4Q7HA

Crystal structure of samhd1 catalytic core with gtp
Total Genus 149
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
149
sequence length
470
structure length
459
Chain Sequence
MKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASHNRFEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCHDLGHGPFSHMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPEEDIYFIKEQIVGPLESPDSLWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFARDCHHLGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNSLHRRAYQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDDMEAYTKLTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKIKREDYESLPKEVASAKPKVLLDVKLKAEDFIVDVINMDYQEKNPIDHVSFYCKTAPNRAIRITLPEKFAEQLIRVYCKKVDRKSLYAARQYFVQWCADRNFTKPQDG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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publication title Structural insight into activation mechanism of SAMHD1
rcsb
molecule keywords Deoxynucleoside triphosphate triphosphohydrolase SAMHD1
molecule tags Hydrolase
source organism Homo sapiens
total genus 149
structure length 459
sequence length 470
chains with identical sequence B, C, D
ec nomenclature ec 3.1.5.-:
pdb deposition date 2014-04-25

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01966 HD HD domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.3210.10 Mainly Alpha Orthogonal Bundle Hypothetical protein af1432 Hypothetical protein af1432 4q7hA01
3TMBA 5TKAA 2FLOA 5TK8A 4RXRA 3KH1A 4DMBA 3TMCA 2O6IA 3NQWA 5AO3A 4QFXA 3RF0A 5AO0A 4LRLA 1YOYA 1YNBA 5TK7A 4BZBA 4QG4A 4Q7HA 4ZWEA 3CCGA 4QFZA 4N71A 4RXPA 1VJ7A 2PARA 2OGIA 4XDSA 4MDZA 3I7AA 4RXQA 4R8ZA 2Q14A 4RXSA 3NR1A 1XX7A 4TO1A 2HEKA 4TNQA 4QG1A 3M1TA 4BZCA 4TO5A 4MCWA 4ME4A 3BG2A 5AO2A 4MLNA 2PGSA 1VQRA 4TO0A 4TNRA 3TMDA 4TNXA 5AO1A 4L7EA 4L7WA 5AO4A 4N6WA 1U6ZA 4TO3A 4L1JA 4TNZA 4X9EA 2CQZA 4ZWGA 2PAUA 4TO4A 4RXOA 3TM8A 3U1NA 2GZ4A 3LJXA 4TO2A 3P3QA 4MLMA 3HC1A 4QG0A 3IRHA 2PAQA 3MEMA 4L1JB 4MZ7A 4QFYA 5TK6A 4TNPA 2O08A 3HI0A 2PQ7A 4QG2A 2DQBA 4TO6A 3MZOA 4TNYA 5TK9A
chains in the Genus database with same CATH superfamily
