4ZWGA

Crystal structure of the gtp-datp-bound catalytic core of samhd1 phosphomimetic t592e mutant
Total Genus 164
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
164
sequence length
468
structure length
461
Chain Sequence
TMKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASHNRFEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCRNLGHGPFSHMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPEEDICFIKEQIVGPLEEDSLWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFARDCHHLGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNSLHRRAYQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDDMEAYTKLTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKIKREDYESLPKEVASAKPKVKLKAEDFIVDVINMDYGMQEKNPIDHVSFYCKTAPNRAIRITKNQVSQLLPEKFAEQLIRVYCKKVDRKSLYAARQYFVQWCADRNFTKP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase
molecule keywords Deoxynucleoside triphosphate triphosphohydrolase SAMHD1
publication title Impaired dNTPase Activity of SAMHD1 by Phosphomimetic Mutation of Thr-592.
pubmed doi rcsb
source organism Homo sapiens
total genus 164
structure length 461
sequence length 468
chains with identical sequence B, C, D
ec nomenclature ec 3.1.5.-:
pdb deposition date 2015-05-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01966 HD HD domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.3210.10 Mainly Alpha Orthogonal Bundle Hypothetical protein af1432 Hypothetical protein af1432 4zwgA01
4MLMA 5AO0A 2OGIA 3M1TA 1U6ZA 4RXOA 2O6IA 4MCWA 3MZOA 4TO5A 5TK6A 4ZWEA 4RXQA 3TMCA 4ZWGA 4QFXA 4TNQA 4XDSA 2Q14A 3IRHA 4N71A 1VQRA 3HI0A 4QFYA 5TKAA 4DMBA 3KH1A 4BZCA 2PAQA 3LJXA 2FLOA 1YNBA 5TK7A 4TO6A 3P3QA 2CQZA 4N6WA 4TO1A 4LRLA 4QG1A 4ME4A 1VJ7A 3RF0A 4RXPA 4TO2A 5TK8A 3TMBA 5AO3A 5AO2A 3CCGA 3BG2A 4TNZA 4L7EA 4TO4A 5AO4A 3NR1A 1XX7A 4Q7HA 4TO3A 4L7WA 1YOYA 4RXRA 3TMDA 4TNRA 4R8ZA 4MDZA 3I7AA 2PARA 2PGSA 4BZBA 5AO1A 2PQ7A 2DQBA 4X9EA 3TM8A 3MEMA 4QFZA 3HC1A 3NQWA 4RXSA 2O08A 5TK9A 4L1JB 4QG4A 4TNYA 4QG2A 2HEKA 4TNXA 4MZ7A 4QG0A 4TNPA 3U1NA 2PAUA 4MLNA 4L1JA 2GZ4A 4TO0A
chains in the Genus database with same CATH superfamily
