4QG0 | Genus

Total Genus 159

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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	159
sequence length	487
structure length	481
Chain Sequence	DTMKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASHNRFEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCRNLGHGPFSHMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPEEDICFIKEQIVGPLELWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFARDCHHLGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNSLHRRAYQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDDMEAYTKLTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKIKREDYESLPKEVASAKPKVLLDVKLKAEDFIVDVINMDYGMQEKNPIDHVSFYCKTAPNRAIRITKNQVSQLLPEKFAEQLIRVYCKKVDRKSLYAARQYFVQWCADRNFTKPQDGDVIAPLITPQKKEWN

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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

Chord Diagram

molecule tags	Hydrolase
source organism	Homo sapiens
publication title	Structural Basis of Allosteric Activation of Sterile alpha Motif and Histidine-Aspartate Domain-containing Protein 1 (SAMHD1) by Nucleoside Triphosphates. pubmed doi rcsb
molecule keywords	Deoxynucleoside triphosphate triphosphohydrolase SAMHD1
total genus	159
structure length	481
sequence length	487
chains with identical sequence	B, C, D
ec nomenclature	ec 3.1.5.-:
pdb deposition date	2014-05-22

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF01966	HD	HD domain

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
1.10.3210.10	Mainly Alpha	Orthogonal Bundle	Hypothetical protein af1432	Hypothetical protein af1432	4qg0A01

3BG2A 2PAQA 4XDSA 5AO2A 4TNRA 4QFZA 3NR1A 4L1JB 4MLMA 4TO2A 3IRHA 3LJXA 4ZWGA 1U6ZA 4Q7HA 2OGIA 2PAUA 3TMCA 5TK9A 4TNZA 4QG4A 5AO4A 4TO5A 4QFXA 3I7AA 4L7WA 4MDZA 4RXPA 4QFYA 4N6WA 5AO3A 2HEKA 4LRLA 5TK6A 4RXOA 5TKAA 4DMBA 4TNXA 4RXSA 3CCGA 2PGSA 4L1JA 4X9EA 1XX7A 4BZCA 2PQ7A 3RF0A 2PARA 2FLOA 1VQRA 4QG2A 1YOYA 1VJ7A 3MZOA 4MCWA 4TNYA 3M1TA 4TO1A 5AO1A 4TO4A 4L7EA 4TNQA 2DQBA 4R8ZA 3MEMA 2Q14A 4ZWEA 4RXQA 5TK8A 4TNPA 4MZ7A 3TMBA 4QG0A 4RXRA 4TO0A 3TM8A 4MLNA 4TO6A 4ME4A 4TO3A 3KH1A 1YNBA 3NQWA 5AO0A 4BZBA 5TK7A 3TMDA 4N71A 2O08A 4QG1A 2GZ4A 3HI0A 3HC1A 2CQZA 3P3QA 3U1NA 2O6IA
chains in the Genus database with same CATH superfamily

3BG2A 2PAQA 4XDSA 5AO2A 4TNRA 4QFZA 3NR1A 4L1JB 4MLMA 4TO2A 3IRHA 3LJXA 4ZWGA 1U6ZA 4Q7HA 2OGIA 2PAUA 3TMCA 5TK9A 4TNZA 4QG4A 5AO4A 4TO5A 4QFXA 3I7AA 4L7WA 4MDZA 4RXPA 4QFYA 4N6WA 4Q2CA 5AO3A 2HEKA 4LRLA 5TK6A 4RXOA 5TKAA 4DMBA 4QQYA 4TNXA 4RXSA 3CCGA 2PGSA 4L1JA 4X9EA 1XX7A 4BZCA 2PQ7A 3RF0A 4QQWA 4QQZA 2PARA 2FLOA 1VQRA 4QG2A 1YOYA 1VJ7A 3MZOA 3S4LA 4MCWA 4TNYA 3M1TA 4TO1A 5AO1A 4TO4A 4L7EA 4TNQA 2DQBA 4R8ZA 3MEMA 2Q14A 4ZWEA 3SK9A 4RXQA 5TK8A 4TNPA 3SKDA 4MZ7A 3TMBA 4QG0A 4RXRA 4TO0A 3TM8A 4MLNA 4TO6A 4ME4A 4QQXA 4TO3A 3KH1A 1YNBA 3KQ5A 3NQWA 5AO0A 4BZBA 5TK7A 4Q2DA 3TMDA 4N71A 2O08A 4QG1A 2GZ4A 3HI0A 3HC1A 2CQZA 3P3QA 3GW7A 3U1NA 2O6IA
chains in the Genus database with same CATH topology

