3ZURA

Crystal structure of an engineered botulinum neurotoxin type a- snare23 derivative, lc0-a-snap25-hn-a
Total Genus 280
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
280
sequence length
944
structure length
847
Chain Sequence
MEFVNKQFNYKDPVNGVDIAYIKIPNAGQMQPVKAFKIHNKIWVIPERDTFTNPEEGDLNPPPEAKQVPVSYYDSTYLSTDNEKDNYLKGVTKLFERIYSTDLGRMLLTSIVRGIPFWGGSTIDTELKVIDTNCINVIQPDGSYRSEELNLVIIGPSADIIQFECKSFGHEVLNLTRNGYGSTQYIRFSPDFTFGFEESLEVDTNPLLGAGKFATDPAVTLAHQLIYAGHRLYGIAINPNRVFKVNTNAYYEMSGLEVSFEELRTFGGHDAKFIDSLQENEFRLYYYNKFKDIASTLNKAKSIVGTTASLQYMKNVFKEKYLLSEDTSGKFSVDKLKFDKLYKMLTEIYTEDNFVKFFKVLNRKTYLNFDKAVFKINIVPKVNYTIYDGFNLRNTNLAANFNGQNTEINNMNFTKLKNFTGLFEFYKLLCVDGGSLQCIKVNNWDLFFSPSEDNFTNDLNKGEEITSDTNIEAAEENISLDLIQQYYLTFNFDNEPENISIENLSSDIIGQLELMPNIERFPNGKKYELDKYTMFHYLRAQEFEHSRIALTNSVNEALLNPSRVYTFFSSDYVKKVNKATEAAMFLGWVEQLVYDFTDETSEVSTTDKIADITIIIPYIGPALNIGNMLYKDDFVGALIFSGAVILLEFIPEIAIPVLGTFALVSYIANKVLTVQTIDNALSKRNEKWDEVYKYIVTNWLAKVNTQIDLIRKKMKEALENQAEATKAIINYQYNQYTEEEKNNINFNIDDLSSKLNESINKAMININKFLNQCSVSYLMNSMIPYGVKRLEDFDASLKDALLKYIYDNRGTLIGQVDRLKDKVNNTLSTDIPFQLSKYVDNQRLLST
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structures of Engineered Clostridium Botulinum Neurotoxin Derivatives
pubmed doi rcsb
molecule tags Hydrolase/signaling protein
source organism Clostridium botulinum
molecule keywords BOTULINUM NEUROTOXIN TYPE A, SYNAPTOSOMAL-ASSOCIATED PROTEIN
total genus 280
structure length 847
sequence length 944
chains with identical sequence B
ec nomenclature ec 3.4.24.69: Bontoxilysin.
pdb deposition date 2011-07-19
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.1120.10 Mainly Alpha Up-down Bundle Clostridium botulinum neurotoxin B, "coiled-coil" domain Clostridium botulinum neurotoxin b, "coiled-coil" domain 3zurA02
3.90.1240.10 Alpha Beta Alpha-Beta Complex Zincin-like Metalloproteases ("zincins"), catalytic domain like 3zurA01
1ZN3A 2FPQA 1G9DA 3VUOA 3QW8A 3K3QB 2ILPA 3C89A 3QW6A 2G7KA 3BONA 2A8AA 2XHLB 3C8AA 1S0DA 1ZB7A 4J1LA 3C88A 2IMAA 1T3AA 4KTXA 3D3XA 3FIEA 2IMBA 2W2DB 1G9AA 1EPWA 2NYYA 2ETFA 4ELCA 4EL4A 3FFZA 3BOOA 1G9CA 1ZL5A 3DSEA 3QIXA 3BWIA 4KUFA 3QW5A 1T3CA 1ZL6A 3QIYA 3V0BB 3ZUSA 1S0GA 1E1HA 1F31A 1S0FA 1XTFA 3DDBA 3BOKA 3QW7A 5BQMA 5BQNA 4EJ5A 4ZKTB 1F82A 3ZUQA 3DDAA 3FIIA 3V0AA 3C8BA 2G7QA 2NP0A 3QIZA 2G7PA 1Z7HA 4HEVA 2W2DA 3NF3A 3ZURA 2IMCA 1G9BA 1ZKWA 2G7NA 3DS9A 1S0CA 2ISEA 4ZJXA 3BTAA 1XTGA 1ZKXA 1S0BA 3DEBA 1S0EA 2NZ9A 3QJ0A 2XHLA 5BQMB 2ISHA 2ISGA 2QN0A 4KS6A 1YVGA 2A97A 3V0AB 3V0BA 1I1EA
