4E45B

Crystal structure of the hmhf1/hmhf2 histone-fold tetramer in complex with fanconi anemia associated helicase hfancm
Total Genus 25
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
25
sequence length
74
structure length
74
Chain Sequence
SGFRKELVSRLLHLHFKDDKTKVSGDALQLMVELLKVFVVEAAVRGVRQAQAEDALRVDVDQLEKVLPQLLLDF
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal Structures Reveal that FANCM remodels the MHF Tetramer in favor of binding Branched DNA
rcsb
molecule keywords Centromere protein S
molecule tags Dna binding protein/hydrolase
source organism Homo sapiens
total genus 25
structure length 74
sequence length 74
chains with identical sequence D, G, I, L, N
ec nomenclature
pdb deposition date 2012-03-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF09415 CENP-X CENP-S associating Centromere protein X
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.286.100 Mainly Alpha Orthogonal Bundle GTP Cyclohydrolase I; Chain A, domain 1 GTP Cyclohydrolase I; Chain A, domain 1 4e45B02
4NE6B 4E45B 4NE3B 4NE5B 4DRAE 4E44B 3B0BC 4DRBJ
chains in the Genus database with same CATH superfamily
4NE6B 5DMZA 1EFUB 1N3TA 1TFEA 2WSEG 4NE5B 3VEJA 3LW5G 4DRAE 1N3RA 2KR1A 3B0BC 4R8QA 1FB1A 1EL6A 4QPMA 3BMBA 1WUQA 1FBXA 4DU6A 1WM9A 4E44B 2WSCG 2WSFG 4DRBJ 4E45B 1IS7A 1IS8A 1WPLA 2P11A 2WSEK 1AIPC 3LW5K 4JA3A 1GTPA 4NE3B 2LNZA 1N3SA 2PN0A 2WSFK 2LO0A 4Q7JA 2O01G 1WURA 1A8RA 1A9CA 2WSCK
chains in the Genus database with same CATH topology
4NE6B 5DMZA 1EFUB 1N3TA 1TFEA 4NE5B 3VEJA 4DRAE 1N3RA 2KR1A 3B0BC 4R8QA 1FB1A 1EL6A 4QPMA 3BMBA 1WUQA 1FBXA 4DU6A 1WM9A 4E44B 4DRBJ 4E45B 1IS7A 1IS8A 1WPLA 2P11A 1AIPC 4JA3A 1GTPA 4NE3B 2LNZA 1N3SA 2PN0A 2LO0A 4Q7JA 1WURA 1A8RA 1A9CA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4NE6 B;  4E45 B;  4NE3 B;  4NE5 B;  4DRA E;  4E44 B;  3B0B C;  4DRB J; 
#chains in the Genus database with same CATH topology
 4NE6 B;  5DMZ A;  1EFU B;  1N3T A;  1TFE A;  2WSE G;  4NE5 B;  3VEJ A;  3LW5 G;  4DRA E;  1N3R A;  2KR1 A;  3B0B C;  4R8Q A;  1FB1 A;  1EL6 A;  4QPM A;  3BMB A;  1WUQ A;  1FBX A;  4DU6 A;  1WM9 A;  4E44 B;  2WSC G;  2WSF G;  4DRB J;  4E45 B;  1IS7 A;  1IS8 A;  1WPL A;  2P11 A;  2WSE K;  1AIP C;  3LW5 K;  4JA3 A;  1GTP A;  4NE3 B;  2LNZ A;  1N3S A;  2PN0 A;  2WSF K;  2LO0 A;  4Q7J A;  2O01 G;  1WUR A;  1A8R A;  1A9C A;  2WSC K; 
#chains in the Genus database with same CATH homology
 4NE6 B;  5DMZ A;  1EFU B;  1N3T A;  1TFE A;  4NE5 B;  3VEJ A;  4DRA E;  1N3R A;  2KR1 A;  3B0B C;  4R8Q A;  1FB1 A;  1EL6 A;  4QPM A;  3BMB A;  1WUQ A;  1FBX A;  4DU6 A;  1WM9 A;  4E44 B;  4DRB J;  4E45 B;  1IS7 A;  1IS8 A;  1WPL A;  2P11 A;  1AIP C;  4JA3 A;  1GTP A;  4NE3 B;  2LNZ A;  1N3S A;  2PN0 A;  2LO0 A;  4Q7J A;  1WUR A;  1A8R A;  1A9C A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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