4E45B

Crystal structure of the hmhf1/hmhf2 histone-fold tetramer in complex with fanconi anemia associated helicase hfancm
Total Genus 25
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
25
sequence length
74
structure length
74
Chain Sequence
SGFRKELVSRLLHLHFKDDKTKVSGDALQLMVELLKVFVVEAAVRGVRQAQAEDALRVDVDQLEKVLPQLLLDF
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal Structures Reveal that FANCM remodels the MHF Tetramer in favor of binding Branched DNA
rcsb
molecule tags Dna binding protein/hydrolase
source organism Homo sapiens
molecule keywords Centromere protein S
total genus 25
structure length 74
sequence length 74
chains with identical sequence D, G, I, L, N
ec nomenclature
pdb deposition date 2012-03-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF09415 CENP-X CENP-S associating Centromere protein X
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.286.100 Mainly Alpha Orthogonal Bundle GTP Cyclohydrolase I; Chain A, domain 1 GTP Cyclohydrolase I; Chain A, domain 1 4e45B02
4DRBJ 4NE5B 3B0BC 4NE3B 4E45B 4DRAE 4NE6B 4E44B
chains in the Genus database with same CATH superfamily
4DRBJ 2KR1A 2WSFG 1EFUB 1IS8A 4JA3A 4NE5B 3B0BC 1GTPA 4DRAE 1IS7A 2LO0A 4NE6B 3VEJA 3BMBA 4DU6A 2WSEG 3LW5K 4E45B 1A8RA 1FB1A 1WM9A 2WSFK 1AIPC 1FBXA 2WSCG 4NE3B 4QPMA 2LNZA 1N3TA 4Q7JA 5DMZA 2PN0A 1TFEA 1WURA 1A9CA 2WSEK 4R8QA 1EL6A 2P11A 1N3RA 2O01G 3LW5G 1WUQA 2WSCK 1WPLA 1N3SA 4E44B
chains in the Genus database with same CATH topology
4DRBJ 2KR1A 1EFUB 1IS8A 4JA3A 4NE5B 3B0BC 1GTPA 4DRAE 1IS7A 2LO0A 4NE6B 3VEJA 3BMBA 4DU6A 4E45B 1A8RA 1FB1A 1WM9A 1AIPC 1FBXA 4NE3B 4QPMA 2LNZA 1N3TA 4Q7JA 5DMZA 2PN0A 1TFEA 1WURA 1A9CA 4R8QA 1EL6A 2P11A 1N3RA 1WUQA 1WPLA 1N3SA 4E44B
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4DRB J;  4NE5 B;  3B0B C;  4NE3 B;  4E45 B;  4DRA E;  4NE6 B;  4E44 B; 
#chains in the Genus database with same CATH topology
 4DRB J;  2KR1 A;  2WSF G;  1EFU B;  1IS8 A;  4JA3 A;  4NE5 B;  3B0B C;  1GTP A;  4DRA E;  1IS7 A;  2LO0 A;  4NE6 B;  3VEJ A;  3BMB A;  4DU6 A;  2WSE G;  3LW5 K;  4E45 B;  1A8R A;  1FB1 A;  1WM9 A;  2WSF K;  1AIP C;  1FBX A;  2WSC G;  4NE3 B;  4QPM A;  2LNZ A;  1N3T A;  4Q7J A;  5DMZ A;  2PN0 A;  1TFE A;  1WUR A;  1A9C A;  2WSE K;  4R8Q A;  1EL6 A;  2P11 A;  1N3R A;  2O01 G;  3LW5 G;  1WUQ A;  2WSC K;  1WPL A;  1N3S A;  4E44 B; 
#chains in the Genus database with same CATH homology
 4DRB J;  2KR1 A;  1EFU B;  1IS8 A;  4JA3 A;  4NE5 B;  3B0B C;  1GTP A;  4DRA E;  1IS7 A;  2LO0 A;  4NE6 B;  3VEJ A;  3BMB A;  4DU6 A;  4E45 B;  1A8R A;  1FB1 A;  1WM9 A;  1AIP C;  1FBX A;  4NE3 B;  4QPM A;  2LNZ A;  1N3T A;  4Q7J A;  5DMZ A;  2PN0 A;  1TFE A;  1WUR A;  1A9C A;  4R8Q A;  1EL6 A;  2P11 A;  1N3R A;  1WUQ A;  1WPL A;  1N3S A;  4E44 B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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