4RXQA

The structure of gtp-dutp-bound samhd1
Total Genus 168
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
168
sequence length
486
structure length
481
Chain Sequence
TMKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASHNRFEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCHDLGHGPFSHMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPEEDIYFIKEQIVGPLESLWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFARDCHHLGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNSLHRRAYQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDDMEAYTKLTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKIKREDYESLPKEVASAKPKVLLDVKLKAEDFIVDVINMDYGMQEKNPIDHVSFYCKTAPNRAIRITKNQVSQLLPEKFAEQLIRVYCKKVDRKSLYAARQYFVQWCADRNFTKPQDGDVIAPLITPQKKEWN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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molecule tags Hydrolase
molecule keywords Deoxynucleoside triphosphate triphosphohydrolase SAMHD1
publication title The mechanism of substrate-controlled allosteric regulation of SAMHD1 activated by GTP.
pubmed doi rcsb
source organism Homo sapiens
total genus 168
structure length 481
sequence length 486
chains with identical sequence B
ec nomenclature ec 3.1.5.-:
pdb deposition date 2014-12-11

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01966 HD HD domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.3210.10 Mainly Alpha Orthogonal Bundle Hypothetical protein af1432 Hypothetical protein af1432 4rxqA01
4L7EA 1VQRA 5TK6A 3M1TA 4RXRA 2GZ4A 4XDSA 2FLOA 2PQ7A 4L1JB 3LJXA 4RXPA 3HI0A 4TO2A 4TNZA 4LRLA 2O08A 4MLMA 4N6WA 3NR1A 4TO1A 4MZ7A 1YNBA 4X9EA 4TNXA 2OGIA 4TNQA 3KH1A 2Q14A 4ZWEA 5TK8A 3NQWA 4MLNA 5TK9A 4TNPA 3TMBA 4RXSA 4QFXA 3MZOA 4ZWGA 4TO4A 3MEMA 4MDZA 3TMDA 1XX7A 4Q7HA 3IRHA 5AO2A 5TKAA 4TNRA 4R8ZA 4TO0A 4QG2A 4BZBA 3BG2A 3U1NA 3P3QA 4BZCA 5AO4A 4TO5A 3CCGA 4QG0A 3TMCA 2PARA 2PAQA 4L1JA 2DQBA 2CQZA 4TO3A 4L7WA 1U6ZA 4QG1A 3I7AA 5AO1A 2O6IA 5AO3A 2PAUA 4TO6A 3HC1A 5AO0A 5TK7A 2PGSA 1YOYA 4ME4A 1VJ7A 4RXQA 2HEKA 4QG4A 4TNYA 4N71A 3TM8A 4QFZA 4DMBA 3RF0A 4MCWA 4RXOA 4QFYA
chains in the Genus database with same CATH superfamily
