4QFYA

Crystal structure of the tetrameric dgtp/dctp-bound samhd1 (rn206) mutant catalytic core
Total Genus 156
50100150200250300350400450020406080100120140160
Genus TraceResidueGenus

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
156
sequence length
486
structure length
480
Chain Sequence
TMKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASHNRFEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCRNLGHGPFSHMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPEEDICFIKEQIVGPLELWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFARDCHHLGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNSLHRRAYQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDDMEAYTKLTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKIKREDYESLPKEVASAKPKVLLDVKLKAEDFIVDVINMDYGMQEKNPIDHVSFYCKTAPNRAIRITKNQVSQLLPEKFAEQLIRVYCKKVDRKSLYAARQYFVQWCADRNFTKPQDGDVIAPLITPQKKEWN
50100150200250300350400450400300200100
050100150Genus Matrix

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
EMPTYTVIII1 (300-303)TI2 (148-151)S1 (116-120)S2 (124-128)AH1 (130-137)AH2 (139-142)3H2 (151-155)AH3 (164-185)TI3 (157-160)TIV3 (155-158)TIV4 (158-161)TI5 (226-229)3H3 (187-189)AH4 (193-205)AH7 (250-257)TIV5 (205-208)TI4 (207-210)TII1 (211-214)AH6 (233-248)AH5 (215-225)TI9 (408-411)S6 (406-407)S5 (399-400)TII2 (401-404)TI7 (393-396)AH12 (377-393)AH14 (424-432)TIV6 (287-290)3H4 (292-298)TIV7 (298-301)TIV8 (299-302)TIV10 (304-307)TIV9 (303-306)AH9 (310-323)S4 (346-352)3H5 (353-355)AH11 (356-373)S7 (455-462)TI8 (394-397)3H6 (412-414)AH13 (416-420)3H7 (436-438)AH16 (474-482)TI11 (469-472)TII'1 (463-466)TI12 (470-473)TIV1 (120-123)AH8 (261-273)S3 (338-343)TI6 (373-376)3H1 (143-145)AH10 (331-337)AH15 (439-450)Updating...
connected with : NaN
publication title Structural Basis of Allosteric Activation of Sterile alpha Motif and Histidine-Aspartate Domain-containing Protein 1 (SAMHD1) by Nucleoside Triphosphates.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords Deoxynucleoside triphosphate triphosphohydrolase SAMHD1
total genus 156
structure length 480
sequence length 486
chains with identical sequence B, C, D
ec nomenclature ec 3.1.5.-:
pdb deposition date 2014-05-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01966 HD HD domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.3210.10 Mainly Alpha Orthogonal Bundle Hypothetical protein af1432 Hypothetical protein af1432 4qfyA01
