4HXIB

Crystal structure of klhl3/cul3 complex
Total Genus 139
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
139
sequence length
354
structure length
346
Chain Sequence
DEKYVNSIWDLLKNAIQEIQRKNNSGLSFEELYRNAYTMVLHKHGEKLYTGLREVVTEHLINKVREDVLNSLNNNFLQTLNQAWNDHQTAMVMIRDILMYMDRVYVQQNNVENVYNLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERKGEVVDRGAIRNACQMLMILGLEGRSVYEEDFEAPFLEMSAEFFQMESQKFLAENSASVYIKKVEARINEEIERVMHCLDKSTEEPIVKVVERELISKHMRTIVEMENSGLVHMLKNGKTEDLGCMYKLFSRVPNGLKTMCECMSSYLREQGKALVSEDYRQGLDDLKSRFDRFLLESFNNDRLFKQTIAGDFEYFLN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural and Functional Characterization of KLHL3/Cul3 complex and implications of FHHt mutations in Cul3 binding
rcsb
molecule keywords Kelch-like protein 3
molecule tags Protein binding
source organism Homo sapiens
total genus 139
structure length 346
sequence length 354
ec nomenclature
pdb deposition date 2012-11-10
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.1310.10 Mainly Alpha Up-down Bundle 5 helical Cullin repeat like Cullin Repeats 4hxiB01
1.20.1310.10 Mainly Alpha Up-down Bundle 5 helical Cullin repeat like Cullin Repeats 4hxiB02
1.20.1310.10 Mainly Alpha Up-down Bundle 5 helical Cullin repeat like Cullin Repeats 4hxiB03
3DQVC 3DPLC 4WQOD 4EOZB 1LDJA 4F52A 4APFB 4AP2B 1LDKB 4P5OA 4N9F3 4A64A 1U6GA 1LDKA 2WZKA 4HXIB 4JGHD 3RTRA
chains in the Genus database with same CATH superfamily
4WQOD 2WAUA 4APFB 4AP2B 3BQLA 4A64A 1U6GA 3RRCA 4YFSA 3CPZA 4HXIB 4F52A 3DQVC 1LDJA 4N9F3 2WZKA 3BQKA 2XU0A 3DPLC 2B1EA 4NUUA 4P5OA 3BQIA 1LDKA 4JGHD 3RTRA 4EOZB 5F3JA 1LDKB 4NUVA 2PFVA 3CMLA 2Y8DA
chains in the Genus database with same CATH topology
3DQVC 3DPLC 4WQOD 4EOZB 1LDJA 4F52A 4APFB 4AP2B 1LDKB 4P5OA 4N9F3 4A64A 1U6GA 1LDKA 2WZKA 4HXIB 4JGHD 3RTRA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3DQV C;  3DPL C;  4WQO D;  4EOZ B;  1LDJ A;  4F52 A;  4APF B;  4AP2 B;  1LDK B;  4P5O A;  4N9F 3;  4A64 A;  1U6G A;  1LDK A;  2WZK A;  4HXI B;  4JGH D;  3RTR A; 
#chains in the Genus database with same CATH topology
 4WQO D;  2WAU A;  4APF B;  4AP2 B;  3BQL A;  4A64 A;  1U6G A;  3RRC A;  4YFS A;  3CPZ A;  4HXI B;  4F52 A;  3DQV C;  1LDJ A;  4N9F 3;  2WZK A;  3BQK A;  2XU0 A;  3DPL C;  2B1E A;  4NUU A;  4P5O A;  3BQI A;  1LDK A;  4JGH D;  3RTR A;  4EOZ B;  5F3J A;  1LDK B;  4NUV A;  2PFV A;  3CML A;  2Y8D A; 
#chains in the Genus database with same CATH homology
 3DQV C;  3DPL C;  4WQO D;  4EOZ B;  1LDJ A;  4F52 A;  4APF B;  4AP2 B;  1LDK B;  4P5O A;  4N9F 3;  4A64 A;  1U6G A;  1LDK A;  2WZK A;  4HXI B;  4JGH D;  3RTR A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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