4E44B

Crystal structure of the hmhf1/hmhf2 histone-fold tetramer
Total Genus 26
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
26
sequence length
75
structure length
75
Chain Sequence
GSGFRKELVSRLLHLHFKDDKTKVSGDALQLMVELLKVFVVEAAVRGVRQAQAEDALRVDVDQLEKVLPQLLLDF
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal Structures Reveal that FANCM remodels the MHF Tetramer in favor of binding Branched DNA
rcsb
molecule keywords Centromere protein S
molecule tags Dna binding protein
source organism Homo sapiens
total genus 26
structure length 75
sequence length 75
chains with identical sequence D
ec nomenclature
pdb deposition date 2012-03-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF09415 CENP-X CENP-S associating Centromere protein X
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.286.100 Mainly Alpha Orthogonal Bundle GTP Cyclohydrolase I; Chain A, domain 1 GTP Cyclohydrolase I; Chain A, domain 1 4e44B02
4NE6B 4NE3B 4E44B 3B0BC 4DRAE 4E45B 4DRBJ 4NE5B
chains in the Genus database with same CATH superfamily
3LW5G 4NE6B 1N3RA 4Q7JA 1IS8A 1FBXA 5DMZA 2LNZA 1EL6A 4E45B 1A9CA 2WSEK 2WSCK 4QPMA 4DRBJ 2WSEG 1IS7A 2WSCG 2PN0A 3VEJA 1FB1A 2LO0A 4NE3B 4E44B 1TFEA 1WPLA 2KR1A 2WSFK 1GTPA 1EFUB 1A8RA 2O01G 2WSFG 2P11A 1N3SA 3B0BC 4JA3A 4DRAE 1N3TA 4R8QA 4NE5B 3BMBA 4DU6A 1WURA 1WM9A 1AIPC 1WUQA 3LW5K
chains in the Genus database with same CATH topology
4NE6B 1N3RA 4Q7JA 1IS8A 1FBXA 5DMZA 2LNZA 1EL6A 4E45B 1A9CA 4QPMA 4DRBJ 1IS7A 2PN0A 3VEJA 1FB1A 2LO0A 4NE3B 4E44B 1TFEA 1WPLA 2KR1A 1GTPA 1EFUB 1A8RA 2P11A 1N3SA 3B0BC 4JA3A 1N3TA 4R8QA 4NE5B 3BMBA 4DU6A 1WURA 1WM9A 1AIPC 1WUQA 4DRAE
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4NE6 B;  4NE3 B;  4E44 B;  3B0B C;  4DRA E;  4E45 B;  4DRB J;  4NE5 B; 
#chains in the Genus database with same CATH topology
 3LW5 G;  4NE6 B;  1N3R A;  4Q7J A;  1IS8 A;  1FBX A;  5DMZ A;  2LNZ A;  1EL6 A;  4E45 B;  1A9C A;  2WSE K;  2WSC K;  4QPM A;  4DRB J;  2WSE G;  1IS7 A;  2WSC G;  2PN0 A;  3VEJ A;  1FB1 A;  2LO0 A;  4NE3 B;  4E44 B;  1TFE A;  1WPL A;  2KR1 A;  2WSF K;  1GTP A;  1EFU B;  1A8R A;  2O01 G;  2WSF G;  2P11 A;  1N3S A;  3B0B C;  4JA3 A;  4DRA E;  1N3T A;  4R8Q A;  4NE5 B;  3BMB A;  4DU6 A;  1WUR A;  1WM9 A;  1AIP C;  1WUQ A;  3LW5 K; 
#chains in the Genus database with same CATH homology
 4NE6 B;  1N3R A;  4Q7J A;  1IS8 A;  1FBX A;  5DMZ A;  2LNZ A;  1EL6 A;  4E45 B;  1A9C A;  4QPM A;  4DRB J;  1IS7 A;  2PN0 A;  3VEJ A;  1FB1 A;  2LO0 A;  4NE3 B;  4E44 B;  1TFE A;  1WPL A;  2KR1 A;  1GTP A;  1EFU B;  1A8R A;  2P11 A;  1N3S A;  3B0B C;  4JA3 A;  1N3T A;  4R8Q A;  4NE5 B;  3BMB A;  4DU6 A;  1WUR A;  1WM9 A;  1AIP C;  1WUQ A;  4DRA E; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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