chains in the Genus database with same CATH superfamily
1ZN3A 2FPQA 1G9DA 3VUOA 3QW8A 3E11A 3K3QB 2ILPA 3C89A 3QW6A 2G7KA 3BONA 2A8AA 2XHLB 3C8AA 1S0DA 1ZB7A 4J1LA 3C88A 2IMAA 1T3AA 4KTXA 3D3XA 3FIEA 2IMBA 2W2DB 1G9AA 1EPWA 2NYYA 2ETFA 4ELCA 4EL4A 3FFZA 3BOOA 1G9CA 1ZL5A 3DSEA 4JIUA 3QIXA 3BWIA 4KUFA 3QW5A 1T3CA 1ZL6A 2EJQA 3QIYA 3V0BB 4JIXA 3ZUSA 2YPTA 1S0GA 1E1HA 1F31A 1S0FA 1XTFA 3DDBA 3CQBA 3BOKA 3QW7A 4IL3A 5BQMA 5BQNA 4EJ5A 4ZKTB 1F82A 3ZUQA 3DDAA 3FIIA 3V0AA 3C8BA 2G7QA 2NP0A 3QIZA 2G7PA 1Z7HA 4HEVA 2W2DA 3NF3A 3ZURA 2IMCA 1G9BA 1ZKWA 4AW6A 2G7NA 3DS9A 1S0CA 2ISEA 4ZJXA 3BTAA 1XTGA 1ZKXA 1S0BA 3DEBA 4QHFA 1S0EA 2NZ9A 3QJ0A 2XHLA 5BQMB 2ISHA 2ISGA 2QN0A 4KS6A 1YVGA 2A97A 3V0AB 3V0BA 1I1EA
chains in the Genus database with same CATH topology
1ZN3A 2FPQA 1G9DA 3VUOA 3QW8A 3K3QB 2ILPA 3C89A 3QW6A 2G7KA 3BONA 2A8AA 2XHLB 3C8AA 1S0DA 1ZB7A 4J1LA 3C88A 2IMAA 1T3AA 4KTXA 3D3XA 3FIEA 2IMBA 2W2DB 1G9AA 1EPWA 2NYYA 2ETFA 4ELCA 4EL4A 3FFZA 3BOOA 1G9CA 1ZL5A 3DSEA 3QIXA 3BWIA 4KUFA 3QW5A 1T3CA 1ZL6A 3QIYA 3V0BB 3ZUSA 1S0GA 1E1HA 1F31A 1S0FA 1XTFA 3DDBA 3BOKA 3QW7A 5BQMA 5BQNA 4EJ5A 4ZKTB 1F82A 3ZUQA 3DDAA 3FIIA 3V0AA 3C8BA 2G7QA 2NP0A 3QIZA 2G7PA 1Z7HA 4HEVA 2W2DA 3NF3A 3ZURA 2IMCA 1G9BA 1ZKWA 2G7NA 3DS9A 1S0CA 2ISEA 4ZJXA 3BTAA 1XTGA 1ZKXA 1S0BA 3DEBA 1S0EA 2NZ9A 3QJ0A 2XHLA 5BQMB 2ISHA 2ISGA 2QN0A 4KS6A 1YVGA 2A97A 3V0AB 3V0BA 1I1EA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1ZN3 A;  2FPQ A;  1G9D A;  3VUO A;  3QW8 A;  3K3Q B;  2ILP A;  3C89 A;  3QW6 A;  2G7K A;  3BON A;  2A8A A;  2XHL B;  3C8A A;  1S0D A;  1ZB7 A;  4J1L A;  3C88 A;  2IMA A;  1T3A A;  4KTX A;  3D3X A;  3FIE A;  2IMB A;  2W2D B;  1G9A A;  1EPW A;  2NYY A;  2ETF A;  4ELC A;  4EL4 A;  3FFZ A;  3BOO A;  1G9C A;  1ZL5 A;  3DSE A;  3QIX A;  3BWI A;  4KUF A;  3QW5 A;  1T3C A;  1ZL6 A;  3QIY A;  3V0B B;  3ZUS A;  1S0G A;  1E1H A;  1F31 A;  1S0F A;  1XTF A;  3DDB A;  3BOK A;  3QW7 A;  5BQM A;  5BQN A;  4EJ5 A;  4ZKT B;  1F82 A;  3ZUQ A;  3DDA A;  3FII A;  3V0A A;  3C8B A;  2G7Q A;  2NP0 A;  3QIZ A;  2G7P A;  1Z7H A;  4HEV A;  2W2D A;  3NF3 A;  3ZUR A;  2IMC A;  1G9B A;  1ZKW A;  2G7N A;  3DS9 A;  1S0C A;  2ISE A;  4ZJX A;  3BTA A;  1XTG A;  1ZKX A;  1S0B A;  3DEB A;  1S0E A;  2NZ9 A;  3QJ0 A;  2XHL A;  5BQM B;  2ISH A;  2ISG A;  2QN0 A;  4KS6 A;  1YVG A;  2A97 A;  3V0A B;  3V0B A;  1I1E A; 
