4E45B

Crystal structure of the hmhf1/hmhf2 histone-fold tetramer in complex with fanconi anemia associated helicase hfancm
Total Genus 25
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
25
sequence length
74
structure length
74
Chain Sequence
SGFRKELVSRLLHLHFKDDKTKVSGDALQLMVELLKVFVVEAAVRGVRQAQAEDALRVDVDQLEKVLPQLLLDF
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal Structures Reveal that FANCM remodels the MHF Tetramer in favor of binding Branched DNA
rcsb
molecule keywords Centromere protein S
molecule tags Dna binding protein/hydrolase
source organism Homo sapiens
total genus 25
structure length 74
sequence length 74
chains with identical sequence D, G, I, L, N
ec nomenclature
pdb deposition date 2012-03-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF09415 CENP-X CENP-S associating Centromere protein X
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.286.100 Mainly Alpha Orthogonal Bundle GTP Cyclohydrolase I; Chain A, domain 1 GTP Cyclohydrolase I; Chain A, domain 1 4e45B02
4NE3B 4E45B 4NE6B 4NE5B 4DRBJ 4E44B 3B0BC 4DRAE
chains in the Genus database with same CATH superfamily
1TFEA 1FB1A 2PN0A 1FBXA 2WSFK 2WSEK 1EFUB 4E44B 3B0BC 4E45B 2KR1A 1N3RA 1WUQA 4NE3B 3VEJA 1GTPA 4DU6A 1N3SA 2LO0A 1IS7A 1WPLA 1A8RA 1EL6A 2P11A 2O01G 4NE5B 1IS8A 2LNZA 4DRBJ 1A9CA 1N3TA 2WSCG 3LW5G 1AIPC 3BMBA 4JA3A 4NE6B 4Q7JA 2WSFG 2WSEG 1WURA 1WM9A 5DMZA 4QPMA 4R8QA 4DRAE 2WSCK 3LW5K
chains in the Genus database with same CATH topology
1TFEA 1FB1A 2PN0A 1FBXA 1EFUB 4E44B 3B0BC 4E45B 2KR1A 1N3RA 1WUQA 4NE3B 3VEJA 1GTPA 4DU6A 1N3SA 2LO0A 1IS7A 1WPLA 1A8RA 1EL6A 2P11A 4NE5B 1IS8A 2LNZA 4DRBJ 1A9CA 1N3TA 1AIPC 3BMBA 4JA3A 4NE6B 4Q7JA 1WURA 1WM9A 5DMZA 4QPMA 4R8QA 4DRAE
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4NE3 B;  4E45 B;  4NE6 B;  4NE5 B;  4DRB J;  4E44 B;  3B0B C;  4DRA E; 
#chains in the Genus database with same CATH topology
 1TFE A;  1FB1 A;  2PN0 A;  1FBX A;  2WSF K;  2WSE K;  1EFU B;  4E44 B;  3B0B C;  4E45 B;  2KR1 A;  1N3R A;  1WUQ A;  4NE3 B;  3VEJ A;  1GTP A;  4DU6 A;  1N3S A;  2LO0 A;  1IS7 A;  1WPL A;  1A8R A;  1EL6 A;  2P11 A;  2O01 G;  4NE5 B;  1IS8 A;  2LNZ A;  4DRB J;  1A9C A;  1N3T A;  2WSC G;  3LW5 G;  1AIP C;  3BMB A;  4JA3 A;  4NE6 B;  4Q7J A;  2WSF G;  2WSE G;  1WUR A;  1WM9 A;  5DMZ A;  4QPM A;  4R8Q A;  4DRA E;  2WSC K;  3LW5 K; 
#chains in the Genus database with same CATH homology
 1TFE A;  1FB1 A;  2PN0 A;  1FBX A;  1EFU B;  4E44 B;  3B0B C;  4E45 B;  2KR1 A;  1N3R A;  1WUQ A;  4NE3 B;  3VEJ A;  1GTP A;  4DU6 A;  1N3S A;  2LO0 A;  1IS7 A;  1WPL A;  1A8R A;  1EL6 A;  2P11 A;  4NE5 B;  1IS8 A;  2LNZ A;  4DRB J;  1A9C A;  1N3T A;  1AIP C;  3BMB A;  4JA3 A;  4NE6 B;  4Q7J A;  1WUR A;  1WM9 A;  5DMZ A;  4QPM A;  4R8Q A;  4DRA E; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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