3TMBA 5TKAA 3SK9A 2FLOA 5TK8A 4RXRA 3KH1A 4DMBA 3TMCA 2O6IA 3NQWA 5AO3A 4QFXA 3RF0A 4Q2CA 5AO0A 4LRLA 1YOYA 1YNBA 5TK7A 4BZBA 4QG4A 4Q7HA 4ZWEA 3CCGA 4QFZA 4N71A 4RXPA 1VJ7A 2PARA 2OGIA 4XDSA 4MDZA 3GW7A 3I7AA 4RXQA 4R8ZA 4QQXA 2Q14A 4RXSA 3NR1A 1XX7A 4TO1A 2HEKA 4TNQA 4QG1A 3SKDA 3M1TA 4BZCA 4TO5A 4MCWA 4QQYA 4ME4A 3BG2A 5AO2A 4MLNA 2PGSA 1VQRA 4TO0A 4TNRA 3TMDA 4TNXA 5AO1A 4L7EA 4L7WA 5AO4A 3S4LA 4N6WA 1U6ZA 4TO3A 4L1JA 4TNZA 4X9EA 2CQZA 4ZWGA 2PAUA 4TO4A 4RXOA 3TM8A 3U1NA 2GZ4A 3LJXA 4QQZA 4TO2A 3P3QA 4MLMA 3HC1A 4QG0A 3IRHA 2PAQA 3MEMA 4L1JB 4MZ7A 4QFYA 4QQWA 4Q2DA 5TK6A 4TNPA 3KQ5A 2O08A 3HI0A 2PQ7A 4QG2A 2DQBA 4TO6A 3MZOA 4TNYA 5TK9A
chains in the Genus database with same CATH topology
3TMBA 5TKAA 3SK9A 2FLOA 5TK8A 4RXRA 3KH1A 4DMBA 3TMCA 2O6IA 3NQWA 5AO3A 4QFXA 3RF0A 4Q2CA 5AO0A 4LRLA 1YOYA 1YNBA 5TK7A 4BZBA 4QG4A 4Q7HA 4ZWEA 3CCGA 4QFZA 4N71A 4RXPA 1VJ7A 2PARA 2OGIA 4XDSA 4MDZA 3GW7A 3I7AA 4RXQA 4R8ZA 4QQXA 2Q14A 4RXSA 3NR1A 1XX7A 4TO1A 2HEKA 4TNQA 4QG1A 3SKDA 3M1TA 4BZCA 4TO5A 4MCWA 4QQYA 4ME4A 3BG2A 5AO2A 4MLNA 2PGSA 1VQRA 4TO0A 4TNRA 3TMDA 4TNXA 5AO1A 4L7EA 4L7WA 5AO4A 3S4LA 4N6WA 1U6ZA 4TO3A 4L1JA 4TNZA 4X9EA 2CQZA 4ZWGA 2PAUA 4TO4A 4RXOA 3TM8A 3U1NA 2GZ4A 3LJXA 4QQZA 4TO2A 3P3QA 4MLMA 3HC1A 4QG0A 3IRHA 2PAQA 3MEMA 4L1JB 4MZ7A 4QFYA 4QQWA 4Q2DA 5TK6A 4TNPA 3KQ5A 2O08A 3HI0A 2PQ7A 4QG2A 2DQBA 4TO6A 3MZOA 4TNYA 5TK9A
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 3TMB A;  5TKA A;  2FLO A;  5TK8 A;  4RXR A;  3KH1 A;  4DMB A;  3TMC A;  2O6I A;  3NQW A;  5AO3 A;  4QFX A;  3RF0 A;  5AO0 A;  4LRL A;  1YOY A;  1YNB A;  5TK7 A;  4BZB A;  4QG4 A;  4Q7H A;  4ZWE A;  3CCG A;  4QFZ A;  4N71 A;  4RXP A;  1VJ7 A;  2PAR A;  2OGI A;  4XDS A;  4MDZ A;  3I7A A;  4RXQ A;  4R8Z A;  2Q14 A;  4RXS A;  3NR1 A;  1XX7 A;  4TO1 A;  2HEK A;  4TNQ A;  4QG1 A;  3M1T A;  4BZC A;  4TO5 A;  4MCW A;  4ME4 A;  3BG2 A;  5AO2 A;  4MLN A;  2PGS A;  1VQR A;  4TO0 A;  4TNR A;  3TMD A;  4TNX A;  5AO1 A;  4L7E A;  4L7W A;  5AO4 A;  4N6W A;  1U6Z A;  4TO3 A;  4L1J A;  4TNZ A;  4X9E A;  2CQZ A;  4ZWG A;  2PAU A;  4TO4 A;  4RXO A;  3TM8 A;  3U1N A;  2GZ4 A;  3LJX A;  4TO2 A;  3P3Q A;  4MLM A;  3HC1 A;  4QG0 A;  3IRH A;  2PAQ A;  3MEM A;  4L1J B;  4MZ7 A;  4QFY A;  5TK6 A;  4TNP A;  2O08 A;  3HI0 A;  2PQ7 A;  4QG2 A;  2DQB A;  4TO6 A;  3MZO A;  4TNY A;  5TK9 A; 
