4Q7H | Genus

Total Genus 149

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	149
sequence length	470
structure length	459
Chain Sequence	MKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASHNRFEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCHDLGHGPFSHMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPEEDIYFIKEQIVGPLESPDSLWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFARDCHHLGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNSLHRRAYQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDDMEAYTKLTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKIKREDYESLPKEVASAKPKVLLDVKLKAEDFIVDVINMDYQEKNPIDHVSFYCKTAPNRAIRITLPEKFAEQLIRVYCKKVDRKSLYAARQYFVQWCADRNFTKPQDG

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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

Chord Diagram

molecule tags	Hydrolase
source organism	Homo sapiens
publication title	Structural insight into activation mechanism of SAMHD1 rcsb
molecule keywords	Deoxynucleoside triphosphate triphosphohydrolase SAMHD1
total genus	149
structure length	459
sequence length	470
chains with identical sequence	B, C, D
ec nomenclature	ec 3.1.5.-:
pdb deposition date	2014-04-25

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF01966	HD	HD domain

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
1.10.3210.10	Mainly Alpha	Orthogonal Bundle	Hypothetical protein af1432	Hypothetical protein af1432	4q7hA01

2O6IA 4ZWEA 4X9EA 4QG0A 4MDZA 4L1JA 3HI0A 2Q14A 1XX7A 4TO1A 1YNBA 4QFYA 5TK8A 3TMCA 5AO1A 5TKAA 2CQZA 5AO0A 4QG2A 4LRLA 4TO0A 4DMBA 2PARA 2FLOA 4MLNA 4TO2A 4QG1A 1VQRA 4RXPA 4TNPA 4TNQA 5AO4A 4N6WA 2HEKA 3CCGA 3I7AA 4RXRA 4MCWA 4Q7HA 4TNXA 3HC1A 3KH1A 2GZ4A 4L1JB 2DQBA 4N71A 1U6ZA 4TNRA 4TO3A 3IRHA 4L7WA 2PAQA 5AO2A 3M1TA 3NQWA 3TMBA 4L7EA 4QFZA 4RXQA 3NR1A 5TK9A 3RF0A 3P3QA 2PGSA 4RXSA 2PAUA 4MLMA 4ZWGA 3LJXA 3MEMA 4XDSA 4TNYA 4MZ7A 5AO3A 4TNZA 5TK7A 5TK6A 4TO5A 4QFXA 3TMDA 4BZBA 4BZCA 4TO4A 3BG2A 2PQ7A 1VJ7A 3MZOA 4RXOA 4R8ZA 4TO6A 4ME4A 2O08A 1YOYA 2OGIA 4QG4A 3U1NA 3TM8A
chains in the Genus database with same CATH superfamily

2O6IA 4ZWEA 4X9EA 4QG0A 4MDZA 4L1JA 3HI0A 2Q14A 1XX7A 4TO1A 1YNBA 4QFYA 5TK8A 3TMCA 5AO1A 5TKAA 2CQZA 4Q2DA 4QG2A 5AO0A 4LRLA 4TO0A 4DMBA 2PARA 2FLOA 3GW7A 3S4LA 4MLNA 4TO2A 3KQ5A 4QG1A 1VQRA 4RXPA 3SK9A 4TNPA 4TNQA 5AO4A 4N6WA 2HEKA 3CCGA 3I7AA 4RXRA 4MCWA 4Q7HA 4TNXA 4QQXA 3HC1A 3KH1A 2GZ4A 4L1JB 2DQBA 4N71A 1U6ZA 4Q2CA 4TNRA 4TO3A 3IRHA 4L7WA 2PAQA 5AO2A 3M1TA 3NQWA 3TMBA 4L7EA 4QFZA 4RXQA 3NR1A 5TK9A 3RF0A 3P3QA 2PGSA 4RXSA 2PAUA 4QQWA 4MLMA 4ZWGA 3LJXA 3MEMA 4XDSA 4TNYA 4MZ7A 5AO3A 4TNZA 5TK7A 5TK6A 4QQYA 4TO5A 4QFXA 3TMDA 4BZBA 4BZCA 4TO4A 3BG2A 2PQ7A 1VJ7A 3MZOA 4RXOA 3SKDA 4R8ZA 4QQZA 4TO6A 4ME4A 2O08A 1YOYA 2OGIA 4QG4A 3U1NA 3TM8A
chains in the Genus database with same CATH topology

