4QFZA

Crystal structure of the tetrameric dgtp/dttp-bound samhd1 (rn206) mutant catalytic core
Total Genus 162
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
162
sequence length
487
structure length
481
Chain Sequence
DTMKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASHNRFEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCRNLGHGPFSHMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPEEDICFIKEQIVGPLELWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFARDCHHLGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNSLHRRAYQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDDMEAYTKLTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKIKREDYESLPKEVASAKPKVLLDVKLKAEDFIVDVINMDYGMQEKNPIDHVSFYCKTAPNRAIRITKNQVSQLLPEKFAEQLIRVYCKKVDRKSLYAARQYFVQWCADRNFTKPQDGDVIAPLITPQKKEWN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase
source organism Homo sapiens
publication title Structural Basis of Allosteric Activation of Sterile alpha Motif and Histidine-Aspartate Domain-containing Protein 1 (SAMHD1) by Nucleoside Triphosphates.
pubmed doi rcsb
molecule keywords Deoxynucleoside triphosphate triphosphohydrolase SAMHD1
total genus 162
structure length 481
sequence length 487
chains with identical sequence B, C, D
ec nomenclature ec 3.1.5.-:
pdb deposition date 2014-05-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01966 HD HD domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.3210.10 Mainly Alpha Orthogonal Bundle Hypothetical protein af1432 Hypothetical protein af1432 4qfzA01
4MLMA 4LRLA 4L1JA 4TO2A 4ME4A 4ZWGA 4MDZA 4N71A 2CQZA 5AO3A 3TMCA 3TMDA 2PAUA 3IRHA 4L7EA 4RXOA 4TO0A 4QG0A 3TMBA 4MLNA 4RXSA 1YNBA 4QG2A 4XDSA 3BG2A 3NR1A 4Q7HA 5AO0A 3LJXA 5TK9A 4BZCA 4L7WA 4MCWA 2PARA 4QFYA 5AO2A 4DMBA 4QFXA 5AO4A 3HI0A 4N6WA 4RXPA 4RXQA 3NQWA 2O08A 2Q14A 4TNRA 4RXRA 1YOYA 4TNYA 3P3QA 4BZBA 1U6ZA 4QG1A 4TNZA 2FLOA 3I7AA 4TNPA 3CCGA 4TO1A 5AO1A 4X9EA 4MZ7A 1VJ7A 4R8ZA 3M1TA 2PAQA 2PQ7A 2HEKA 4TNQA 1XX7A 5TK8A 4TNXA 3MZOA 4L1JB 5TKAA 3HC1A 2DQBA 4TO4A 5TK7A 2PGSA 3MEMA 5TK6A 2O6IA 4TO5A 3RF0A 4QFZA 4TO3A 2GZ4A 3KH1A 3TM8A 2OGIA 4ZWEA 4QG4A 3U1NA 4TO6A 1VQRA
chains in the Genus database with same CATH superfamily