#chains in the Genus database with same CATH topology
 3TMB A;  5TKA A;  3SK9 A;  2FLO A;  5TK8 A;  4RXR A;  3KH1 A;  4DMB A;  3TMC A;  2O6I A;  3NQW A;  5AO3 A;  4QFX A;  3RF0 A;  4Q2C A;  5AO0 A;  4LRL A;  1YOY A;  1YNB A;  5TK7 A;  4BZB A;  4QG4 A;  4Q7H A;  4ZWE A;  3CCG A;  4QFZ A;  4N71 A;  4RXP A;  1VJ7 A;  2PAR A;  2OGI A;  4XDS A;  4MDZ A;  3GW7 A;  3I7A A;  4RXQ A;  4R8Z A;  4QQX A;  2Q14 A;  4RXS A;  3NR1 A;  1XX7 A;  4TO1 A;  2HEK A;  4TNQ A;  4QG1 A;  3SKD A;  3M1T A;  4BZC A;  4TO5 A;  4MCW A;  4QQY A;  4ME4 A;  3BG2 A;  5AO2 A;  4MLN A;  2PGS A;  1VQR A;  4TO0 A;  4TNR A;  3TMD A;  4TNX A;  5AO1 A;  4L7E A;  4L7W A;  5AO4 A;  3S4L A;  4N6W A;  1U6Z A;  4TO3 A;  4L1J A;  4TNZ A;  4X9E A;  2CQZ A;  4ZWG A;  2PAU A;  4TO4 A;  4RXO A;  3TM8 A;  3U1N A;  2GZ4 A;  3LJX A;  4QQZ A;  4TO2 A;  3P3Q A;  4MLM A;  3HC1 A;  4QG0 A;  3IRH A;  2PAQ A;  3MEM A;  4L1J B;  4MZ7 A;  4QFY A;  4QQW A;  4Q2D A;  5TK6 A;  4TNP A;  3KQ5 A;  2O08 A;  3HI0 A;  2PQ7 A;  4QG2 A;  2DQB A;  4TO6 A;  3MZO A;  4TNY A;  5TK9 A; 
#chains in the Genus database with same CATH homology
 3TMB A;  5TKA A;  3SK9 A;  2FLO A;  5TK8 A;  4RXR A;  3KH1 A;  4DMB A;  3TMC A;  2O6I A;  3NQW A;  5AO3 A;  4QFX A;  3RF0 A;  4Q2C A;  5AO0 A;  4LRL A;  1YOY A;  1YNB A;  5TK7 A;  4BZB A;  4QG4 A;  4Q7H A;  4ZWE A;  3CCG A;  4QFZ A;  4N71 A;  4RXP A;  1VJ7 A;  2PAR A;  2OGI A;  4XDS A;  4MDZ A;  3GW7 A;  3I7A A;  4RXQ A;  4R8Z A;  4QQX A;  2Q14 A;  4RXS A;  3NR1 A;  1XX7 A;  4TO1 A;  2HEK A;  4TNQ A;  4QG1 A;  3SKD A;  3M1T A;  4BZC A;  4TO5 A;  4MCW A;  4QQY A;  4ME4 A;  3BG2 A;  5AO2 A;  4MLN A;  2PGS A;  1VQR A;  4TO0 A;  4TNR A;  3TMD A;  4TNX A;  5AO1 A;  4L7E A;  4L7W A;  5AO4 A;  3S4L A;  4N6W A;  1U6Z A;  4TO3 A;  4L1J A;  4TNZ A;  4X9E A;  2CQZ A;  4ZWG A;  2PAU A;  4TO4 A;  4RXO A;  3TM8 A;  3U1N A;  2GZ4 A;  3LJX A;  4QQZ A;  4TO2 A;  3P3Q A;  4MLM A;  3HC1 A;  4QG0 A;  3IRH A;  2PAQ A;  3MEM A;  4L1J B;  4MZ7 A;  4QFY A;  4QQW A;  4Q2D A;  5TK6 A;  4TNP A;  3KQ5 A;  2O08 A;  3HI0 A;  2PQ7 A;  4QG2 A;  2DQB A;  4TO6 A;  3MZO A;  4TNY A;  5TK9 A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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