2XU0A

Crystal structure of the nts-dbl1(alpha-1) domain of the plasmodium falciparum membrane protein 1 (pfemp1) from the varo strain.
Total Genus 169
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
169
sequence length
476
structure length
447
Chain Sequence
SPTLSESHKSARNVLENIGIKIYNQEIKKKNPYEQQLKGTLDGNSCNLDHLFGRKPCYGREQNRFDENAEAYCNSDKIRGNENNANGAACAPPRRRHICDQNLEFLDNKNTNTAHDLLGNVLVTAKYEGNYIVNDHPDKNSNGNKAGICTSLARSFADIGDIVRGRDMFLPNKDDKVQKGLQVVFKKIYKSLTPEARKHYAHGDGSGNYAKLREDWWTINREQIWKALTCSAPYYADYFRKGSDGTLHFSSHGKCGHNEGAPPTYLDYVPQFLRWFEEWSEEFCRIKKIKIDKVKKECRDEQNKKYCSGDGHDCTQTNLAHNQIFVDLDCPRCQDQCIKYNEWIVKKLEEFYKQNLKYSMEIQKWKKTKNNYYDKEFYENLDKKSYSTIDKFLNLLNNGKHCHDNKDEKNKIDFNKPIKTFSISEYCKTCPLYGVTCTNRGICIHNS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure of a Plasmodium Falciparum Pfemp1 Rosetting Domain Reveals a Role for the N-Terminal Segment in Heparin-Mediated Rosette Inhibition.
pubmed doi rcsb
molecule keywords ERYTHROCYTE MEMBRANE PROTEIN 1
molecule tags Membrane protein
source organism Plasmodium falciparum palo alto/uganda
total genus 169
structure length 447
sequence length 476
ec nomenclature
pdb deposition date 2010-10-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF05424 Duffy_binding Duffy binding domain
A PF15447 NTS N-terminal segments of PfEMP1
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.1310.20 Mainly Alpha Up-down Bundle 5 helical Cullin repeat like 5 helical Cullin repeat like 2xu0A00
3RRCA 2WAUA 3CPZA 3CMLA 4YFSA 3BQKA 2XU0A 2Y8DA 4NUVA 3BQLA 3BQIA 5F3JA 4NUUA
chains in the Genus database with same CATH superfamily
4A64A 3DQVC 2B1EA 4YFSA 4AP2B 3BQKA 5F3JA 2WZKA 4P5OA 2PFVA 3RRCA 2WAUA 3CPZA 1U6GA 3BQIA 4APFB 1LDJA 3RTRA 4JGHD 4F52A 2XU0A 3DPLC 3BQLA 4NUUA 4EOZB 1LDKB 1LDKA 4HXIB 4WQOD 3CMLA 2Y8DA 4NUVA 4N9F3
chains in the Genus database with same CATH topology
2PFVA 3RRCA 2WAUA 3CPZA 3CMLA 2B1EA 4YFSA 2XU0A 3BQKA 2Y8DA 4NUVA 3BQLA 3BQIA 5F3JA 4NUUA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3RRC A;  2WAU A;  3CPZ A;  3CML A;  4YFS A;  3BQK A;  2XU0 A;  2Y8D A;  4NUV A;  3BQL A;  3BQI A;  5F3J A;  4NUU A; 
#chains in the Genus database with same CATH topology
 4A64 A;  3DQV C;  2B1E A;  4YFS A;  4AP2 B;  3BQK A;  5F3J A;  2WZK A;  4P5O A;  2PFV A;  3RRC A;  2WAU A;  3CPZ A;  1U6G A;  3BQI A;  4APF B;  1LDJ A;  3RTR A;  4JGH D;  4F52 A;  2XU0 A;  3DPL C;  3BQL A;  4NUU A;  4EOZ B;  1LDK B;  1LDK A;  4HXI B;  4WQO D;  3CML A;  2Y8D A;  4NUV A;  4N9F 3; 
#chains in the Genus database with same CATH homology
 2PFV A;  3RRC A;  2WAU A;  3CPZ A;  3CML A;  2B1E A;  4YFS A;  2XU0 A;  3BQK A;  2Y8D A;  4NUV A;  3BQL A;  3BQI A;  5F3J A;  4NUU A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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