4Q7HA

Crystal structure of samhd1 catalytic core with gtp
Total Genus 149
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
149
sequence length
470
structure length
459
Chain Sequence
MKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASHNRFEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCHDLGHGPFSHMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPEEDIYFIKEQIVGPLESPDSLWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFARDCHHLGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNSLHRRAYQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDDMEAYTKLTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKIKREDYESLPKEVASAKPKVLLDVKLKAEDFIVDVINMDYQEKNPIDHVSFYCKTAPNRAIRITLPEKFAEQLIRVYCKKVDRKSLYAARQYFVQWCADRNFTKPQDG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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publication title Structural insight into activation mechanism of SAMHD1
rcsb
molecule keywords Deoxynucleoside triphosphate triphosphohydrolase SAMHD1
molecule tags Hydrolase
source organism Homo sapiens
total genus 149
structure length 459
sequence length 470
chains with identical sequence B, C, D
ec nomenclature ec 3.1.5.-:
pdb deposition date 2014-04-25

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01966 HD HD domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.3210.10 Mainly Alpha Orthogonal Bundle Hypothetical protein af1432 Hypothetical protein af1432 4q7hA01
4ZWEA 4MLMA 4DMBA 4TO4A 5TK7A 4TNYA 1VJ7A 4QG1A 3I7AA 3HC1A 4RXQA 4TNQA 3P3QA 1U6ZA 3LJXA 4MLNA 4XDSA 1YNBA 4QFZA 2OGIA 4TO6A 4TNZA 3HI0A 4R8ZA 2O08A 4L1JB 4RXPA 4TNXA 2HEKA 5AO1A 4N6WA 3U1NA 4BZBA 4TNRA 3TMBA 3TM8A 5AO0A 5AO2A 4LRLA 2FLOA 3BG2A 4L7WA 4QG0A 3TMDA 2CQZA 4Q7HA 2DQBA 3IRHA 4MZ7A 2PAQA 4QFXA 4ZWGA 5TK8A 4QFYA 4TO5A 4X9EA 2PGSA 3RF0A 2PQ7A 3NR1A 5TKAA 4L1JA 4RXRA 1YOYA 4MCWA 2O6IA 3MZOA 4RXSA 5TK6A 4TO2A 3KH1A 4QG4A 4TO1A 4L7EA 3TMCA 3MEMA 4MDZA 5TK9A 2Q14A 4RXOA 1VQRA 2GZ4A 2PARA 5AO4A 2PAUA 4QG2A 1XX7A 5AO3A 4N71A 4TNPA 4TO3A 4BZCA 4ME4A 3CCGA 3NQWA 3M1TA 4TO0A
chains in the Genus database with same CATH superfamily
