4E44B

Crystal structure of the hmhf1/hmhf2 histone-fold tetramer
Total Genus 26
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
26
sequence length
75
structure length
75
Chain Sequence
GSGFRKELVSRLLHLHFKDDKTKVSGDALQLMVELLKVFVVEAAVRGVRQAQAEDALRVDVDQLEKVLPQLLLDF
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal Structures Reveal that FANCM remodels the MHF Tetramer in favor of binding Branched DNA
rcsb
molecule tags Dna binding protein
source organism Homo sapiens
molecule keywords Centromere protein S
total genus 26
structure length 75
sequence length 75
chains with identical sequence D
ec nomenclature
pdb deposition date 2012-03-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF09415 CENP-X CENP-S associating Centromere protein X
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.286.100 Mainly Alpha Orthogonal Bundle GTP Cyclohydrolase I; Chain A, domain 1 GTP Cyclohydrolase I; Chain A, domain 1 4e44B02
4E45B 4DRBJ 3B0BC 4NE3B 4NE6B 4NE5B 4E44B 4DRAE
chains in the Genus database with same CATH superfamily
3VEJA 1A9CA 1N3SA 4DRAE 2WSFG 3B0BC 2WSCK 4NE3B 4E44B 1WPLA 4DU6A 1N3RA 1IS7A 1AIPC 1TFEA 1WURA 2KR1A 2WSEK 2P11A 2O01G 4DRBJ 4E45B 4NE6B 4JA3A 3LW5K 4QPMA 2LO0A 1A8RA 2PN0A 2WSCG 1FBXA 2WSFK 2WSEG 1EFUB 1N3TA 4Q7JA 1FB1A 5DMZA 1WUQA 1IS8A 2LNZA 3BMBA 3LW5G 4NE5B 1EL6A 1GTPA 4R8QA 1WM9A
chains in the Genus database with same CATH topology
3VEJA 1A9CA 1N3SA 4DRAE 3B0BC 4NE3B 4E44B 1WPLA 4DU6A 1N3RA 1IS7A 1AIPC 1TFEA 1WURA 2KR1A 4E45B 2P11A 4DRBJ 4NE6B 4JA3A 4QPMA 2LO0A 1A8RA 2PN0A 1FBXA 1EFUB 1N3TA 4Q7JA 1FB1A 5DMZA 1WUQA 1IS8A 2LNZA 3BMBA 4NE5B 1EL6A 1GTPA 4R8QA 1WM9A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4E45 B;  4DRB J;  3B0B C;  4NE3 B;  4NE6 B;  4NE5 B;  4E44 B;  4DRA E; 
#chains in the Genus database with same CATH topology
 3VEJ A;  1A9C A;  1N3S A;  4DRA E;  2WSF G;  3B0B C;  2WSC K;  4NE3 B;  4E44 B;  1WPL A;  4DU6 A;  1N3R A;  1IS7 A;  1AIP C;  1TFE A;  1WUR A;  2KR1 A;  2WSE K;  2P11 A;  2O01 G;  4DRB J;  4E45 B;  4NE6 B;  4JA3 A;  3LW5 K;  4QPM A;  2LO0 A;  1A8R A;  2PN0 A;  2WSC G;  1FBX A;  2WSF K;  2WSE G;  1EFU B;  1N3T A;  4Q7J A;  1FB1 A;  5DMZ A;  1WUQ A;  1IS8 A;  2LNZ A;  3BMB A;  3LW5 G;  4NE5 B;  1EL6 A;  1GTP A;  4R8Q A;  1WM9 A; 
#chains in the Genus database with same CATH homology
 3VEJ A;  1A9C A;  1N3S A;  4DRA E;  3B0B C;  4NE3 B;  4E44 B;  1WPL A;  4DU6 A;  1N3R A;  1IS7 A;  1AIP C;  1TFE A;  1WUR A;  2KR1 A;  4E45 B;  2P11 A;  4DRB J;  4NE6 B;  4JA3 A;  4QPM A;  2LO0 A;  1A8R A;  2PN0 A;  1FBX A;  1EFU B;  1N3T A;  4Q7J A;  1FB1 A;  5DMZ A;  1WUQ A;  1IS8 A;  2LNZ A;  3BMB A;  4NE5 B;  1EL6 A;  1GTP A;  4R8Q A;  1WM9 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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