4MLMA 5AO0A 2OGIA 3M1TA 1U6ZA 4RXOA 2O6IA 4MCWA 3MZOA 4TO5A 5TK6A 4QQYA 4ZWEA 4RXQA 3TMCA 4ZWGA 4QFXA 4TNQA 4XDSA 2Q14A 3IRHA 4N71A 1VQRA 3HI0A 4QFYA 5TKAA 4DMBA 3KH1A 4BZCA 2PAQA 3LJXA 2FLOA 1YNBA 5TK7A 4TO6A 3P3QA 2CQZA 4N6WA 4TO1A 4LRLA 4QG1A 4ME4A 1VJ7A 3GW7A 3RF0A 4Q2DA 4RXPA 4TO2A 5TK8A 3TMBA 5AO3A 5AO2A 3CCGA 3BG2A 4Q2CA 4TNZA 4L7EA 4TO4A 5AO4A 3NR1A 1XX7A 4Q7HA 4TO3A 4QQXA 4L7WA 1YOYA 4RXRA 3TMDA 4TNRA 4R8ZA 4MDZA 3I7AA 2PARA 2PGSA 4BZBA 5AO1A 2PQ7A 2DQBA 3SK9A 4X9EA 3TM8A 3MEMA 4QFZA 3HC1A 3NQWA 4RXSA 4QQWA 2O08A 3S4LA 5TK9A 4L1JB 4QG4A 4TNYA 4QG2A 3KQ5A 3SKDA 2HEKA 4TNXA 4MZ7A 4QG0A 4TNPA 3U1NA 4QQZA 2PAUA 4MLNA 4L1JA 2GZ4A 4TO0A
chains in the Genus database with same CATH topology
4MLMA 5AO0A 2OGIA 3M1TA 1U6ZA 4RXOA 2O6IA 4MCWA 3MZOA 4TO5A 5TK6A 4QQYA 4ZWEA 4RXQA 3TMCA 4ZWGA 4QFXA 4TNQA 4XDSA 2Q14A 3IRHA 4N71A 1VQRA 3HI0A 4QFYA 5TKAA 4DMBA 3KH1A 4BZCA 2PAQA 3LJXA 2FLOA 1YNBA 5TK7A 4TO6A 3P3QA 2CQZA 4N6WA 4TO1A 4LRLA 4QG1A 4ME4A 1VJ7A 3GW7A 3RF0A 4Q2DA 4RXPA 4TO2A 5TK8A 3TMBA 5AO3A 5AO2A 3CCGA 3BG2A 4Q2CA 4TNZA 4L7EA 4TO4A 5AO4A 3NR1A 1XX7A 4Q7HA 4TO3A 4QQXA 4L7WA 1YOYA 4RXRA 3TMDA 4TNRA 4R8ZA 4MDZA 3I7AA 2PARA 2PGSA 4BZBA 5AO1A 2PQ7A 2DQBA 3SK9A 4X9EA 3TM8A 3MEMA 4QFZA 3HC1A 3NQWA 4RXSA 4QQWA 2O08A 3S4LA 5TK9A 4L1JB 4QG4A 4TNYA 4QG2A 3KQ5A 3SKDA 2HEKA 4TNXA 4MZ7A 4QG0A 4TNPA 3U1NA 4QQZA 2PAUA 4MLNA 4L1JA 2GZ4A 4TO0A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4MLM A;  5AO0 A;  2OGI A;  3M1T A;  1U6Z A;  4RXO A;  2O6I A;  4MCW A;  3MZO A;  4TO5 A;  5TK6 A;  4ZWE A;  4RXQ A;  3TMC A;  4ZWG A;  4QFX A;  4TNQ A;  4XDS A;  2Q14 A;  3IRH A;  4N71 A;  1VQR A;  3HI0 A;  4QFY A;  5TKA A;  4DMB A;  3KH1 A;  4BZC A;  2PAQ A;  3LJX A;  2FLO A;  1YNB A;  5TK7 A;  4TO6 A;  3P3Q A;  2CQZ A;  4N6W A;  4TO1 A;  4LRL A;  4QG1 A;  4ME4 A;  1VJ7 A;  3RF0 A;  4RXP A;  4TO2 A;  5TK8 A;  3TMB A;  5AO3 A;  5AO2 A;  3CCG A;  3BG2 A;  4TNZ A;  4L7E A;  4TO4 A;  5AO4 A;  3NR1 A;  1XX7 A;  4Q7H A;  4TO3 A;  4L7W A;  1YOY A;  4RXR A;  3TMD A;  4TNR A;  4R8Z A;  4MDZ A;  3I7A A;  2PAR A;  2PGS A;  4BZB A;  5AO1 A;  2PQ7 A;  2DQB A;  4X9E A;  3TM8 A;  3MEM A;  4QFZ A;  3HC1 A;  3NQW A;  4RXS A;  2O08 A;  5TK9 A;  4L1J B;  4QG4 A;  4TNY A;  4QG2 A;  2HEK A;  4TNX A;  4MZ7 A;  4QG0 A;  4TNP A;  3U1N A;  2PAU A;  4MLN A;  4L1J A;  2GZ4 A;  4TO0 A; 
