4BZBA

Crystal structure of the tetrameric dgtp-bound samhd1 mutant catalytic core
Total Genus 165
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
165
sequence length
487
structure length
481
Chain Sequence
DTMKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASHNRFEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCRNLGHGPFSHMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPEEDICFIKEQIVGPLELWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFARDCHHLGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNSLHRRAYQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDDMEAYTKLTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKIKREDYESLPKEVASAKPKVLLDVKLKAEDFIVDVINMDYGMQEKNPIDHVSFYCKTAPNRAIRITKNQVSQLLPEKFAEQLIRVYCKKVDRKSLYAARQYFVQWCADRNFTKPQDGDVIAPLITPQKKEWN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Mechanism of Allosteric Activation of Samhd1 by Dgtp
pubmed doi rcsb
molecule keywords DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE SAMHD1
molecule tags Hydrolase
source organism Homo sapiens
total genus 165
structure length 481
sequence length 487
chains with identical sequence B, C, D
ec nomenclature ec 3.1.5.-:
pdb deposition date 2013-07-25

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01966 HD HD domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.3210.10 Mainly Alpha Orthogonal Bundle Hypothetical protein af1432 Hypothetical protein af1432 4bzbA01
1VQRA 5TK7A 4L1JB 1U6ZA 5AO2A 4RXQA 2CQZA 4RXOA 4RXSA 5TK9A 4MLNA 3NQWA 4ZWGA 3I7AA 4ZWEA 4MLMA 3LJXA 2PAQA 4TNXA 4MDZA 4N6WA 4QG2A 4QG0A 3U1NA 3TMCA 2PAUA 3TMBA 4TNRA 4QFXA 2PGSA 3HC1A 4BZBA 4TO4A 4RXPA 4TO2A 3HI0A 4RXRA 4TO6A 4Q7HA 5TKAA 4BZCA 4DMBA 3M1TA 3CCGA 4X9EA 2GZ4A 2HEKA 5TK6A 4LRLA 4TNYA 4QG1A 4TNQA 3KH1A 1VJ7A 3BG2A 4MZ7A 2PQ7A 2DQBA 2PARA 4L7WA 1YOYA 4TO1A 4TO5A 5AO0A 4L7EA 3MEMA 4N71A 3P3QA 2FLOA 1YNBA 3RF0A 5AO3A 3IRHA 4TNZA 5AO1A 2O6IA 5AO4A 3NR1A 4QG4A 4L1JA 4MCWA 4TO0A 2Q14A 3TMDA 4R8ZA 5TK8A 3TM8A 3MZOA 4ME4A 4QFYA 4TNPA 4QFZA 2O08A 4XDSA 2OGIA 4TO3A 1XX7A
chains in the Genus database with same CATH superfamily
