4HXIB

Crystal structure of klhl3/cul3 complex
Total Genus 139
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
139
sequence length
354
structure length
346
Chain Sequence
DEKYVNSIWDLLKNAIQEIQRKNNSGLSFEELYRNAYTMVLHKHGEKLYTGLREVVTEHLINKVREDVLNSLNNNFLQTLNQAWNDHQTAMVMIRDILMYMDRVYVQQNNVENVYNLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERKGEVVDRGAIRNACQMLMILGLEGRSVYEEDFEAPFLEMSAEFFQMESQKFLAENSASVYIKKVEARINEEIERVMHCLDKSTEEPIVKVVERELISKHMRTIVEMENSGLVHMLKNGKTEDLGCMYKLFSRVPNGLKTMCECMSSYLREQGKALVSEDYRQGLDDLKSRFDRFLLESFNNDRLFKQTIAGDFEYFLN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural and Functional Characterization of KLHL3/Cul3 complex and implications of FHHt mutations in Cul3 binding
rcsb
molecule tags Protein binding
source organism Homo sapiens
molecule keywords Kelch-like protein 3
total genus 139
structure length 346
sequence length 354
ec nomenclature
pdb deposition date 2012-11-10
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.1310.10 Mainly Alpha Up-down Bundle 5 helical Cullin repeat like Cullin Repeats 4hxiB01
1.20.1310.10 Mainly Alpha Up-down Bundle 5 helical Cullin repeat like Cullin Repeats 4hxiB02
1.20.1310.10 Mainly Alpha Up-down Bundle 5 helical Cullin repeat like Cullin Repeats 4hxiB03
4AP2B 4JGHD 1U6GA 4EOZB 1LDKA 4N9F3 3DQVC 4HXIB 4WQOD 1LDKB 1LDJA 4P5OA 3DPLC 4A64A 4APFB 3RTRA 2WZKA 4F52A
chains in the Genus database with same CATH superfamily
3CPZA 3CMLA 4EOZB 4N9F3 4HXIB 4NUUA 2Y8DA 4WQOD 4A64A 4F52A 4JGHD 1U6GA 4APFB 2WZKA 4AP2B 1LDKA 3DQVC 4YFSA 2PFVA 1LDKB 1LDJA 3BQLA 3RRCA 2B1EA 2XU0A 3RTRA 3BQKA 3BQIA 4NUVA 4P5OA 3DPLC 5F3JA 2WAUA
chains in the Genus database with same CATH topology
4AP2B 4JGHD 1U6GA 4EOZB 1LDKA 4N9F3 3DQVC 4HXIB 4WQOD 1LDKB 1LDJA 4P5OA 3DPLC 4A64A 4APFB 3RTRA 2WZKA 4F52A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4AP2 B;  4JGH D;  1U6G A;  4EOZ B;  1LDK A;  4N9F 3;  3DQV C;  4HXI B;  4WQO D;  1LDK B;  1LDJ A;  4P5O A;  3DPL C;  4A64 A;  4APF B;  3RTR A;  2WZK A;  4F52 A; 
#chains in the Genus database with same CATH topology
 3CPZ A;  3CML A;  4EOZ B;  4N9F 3;  4HXI B;  4NUU A;  2Y8D A;  4WQO D;  4A64 A;  4F52 A;  4JGH D;  1U6G A;  4APF B;  2WZK A;  4AP2 B;  1LDK A;  3DQV C;  4YFS A;  2PFV A;  1LDK B;  1LDJ A;  3BQL A;  3RRC A;  2B1E A;  2XU0 A;  3RTR A;  3BQK A;  3BQI A;  4NUV A;  4P5O A;  3DPL C;  5F3J A;  2WAU A; 
#chains in the Genus database with same CATH homology
 4AP2 B;  4JGH D;  1U6G A;  4EOZ B;  1LDK A;  4N9F 3;  3DQV C;  4HXI B;  4WQO D;  1LDK B;  1LDJ A;  4P5O A;  3DPL C;  4A64 A;  4APF B;  3RTR A;  2WZK A;  4F52 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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