4GYV | Genus

Total Genus 96

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	96
sequence length	216
structure length	216
Chain Sequence	GPHMEDEAYFIAKEILATERTYLKDLEVITVWFRSVLIKEEAMPAALMALLFSNIDPVYEFHRGFLHEVEQRLALWEGPSSAHLKGDHQRIGDILLRNMRQLKEFTSYFQRHDEVLTELEKATKHCKKLEAVYKEFELQKVCYLPLNTFLLKPVQRLVHYRLLLSRLCAHYSPGHRDYADCHEALKAITEVTTELQQSLTRLENLQKLTELQRDLV

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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

molecule tags	Signaling protein
source organism	Mus musculus
publication title	Structural Basis for Autoinhibition of the Guanine Nucleotide Exchange Factor FARP2. pubmed doi rcsb
molecule keywords	FERM, RhoGEF and pleckstrin domain-containing protein 2
total genus	96
structure length	216
sequence length	216
chains with identical sequence	B, C, D, E, F, G, H, I
ec nomenclature
pdb deposition date	2012-09-05

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF00621	RhoGEF	RhoGEF domain

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
1.20.900.10	Mainly Alpha	Up-down Bundle	Dbl Homology Domain; Chain A	Dbl homology (DH) domain	4gyvA00

1LB1A 1NTYA 1KI1B 2KR9A 4D0OA 2VRWB 1F5XA 3GF9A 3P6AA 5FI0A 3ODWA 3KY9A 5JHHA 5JHGA 2NZ8B 4GOUA 3QBVB 4GZUA 3ODXA 3KSYA 1KZGA 2Z0QA 1KZ7A 3KZ1A 1DBHA 2PZ1A 4YONA 2DFKA 3BJIA 4GYVA 3ODOA 4MT7A 1BY1A 1TXDA 1XCGA 3EO2A 2RGNB 4D0NB 1RJ2A 3T06A 2DX1A 1FOEA 3JV3A 5FI1A 1X86A 3MPXA 1XD4A
chains in the Genus database with same CATH superfamily

#chains in the Genus database with same CATH superfamily
 1LB1 A;  1NTY A;  1KI1 B;  2KR9 A;  4D0O A;  2VRW B;  1F5X A;  3GF9 A;  3P6A A;  5FI0 A;  3ODW A;  3KY9 A;  5JHH A;  5JHG A;  2NZ8 B;  4GOU A;  3QBV B;  4GZU A;  3ODX A;  3KSY A;  1KZG A;  2Z0Q A;  1KZ7 A;  3KZ1 A;  1DBH A;  2PZ1 A;  4YON A;  2DFK A;  3BJI A;  4GYV A;  3ODO A;  4MT7 A;  1BY1 A;  1TXD A;  1XCG A;  3EO2 A;  2RGN B;  4D0N B;  1RJ2 A;  3T06 A;  2DX1 A;  1FOE A;  3JV3 A;  5FI1 A;  1X86 A;  3MPX A;  1XD4 A; 
#chains in the Genus database with same CATH topology
 1LB1 A;  1NTY A;  1KI1 B;  2KR9 A;  4D0O A;  2VRW B;  1F5X A;  3GF9 A;  3P6A A;  5FI0 A;  3ODW A;  3KY9 A;  5JHH A;  5JHG A;  2NZ8 B;  4GOU A;  3QBV B;  4GZU A;  3ODX A;  3KSY A;  1KZG A;  2Z0Q A;  1KZ7 A;  3KZ1 A;  1DBH A;  2PZ1 A;  4YON A;  2DFK A;  3BJI A;  4GYV A;  3ODO A;  4MT7 A;  1BY1 A;  1TXD A;  1XCG A;  3EO2 A;  2RGN B;  4D0N B;  1RJ2 A;  3T06 A;  2DX1 A;  1FOE A;  3JV3 A;  5FI1 A;  1X86 A;  3MPX A;  1XD4 A; 
#chains in the Genus database with same CATH homology
 1LB1 A;  1NTY A;  1KI1 B;  2KR9 A;  4D0O A;  2VRW B;  1F5X A;  3GF9 A;  3P6A A;  5FI0 A;  3ODW A;  3KY9 A;  5JHH A;  5JHG A;  2NZ8 B;  4GOU A;  3QBV B;  4GZU A;  3ODX A;  3KSY A;  1KZG A;  2Z0Q A;  1KZ7 A;  3KZ1 A;  1DBH A;  2PZ1 A;  4YON A;  2DFK A;  3BJI A;  4GYV A;  3ODO A;  4MT7 A;  1BY1 A;  1TXD A;  1XCG A;  3EO2 A;  2RGN B;  4D0N B;  1RJ2 A;  3T06 A;  2DX1 A;  1FOE A;  3JV3 A;  5FI1 A;  1X86 A;  3MPX A;  1XD4 A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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4GYVA

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

pfam database annotations