4HXIB

Crystal structure of klhl3/cul3 complex
Total Genus 139
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
139
sequence length
354
structure length
346
Chain Sequence
DEKYVNSIWDLLKNAIQEIQRKNNSGLSFEELYRNAYTMVLHKHGEKLYTGLREVVTEHLINKVREDVLNSLNNNFLQTLNQAWNDHQTAMVMIRDILMYMDRVYVQQNNVENVYNLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERKGEVVDRGAIRNACQMLMILGLEGRSVYEEDFEAPFLEMSAEFFQMESQKFLAENSASVYIKKVEARINEEIERVMHCLDKSTEEPIVKVVERELISKHMRTIVEMENSGLVHMLKNGKTEDLGCMYKLFSRVPNGLKTMCECMSSYLREQGKALVSEDYRQGLDDLKSRFDRFLLESFNNDRLFKQTIAGDFEYFLN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural and Functional Characterization of KLHL3/Cul3 complex and implications of FHHt mutations in Cul3 binding
rcsb
molecule tags Protein binding
source organism Homo sapiens
molecule keywords Kelch-like protein 3
total genus 139
structure length 346
sequence length 354
ec nomenclature
pdb deposition date 2012-11-10
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.1310.10 Mainly Alpha Up-down Bundle 5 helical Cullin repeat like Cullin Repeats 4hxiB01
1.20.1310.10 Mainly Alpha Up-down Bundle 5 helical Cullin repeat like Cullin Repeats 4hxiB02
1.20.1310.10 Mainly Alpha Up-down Bundle 5 helical Cullin repeat like Cullin Repeats 4hxiB03
1U6GA 4APFB 1LDKB 3DPLC 4HXIB 3RTRA 4EOZB 4F52A 2WZKA 4WQOD 1LDKA 4AP2B 3DQVC 4JGHD 4A64A 4N9F3 1LDJA 4P5OA
chains in the Genus database with same CATH superfamily
3CMLA 1LDKB 4HXIB 4EOZB 3BQKA 4NUVA 1LDKA 2Y8DA 1U6GA 3BQIA 4NUUA 3DQVC 4JGHD 3CPZA 4P5OA 3RTRA 4APFB 3RRCA 4YFSA 2PFVA 5F3JA 2B1EA 4A64A 1LDJA 4F52A 2WAUA 2WZKA 4WQOD 4AP2B 2XU0A 3BQLA 4N9F3 3DPLC
chains in the Genus database with same CATH topology
1U6GA 4APFB 1LDKB 3DPLC 4HXIB 3RTRA 4EOZB 4F52A 2WZKA 4WQOD 1LDKA 4AP2B 3DQVC 4JGHD 4A64A 4N9F3 1LDJA 4P5OA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1U6G A;  4APF B;  1LDK B;  3DPL C;  4HXI B;  3RTR A;  4EOZ B;  4F52 A;  2WZK A;  4WQO D;  1LDK A;  4AP2 B;  3DQV C;  4JGH D;  4A64 A;  4N9F 3;  1LDJ A;  4P5O A; 
#chains in the Genus database with same CATH topology
 3CML A;  1LDK B;  4HXI B;  4EOZ B;  3BQK A;  4NUV A;  1LDK A;  2Y8D A;  1U6G A;  3BQI A;  4NUU A;  3DQV C;  4JGH D;  3CPZ A;  4P5O A;  3RTR A;  4APF B;  3RRC A;  4YFS A;  2PFV A;  5F3J A;  2B1E A;  4A64 A;  1LDJ A;  4F52 A;  2WAU A;  2WZK A;  4WQO D;  4AP2 B;  2XU0 A;  3BQL A;  4N9F 3;  3DPL C; 
#chains in the Genus database with same CATH homology
 1U6G A;  4APF B;  1LDK B;  3DPL C;  4HXI B;  3RTR A;  4EOZ B;  4F52 A;  2WZK A;  4WQO D;  1LDK A;  4AP2 B;  3DQV C;  4JGH D;  4A64 A;  4N9F 3;  1LDJ A;  4P5O A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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