4Q7HA

Crystal structure of samhd1 catalytic core with gtp
Total Genus 149
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
149
sequence length
470
structure length
459
Chain Sequence
MKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASHNRFEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCHDLGHGPFSHMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPEEDIYFIKEQIVGPLESPDSLWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFARDCHHLGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNSLHRRAYQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDDMEAYTKLTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKIKREDYESLPKEVASAKPKVLLDVKLKAEDFIVDVINMDYQEKNPIDHVSFYCKTAPNRAIRITLPEKFAEQLIRVYCKKVDRKSLYAARQYFVQWCADRNFTKPQDG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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molecule tags Hydrolase
molecule keywords Deoxynucleoside triphosphate triphosphohydrolase SAMHD1
publication title Structural insight into activation mechanism of SAMHD1
rcsb
source organism Homo sapiens
total genus 149
structure length 459
sequence length 470
chains with identical sequence B, C, D
ec nomenclature ec 3.1.5.-:
pdb deposition date 2014-04-25

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01966 HD HD domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.3210.10 Mainly Alpha Orthogonal Bundle Hypothetical protein af1432 Hypothetical protein af1432 4q7hA01
2PGSA 4BZBA 4RXRA 3LJXA 4TO3A 5AO3A 3HI0A 4TO2A 3HC1A 5AO0A 2PARA 4TO6A 3CCGA 2DQBA 3IRHA 5AO2A 5TK8A 3I7AA 4DMBA 2CQZA 4TNYA 5TKAA 3U1NA 5TK6A 3NR1A 3TMBA 3TM8A 3RF0A 4ME4A 4TO0A 2OGIA 3TMCA 4QG4A 4TO1A 4QG0A 4L1JB 4TNRA 4N71A 4RXOA 4TNPA 3TMDA 2O08A 4ZWEA 1U6ZA 4Q7HA 2PAQA 2Q14A 3BG2A 4QFXA 4ZWGA 4MZ7A 4N6WA 4QFYA 4XDSA 2O6IA 4RXPA 4QFZA 1VQRA 3P3QA 2GZ4A 4QG1A 2FLOA 4MLNA 1XX7A 4TO5A 4X9EA 3M1TA 4LRLA 3KH1A 5AO1A 4MCWA 2HEKA 4QG2A 4RXSA 2PQ7A 4R8ZA 3MEMA 4L1JA 2PAUA 1VJ7A 4L7EA 4BZCA 4TNXA 5TK9A 4L7WA 3NQWA 5TK7A 4MLMA 1YOYA 4TO4A 3MZOA 4RXQA 4TNZA 5AO4A 1YNBA 4MDZA 4TNQA
chains in the Genus database with same CATH superfamily
