0QA 3KSYA 4GOUA 2KR9A 1FOEA 3P6AA 4GZUA 4YONA 1XD4A 3KZ1A 2RGNB 3EO2A 4D0OA 4D0NB 2PZ1A 1X86A 3KY9A 1KZGA 1KZ7A 1LB1A 5JHGA 2NZ8B 1XCGA 3GF9A 3JV3A 3ODOA 4MT7A 2DFKA 3QBVB 5FI0A 4GYVA 1TXDA 3ODWA
chains in the Genus database with same CATH topology
1BY1A 3ODXA 3BJIA 5JHHA 3MPXA 5FI1A 1RJ2A 2VRWB 1F5XA 3T06A 2DX1A 1KI1B 1DBHA 1NTYA 2Z0QA 3KSYA 4GOUA 2KR9A 1FOEA 3P6AA 4GZUA 4YONA 1XD4A 3KZ1A 2RGNB 3EO2A 4D0OA 4D0NB 2PZ1A 1X86A 3KY9A 1KZGA 1KZ7A 1LB1A 5JHGA 2NZ8B 1XCGA 3GF9A 3JV3A 3ODOA 4MT7A 2DFKA 3QBVB 5FI0A 4GYVA 1TXDA 3ODWA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1BY1 A;  3ODX A;  3BJI A;  5JHH A;  3MPX A;  5FI1 A;  1RJ2 A;  2VRW B;  1F5X A;  3T06 A;  2DX1 A;  1KI1 B;  1DBH A;  1NTY A;  2Z0Q A;  3KSY A;  4GOU A;  2KR9 A;  1FOE A;  3P6A A;  4GZU A;  4YON A;  1XD4 A;  3KZ1 A;  2RGN B;  3EO2 A;  4D0O A;  4D0N B;  2PZ1 A;  1X86 A;  3KY9 A;  1KZG A;  1KZ7 A;  1LB1 A;  5JHG A;  2NZ8 B;  1XCG A;  3GF9 A;  3JV3 A;  3ODO A;  4MT7 A;  2DFK A;  3QBV B;  5FI0 A;  4GYV A;  1TXD A;  3ODW A; 
#chains in the Genus database with same CATH topology
 1BY1 A;  3ODX A;  3BJI A;  5JHH A;  3MPX A;  5FI1 A;  1RJ2 A;  2VRW B;  1F5X A;  3T06 A;  2DX1 A;  1KI1 B;  1DBH A;  1NTY A;  2Z0Q A;  3KSY A;  4GOU A;  2KR9 A;  1FOE A;  3P6A A;  4GZU A;  4YON A;  1XD4 A;  3KZ1 A;  2RGN B;  3EO2 A;  4D0O A;  4D0N B;  2PZ1 A;  1X86 A;  3KY9 A;  1KZG A;  1KZ7 A;  1LB1 A;  5JHG A;  2NZ8 B;  1XCG A;  3GF9 A;  3JV3 A;  3ODO A;  4MT7 A;  2DFK A;  3QBV B;  5FI0 A;  4GYV A;  1TXD A;  3ODW A; 
#chains in the Genus database with same CATH homology
 1BY1 A;  3ODX A;  3BJI A;  5JHH A;  3MPX A;  5FI1 A;  1RJ2 A;  2VRW B;  1F5X A;  3T06 A;  2DX1 A;  1KI1 B;  1DBH A;  1NTY A;  2Z0Q A;  3KSY A;  4GOU A;  2KR9 A;  1FOE A;  3P6A A;  4GZU A;  4YON A;  1XD4 A;  3KZ1 A;  2RGN B;  3EO2 A;  4D0O A;  4D0N B;  2PZ1 A;  1X86 A;  3KY9 A;  1KZG A;  1KZ7 A;  1LB1 A;  5JHG A;  2NZ8 B;  1XCG A;  3GF9 A;  3JV3 A;  3ODO A;  4MT7 A;  2DFK A;  3QBV B;  5FI0 A;  4GYV A;  1TXD A;  3ODW A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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