2XU0A

Crystal structure of the nts-dbl1(alpha-1) domain of the plasmodium falciparum membrane protein 1 (pfemp1) from the varo strain.
Total Genus 169
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
169
sequence length
476
structure length
447
Chain Sequence
SPTLSESHKSARNVLENIGIKIYNQEIKKKNPYEQQLKGTLDGNSCNLDHLFGRKPCYGREQNRFDENAEAYCNSDKIRGNENNANGAACAPPRRRHICDQNLEFLDNKNTNTAHDLLGNVLVTAKYEGNYIVNDHPDKNSNGNKAGICTSLARSFADIGDIVRGRDMFLPNKDDKVQKGLQVVFKKIYKSLTPEARKHYAHGDGSGNYAKLREDWWTINREQIWKALTCSAPYYADYFRKGSDGTLHFSSHGKCGHNEGAPPTYLDYVPQFLRWFEEWSEEFCRIKKIKIDKVKKECRDEQNKKYCSGDGHDCTQTNLAHNQIFVDLDCPRCQDQCIKYNEWIVKKLEEFYKQNLKYSMEIQKWKKTKNNYYDKEFYENLDKKSYSTIDKFLNLLNNGKHCHDNKDEKNKIDFNKPIKTFSISEYCKTCPLYGVTCTNRGICIHNS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure of a Plasmodium Falciparum Pfemp1 Rosetting Domain Reveals a Role for the N-Terminal Segment in Heparin-Mediated Rosette Inhibition.
pubmed doi rcsb
molecule tags Membrane protein
source organism Plasmodium falciparum palo alto/uganda
molecule keywords ERYTHROCYTE MEMBRANE PROTEIN 1
total genus 169
structure length 447
sequence length 476
ec nomenclature
pdb deposition date 2010-10-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF05424 Duffy_binding Duffy binding domain
A PF15447 NTS N-terminal segments of PfEMP1
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.1310.20 Mainly Alpha Up-down Bundle 5 helical Cullin repeat like 5 helical Cullin repeat like 2xu0A00
4YFSA 3RRCA 5F3JA 3CPZA 2Y8DA 2WAUA 3BQIA 3BQKA 3BQLA 3CMLA 4NUVA 4NUUA 2XU0A
chains in the Genus database with same CATH superfamily
3RRCA 4AP2B 2Y8DA 3BQIA 2WZKA 1LDKA 4NUVA 4APFB 4YFSA 4EOZB 5F3JA 3DQVC 2B1EA 3RTRA 1LDKB 3DPLC 4P5OA 1U6GA 4WQOD 2PFVA 4N9F3 4NUUA 4F52A 4JGHD 4A64A 3CPZA 2WAUA 3CMLA 3BQKA 3BQLA 1LDJA 2XU0A 4HXIB
chains in the Genus database with same CATH topology
4YFSA 3RRCA 5F3JA 3CPZA 2Y8DA 2WAUA 2PFVA 3BQKA 3BQLA 3BQIA 2B1EA 3CMLA 4NUVA 4NUUA 2XU0A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4YFS A;  3RRC A;  5F3J A;  3CPZ A;  2Y8D A;  2WAU A;  3BQI A;  3BQK A;  3BQL A;  3CML A;  4NUV A;  4NUU A;  2XU0 A; 
#chains in the Genus database with same CATH topology
 3RRC A;  4AP2 B;  2Y8D A;  3BQI A;  2WZK A;  1LDK A;  4NUV A;  4APF B;  4YFS A;  4EOZ B;  5F3J A;  3DQV C;  2B1E A;  3RTR A;  1LDK B;  3DPL C;  4P5O A;  1U6G A;  4WQO D;  2PFV A;  4N9F 3;  4NUU A;  4F52 A;  4JGH D;  4A64 A;  3CPZ A;  2WAU A;  3CML A;  3BQK A;  3BQL A;  1LDJ A;  2XU0 A;  4HXI B; 
#chains in the Genus database with same CATH homology
 4YFS A;  3RRC A;  5F3J A;  3CPZ A;  2Y8D A;  2WAU A;  2PFV A;  3BQK A;  3BQL A;  3BQI A;  2B1E A;  3CML A;  4NUV A;  4NUU A;  2XU0 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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