4ZWEA 4MLMA 4DMBA 4TO4A 5TK7A 4TNYA 1VJ7A 4QG1A 3I7AA 3HC1A 4RXQA 4Q2CA 4TNQA 3P3QA 1U6ZA 3LJXA 4MLNA 4QQWA 4QQYA 4XDSA 1YNBA 4QFZA 2OGIA 4Q2DA 4TO6A 4TNZA 3HI0A 4R8ZA 2O08A 4L1JB 4RXPA 4TNXA 2HEKA 5AO1A 4N6WA 3U1NA 4BZBA 4TNRA 3TMBA 3TM8A 5AO0A 3SKDA 5AO2A 4LRLA 2FLOA 3BG2A 4L7WA 4QG0A 3TMDA 2CQZA 4Q7HA 2DQBA 3IRHA 4MZ7A 2PAQA 4QFXA 4ZWGA 5TK8A 4QFYA 4TO5A 4X9EA 2PGSA 3RF0A 2PQ7A 3SK9A 3NR1A 5TKAA 4L1JA 4RXRA 1YOYA 4MCWA 2O6IA 3MZOA 4RXSA 5TK6A 4TO2A 3KH1A 4QG4A 4TO1A 4L7EA 3TMCA 3MEMA 4MDZA 5TK9A 2Q14A 4RXOA 4QQZA 1VQRA 2GZ4A 3GW7A 2PARA 3KQ5A 5AO4A 2PAUA 4QG2A 1XX7A 5AO3A 3S4LA 4N71A 4TNPA 4TO3A 4BZCA 4ME4A 3CCGA 4QQXA 3NQWA 3M1TA 4TO0A
chains in the Genus database with same CATH topology
4ZWEA 4MLMA 4DMBA 4TO4A 5TK7A 4TNYA 1VJ7A 4QG1A 3I7AA 3HC1A 4RXQA 4Q2CA 4TNQA 3P3QA 1U6ZA 3LJXA 4MLNA 4QQWA 4QQYA 4XDSA 1YNBA 4QFZA 2OGIA 4Q2DA 4TO6A 4TNZA 3HI0A 4R8ZA 2O08A 4L1JB 4RXPA 4TNXA 2HEKA 5AO1A 4N6WA 3U1NA 4BZBA 4TNRA 3TMBA 3TM8A 5AO0A 3SKDA 5AO2A 4LRLA 2FLOA 3BG2A 4L7WA 4QG0A 3TMDA 2CQZA 4Q7HA 2DQBA 3IRHA 4MZ7A 2PAQA 4QFXA 4ZWGA 5TK8A 4QFYA 4TO5A 4X9EA 2PGSA 3RF0A 2PQ7A 3SK9A 3NR1A 5TKAA 4L1JA 4RXRA 1YOYA 4MCWA 2O6IA 3MZOA 4RXSA 5TK6A 4TO2A 3KH1A 4QG4A 4TO1A 4L7EA 3TMCA 3MEMA 4MDZA 5TK9A 2Q14A 4RXOA 4QQZA 1VQRA 2GZ4A 3GW7A 2PARA 3KQ5A 5AO4A 2PAUA 4QG2A 1XX7A 5AO3A 3S4LA 4N71A 4TNPA 4TO3A 4BZCA 4ME4A 3CCGA 4QQXA 3NQWA 3M1TA 4TO0A
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 4ZWE A;  4MLM A;  4DMB A;  4TO4 A;  5TK7 A;  4TNY A;  1VJ7 A;  4QG1 A;  3I7A A;  3HC1 A;  4RXQ A;  4TNQ A;  3P3Q A;  1U6Z A;  3LJX A;  4MLN A;  4XDS A;  1YNB A;  4QFZ A;  2OGI A;  4TO6 A;  4TNZ A;  3HI0 A;  4R8Z A;  2O08 A;  4L1J B;  4RXP A;  4TNX A;  2HEK A;  5AO1 A;  4N6W A;  3U1N A;  4BZB A;  4TNR A;  3TMB A;  3TM8 A;  5AO0 A;  5AO2 A;  4LRL A;  2FLO A;  3BG2 A;  4L7W A;  4QG0 A;  3TMD A;  2CQZ A;  4Q7H A;  2DQB A;  3IRH A;  4MZ7 A;  2PAQ A;  4QFX A;  4ZWG A;  5TK8 A;  4QFY A;  4TO5 A;  4X9E A;  2PGS A;  3RF0 A;  2PQ7 A;  3NR1 A;  5TKA A;  4L1J A;  4RXR A;  1YOY A;  4MCW A;  2O6I A;  3MZO A;  4RXS A;  5TK6 A;  4TO2 A;  3KH1 A;  4QG4 A;  4TO1 A;  4L7E A;  3TMC A;  3MEM A;  4MDZ A;  5TK9 A;  2Q14 A;  4RXO A;  1VQR A;  2GZ4 A;  2PAR A;  5AO4 A;  2PAU A;  4QG2 A;  1XX7 A;  5AO3 A;  4N71 A;  4TNP A;  4TO3 A;  4BZC A;  4ME4 A;  3CCG A;  3NQW A;  3M1T A;  4TO0 A; 