4MLMA 4LRLA 4L1JA 4TO2A 4ME4A 4ZWGA 4MDZA 4N71A 2CQZA 5AO3A 3TMCA 3TMDA 4QQZA 2PAUA 3IRHA 4L7EA 4RXOA 4TO0A 3S4LA 4QG0A 3TMBA 4MLNA 4RXSA 1YNBA 4QG2A 4XDSA 4Q2DA 3BG2A 3NR1A 4Q7HA 5AO0A 3LJXA 5TK9A 4BZCA 4L7WA 4MCWA 2PARA 4QFYA 5AO2A 4DMBA 4QFXA 3SKDA 5AO4A 3HI0A 4N6WA 4RXPA 4RXQA 3NQWA 4QQXA 2O08A 2Q14A 4QQYA 4TNRA 4RXRA 1YOYA 4TNYA 3P3QA 4BZBA 1U6ZA 4QG1A 4TNZA 2FLOA 3I7AA 4TNPA 3CCGA 3KQ5A 4TO1A 5AO1A 4X9EA 4MZ7A 3GW7A 3SK9A 1VJ7A 4R8ZA 3M1TA 2PAQA 2PQ7A 2HEKA 4TNQA 1XX7A 5TK8A 4TNXA 3MZOA 4L1JB 5TKAA 3HC1A 2DQBA 4TO4A 5TK7A 4QQWA 4Q2CA 2PGSA 3MEMA 5TK6A 2O6IA 4TO5A 3RF0A 4QFZA 4TO3A 2GZ4A 3KH1A 3TM8A 2OGIA 4ZWEA 4QG4A 3U1NA 4TO6A 1VQRA
chains in the Genus database with same CATH topology
4MLMA 4LRLA 4L1JA 4TO2A 4ME4A 4ZWGA 4MDZA 4N71A 2CQZA 5AO3A 3TMCA 3TMDA 4QQZA 2PAUA 3IRHA 4L7EA 4RXOA 4TO0A 3S4LA 4QG0A 3TMBA 4MLNA 4RXSA 1YNBA 4QG2A 4XDSA 4Q2DA 3BG2A 3NR1A 4Q7HA 5AO0A 3LJXA 5TK9A 4BZCA 4L7WA 4MCWA 2PARA 4QFYA 5AO2A 4DMBA 4QFXA 3SKDA 5AO4A 3HI0A 4N6WA 4RXPA 4RXQA 3NQWA 4QQXA 2O08A 2Q14A 4QQYA 4TNRA 4RXRA 1YOYA 4TNYA 3P3QA 4BZBA 1U6ZA 4QG1A 4TNZA 2FLOA 3I7AA 4TNPA 3CCGA 3KQ5A 4TO1A 5AO1A 4X9EA 4MZ7A 3GW7A 3SK9A 1VJ7A 4R8ZA 3M1TA 2PAQA 2PQ7A 2HEKA 4TNQA 1XX7A 5TK8A 4TNXA 3MZOA 4L1JB 5TKAA 3HC1A 2DQBA 4TO4A 5TK7A 4QQWA 4Q2CA 2PGSA 3MEMA 5TK6A 2O6IA 4TO5A 3RF0A 4QFZA 4TO3A 2GZ4A 3KH1A 3TM8A 2OGIA 4ZWEA 4QG4A 3U1NA 4TO6A 1VQRA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4MLM A;  4LRL A;  4L1J A;  4TO2 A;  4ME4 A;  4ZWG A;  4MDZ A;  4N71 A;  2CQZ A;  5AO3 A;  3TMC A;  3TMD A;  2PAU A;  3IRH A;  4L7E A;  4RXO A;  4TO0 A;  4QG0 A;  3TMB A;  4MLN A;  4RXS A;  1YNB A;  4QG2 A;  4XDS A;  3BG2 A;  3NR1 A;  4Q7H A;  5AO0 A;  3LJX A;  5TK9 A;  4BZC A;  4L7W A;  4MCW A;  2PAR A;  4QFY A;  5AO2 A;  4DMB A;  4QFX A;  5AO4 A;  3HI0 A;  4N6W A;  4RXP A;  4RXQ A;  3NQW A;  2O08 A;  2Q14 A;  4TNR A;  4RXR A;  1YOY A;  4TNY A;  3P3Q A;  4BZB A;  1U6Z A;  4QG1 A;  4TNZ A;  2FLO A;  3I7A A;  4TNP A;  3CCG A;  4TO1 A;  5AO1 A;  4X9E A;  4MZ7 A;  1VJ7 A;  4R8Z A;  3M1T A;  2PAQ A;  2PQ7 A;  2HEK A;  4TNQ A;  1XX7 A;  5TK8 A;  4TNX A;  3MZO A;  4L1J B;  5TKA A;  3HC1 A;  2DQB A;  4TO4 A;  5TK7 A;  2PGS A;  3MEM A;  5TK6 A;  2O6I A;  4TO5 A;  3RF0 A;  4QFZ A;  4TO3 A;  2GZ4 A;  3KH1 A;  3TM8 A;  2OGI A;  4ZWE A;  4QG4 A;  3U1N A;  4TO6 A;  1VQR A; 
