4Q7HA

Crystal structure of samhd1 catalytic core with gtp
Total Genus 149
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
149
sequence length
470
structure length
459
Chain Sequence
MKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASHNRFEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCHDLGHGPFSHMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPEEDIYFIKEQIVGPLESPDSLWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFARDCHHLGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNSLHRRAYQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDDMEAYTKLTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKIKREDYESLPKEVASAKPKVLLDVKLKAEDFIVDVINMDYQEKNPIDHVSFYCKTAPNRAIRITLPEKFAEQLIRVYCKKVDRKSLYAARQYFVQWCADRNFTKPQDG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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publication title Structural insight into activation mechanism of SAMHD1
rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords Deoxynucleoside triphosphate triphosphohydrolase SAMHD1
total genus 149
structure length 459
sequence length 470
chains with identical sequence B, C, D
ec nomenclature ec 3.1.5.-:
pdb deposition date 2014-04-25

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01966 HD HD domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.3210.10 Mainly Alpha Orthogonal Bundle Hypothetical protein af1432 Hypothetical protein af1432 4q7hA01
4QG1A 4QFZA 5TK9A 4TO3A 1YOYA 2PGSA 4XDSA 3TM8A 4TO5A 2FLOA 3P3QA 4RXRA 5AO3A 1VQRA 3MZOA 3RF0A 3NQWA 4Q7HA 4QFYA 4TNXA 4QG4A 3KH1A 4RXPA 4L1JA 4MZ7A 4TO0A 2Q14A 4TNQA 3M1TA 4TNPA 1YNBA 5TK8A 4N6WA 4ME4A 4MLNA 4TO2A 3TMBA 5AO2A 4L1JB 3HC1A 3LJXA 4RXQA 4ZWGA 5TK7A 4LRLA 2DQBA 2PQ7A 3BG2A 3IRHA 4RXSA 4L7EA 1VJ7A 2CQZA 4QFXA 5AO4A 4TO4A 4MDZA 3MEMA 2OGIA 4X9EA 4ZWEA 5TK6A 4TNYA 5TKAA 4TNRA 2O08A 4QG2A 5AO1A 4L7WA 4BZBA 4DMBA 2PARA 1U6ZA 4RXOA 3U1NA 4QG0A 3I7AA 4R8ZA 2O6IA 3TMDA 1XX7A 4TO1A 2GZ4A 4N71A 3CCGA 3TMCA 4MCWA 2PAQA 4TNZA 5AO0A 2HEKA 4BZCA 2PAUA 3NR1A 4MLMA 4TO6A 3HI0A
chains in the Genus database with same CATH superfamily