1VQRA 5TK7A 4L1JB 1U6ZA 5AO2A 4RXQA 2CQZA 4RXOA 4RXSA 5TK9A 4MLNA 3NQWA 4ZWGA 3SKDA 3I7AA 4ZWEA 4MLMA 3LJXA 4Q2CA 2PAQA 4TNXA 4QQZA 4MDZA 4N6WA 4QG2A 4QG0A 3U1NA 3TMCA 2PAUA 3TMBA 4QQYA 4TNRA 4QFXA 2PGSA 3HC1A 4BZBA 4TO4A 4RXPA 4TO2A 3HI0A 4RXRA 4TO6A 4Q7HA 5TKAA 4BZCA 4DMBA 3M1TA 3CCGA 4X9EA 4QQXA 2GZ4A 2HEKA 5TK6A 4LRLA 4TNYA 4Q2DA 4QG1A 4TNQA 3S4LA 3KH1A 1VJ7A 3BG2A 4MZ7A 2PQ7A 2DQBA 2PARA 4L7WA 1YOYA 4TO1A 4TO5A 5AO0A 4L7EA 3MEMA 4N71A 3P3QA 2FLOA 1YNBA 3RF0A 5AO3A 3IRHA 4TNZA 5AO1A 2O6IA 5AO4A 3NR1A 4QG4A 3GW7A 4L1JA 4MCWA 4TO0A 2Q14A 3KQ5A 3TMDA 4R8ZA 5TK8A 3TM8A 3MZOA 4ME4A 4QFYA 4QQWA 4TNPA 4QFZA 2O08A 3SK9A 4XDSA 2OGIA 4TO3A 1XX7A
chains in the Genus database with same CATH topology
1VQRA 5TK7A 4L1JB 1U6ZA 5AO2A 4RXQA 2CQZA 4RXOA 4RXSA 5TK9A 4MLNA 3NQWA 4ZWGA 3SKDA 3I7AA 4ZWEA 4MLMA 3LJXA 4Q2CA 2PAQA 4TNXA 4QQZA 4MDZA 4N6WA 4QG2A 4QG0A 3U1NA 3TMCA 2PAUA 3TMBA 4QQYA 4TNRA 4QFXA 2PGSA 3HC1A 4BZBA 4TO4A 4RXPA 4TO2A 3HI0A 4RXRA 4TO6A 4Q7HA 5TKAA 4BZCA 4DMBA 3M1TA 3CCGA 4X9EA 4QQXA 2GZ4A 2HEKA 5TK6A 4LRLA 4TNYA 4Q2DA 4QG1A 4TNQA 3S4LA 3KH1A 1VJ7A 3BG2A 4MZ7A 2PQ7A 2DQBA 2PARA 4L7WA 1YOYA 4TO1A 4TO5A 5AO0A 4L7EA 3MEMA 4N71A 3P3QA 2FLOA 1YNBA 3RF0A 5AO3A 3IRHA 4TNZA 5AO1A 2O6IA 5AO4A 3NR1A 4QG4A 3GW7A 4L1JA 4MCWA 4TO0A 2Q14A 3KQ5A 3TMDA 4R8ZA 5TK8A 3TM8A 3MZOA 4ME4A 4QFYA 4QQWA 4TNPA 4QFZA 2O08A 3SK9A 4XDSA 2OGIA 4TO3A 1XX7A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1VQR A;  5TK7 A;  4L1J B;  1U6Z A;  5AO2 A;  4RXQ A;  2CQZ A;  4RXO A;  4RXS A;  5TK9 A;  4MLN A;  3NQW A;  4ZWG A;  3I7A A;  4ZWE A;  4MLM A;  3LJX A;  2PAQ A;  4TNX A;  4MDZ A;  4N6W A;  4QG2 A;  4QG0 A;  3U1N A;  3TMC A;  2PAU A;  3TMB A;  4TNR A;  4QFX A;  2PGS A;  3HC1 A;  4BZB A;  4TO4 A;  4RXP A;  4TO2 A;  3HI0 A;  4RXR A;  4TO6 A;  4Q7H A;  5TKA A;  4BZC A;  4DMB A;  3M1T A;  3CCG A;  4X9E A;  2GZ4 A;  2HEK A;  5TK6 A;  4LRL A;  4TNY A;  4QG1 A;  4TNQ A;  3KH1 A;  1VJ7 A;  3BG2 A;  4MZ7 A;  2PQ7 A;  2DQB A;  2PAR A;  4L7W A;  1YOY A;  4TO1 A;  4TO5 A;  5AO0 A;  4L7E A;  3MEM A;  4N71 A;  3P3Q A;  2FLO A;  1YNB A;  3RF0 A;  5AO3 A;  3IRH A;  4TNZ A;  5AO1 A;  2O6I A;  5AO4 A;  3NR1 A;  4QG4 A;  4L1J A;  4MCW A;  4TO0 A;  2Q14 A;  3TMD A;  4R8Z A;  5TK8 A;  3TM8 A;  3MZO A;  4ME4 A;  4QFY A;  4TNP A;  4QFZ A;  2O08 A;  4XDS A;  2OGI A;  4TO3 A;  1XX7 A; 