#chains in the Genus database with same CATH topology
 4ZWE A;  4MLM A;  4DMB A;  4TO4 A;  5TK7 A;  4TNY A;  1VJ7 A;  4QG1 A;  3I7A A;  3HC1 A;  4RXQ A;  4Q2C A;  4TNQ A;  3P3Q A;  1U6Z A;  3LJX A;  4MLN A;  4QQW A;  4QQY A;  4XDS A;  1YNB A;  4QFZ A;  2OGI A;  4Q2D A;  4TO6 A;  4TNZ A;  3HI0 A;  4R8Z A;  2O08 A;  4L1J B;  4RXP A;  4TNX A;  2HEK A;  5AO1 A;  4N6W A;  3U1N A;  4BZB A;  4TNR A;  3TMB A;  3TM8 A;  5AO0 A;  3SKD A;  5AO2 A;  4LRL A;  2FLO A;  3BG2 A;  4L7W A;  4QG0 A;  3TMD A;  2CQZ A;  4Q7H A;  2DQB A;  3IRH A;  4MZ7 A;  2PAQ A;  4QFX A;  4ZWG A;  5TK8 A;  4QFY A;  4TO5 A;  4X9E A;  2PGS A;  3RF0 A;  2PQ7 A;  3SK9 A;  3NR1 A;  5TKA A;  4L1J A;  4RXR A;  1YOY A;  4MCW A;  2O6I A;  3MZO A;  4RXS A;  5TK6 A;  4TO2 A;  3KH1 A;  4QG4 A;  4TO1 A;  4L7E A;  3TMC A;  3MEM A;  4MDZ A;  5TK9 A;  2Q14 A;  4RXO A;  4QQZ A;  1VQR A;  2GZ4 A;  3GW7 A;  2PAR A;  3KQ5 A;  5AO4 A;  2PAU A;  4QG2 A;  1XX7 A;  5AO3 A;  3S4L A;  4N71 A;  4TNP A;  4TO3 A;  4BZC A;  4ME4 A;  3CCG A;  4QQX A;  3NQW A;  3M1T A;  4TO0 A; 
#chains in the Genus database with same CATH homology
 4ZWE A;  4MLM A;  4DMB A;  4TO4 A;  5TK7 A;  4TNY A;  1VJ7 A;  4QG1 A;  3I7A A;  3HC1 A;  4RXQ A;  4Q2C A;  4TNQ A;  3P3Q A;  1U6Z A;  3LJX A;  4MLN A;  4QQW A;  4QQY A;  4XDS A;  1YNB A;  4QFZ A;  2OGI A;  4Q2D A;  4TO6 A;  4TNZ A;  3HI0 A;  4R8Z A;  2O08 A;  4L1J B;  4RXP A;  4TNX A;  2HEK A;  5AO1 A;  4N6W A;  3U1N A;  4BZB A;  4TNR A;  3TMB A;  3TM8 A;  5AO0 A;  3SKD A;  5AO2 A;  4LRL A;  2FLO A;  3BG2 A;  4L7W A;  4QG0 A;  3TMD A;  2CQZ A;  4Q7H A;  2DQB A;  3IRH A;  4MZ7 A;  2PAQ A;  4QFX A;  4ZWG A;  5TK8 A;  4QFY A;  4TO5 A;  4X9E A;  2PGS A;  3RF0 A;  2PQ7 A;  3SK9 A;  3NR1 A;  5TKA A;  4L1J A;  4RXR A;  1YOY A;  4MCW A;  2O6I A;  3MZO A;  4RXS A;  5TK6 A;  4TO2 A;  3KH1 A;  4QG4 A;  4TO1 A;  4L7E A;  3TMC A;  3MEM A;  4MDZ A;  5TK9 A;  2Q14 A;  4RXO A;  4QQZ A;  1VQR A;  2GZ4 A;  3GW7 A;  2PAR A;  3KQ5 A;  5AO4 A;  2PAU A;  4QG2 A;  1XX7 A;  5AO3 A;  3S4L A;  4N71 A;  4TNP A;  4TO3 A;  4BZC A;  4ME4 A;  3CCG A;  4QQX A;  3NQW A;  3M1T A;  4TO0 A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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