4L7EA 1VQRA 5TK6A 3M1TA 4RXRA 2GZ4A 4Q2DA 4XDSA 2FLOA 2PQ7A 4L1JB 3LJXA 4RXPA 3HI0A 4TO2A 4TNZA 4LRLA 4QQZA 2O08A 4MLMA 4N6WA 3NR1A 4TO1A 4MZ7A 1YNBA 4X9EA 4TNXA 2OGIA 4TNQA 3SK9A 3SKDA 3KH1A 2Q14A 4ZWEA 5TK8A 3NQWA 3KQ5A 4MLNA 5TK9A 4QQYA 4TNPA 3TMBA 4RXSA 4QFXA 3MZOA 4ZWGA 4TO4A 3MEMA 4MDZA 3TMDA 1XX7A 4Q7HA 3IRHA 5AO2A 5TKAA 4TNRA 4R8ZA 4TO0A 4QG2A 4BZBA 3BG2A 3U1NA 3P3QA 4BZCA 5AO4A 3GW7A 4TO5A 3CCGA 4QG0A 3TMCA 2PARA 2PAQA 4L1JA 2DQBA 2CQZA 4TO3A 4L7WA 1U6ZA 4QG1A 3I7AA 5AO1A 2O6IA 5AO3A 2PAUA 4TO6A 3HC1A 5AO0A 5TK7A 2PGSA 3S4LA 1YOYA 4ME4A 1VJ7A 4RXQA 2HEKA 4QG4A 4Q2CA 4TNYA 4QQWA 4N71A 3TM8A 4QFZA 4DMBA 3RF0A 4QQXA 4MCWA 4RXOA 4QFYA
chains in the Genus database with same CATH topology
4L7EA 1VQRA 5TK6A 3M1TA 4RXRA 2GZ4A 4Q2DA 4XDSA 2FLOA 2PQ7A 4L1JB 3LJXA 4RXPA 3HI0A 4TO2A 4TNZA 4LRLA 4QQZA 2O08A 4MLMA 4N6WA 3NR1A 4TO1A 4MZ7A 1YNBA 4X9EA 4TNXA 2OGIA 4TNQA 3SK9A 3SKDA 3KH1A 2Q14A 4ZWEA 5TK8A 3NQWA 3KQ5A 4MLNA 5TK9A 4QQYA 4TNPA 3TMBA 4RXSA 4QFXA 3MZOA 4ZWGA 4TO4A 3MEMA 4MDZA 3TMDA 1XX7A 4Q7HA 3IRHA 5AO2A 5TKAA 4TNRA 4R8ZA 4TO0A 4QG2A 4BZBA 3BG2A 3U1NA 3P3QA 4BZCA 5AO4A 3GW7A 4TO5A 3CCGA 4QG0A 3TMCA 2PARA 2PAQA 4L1JA 2DQBA 2CQZA 4TO3A 4L7WA 1U6ZA 4QG1A 3I7AA 5AO1A 2O6IA 5AO3A 2PAUA 4TO6A 3HC1A 5AO0A 5TK7A 2PGSA 3S4LA 1YOYA 4ME4A 1VJ7A 4RXQA 2HEKA 4QG4A 4Q2CA 4TNYA 4QQWA 4N71A 3TM8A 4QFZA 4DMBA 3RF0A 4QQXA 4MCWA 4RXOA 4QFYA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 4L7E A;  1VQR A;  5TK6 A;  3M1T A;  4RXR A;  2GZ4 A;  4XDS A;  2FLO A;  2PQ7 A;  4L1J B;  3LJX A;  4RXP A;  3HI0 A;  4TO2 A;  4TNZ A;  4LRL A;  2O08 A;  4MLM A;  4N6W A;  3NR1 A;  4TO1 A;  4MZ7 A;  1YNB A;  4X9E A;  4TNX A;  2OGI A;  4TNQ A;  3KH1 A;  2Q14 A;  4ZWE A;  5TK8 A;  3NQW A;  4MLN A;  5TK9 A;  4TNP A;  3TMB A;  4RXS A;  4QFX A;  3MZO A;  4ZWG A;  4TO4 A;  3MEM A;  4MDZ A;  3TMD A;  1XX7 A;  4Q7H A;  3IRH A;  5AO2 A;  5TKA A;  4TNR A;  4R8Z A;  4TO0 A;  4QG2 A;  4BZB A;  3BG2 A;  3U1N A;  3P3Q A;  4BZC A;  5AO4 A;  4TO5 A;  3CCG A;  4QG0 A;  3TMC A;  2PAR A;  2PAQ A;  4L1J A;  2DQB A;  2CQZ A;  4TO3 A;  4L7W A;  1U6Z A;  4QG1 A;  3I7A A;  5AO1 A;  2O6I A;  5AO3 A;  2PAU A;  4TO6 A;  3HC1 A;  5AO0 A;  5TK7 A;  2PGS A;  1YOY A;  4ME4 A;  1VJ7 A;  4RXQ A;  2HEK A;  4QG4 A;  4TNY A;  4N71 A;  3TM8 A;  4QFZ A;  4DMB A;  3RF0 A;  4MCW A;  4RXO A;  4QFY A; 