#chains in the Genus database with same CATH topology
 1VQR A;  5TK7 A;  4L1J B;  1U6Z A;  5AO2 A;  4RXQ A;  2CQZ A;  4RXO A;  4RXS A;  5TK9 A;  4MLN A;  3NQW A;  4ZWG A;  3SKD A;  3I7A A;  4ZWE A;  4MLM A;  3LJX A;  4Q2C A;  2PAQ A;  4TNX A;  4QQZ A;  4MDZ A;  4N6W A;  4QG2 A;  4QG0 A;  3U1N A;  3TMC A;  2PAU A;  3TMB A;  4QQY A;  4TNR A;  4QFX A;  2PGS A;  3HC1 A;  4BZB A;  4TO4 A;  4RXP A;  4TO2 A;  3HI0 A;  4RXR A;  4TO6 A;  4Q7H A;  5TKA A;  4BZC A;  4DMB A;  3M1T A;  3CCG A;  4X9E A;  4QQX A;  2GZ4 A;  2HEK A;  5TK6 A;  4LRL A;  4TNY A;  4Q2D A;  4QG1 A;  4TNQ A;  3S4L A;  3KH1 A;  1VJ7 A;  3BG2 A;  4MZ7 A;  2PQ7 A;  2DQB A;  2PAR A;  4L7W A;  1YOY A;  4TO1 A;  4TO5 A;  5AO0 A;  4L7E A;  3MEM A;  4N71 A;  3P3Q A;  2FLO A;  1YNB A;  3RF0 A;  5AO3 A;  3IRH A;  4TNZ A;  5AO1 A;  2O6I A;  5AO4 A;  3NR1 A;  4QG4 A;  3GW7 A;  4L1J A;  4MCW A;  4TO0 A;  2Q14 A;  3KQ5 A;  3TMD A;  4R8Z A;  5TK8 A;  3TM8 A;  3MZO A;  4ME4 A;  4QFY A;  4QQW A;  4TNP A;  4QFZ A;  2O08 A;  3SK9 A;  4XDS A;  2OGI A;  4TO3 A;  1XX7 A; 
#chains in the Genus database with same CATH homology
 1VQR A;  5TK7 A;  4L1J B;  1U6Z A;  5AO2 A;  4RXQ A;  2CQZ A;  4RXO A;  4RXS A;  5TK9 A;  4MLN A;  3NQW A;  4ZWG A;  3SKD A;  3I7A A;  4ZWE A;  4MLM A;  3LJX A;  4Q2C A;  2PAQ A;  4TNX A;  4QQZ A;  4MDZ A;  4N6W A;  4QG2 A;  4QG0 A;  3U1N A;  3TMC A;  2PAU A;  3TMB A;  4QQY A;  4TNR A;  4QFX A;  2PGS A;  3HC1 A;  4BZB A;  4TO4 A;  4RXP A;  4TO2 A;  3HI0 A;  4RXR A;  4TO6 A;  4Q7H A;  5TKA A;  4BZC A;  4DMB A;  3M1T A;  3CCG A;  4X9E A;  4QQX A;  2GZ4 A;  2HEK A;  5TK6 A;  4LRL A;  4TNY A;  4Q2D A;  4QG1 A;  4TNQ A;  3S4L A;  3KH1 A;  1VJ7 A;  3BG2 A;  4MZ7 A;  2PQ7 A;  2DQB A;  2PAR A;  4L7W A;  1YOY A;  4TO1 A;  4TO5 A;  5AO0 A;  4L7E A;  3MEM A;  4N71 A;  3P3Q A;  2FLO A;  1YNB A;  3RF0 A;  5AO3 A;  3IRH A;  4TNZ A;  5AO1 A;  2O6I A;  5AO4 A;  3NR1 A;  4QG4 A;  3GW7 A;  4L1J A;  4MCW A;  4TO0 A;  2Q14 A;  3KQ5 A;  3TMD A;  4R8Z A;  5TK8 A;  3TM8 A;  3MZO A;  4ME4 A;  4QFY A;  4QQW A;  4TNP A;  4QFZ A;  2O08 A;  3SK9 A;  4XDS A;  2OGI A;  4TO3 A;  1XX7 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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