2PGSA 4BZBA 3KQ5A 4RXRA 3LJXA 4TO3A 5AO3A 3HI0A 4TO2A 3HC1A 5AO0A 3SK9A 2PARA 4QQYA 3GW7A 4TO6A 3CCGA 2DQBA 3IRHA 5AO2A 5TK8A 3I7AA 4DMBA 2CQZA 4Q2DA 4TNYA 5TKAA 3U1NA 5TK6A 3NR1A 3TMBA 3TM8A 3RF0A 4ME4A 4TO0A 2OGIA 3TMCA 4QG4A 4TO1A 4QG0A 4L1JB 4TNRA 4N71A 4RXOA 4TNPA 3TMDA 2O08A 4ZWEA 1U6ZA 4Q7HA 2PAQA 2Q14A 3BG2A 4QFXA 3S4LA 4ZWGA 4MZ7A 4N6WA 3SKDA 4QFYA 4XDSA 2O6IA 4Q2CA 4RXPA 4QFZA 1VQRA 3P3QA 2GZ4A 4QQZA 4QG1A 4QQXA 2FLOA 4MLNA 1XX7A 4TO5A 4X9EA 3M1TA 4LRLA 3KH1A 5AO1A 4MCWA 2HEKA 4QG2A 4RXSA 2PQ7A 4R8ZA 3MEMA 4L1JA 2PAUA 1VJ7A 4L7EA 4BZCA 4TNXA 5TK9A 4L7WA 3NQWA 5TK7A 4QQWA 4MLMA 1YOYA 4TO4A 3MZOA 4RXQA 4TNZA 5AO4A 1YNBA 4MDZA 4TNQA
chains in the Genus database with same CATH topology
2PGSA 4BZBA 3KQ5A 4RXRA 3LJXA 4TO3A 5AO3A 3HI0A 4TO2A 3HC1A 5AO0A 3SK9A 2PARA 4QQYA 3GW7A 4TO6A 3CCGA 2DQBA 3IRHA 5AO2A 5TK8A 3I7AA 4DMBA 2CQZA 4Q2DA 4TNYA 5TKAA 3U1NA 5TK6A 3NR1A 3TMBA 3TM8A 3RF0A 4ME4A 4TO0A 2OGIA 3TMCA 4QG4A 4TO1A 4QG0A 4L1JB 4TNRA 4N71A 4RXOA 4TNPA 3TMDA 2O08A 4ZWEA 1U6ZA 4Q7HA 2PAQA 2Q14A 3BG2A 4QFXA 3S4LA 4ZWGA 4MZ7A 4N6WA 3SKDA 4QFYA 4XDSA 2O6IA 4Q2CA 4RXPA 4QFZA 1VQRA 3P3QA 2GZ4A 4QQZA 4QG1A 4QQXA 2FLOA 4MLNA 1XX7A 4TO5A 4X9EA 3M1TA 4LRLA 3KH1A 5AO1A 4MCWA 2HEKA 4QG2A 4RXSA 2PQ7A 4R8ZA 3MEMA 4L1JA 2PAUA 1VJ7A 4L7EA 4BZCA 4TNXA 5TK9A 4L7WA 3NQWA 5TK7A 4QQWA 4MLMA 1YOYA 4TO4A 3MZOA 4RXQA 4TNZA 5AO4A 1YNBA 4MDZA 4TNQA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 2PGS A;  4BZB A;  4RXR A;  3LJX A;  4TO3 A;  5AO3 A;  3HI0 A;  4TO2 A;  3HC1 A;  5AO0 A;  2PAR A;  4TO6 A;  3CCG A;  2DQB A;  3IRH A;  5AO2 A;  5TK8 A;  3I7A A;  4DMB A;  2CQZ A;  4TNY A;  5TKA A;  3U1N A;  5TK6 A;  3NR1 A;  3TMB A;  3TM8 A;  3RF0 A;  4ME4 A;  4TO0 A;  2OGI A;  3TMC A;  4QG4 A;  4TO1 A;  4QG0 A;  4L1J B;  4TNR A;  4N71 A;  4RXO A;  4TNP A;  3TMD A;  2O08 A;  4ZWE A;  1U6Z A;  4Q7H A;  2PAQ A;  2Q14 A;  3BG2 A;  4QFX A;  4ZWG A;  4MZ7 A;  4N6W A;  4QFY A;  4XDS A;  2O6I A;  4RXP A;  4QFZ A;  1VQR A;  3P3Q A;  2GZ4 A;  4QG1 A;  2FLO A;  4MLN A;  1XX7 A;  4TO5 A;  4X9E A;  3M1T A;  4LRL A;  3KH1 A;  5AO1 A;  4MCW A;  2HEK A;  4QG2 A;  4RXS A;  2PQ7 A;  4R8Z A;  3MEM A;  4L1J A;  2PAU A;  1VJ7 A;  4L7E A;  4BZC A;  4TNX A;  5TK9 A;  4L7W A;  3NQW A;  5TK7 A;  4MLM A;  1YOY A;  4TO4 A;  3MZO A;  4RXQ A;  4TNZ A;  5AO4 A;  1YNB A;  4MDZ A;  4TNQ A; 