3BG2A 2PAQA 4XDSA 5AO2A 4TNRA 4QFZA 3NR1A 4L1JB 4MLMA 4TO2A 3IRHA 3LJXA 4ZWGA 1U6ZA 4Q7HA 2OGIA 2PAUA 3TMCA 5TK9A 4TNZA 4QG4A 5AO4A 4TO5A 4QFXA 3I7AA 4L7WA 4MDZA 4RXPA 4QFYA 4N6WA 4Q2CA 5AO3A 2HEKA 4LRLA 5TK6A 4RXOA 5TKAA 4DMBA 4QQYA 4TNXA 4RXSA 3CCGA 2PGSA 4L1JA 4X9EA 1XX7A 4BZCA 2PQ7A 3RF0A 4QQWA 4QQZA 2PARA 2FLOA 1VQRA 4QG2A 1YOYA 1VJ7A 3MZOA 3S4LA 4MCWA 4TNYA 3M1TA 4TO1A 5AO1A 4TO4A 4L7EA 4TNQA 2DQBA 4R8ZA 3MEMA 2Q14A 4ZWEA 3SK9A 4RXQA 5TK8A 4TNPA 3SKDA 4MZ7A 3TMBA 4QG0A 4RXRA 4TO0A 3TM8A 4MLNA 4TO6A 4ME4A 4QQXA 4TO3A 3KH1A 1YNBA 3KQ5A 3NQWA 5AO0A 4BZBA 5TK7A 4Q2DA 3TMDA 4N71A 2O08A 4QG1A 2GZ4A 3HI0A 3HC1A 2CQZA 3P3QA 3GW7A 3U1NA 2O6IA
chains in the Genus database with same CATH homology