#chains in the Genus database with same CATH superfamily
 2O6I A;  4ZWE A;  4X9E A;  4QG0 A;  4MDZ A;  4L1J A;  3HI0 A;  2Q14 A;  1XX7 A;  4TO1 A;  1YNB A;  4QFY A;  5TK8 A;  3TMC A;  5AO1 A;  5TKA A;  2CQZ A;  5AO0 A;  4QG2 A;  4LRL A;  4TO0 A;  4DMB A;  2PAR A;  2FLO A;  4MLN A;  4TO2 A;  4QG1 A;  1VQR A;  4RXP A;  4TNP A;  4TNQ A;  5AO4 A;  4N6W A;  2HEK A;  3CCG A;  3I7A A;  4RXR A;  4MCW A;  4Q7H A;  4TNX A;  3HC1 A;  3KH1 A;  2GZ4 A;  4L1J B;  2DQB A;  4N71 A;  1U6Z A;  4TNR A;  4TO3 A;  3IRH A;  4L7W A;  2PAQ A;  5AO2 A;  3M1T A;  3NQW A;  3TMB A;  4L7E A;  4QFZ A;  4RXQ A;  3NR1 A;  5TK9 A;  3RF0 A;  3P3Q A;  2PGS A;  4RXS A;  2PAU A;  4MLM A;  4ZWG A;  3LJX A;  3MEM A;  4XDS A;  4TNY A;  4MZ7 A;  5AO3 A;  4TNZ A;  5TK7 A;  5TK6 A;  4TO5 A;  4QFX A;  3TMD A;  4BZB A;  4BZC A;  4TO4 A;  3BG2 A;  2PQ7 A;  1VJ7 A;  3MZO A;  4RXO A;  4R8Z A;  4TO6 A;  4ME4 A;  2O08 A;  1YOY A;  2OGI A;  4QG4 A;  3U1N A;  3TM8 A; 
#chains in the Genus database with same CATH topology
 2O6I A;  4ZWE A;  4X9E A;  4QG0 A;  4MDZ A;  4L1J A;  3HI0 A;  2Q14 A;  1XX7 A;  4TO1 A;  1YNB A;  4QFY A;  5TK8 A;  3TMC A;  5AO1 A;  5TKA A;  2CQZ A;  4Q2D A;  4QG2 A;  5AO0 A;  4LRL A;  4TO0 A;  4DMB A;  2PAR A;  2FLO A;  3GW7 A;  3S4L A;  4MLN A;  4TO2 A;  3KQ5 A;  4QG1 A;  1VQR A;  4RXP A;  3SK9 A;  4TNP A;  4TNQ A;  5AO4 A;  4N6W A;  2HEK A;  3CCG A;  3I7A A;  4RXR A;  4MCW A;  4Q7H A;  4TNX A;  4QQX A;  3HC1 A;  3KH1 A;  2GZ4 A;  4L1J B;  2DQB A;  4N71 A;  1U6Z A;  4Q2C A;  4TNR A;  4TO3 A;  3IRH A;  4L7W A;  2PAQ A;  5AO2 A;  3M1T A;  3NQW A;  3TMB A;  4L7E A;  4QFZ A;  4RXQ A;  3NR1 A;  5TK9 A;  3RF0 A;  3P3Q A;  2PGS A;  4RXS A;  2PAU A;  4QQW A;  4MLM A;  4ZWG A;  3LJX A;  3MEM A;  4XDS A;  4TNY A;  4MZ7 A;  5AO3 A;  4TNZ A;  5TK7 A;  5TK6 A;  4QQY A;  4TO5 A;  4QFX A;  3TMD A;  4BZB A;  4BZC A;  4TO4 A;  3BG2 A;  2PQ7 A;  1VJ7 A;  3MZO A;  4RXO A;  3SKD A;  4R8Z A;  4QQZ A;  4TO6 A;  4ME4 A;  2O08 A;  1YOY A;  2OGI A;  4QG4 A;  3U1N A;  3TM8 A; 
#chains in the Genus database with same CATH homology
 2O6I A;  4ZWE A;  4X9E A;  4QG0 A;  4MDZ A;  4L1J A;  3HI0 A;  2Q14 A;  1XX7 A;  4TO1 A;  1YNB A;  4QFY A;  5TK8 A;  3TMC A;  5AO1 A;  5TKA A;  2CQZ A;  4Q2D A;  4QG2 A;  5AO0 A;  4LRL A;  4TO0 A;  4DMB A;  2PAR A;  2FLO A;  3GW7 A;  3S4L A;  4MLN A;  4TO2 A;  3KQ5 A;  4QG1 A;  1VQR A;  4RXP A;  3SK9 A;  4TNP A;  4TNQ A;  5AO4 A;  4N6W A;  2HEK A;  3CCG A;  3I7A A;  4RXR A;  4MCW A;  4Q7H A;  4TNX A;  4QQX A;  3HC1 A;  3KH1 A;  2GZ4 A;  4L1J B;  2DQB A;  4N71 A;  1U6Z A;  4Q2C A;  4TNR A;  4TO3 A;  3IRH A;  4L7W A;  2PAQ A;  5AO2 A;  3M1T A;  3NQW A;  3TMB A;  4L7E A;  4QFZ A;  4RXQ A;  3NR1 A;  5TK9 A;  3RF0 A;  3P3Q A;  2PGS A;  4RXS A;  2PAU A;  4QQW A;  4MLM A;  4ZWG A;  3LJX A;  3MEM A;  4XDS A;  4TNY A;  4MZ7 A;  5AO3 A;  4TNZ A;  5TK7 A;  5TK6 A;  4QQY A;  4TO5 A;  4QFX A;  3TMD A;  4BZB A;  4BZC A;  4TO4 A;  3BG2 A;  2PQ7 A;  1VJ7 A;  3MZO A;  4RXO A;  3SKD A;  4R8Z A;  4QQZ A;  4TO6 A;  4ME4 A;  2O08 A;  1YOY A;  2OGI A;  4QG4 A;  3U1N A;  3TM8 A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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4Q7HA

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

Chord Diagram

connected with : NaN

pfam database annotations