#chains in the Genus database with same CATH topology
 2PGS A;  4BZB A;  3KQ5 A;  4RXR A;  3LJX A;  4TO3 A;  5AO3 A;  3HI0 A;  4TO2 A;  3HC1 A;  5AO0 A;  3SK9 A;  2PAR A;  4QQY A;  3GW7 A;  4TO6 A;  3CCG A;  2DQB A;  3IRH A;  5AO2 A;  5TK8 A;  3I7A A;  4DMB A;  2CQZ A;  4Q2D A;  4TNY A;  5TKA A;  3U1N A;  5TK6 A;  3NR1 A;  3TMB A;  3TM8 A;  3RF0 A;  4ME4 A;  4TO0 A;  2OGI A;  3TMC A;  4QG4 A;  4TO1 A;  4QG0 A;  4L1J B;  4TNR A;  4N71 A;  4RXO A;  4TNP A;  3TMD A;  2O08 A;  4ZWE A;  1U6Z A;  4Q7H A;  2PAQ A;  2Q14 A;  3BG2 A;  4QFX A;  3S4L A;  4ZWG A;  4MZ7 A;  4N6W A;  3SKD A;  4QFY A;  4XDS A;  2O6I A;  4Q2C A;  4RXP A;  4QFZ A;  1VQR A;  3P3Q A;  2GZ4 A;  4QQZ A;  4QG1 A;  4QQX A;  2FLO A;  4MLN A;  1XX7 A;  4TO5 A;  4X9E A;  3M1T A;  4LRL A;  3KH1 A;  5AO1 A;  4MCW A;  2HEK A;  4QG2 A;  4RXS A;  2PQ7 A;  4R8Z A;  3MEM A;  4L1J A;  2PAU A;  1VJ7 A;  4L7E A;  4BZC A;  4TNX A;  5TK9 A;  4L7W A;  3NQW A;  5TK7 A;  4QQW A;  4MLM A;  1YOY A;  4TO4 A;  3MZO A;  4RXQ A;  4TNZ A;  5AO4 A;  1YNB A;  4MDZ A;  4TNQ A; 
#chains in the Genus database with same CATH homology
 2PGS A;  4BZB A;  3KQ5 A;  4RXR A;  3LJX A;  4TO3 A;  5AO3 A;  3HI0 A;  4TO2 A;  3HC1 A;  5AO0 A;  3SK9 A;  2PAR A;  4QQY A;  3GW7 A;  4TO6 A;  3CCG A;  2DQB A;  3IRH A;  5AO2 A;  5TK8 A;  3I7A A;  4DMB A;  2CQZ A;  4Q2D A;  4TNY A;  5TKA A;  3U1N A;  5TK6 A;  3NR1 A;  3TMB A;  3TM8 A;  3RF0 A;  4ME4 A;  4TO0 A;  2OGI A;  3TMC A;  4QG4 A;  4TO1 A;  4QG0 A;  4L1J B;  4TNR A;  4N71 A;  4RXO A;  4TNP A;  3TMD A;  2O08 A;  4ZWE A;  1U6Z A;  4Q7H A;  2PAQ A;  2Q14 A;  3BG2 A;  4QFX A;  3S4L A;  4ZWG A;  4MZ7 A;  4N6W A;  3SKD A;  4QFY A;  4XDS A;  2O6I A;  4Q2C A;  4RXP A;  4QFZ A;  1VQR A;  3P3Q A;  2GZ4 A;  4QQZ A;  4QG1 A;  4QQX A;  2FLO A;  4MLN A;  1XX7 A;  4TO5 A;  4X9E A;  3M1T A;  4LRL A;  3KH1 A;  5AO1 A;  4MCW A;  2HEK A;  4QG2 A;  4RXS A;  2PQ7 A;  4R8Z A;  3MEM A;  4L1J A;  2PAU A;  1VJ7 A;  4L7E A;  4BZC A;  4TNX A;  5TK9 A;  4L7W A;  3NQW A;  5TK7 A;  4QQW A;  4MLM A;  1YOY A;  4TO4 A;  3MZO A;  4RXQ A;  4TNZ A;  5AO4 A;  1YNB A;  4MDZ A;  4TNQ A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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