4QG1A 4QFZA 5TK9A 4TO3A 1YOYA 2PGSA 4XDSA 4QQWA 3TM8A 4TO5A 2FLOA 3P3QA 4RXRA 5AO3A 1VQRA 3MZOA 3RF0A 3NQWA 4Q7HA 4QQZA 4QFYA 4TNXA 4QG4A 4QQYA 3SKDA 3KH1A 3KQ5A 4RXPA 4L1JA 4MZ7A 4TO0A 2Q14A 4TNQA 3M1TA 4TNPA 1YNBA 5TK8A 4N6WA 4ME4A 4MLNA 4TO2A 3TMBA 5AO2A 4L1JB 3HC1A 3LJXA 4RXQA 4ZWGA 5TK7A 4LRLA 2DQBA 2PQ7A 3BG2A 3IRHA 4RXSA 4L7EA 1VJ7A 2CQZA 4QFXA 5AO4A 4TO4A 4MDZA 3MEMA 2OGIA 4QQXA 4X9EA 4ZWEA 5TK6A 4TNYA 5TKAA 4TNRA 2O08A 4QG2A 5AO1A 4L7WA 4BZBA 4DMBA 3S4LA 2PARA 1U6ZA 4RXOA 3U1NA 4QG0A 3I7AA 4R8ZA 2O6IA 3TMDA 1XX7A 4TO1A 2GZ4A 4N71A 3CCGA 3TMCA 4MCWA 4Q2CA 2PAQA 4TNZA 3GW7A 5AO0A 3SK9A 2HEKA 4BZCA 2PAUA 3NR1A 4MLMA 4Q2DA 3HI0A 4TO6A
chains in the Genus database with same CATH topology
4QG1A 4QFZA 5TK9A 4TO3A 1YOYA 2PGSA 4XDSA 4QQWA 3TM8A 4TO5A 2FLOA 3P3QA 4RXRA 5AO3A 1VQRA 3MZOA 3RF0A 3NQWA 4Q7HA 4QQZA 4QFYA 4TNXA 4QG4A 4QQYA 3SKDA 3KH1A 3KQ5A 4RXPA 4L1JA 4MZ7A 4TO0A 2Q14A 4TNQA 3M1TA 4TNPA 1YNBA 5TK8A 4N6WA 4ME4A 4MLNA 4TO2A 3TMBA 5AO2A 4L1JB 3HC1A 3LJXA 4RXQA 4ZWGA 5TK7A 4LRLA 2DQBA 2PQ7A 3BG2A 3IRHA 4RXSA 4L7EA 1VJ7A 2CQZA 4QFXA 5AO4A 4TO4A 4MDZA 3MEMA 2OGIA 4QQXA 4X9EA 4ZWEA 5TK6A 4TNYA 5TKAA 4TNRA 2O08A 4QG2A 5AO1A 4L7WA 4BZBA 4DMBA 3S4LA 2PARA 1U6ZA 4RXOA 3U1NA 4QG0A 3I7AA 4R8ZA 2O6IA 3TMDA 1XX7A 4TO1A 2GZ4A 4N71A 3CCGA 3TMCA 4MCWA 4Q2CA 2PAQA 4TNZA 3GW7A 5AO0A 3SK9A 2HEKA 4BZCA 2PAUA 3NR1A 4MLMA 4Q2DA 3HI0A 4TO6A
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 4QG1 A;  4QFZ A;  5TK9 A;  4TO3 A;  1YOY A;  2PGS A;  4XDS A;  3TM8 A;  4TO5 A;  2FLO A;  3P3Q A;  4RXR A;  5AO3 A;  1VQR A;  3MZO A;  3RF0 A;  3NQW A;  4Q7H A;  4QFY A;  4TNX A;  4QG4 A;  3KH1 A;  4RXP A;  4L1J A;  4MZ7 A;  4TO0 A;  2Q14 A;  4TNQ A;  3M1T A;  4TNP A;  1YNB A;  5TK8 A;  4N6W A;  4ME4 A;  4MLN A;  4TO2 A;  3TMB A;  5AO2 A;  4L1J B;  3HC1 A;  3LJX A;  4RXQ A;  4ZWG A;  5TK7 A;  4LRL A;  2DQB A;  2PQ7 A;  3BG2 A;  3IRH A;  4RXS A;  4L7E A;  1VJ7 A;  2CQZ A;  4QFX A;  5AO4 A;  4TO4 A;  4MDZ A;  3MEM A;  2OGI A;  4X9E A;  4ZWE A;  5TK6 A;  4TNY A;  5TKA A;  4TNR A;  2O08 A;  4QG2 A;  5AO1 A;  4L7W A;  4BZB A;  4DMB A;  2PAR A;  1U6Z A;  4RXO A;  3U1N A;  4QG0 A;  3I7A A;  4R8Z A;  2O6I A;  3TMD A;  1XX7 A;  4TO1 A;  2GZ4 A;  4N71 A;  3CCG A;  3TMC A;  4MCW A;  2PAQ A;  4TNZ A;  5AO0 A;  2HEK A;  4BZC A;  2PAU A;  3NR1 A;  4MLM A;  4TO6 A;  3HI0 A; 