4QFXA 3P3QA 1XX7A 2PQ7A 4TO3A 5AO3A 3TM8A 1VQRA 3LJXA 5TK7A 5AO2A 1VJ7A 4MDZA 2HEKA 5TK9A 2PAQA 3U1NA 3BG2A 2Q14A 3KH1A 4TO4A 2OGIA 4L1JA 3NR1A 3TMCA 4BZCA 5AO4A 4TNQA 3MEMA 4ZWEA 4L1JB 2GZ4A 3RF0A 4QG2A 4TO0A 4MZ7A 4MLMA 5AO0A 4RXRA 4RXOA 1YOYA 3TMDA 4QFZA 3CCGA 1U6ZA 2O6IA 4L7WA 3TMBA 4QG0A 2CQZA 4RXQA 5TK6A 3HC1A 4TNYA 5TKAA 4LRLA 2FLOA 4MLNA 5TK8A 4TNXA 4N6WA 4TNPA 4XDSA 4ZWGA 4QG4A 4L7EA 2PGSA 4TO1A 4ME4A 5AO1A 4QG1A 4TNRA 4Q7HA 3HI0A 4X9EA 4RXSA 4TO2A 4QFYA 3M1TA 2DQBA 3NQWA 4TO6A 4R8ZA 4TNZA 2PAUA 3I7AA 4N71A 3MZOA 3IRHA 2PARA 4RXPA 4BZBA 4DMBA 2O08A 1YNBA 4TO5A 4MCWA
chains in the Genus database with same CATH superfamily
4QFXA 3GW7A 3P3QA 1XX7A 2PQ7A 4TO3A 5AO3A 3TM8A 1VQRA 3LJXA 3KQ5A 5TK7A 5AO2A 1VJ7A 4MDZA 2HEKA 5TK9A 2PAQA 3U1NA 3BG2A 2Q14A 3KH1A 4TO4A 2OGIA 4L1JA 3NR1A 3TMCA 4BZCA 5AO4A 4TNQA 3MEMA 4QQXA 4Q2DA 4ZWEA 4L1JB 2GZ4A 3RF0A 4QQWA 4QG2A 4TO0A 4MZ7A 4MLMA 5AO0A 4RXRA 4RXOA 1YOYA 3TMDA 4QFZA 3CCGA 1U6ZA 2O6IA 4L7WA 3TMBA 3SKDA 4QG0A 2CQZA 4RXQA 5TK6A 3HC1A 4TNYA 5TKAA 4LRLA 2FLOA 4MLNA 5TK8A 4TNXA 4QQZA 4N6WA 4TNPA 4XDSA 4ZWGA 4QG4A 4L7EA 2PGSA 4TO1A 4ME4A 5AO1A 4QG1A 4TNRA 4Q7HA 3HI0A 4X9EA 4Q2CA 3S4LA 4RXSA 4TO2A 4QFYA 4QQYA 3M1TA 2DQBA 3NQWA 4TO6A 4R8ZA 4TNZA 2PAUA 3SK9A 3I7AA 4N71A 3MZOA 3IRHA 2PARA 4RXPA 4BZBA 4DMBA 2O08A 1YNBA 4TO5A 4MCWA
chains in the Genus database with same CATH topology
4QFXA 3GW7A 3P3QA 1XX7A 2PQ7A 4TO3A 5AO3A 3TM8A 1VQRA 3LJXA 3KQ5A 5TK7A 5AO2A 1VJ7A 4MDZA 2HEKA 5TK9A 2PAQA 3U1NA 3BG2A 2Q14A 3KH1A 4TO4A 2OGIA 4L1JA 3NR1A 3TMCA 4BZCA 5AO4A 4TNQA 3MEMA 4QQXA 4Q2DA 4ZWEA 4L1JB 2GZ4A 3RF0A 4QQWA 4QG2A 4TO0A 4MZ7A 4MLMA 5AO0A 4RXRA 4RXOA 1YOYA 3TMDA 4QFZA 3CCGA 1U6ZA 2O6IA 4L7WA 3TMBA 3SKDA 4QG0A 2CQZA 4RXQA 5TK6A 3HC1A 4TNYA 5TKAA 4LRLA 2FLOA 4MLNA 5TK8A 4TNXA 4QQZA 4N6WA 4TNPA 4XDSA 4ZWGA 4QG4A 4L7EA 2PGSA 4TO1A 4ME4A 5AO1A 4QG1A 4TNRA 4Q7HA 3HI0A 4X9EA 4Q2CA 3S4LA 4RXSA 4TO2A 4QFYA 4QQYA 3M1TA 2DQBA 3NQWA 4TO6A 4R8ZA 4TNZA 2PAUA 3SK9A 3I7AA 4N71A 3MZOA 3IRHA 2PARA 4RXPA 4BZBA 4DMBA 2O08A 1YNBA 4TO5A 4MCWA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4QFX A;  3P3Q A;  1XX7 A;  2PQ7 A;  4TO3 A;  5AO3 A;  3TM8 A;  1VQR A;  3LJX A;  5TK7 A;  5AO2 A;  1VJ7 A;  4MDZ A;  2HEK A;  5TK9 A;  2PAQ A;  3U1N A;  3BG2 A;  2Q14 A;  3KH1 A;  4TO4 A;  2OGI A;  4L1J A;  3NR1 A;  3TMC A;  4BZC A;  5AO4 A;  4TNQ A;  3MEM A;  4ZWE A;  4L1J B;  2GZ4 A;  3RF0 A;  4QG2 A;  4TO0 A;  4MZ7 A;  4MLM A;  5AO0 A;  4RXR A;  4RXO A;  1YOY A;  3TMD A;  4QFZ A;  3CCG A;  1U6Z A;  2O6I A;  4L7W A;  3TMB A;  4QG0 A;  2CQZ A;  4RXQ A;  5TK6 A;  3HC1 A;  4TNY A;  5TKA A;  4LRL A;  2FLO A;  4MLN A;  5TK8 A;  4TNX A;  4N6W A;  4TNP A;  4XDS A;  4ZWG A;  4QG4 A;  4L7E A;  2PGS A;  4TO1 A;  4ME4 A;  5AO1 A;  4QG1 A;  4TNR A;  4Q7H A;  3HI0 A;  4X9E A;  4RXS A;  4TO2 A;  4QFY A;  3M1T A;  2DQB A;  3NQW A;  4TO6 A;  4R8Z A;  4TNZ A;  2PAU A;  3I7A A;  4N71 A;  3MZO A;  3IRH A;  2PAR A;  4RXP A;  4BZB A;  4DMB A;  2O08 A;  1YNB A;  4TO5 A;  4MCW A; 