#chains in the Genus database with same CATH topology
 4L7E A;  1VQR A;  5TK6 A;  3M1T A;  4RXR A;  2GZ4 A;  4Q2D A;  4XDS A;  2FLO A;  2PQ7 A;  4L1J B;  3LJX A;  4RXP A;  3HI0 A;  4TO2 A;  4TNZ A;  4LRL A;  4QQZ A;  2O08 A;  4MLM A;  4N6W A;  3NR1 A;  4TO1 A;  4MZ7 A;  1YNB A;  4X9E A;  4TNX A;  2OGI A;  4TNQ A;  3SK9 A;  3SKD A;  3KH1 A;  2Q14 A;  4ZWE A;  5TK8 A;  3NQW A;  3KQ5 A;  4MLN A;  5TK9 A;  4QQY A;  4TNP A;  3TMB A;  4RXS A;  4QFX A;  3MZO A;  4ZWG A;  4TO4 A;  3MEM A;  4MDZ A;  3TMD A;  1XX7 A;  4Q7H A;  3IRH A;  5AO2 A;  5TKA A;  4TNR A;  4R8Z A;  4TO0 A;  4QG2 A;  4BZB A;  3BG2 A;  3U1N A;  3P3Q A;  4BZC A;  5AO4 A;  3GW7 A;  4TO5 A;  3CCG A;  4QG0 A;  3TMC A;  2PAR A;  2PAQ A;  4L1J A;  2DQB A;  2CQZ A;  4TO3 A;  4L7W A;  1U6Z A;  4QG1 A;  3I7A A;  5AO1 A;  2O6I A;  5AO3 A;  2PAU A;  4TO6 A;  3HC1 A;  5AO0 A;  5TK7 A;  2PGS A;  3S4L A;  1YOY A;  4ME4 A;  1VJ7 A;  4RXQ A;  2HEK A;  4QG4 A;  4Q2C A;  4TNY A;  4QQW A;  4N71 A;  3TM8 A;  4QFZ A;  4DMB A;  3RF0 A;  4QQX A;  4MCW A;  4RXO A;  4QFY A; 
#chains in the Genus database with same CATH homology
 4L7E A;  1VQR A;  5TK6 A;  3M1T A;  4RXR A;  2GZ4 A;  4Q2D A;  4XDS A;  2FLO A;  2PQ7 A;  4L1J B;  3LJX A;  4RXP A;  3HI0 A;  4TO2 A;  4TNZ A;  4LRL A;  4QQZ A;  2O08 A;  4MLM A;  4N6W A;  3NR1 A;  4TO1 A;  4MZ7 A;  1YNB A;  4X9E A;  4TNX A;  2OGI A;  4TNQ A;  3SK9 A;  3SKD A;  3KH1 A;  2Q14 A;  4ZWE A;  5TK8 A;  3NQW A;  3KQ5 A;  4MLN A;  5TK9 A;  4QQY A;  4TNP A;  3TMB A;  4RXS A;  4QFX A;  3MZO A;  4ZWG A;  4TO4 A;  3MEM A;  4MDZ A;  3TMD A;  1XX7 A;  4Q7H A;  3IRH A;  5AO2 A;  5TKA A;  4TNR A;  4R8Z A;  4TO0 A;  4QG2 A;  4BZB A;  3BG2 A;  3U1N A;  3P3Q A;  4BZC A;  5AO4 A;  3GW7 A;  4TO5 A;  3CCG A;  4QG0 A;  3TMC A;  2PAR A;  2PAQ A;  4L1J A;  2DQB A;  2CQZ A;  4TO3 A;  4L7W A;  1U6Z A;  4QG1 A;  3I7A A;  5AO1 A;  2O6I A;  5AO3 A;  2PAU A;  4TO6 A;  3HC1 A;  5AO0 A;  5TK7 A;  2PGS A;  3S4L A;  1YOY A;  4ME4 A;  1VJ7 A;  4RXQ A;  2HEK A;  4QG4 A;  4Q2C A;  4TNY A;  4QQW A;  4N71 A;  3TM8 A;  4QFZ A;  4DMB A;  3RF0 A;  4QQX A;  4MCW A;  4RXO A;  4QFY A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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