#chains in the Genus database with same CATH topology
 4MLM A;  4LRL A;  4L1J A;  4TO2 A;  4ME4 A;  4ZWG A;  4MDZ A;  4N71 A;  2CQZ A;  5AO3 A;  3TMC A;  3TMD A;  4QQZ A;  2PAU A;  3IRH A;  4L7E A;  4RXO A;  4TO0 A;  3S4L A;  4QG0 A;  3TMB A;  4MLN A;  4RXS A;  1YNB A;  4QG2 A;  4XDS A;  4Q2D A;  3BG2 A;  3NR1 A;  4Q7H A;  5AO0 A;  3LJX A;  5TK9 A;  4BZC A;  4L7W A;  4MCW A;  2PAR A;  4QFY A;  5AO2 A;  4DMB A;  4QFX A;  3SKD A;  5AO4 A;  3HI0 A;  4N6W A;  4RXP A;  4RXQ A;  3NQW A;  4QQX A;  2O08 A;  2Q14 A;  4QQY A;  4TNR A;  4RXR A;  1YOY A;  4TNY A;  3P3Q A;  4BZB A;  1U6Z A;  4QG1 A;  4TNZ A;  2FLO A;  3I7A A;  4TNP A;  3CCG A;  3KQ5 A;  4TO1 A;  5AO1 A;  4X9E A;  4MZ7 A;  3GW7 A;  3SK9 A;  1VJ7 A;  4R8Z A;  3M1T A;  2PAQ A;  2PQ7 A;  2HEK A;  4TNQ A;  1XX7 A;  5TK8 A;  4TNX A;  3MZO A;  4L1J B;  5TKA A;  3HC1 A;  2DQB A;  4TO4 A;  5TK7 A;  4QQW A;  4Q2C A;  2PGS A;  3MEM A;  5TK6 A;  2O6I A;  4TO5 A;  3RF0 A;  4QFZ A;  4TO3 A;  2GZ4 A;  3KH1 A;  3TM8 A;  2OGI A;  4ZWE A;  4QG4 A;  3U1N A;  4TO6 A;  1VQR A; 
#chains in the Genus database with same CATH homology
 4MLM A;  4LRL A;  4L1J A;  4TO2 A;  4ME4 A;  4ZWG A;  4MDZ A;  4N71 A;  2CQZ A;  5AO3 A;  3TMC A;  3TMD A;  4QQZ A;  2PAU A;  3IRH A;  4L7E A;  4RXO A;  4TO0 A;  3S4L A;  4QG0 A;  3TMB A;  4MLN A;  4RXS A;  1YNB A;  4QG2 A;  4XDS A;  4Q2D A;  3BG2 A;  3NR1 A;  4Q7H A;  5AO0 A;  3LJX A;  5TK9 A;  4BZC A;  4L7W A;  4MCW A;  2PAR A;  4QFY A;  5AO2 A;  4DMB A;  4QFX A;  3SKD A;  5AO4 A;  3HI0 A;  4N6W A;  4RXP A;  4RXQ A;  3NQW A;  4QQX A;  2O08 A;  2Q14 A;  4QQY A;  4TNR A;  4RXR A;  1YOY A;  4TNY A;  3P3Q A;  4BZB A;  1U6Z A;  4QG1 A;  4TNZ A;  2FLO A;  3I7A A;  4TNP A;  3CCG A;  3KQ5 A;  4TO1 A;  5AO1 A;  4X9E A;  4MZ7 A;  3GW7 A;  3SK9 A;  1VJ7 A;  4R8Z A;  3M1T A;  2PAQ A;  2PQ7 A;  2HEK A;  4TNQ A;  1XX7 A;  5TK8 A;  4TNX A;  3MZO A;  4L1J B;  5TKA A;  3HC1 A;  2DQB A;  4TO4 A;  5TK7 A;  4QQW A;  4Q2C A;  2PGS A;  3MEM A;  5TK6 A;  2O6I A;  4TO5 A;  3RF0 A;  4QFZ A;  4TO3 A;  2GZ4 A;  3KH1 A;  3TM8 A;  2OGI A;  4ZWE A;  4QG4 A;  3U1N A;  4TO6 A;  1VQR A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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