#chains in the Genus database with same CATH topology
 4QFX A;  3GW7 A;  3P3Q A;  1XX7 A;  2PQ7 A;  4TO3 A;  5AO3 A;  3TM8 A;  1VQR A;  3LJX A;  3KQ5 A;  5TK7 A;  5AO2 A;  1VJ7 A;  4MDZ A;  2HEK A;  5TK9 A;  2PAQ A;  3U1N A;  3BG2 A;  2Q14 A;  3KH1 A;  4TO4 A;  2OGI A;  4L1J A;  3NR1 A;  3TMC A;  4BZC A;  5AO4 A;  4TNQ A;  3MEM A;  4QQX A;  4Q2D A;  4ZWE A;  4L1J B;  2GZ4 A;  3RF0 A;  4QQW A;  4QG2 A;  4TO0 A;  4MZ7 A;  4MLM A;  5AO0 A;  4RXR A;  4RXO A;  1YOY A;  3TMD A;  4QFZ A;  3CCG A;  1U6Z A;  2O6I A;  4L7W A;  3TMB A;  3SKD A;  4QG0 A;  2CQZ A;  4RXQ A;  5TK6 A;  3HC1 A;  4TNY A;  5TKA A;  4LRL A;  2FLO A;  4MLN A;  5TK8 A;  4TNX A;  4QQZ A;  4N6W A;  4TNP A;  4XDS A;  4ZWG A;  4QG4 A;  4L7E A;  2PGS A;  4TO1 A;  4ME4 A;  5AO1 A;  4QG1 A;  4TNR A;  4Q7H A;  3HI0 A;  4X9E A;  4Q2C A;  3S4L A;  4RXS A;  4TO2 A;  4QFY A;  4QQY A;  3M1T A;  2DQB A;  3NQW A;  4TO6 A;  4R8Z A;  4TNZ A;  2PAU A;  3SK9 A;  3I7A A;  4N71 A;  3MZO A;  3IRH A;  2PAR A;  4RXP A;  4BZB A;  4DMB A;  2O08 A;  1YNB A;  4TO5 A;  4MCW A; 
#chains in the Genus database with same CATH homology
 4QFX A;  3GW7 A;  3P3Q A;  1XX7 A;  2PQ7 A;  4TO3 A;  5AO3 A;  3TM8 A;  1VQR A;  3LJX A;  3KQ5 A;  5TK7 A;  5AO2 A;  1VJ7 A;  4MDZ A;  2HEK A;  5TK9 A;  2PAQ A;  3U1N A;  3BG2 A;  2Q14 A;  3KH1 A;  4TO4 A;  2OGI A;  4L1J A;  3NR1 A;  3TMC A;  4BZC A;  5AO4 A;  4TNQ A;  3MEM A;  4QQX A;  4Q2D A;  4ZWE A;  4L1J B;  2GZ4 A;  3RF0 A;  4QQW A;  4QG2 A;  4TO0 A;  4MZ7 A;  4MLM A;  5AO0 A;  4RXR A;  4RXO A;  1YOY A;  3TMD A;  4QFZ A;  3CCG A;  1U6Z A;  2O6I A;  4L7W A;  3TMB A;  3SKD A;  4QG0 A;  2CQZ A;  4RXQ A;  5TK6 A;  3HC1 A;  4TNY A;  5TKA A;  4LRL A;  2FLO A;  4MLN A;  5TK8 A;  4TNX A;  4QQZ A;  4N6W A;  4TNP A;  4XDS A;  4ZWG A;  4QG4 A;  4L7E A;  2PGS A;  4TO1 A;  4ME4 A;  5AO1 A;  4QG1 A;  4TNR A;  4Q7H A;  3HI0 A;  4X9E A;  4Q2C A;  3S4L A;  4RXS A;  4TO2 A;  4QFY A;  4QQY A;  3M1T A;  2DQB A;  3NQW A;  4TO6 A;  4R8Z A;  4TNZ A;  2PAU A;  3SK9 A;  3I7A A;  4N71 A;  3MZO A;  3IRH A;  2PAR A;  4RXP A;  4BZB A;  4DMB A;  2O08 A;  1YNB A;  4TO5 A;  4MCW A; 
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