2XHL | Genus

Total Genus 120

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	120
sequence length	415
structure length	410
Chain Sequence	NLQCIDVDNEDLFFIADKNSFSDDLSKNERIEYNTQSNYIENDFPINELILDTDLISKIELPSENTESLTDFNVDVPVYEKQPAIKKIFTDENTIFQYLYSQTFPLDIRDISLTSSFDDALLFSNKVYSFFSMDYIKTANKVVEAGLFAGWVKQIVNDFVIEANKSNTDISLIVPYIGLALNVGNETAKGNFENAFEIAGASILLEFIPELLIPVVGAFLLESYIDNKNKIIKTIDNALTKRNEKWSDMYGLIVAQWLSTVNTQFYTIKEGMYKALNYQAQALEEIIKYRYNIYSEKEKSNINIDFNDINSKLNEGINQAIDNINNFINGCSVSYLMKKMIPLAVEKLLDFDNTLKKNLLNYIDENKLYLIGSAEYEKSKVNKYLKTIMPFDLSIYTNDTILIEMFNKYN

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

molecule tags	Hydrolase
source organism	Clostridium botulinum
publication title	Structure and Activity of a Functional Derivative of Clostridium Botulinum Neurotoxin B. pubmed doi rcsb
molecule keywords	BOTULINUM NEUROTOXIN B LIGHT CHAIN
total genus	120
structure length	410
sequence length	415
ec nomenclature	ec 3.4.24.69: Bontoxilysin.
pdb deposition date	2010-06-18

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
B	PF07952	Toxin_trans	Clostridium neurotoxin, Translocation domain

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
1.20.1120.10	Mainly Alpha	Up-down Bundle	Clostridium botulinum neurotoxin B, "coiled-coil" domain	Clostridium botulinum neurotoxin b, "coiled-coil" domain	2xhlB00

1G9CA 1S0FA 3BTAA 1G9DA 5BQMB 1G9AA 3V0AA 4ZKTB 1S0CA 1G9BA 5BQNA 1F31A 1EPWA 1S0BA 2NZ9A 2XHLB 3VUOA 3V0BA 2NP0A 1I1EA 1S0EA 2W2DB 3ZUSA 3V0AB 2NYYA 3ZURA 3V0BB 1S0GA 3ZUQA 3FFZA 1S0DA
chains in the Genus database with same CATH superfamily

#chains in the Genus database with same CATH superfamily
 1G9C A;  1S0F A;  3BTA A;  1G9D A;  5BQM B;  1G9A A;  3V0A A;  4ZKT B;  1S0C A;  1G9B A;  5BQN A;  1F31 A;  1EPW A;  1S0B A;  2NZ9 A;  2XHL B;  3VUO A;  3V0B A;  2NP0 A;  1I1E A;  1S0E A;  2W2D B;  3ZUS A;  3V0A B;  2NYY A;  3ZUR A;  3V0B B;  1S0G A;  3ZUQ A;  3FFZ A;  1S0D A; 
#chains in the Genus database with same CATH topology
 1G9C A;  1S0F A;  3BTA A;  1G9D A;  5BQM B;  1G9A A;  3V0A A;  4ZKT B;  1S0C A;  1G9B A;  5BQN A;  1F31 A;  1EPW A;  1S0B A;  2NZ9 A;  2XHL B;  3VUO A;  3V0B A;  2NP0 A;  1I1E A;  1S0E A;  2W2D B;  3ZUS A;  3V0A B;  2NYY A;  3ZUR A;  3V0B B;  1S0G A;  3ZUQ A;  3FFZ A;  1S0D A; 
#chains in the Genus database with same CATH homology
 1G9C A;  1S0F A;  3BTA A;  1G9D A;  5BQM B;  1G9A A;  3V0A A;  4ZKT B;  1S0C A;  1G9B A;  5BQN A;  1F31 A;  1EPW A;  1S0B A;  2NZ9 A;  2XHL B;  3VUO A;  3V0B A;  2NP0 A;  1I1E A;  1S0E A;  2W2D B;  3ZUS A;  3V0A B;  2NYY A;  3ZUR A;  3V0B B;  1S0G A;  3ZUQ A;  3FFZ A;  1S0D A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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2XHLB

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

pfam database annotations