#chains in the Genus database with same CATH superfamily
 3BG2 A;  2PAQ A;  4XDS A;  5AO2 A;  4TNR A;  4QFZ A;  3NR1 A;  4L1J B;  4MLM A;  4TO2 A;  3IRH A;  3LJX A;  4ZWG A;  1U6Z A;  4Q7H A;  2OGI A;  2PAU A;  3TMC A;  5TK9 A;  4TNZ A;  4QG4 A;  5AO4 A;  4TO5 A;  4QFX A;  3I7A A;  4L7W A;  4MDZ A;  4RXP A;  4QFY A;  4N6W A;  5AO3 A;  2HEK A;  4LRL A;  5TK6 A;  4RXO A;  5TKA A;  4DMB A;  4TNX A;  4RXS A;  3CCG A;  2PGS A;  4L1J A;  4X9E A;  1XX7 A;  4BZC A;  2PQ7 A;  3RF0 A;  2PAR A;  2FLO A;  1VQR A;  4QG2 A;  1YOY A;  1VJ7 A;  3MZO A;  4MCW A;  4TNY A;  3M1T A;  4TO1 A;  5AO1 A;  4TO4 A;  4L7E A;  4TNQ A;  2DQB A;  4R8Z A;  3MEM A;  2Q14 A;  4ZWE A;  4RXQ A;  5TK8 A;  4TNP A;  4MZ7 A;  3TMB A;  4QG0 A;  4RXR A;  4TO0 A;  3TM8 A;  4MLN A;  4TO6 A;  4ME4 A;  4TO3 A;  3KH1 A;  1YNB A;  3NQW A;  5AO0 A;  4BZB A;  5TK7 A;  3TMD A;  4N71 A;  2O08 A;  4QG1 A;  2GZ4 A;  3HI0 A;  3HC1 A;  2CQZ A;  3P3Q A;  3U1N A;  2O6I A; 
#chains in the Genus database with same CATH topology
 3BG2 A;  2PAQ A;  4XDS A;  5AO2 A;  4TNR A;  4QFZ A;  3NR1 A;  4L1J B;  4MLM A;  4TO2 A;  3IRH A;  3LJX A;  4ZWG A;  1U6Z A;  4Q7H A;  2OGI A;  2PAU A;  3TMC A;  5TK9 A;  4TNZ A;  4QG4 A;  5AO4 A;  4TO5 A;  4QFX A;  3I7A A;  4L7W A;  4MDZ A;  4RXP A;  4QFY A;  4N6W A;  4Q2C A;  5AO3 A;  2HEK A;  4LRL A;  5TK6 A;  4RXO A;  5TKA A;  4DMB A;  4QQY A;  4TNX A;  4RXS A;  3CCG A;  2PGS A;  4L1J A;  4X9E A;  1XX7 A;  4BZC A;  2PQ7 A;  3RF0 A;  4QQW A;  4QQZ A;  2PAR A;  2FLO A;  1VQR A;  4QG2 A;  1YOY A;  1VJ7 A;  3MZO A;  3S4L A;  4MCW A;  4TNY A;  3M1T A;  4TO1 A;  5AO1 A;  4TO4 A;  4L7E A;  4TNQ A;  2DQB A;  4R8Z A;  3MEM A;  2Q14 A;  4ZWE A;  3SK9 A;  4RXQ A;  5TK8 A;  4TNP A;  3SKD A;  4MZ7 A;  3TMB A;  4QG0 A;  4RXR A;  4TO0 A;  3TM8 A;  4MLN A;  4TO6 A;  4ME4 A;  4QQX A;  4TO3 A;  3KH1 A;  1YNB A;  3KQ5 A;  3NQW A;  5AO0 A;  4BZB A;  5TK7 A;  4Q2D A;  3TMD A;  4N71 A;  2O08 A;  4QG1 A;  2GZ4 A;  3HI0 A;  3HC1 A;  2CQZ A;  3P3Q A;  3GW7 A;  3U1N A;  2O6I A; 
#chains in the Genus database with same CATH homology
 3BG2 A;  2PAQ A;  4XDS A;  5AO2 A;  4TNR A;  4QFZ A;  3NR1 A;  4L1J B;  4MLM A;  4TO2 A;  3IRH A;  3LJX A;  4ZWG A;  1U6Z A;  4Q7H A;  2OGI A;  2PAU A;  3TMC A;  5TK9 A;  4TNZ A;  4QG4 A;  5AO4 A;  4TO5 A;  4QFX A;  3I7A A;  4L7W A;  4MDZ A;  4RXP A;  4QFY A;  4N6W A;  4Q2C A;  5AO3 A;  2HEK A;  4LRL A;  5TK6 A;  4RXO A;  5TKA A;  4DMB A;  4QQY A;  4TNX A;  4RXS A;  3CCG A;  2PGS A;  4L1J A;  4X9E A;  1XX7 A;  4BZC A;  2PQ7 A;  3RF0 A;  4QQW A;  4QQZ A;  2PAR A;  2FLO A;  1VQR A;  4QG2 A;  1YOY A;  1VJ7 A;  3MZO A;  3S4L A;  4MCW A;  4TNY A;  3M1T A;  4TO1 A;  5AO1 A;  4TO4 A;  4L7E A;  4TNQ A;  2DQB A;  4R8Z A;  3MEM A;  2Q14 A;  4ZWE A;  3SK9 A;  4RXQ A;  5TK8 A;  4TNP A;  3SKD A;  4MZ7 A;  3TMB A;  4QG0 A;  4RXR A;  4TO0 A;  3TM8 A;  4MLN A;  4TO6 A;  4ME4 A;  4QQX A;  4TO3 A;  3KH1 A;  1YNB A;  3KQ5 A;  3NQW A;  5AO0 A;  4BZB A;  5TK7 A;  4Q2D A;  3TMD A;  4N71 A;  2O08 A;  4QG1 A;  2GZ4 A;  3HI0 A;  3HC1 A;  2CQZ A;  3P3Q A;  3GW7 A;  3U1N A;  2O6I A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

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#similar chains, but unknotted
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4QG0A

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

Chord Diagram

connected with : NaN

pfam database annotations