2XU0A

Crystal structure of the nts-dbl1(alpha-1) domain of the plasmodium falciparum membrane protein 1 (pfemp1) from the varo strain.
Total Genus 169
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
169
sequence length
476
structure length
447
Chain Sequence
SPTLSESHKSARNVLENIGIKIYNQEIKKKNPYEQQLKGTLDGNSCNLDHLFGRKPCYGREQNRFDENAEAYCNSDKIRGNENNANGAACAPPRRRHICDQNLEFLDNKNTNTAHDLLGNVLVTAKYEGNYIVNDHPDKNSNGNKAGICTSLARSFADIGDIVRGRDMFLPNKDDKVQKGLQVVFKKIYKSLTPEARKHYAHGDGSGNYAKLREDWWTINREQIWKALTCSAPYYADYFRKGSDGTLHFSSHGKCGHNEGAPPTYLDYVPQFLRWFEEWSEEFCRIKKIKIDKVKKECRDEQNKKYCSGDGHDCTQTNLAHNQIFVDLDCPRCQDQCIKYNEWIVKKLEEFYKQNLKYSMEIQKWKKTKNNYYDKEFYENLDKKSYSTIDKFLNLLNNGKHCHDNKDEKNKIDFNKPIKTFSISEYCKTCPLYGVTCTNRGICIHNS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure of a Plasmodium Falciparum Pfemp1 Rosetting Domain Reveals a Role for the N-Terminal Segment in Heparin-Mediated Rosette Inhibition.
pubmed doi rcsb
molecule tags Membrane protein
source organism Plasmodium falciparum palo alto/uganda
molecule keywords ERYTHROCYTE MEMBRANE PROTEIN 1
total genus 169
structure length 447
sequence length 476
ec nomenclature
pdb deposition date 2010-10-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF05424 Duffy_binding Duffy binding domain
A PF15447 NTS N-terminal segments of PfEMP1
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.1310.20 Mainly Alpha Up-down Bundle 5 helical Cullin repeat like 5 helical Cullin repeat like 2xu0A00
5F3JA 4NUUA 2WAUA 3BQKA 3RRCA 4NUVA 2Y8DA 3BQIA 3CMLA 2XU0A 4YFSA 3CPZA 3BQLA
chains in the Genus database with same CATH superfamily
5F3JA 2WAUA 3BQKA 4NUVA 4A64A 4F52A 2XU0A 4YFSA 3DPLC 4NUUA 1LDKA 4WQOD 4APFB 3BQIA 3DQVC 2B1EA 3RRCA 2PFVA 1LDKB 2Y8DA 3CPZA 4P5OA 2WZKA 1U6GA 1LDJA 4EOZB 4JGHD 3CMLA 4AP2B 4HXIB 4N9F3 3RTRA 3BQLA
chains in the Genus database with same CATH topology
5F3JA 4NUUA 2WAUA 3BQKA 2B1EA 3RRCA 4NUVA 2PFVA 2Y8DA 3BQIA 3CMLA 2XU0A 4YFSA 3CPZA 3BQLA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5F3J A;  4NUU A;  2WAU A;  3BQK A;  3RRC A;  4NUV A;  2Y8D A;  3BQI A;  3CML A;  2XU0 A;  4YFS A;  3CPZ A;  3BQL A; 
#chains in the Genus database with same CATH topology
 5F3J A;  2WAU A;  3BQK A;  4NUV A;  4A64 A;  4F52 A;  2XU0 A;  4YFS A;  3DPL C;  4NUU A;  1LDK A;  4WQO D;  4APF B;  3BQI A;  3DQV C;  2B1E A;  3RRC A;  2PFV A;  1LDK B;  2Y8D A;  3CPZ A;  4P5O A;  2WZK A;  1U6G A;  1LDJ A;  4EOZ B;  4JGH D;  3CML A;  4AP2 B;  4HXI B;  4N9F 3;  3RTR A;  3BQL A; 
#chains in the Genus database with same CATH homology
 5F3J A;  4NUU A;  2WAU A;  3BQK A;  2B1E A;  3RRC A;  4NUV A;  2PFV A;  2Y8D A;  3BQI A;  3CML A;  2XU0 A;  4YFS A;  3CPZ A;  3BQL A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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