#chains in the Genus database with same CATH topology
 4MLM A;  5AO0 A;  2OGI A;  3M1T A;  1U6Z A;  4RXO A;  2O6I A;  4MCW A;  3MZO A;  4TO5 A;  5TK6 A;  4QQY A;  4ZWE A;  4RXQ A;  3TMC A;  4ZWG A;  4QFX A;  4TNQ A;  4XDS A;  2Q14 A;  3IRH A;  4N71 A;  1VQR A;  3HI0 A;  4QFY A;  5TKA A;  4DMB A;  3KH1 A;  4BZC A;  2PAQ A;  3LJX A;  2FLO A;  1YNB A;  5TK7 A;  4TO6 A;  3P3Q A;  2CQZ A;  4N6W A;  4TO1 A;  4LRL A;  4QG1 A;  4ME4 A;  1VJ7 A;  3GW7 A;  3RF0 A;  4Q2D A;  4RXP A;  4TO2 A;  5TK8 A;  3TMB A;  5AO3 A;  5AO2 A;  3CCG A;  3BG2 A;  4Q2C A;  4TNZ A;  4L7E A;  4TO4 A;  5AO4 A;  3NR1 A;  1XX7 A;  4Q7H A;  4TO3 A;  4QQX A;  4L7W A;  1YOY A;  4RXR A;  3TMD A;  4TNR A;  4R8Z A;  4MDZ A;  3I7A A;  2PAR A;  2PGS A;  4BZB A;  5AO1 A;  2PQ7 A;  2DQB A;  3SK9 A;  4X9E A;  3TM8 A;  3MEM A;  4QFZ A;  3HC1 A;  3NQW A;  4RXS A;  4QQW A;  2O08 A;  3S4L A;  5TK9 A;  4L1J B;  4QG4 A;  4TNY A;  4QG2 A;  3KQ5 A;  3SKD A;  2HEK A;  4TNX A;  4MZ7 A;  4QG0 A;  4TNP A;  3U1N A;  4QQZ A;  2PAU A;  4MLN A;  4L1J A;  2GZ4 A;  4TO0 A; 
#chains in the Genus database with same CATH homology
 4MLM A;  5AO0 A;  2OGI A;  3M1T A;  1U6Z A;  4RXO A;  2O6I A;  4MCW A;  3MZO A;  4TO5 A;  5TK6 A;  4QQY A;  4ZWE A;  4RXQ A;  3TMC A;  4ZWG A;  4QFX A;  4TNQ A;  4XDS A;  2Q14 A;  3IRH A;  4N71 A;  1VQR A;  3HI0 A;  4QFY A;  5TKA A;  4DMB A;  3KH1 A;  4BZC A;  2PAQ A;  3LJX A;  2FLO A;  1YNB A;  5TK7 A;  4TO6 A;  3P3Q A;  2CQZ A;  4N6W A;  4TO1 A;  4LRL A;  4QG1 A;  4ME4 A;  1VJ7 A;  3GW7 A;  3RF0 A;  4Q2D A;  4RXP A;  4TO2 A;  5TK8 A;  3TMB A;  5AO3 A;  5AO2 A;  3CCG A;  3BG2 A;  4Q2C A;  4TNZ A;  4L7E A;  4TO4 A;  5AO4 A;  3NR1 A;  1XX7 A;  4Q7H A;  4TO3 A;  4QQX A;  4L7W A;  1YOY A;  4RXR A;  3TMD A;  4TNR A;  4R8Z A;  4MDZ A;  3I7A A;  2PAR A;  2PGS A;  4BZB A;  5AO1 A;  2PQ7 A;  2DQB A;  3SK9 A;  4X9E A;  3TM8 A;  3MEM A;  4QFZ A;  3HC1 A;  3NQW A;  4RXS A;  4QQW A;  2O08 A;  3S4L A;  5TK9 A;  4L1J B;  4QG4 A;  4TNY A;  4QG2 A;  3KQ5 A;  3SKD A;  2HEK A;  4TNX A;  4MZ7 A;  4QG0 A;  4TNP A;  3U1N A;  4QQZ A;  2PAU A;  4MLN A;  4L1J A;  2GZ4 A;  4TO0 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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