#chains in the Genus database with same CATH topology
 1ZN3 A;  2FPQ A;  1G9D A;  3VUO A;  3QW8 A;  3E11 A;  3K3Q B;  2ILP A;  3C89 A;  3QW6 A;  2G7K A;  3BON A;  2A8A A;  2XHL B;  3C8A A;  1S0D A;  1ZB7 A;  4J1L A;  3C88 A;  2IMA A;  1T3A A;  4KTX A;  3D3X A;  3FIE A;  2IMB A;  2W2D B;  1G9A A;  1EPW A;  2NYY A;  2ETF A;  4ELC A;  4EL4 A;  3FFZ A;  3BOO A;  1G9C A;  1ZL5 A;  3DSE A;  4JIU A;  3QIX A;  3BWI A;  4KUF A;  3QW5 A;  1T3C A;  1ZL6 A;  2EJQ A;  3QIY A;  3V0B B;  4JIX A;  3ZUS A;  2YPT A;  1S0G A;  1E1H A;  1F31 A;  1S0F A;  1XTF A;  3DDB A;  3CQB A;  3BOK A;  3QW7 A;  4IL3 A;  5BQM A;  5BQN A;  4EJ5 A;  4ZKT B;  1F82 A;  3ZUQ A;  3DDA A;  3FII A;  3V0A A;  3C8B A;  2G7Q A;  2NP0 A;  3QIZ A;  2G7P A;  1Z7H A;  4HEV A;  2W2D A;  3NF3 A;  3ZUR A;  2IMC A;  1G9B A;  1ZKW A;  4AW6 A;  2G7N A;  3DS9 A;  1S0C A;  2ISE A;  4ZJX A;  3BTA A;  1XTG A;  1ZKX A;  1S0B A;  3DEB A;  4QHF A;  1S0E A;  2NZ9 A;  3QJ0 A;  2XHL A;  5BQM B;  2ISH A;  2ISG A;  2QN0 A;  4KS6 A;  1YVG A;  2A97 A;  3V0A B;  3V0B A;  1I1E A; 
#chains in the Genus database with same CATH homology
 1ZN3 A;  2FPQ A;  1G9D A;  3VUO A;  3QW8 A;  3K3Q B;  2ILP A;  3C89 A;  3QW6 A;  2G7K A;  3BON A;  2A8A A;  2XHL B;  3C8A A;  1S0D A;  1ZB7 A;  4J1L A;  3C88 A;  2IMA A;  1T3A A;  4KTX A;  3D3X A;  3FIE A;  2IMB A;  2W2D B;  1G9A A;  1EPW A;  2NYY A;  2ETF A;  4ELC A;  4EL4 A;  3FFZ A;  3BOO A;  1G9C A;  1ZL5 A;  3DSE A;  3QIX A;  3BWI A;  4KUF A;  3QW5 A;  1T3C A;  1ZL6 A;  3QIY A;  3V0B B;  3ZUS A;  1S0G A;  1E1H A;  1F31 A;  1S0F A;  1XTF A;  3DDB A;  3BOK A;  3QW7 A;  5BQM A;  5BQN A;  4EJ5 A;  4ZKT B;  1F82 A;  3ZUQ A;  3DDA A;  3FII A;  3V0A A;  3C8B A;  2G7Q A;  2NP0 A;  3QIZ A;  2G7P A;  1Z7H A;  4HEV A;  2W2D A;  3NF3 A;  3ZUR A;  2IMC A;  1G9B A;  1ZKW A;  2G7N A;  3DS9 A;  1S0C A;  2ISE A;  4ZJX A;  3BTA A;  1XTG A;  1ZKX A;  1S0B A;  3DEB A;  1S0E A;  2NZ9 A;  3QJ0 A;  2XHL A;  5BQM B;  2ISH A;  2ISG A;  2QN0 A;  4KS6 A;  1YVG A;  2A97 A;  3V0A B;  3V0B A;  1I1E A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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