#chains in the Genus database with same CATH topology
 4QG1 A;  4QFZ A;  5TK9 A;  4TO3 A;  1YOY A;  2PGS A;  4XDS A;  4QQW A;  3TM8 A;  4TO5 A;  2FLO A;  3P3Q A;  4RXR A;  5AO3 A;  1VQR A;  3MZO A;  3RF0 A;  3NQW A;  4Q7H A;  4QQZ A;  4QFY A;  4TNX A;  4QG4 A;  4QQY A;  3SKD A;  3KH1 A;  3KQ5 A;  4RXP A;  4L1J A;  4MZ7 A;  4TO0 A;  2Q14 A;  4TNQ A;  3M1T A;  4TNP A;  1YNB A;  5TK8 A;  4N6W A;  4ME4 A;  4MLN A;  4TO2 A;  3TMB A;  5AO2 A;  4L1J B;  3HC1 A;  3LJX A;  4RXQ A;  4ZWG A;  5TK7 A;  4LRL A;  2DQB A;  2PQ7 A;  3BG2 A;  3IRH A;  4RXS A;  4L7E A;  1VJ7 A;  2CQZ A;  4QFX A;  5AO4 A;  4TO4 A;  4MDZ A;  3MEM A;  2OGI A;  4QQX A;  4X9E A;  4ZWE A;  5TK6 A;  4TNY A;  5TKA A;  4TNR A;  2O08 A;  4QG2 A;  5AO1 A;  4L7W A;  4BZB A;  4DMB A;  3S4L A;  2PAR A;  1U6Z A;  4RXO A;  3U1N A;  4QG0 A;  3I7A A;  4R8Z A;  2O6I A;  3TMD A;  1XX7 A;  4TO1 A;  2GZ4 A;  4N71 A;  3CCG A;  3TMC A;  4MCW A;  4Q2C A;  2PAQ A;  4TNZ A;  3GW7 A;  5AO0 A;  3SK9 A;  2HEK A;  4BZC A;  2PAU A;  3NR1 A;  4MLM A;  4Q2D A;  3HI0 A;  4TO6 A; 
#chains in the Genus database with same CATH homology
 4QG1 A;  4QFZ A;  5TK9 A;  4TO3 A;  1YOY A;  2PGS A;  4XDS A;  4QQW A;  3TM8 A;  4TO5 A;  2FLO A;  3P3Q A;  4RXR A;  5AO3 A;  1VQR A;  3MZO A;  3RF0 A;  3NQW A;  4Q7H A;  4QQZ A;  4QFY A;  4TNX A;  4QG4 A;  4QQY A;  3SKD A;  3KH1 A;  3KQ5 A;  4RXP A;  4L1J A;  4MZ7 A;  4TO0 A;  2Q14 A;  4TNQ A;  3M1T A;  4TNP A;  1YNB A;  5TK8 A;  4N6W A;  4ME4 A;  4MLN A;  4TO2 A;  3TMB A;  5AO2 A;  4L1J B;  3HC1 A;  3LJX A;  4RXQ A;  4ZWG A;  5TK7 A;  4LRL A;  2DQB A;  2PQ7 A;  3BG2 A;  3IRH A;  4RXS A;  4L7E A;  1VJ7 A;  2CQZ A;  4QFX A;  5AO4 A;  4TO4 A;  4MDZ A;  3MEM A;  2OGI A;  4QQX A;  4X9E A;  4ZWE A;  5TK6 A;  4TNY A;  5TKA A;  4TNR A;  2O08 A;  4QG2 A;  5AO1 A;  4L7W A;  4BZB A;  4DMB A;  3S4L A;  2PAR A;  1U6Z A;  4RXO A;  3U1N A;  4QG0 A;  3I7A A;  4R8Z A;  2O6I A;  3TMD A;  1XX7 A;  4TO1 A;  2GZ4 A;  4N71 A;  3CCG A;  3TMC A;  4MCW A;  4Q2C A;  2PAQ A;  4TNZ A;  3GW7 A;  5AO0 A;  3SK9 A;  2HEK A;  4BZC A;  2PAU A;  3NR1 A;  4MLM A;  4Q2D A;  3HI0 A;  4TO6 A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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