4QG4A

Crystal structure of the tetrameric gtp/datp/atp-bound samhd1 (h210a) mutant catalytic core
Total Genus 155
50100150200250300350400450020406080100120140160
Genus TraceResidueGenus

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
155
sequence length
487
structure length
481
Chain Sequence
DTMKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASHNRFEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCHDLGAGPFSHMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPEEDICFIKEQIVGPLELWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFARDCHHLGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNSLHRRAYQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDDMEAYTKLTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKIKREDYESLPKEVASAKPKVLLDVKLKAEDFIVDVINMDYGMQEKNPIDHVSFYCKTAPNRAIRITKNQVSQLLPEKFAEQLIRVYCKKVDRKSLYAARQYFVQWCADRNFTKPQDGDVIAPLITPQKKEWN
50100150200250300350400450400300200100
050100150Genus Matrix

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
3H2 (151-155)EMPTYTIV1 (120-123)S1 (116-120)S2 (124-128)AH1 (130-137)TIV2 (155-158)AH2 (139-142)3H1 (143-145)AH3 (164-185)TI3 (157-160)TIV3 (158-161)TI6 (226-229)3H3 (187-189)S5 (399-400)AH4 (193-205)AH7 (250-257)TI4 (205-208)TI5 (207-210)TII1 (211-214)AH5 (215-225)AH6 (233-248)3H6 (402-404)TI9 (393-396)AH12 (377-393)AH8 (261-273)3H4 (292-298)TIV4 (287-290)TIV5 (299-302)TVIII1 (300-303)TI7 (303-306)AH9 (310-323)TIV6 (304-307)3H8 (436-438)AH10 (331-337)AH14 (424-432)S3 (338-343)S4 (346-352)TIV7 (342-345)AH11 (356-373)S7 (455-460)AH15 (439-450)TI8 (373-376)TI10 (394-397)3H7 (412-414)S6 (406-407)TI11 (408-411)TIV8 (463-466)3H9 (470-475)3H5 (353-355)AH13 (416-420)AH16 (476-482)TI2 (148-151)Updating...
connected with : NaN
molecule tags Hydrolase
source organism Homo sapiens
publication title Structural Basis of Allosteric Activation of Sterile alpha Motif and Histidine-Aspartate Domain-containing Protein 1 (SAMHD1) by Nucleoside Triphosphates.
pubmed doi rcsb
molecule keywords Deoxynucleoside triphosphate triphosphohydrolase SAMHD1
total genus 155
structure length 481
sequence length 487
chains with identical sequence B, C, D
ec nomenclature ec 3.1.5.-:
pdb deposition date 2014-05-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01966 HD HD domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.3210.10 Mainly Alpha Orthogonal Bundle Hypothetical protein af1432 Hypothetical protein af1432 4qg4A01
3MEMA 2DQBA 2GZ4A 3RF0A 4RXSA 3TMBA 2PQ7A 4L1JB 1YOYA 5TK9A 1XX7A 5TK7A 2FLOA 4MDZA 4QG2A 3P3QA 5AO1A 4X9EA 4RXPA 1VJ7A 4N6WA 3M1TA 5AO2A 4LRLA 3CCGA 3TMDA 5TK8A 2Q14A 4TO2A 4QFZA 4TNXA 2CQZA 2PAUA 3HC1A 4QG4A 4DMBA 4MLMA 3BG2A 4ME4A 2OGIA 4L7EA 4XDSA 5TKAA 3HI0A 3TMCA 4TO1A 4ZWGA 4L1JA 4QG0A 4TO3A 4TO6A 5AO4A 4TNQA 3IRHA 4BZCA 4RXQA 4Q7HA 3I7AA 4L7WA 4TO5A 4TNZA 2O08A 2PARA 4QFXA 4MZ7A 5AO3A 2HEKA 4TNYA 3LJXA 5TK6A 3NR1A 2PGSA 1YNBA 3U1NA 4MLNA 3TM8A 4QFYA 1VQRA 4R8ZA 4ZWEA 4TO0A 4TNRA 4N71A 4BZBA 2O6IA 2PAQA 1U6ZA 4RXOA 3NQWA 4MCWA 4RXRA 4QG1A 3KH1A 4TO4A 3MZOA 4TNPA 5AO0A
chains in the Genus database with same CATH superfamily
3MEMA 2DQBA 2GZ4A 3RF0A 4RXSA 3TMBA 2PQ7A 4L1JB 1YOYA 5TK9A 1XX7A 5TK7A 2FLOA 4MDZA 4QG2A 3P3QA 5AO1A 4X9EA 4RXPA 1VJ7A 4N6WA 3M1TA 5AO2A 4LRLA 3CCGA 3TMDA 5TK8A 2Q14A 3S4LA 4TO2A 4QFZA 4TNXA 2CQZA 2PAUA 3HC1A 4QG4A 4DMBA 4MLMA 3BG2A 4ME4A 2OGIA 4L7EA 4XDSA 5TKAA 3HI0A 3TMCA 4Q2DA 4TO1A 4ZWGA 4L1JA 4QQYA 4QG0A 4TO3A 4TO6A 5AO4A 4TNQA 3IRHA 4QQZA 3KQ5A 4BZCA 4RXQA 4Q7HA 3I7AA 4L7WA 4TO5A 4TNZA 3SKDA 2O08A 2PARA 4QFXA 4MZ7A 5AO3A 2HEKA 4TNYA 3LJXA 5TK6A 3NR1A 2PGSA 1YNBA 3U1NA 4MLNA 3TM8A 3SK9A 4QFYA 1VQRA 3GW7A 4R8ZA 4ZWEA 4QQXA 4Q2CA 4TO0A 4TNRA 4N71A 4BZBA 2O6IA 2PAQA 1U6ZA 4RXOA 3NQWA 4MCWA 4RXRA 4QG1A 3KH1A 4QQWA 4TO4A 3MZOA 4TNPA 5AO0A
chains in the Genus database with same CATH topology
3MEMA 2DQBA 2GZ4A 3RF0A 4RXSA 3TMBA 2PQ7A 4L1JB 1YOYA 5TK9A 1XX7A 5TK7A 2FLOA 4MDZA 4QG2A 3P3QA 5AO1A 4X9EA 4RXPA 1VJ7A 4N6WA 3M1TA 5AO2A 4LRLA 3CCGA 3TMDA 5TK8A 2Q14A 3S4LA 4TO2A 4QFZA 4TNXA 2CQZA 2PAUA 3HC1A 4QG4A 4DMBA 4MLMA 3BG2A 4ME4A 2OGIA 4L7EA 4XDSA 5TKAA 3HI0A 3TMCA 4Q2DA 4TO1A 4ZWGA 4L1JA 4QQYA 4QG0A 4TO3A 4TO6A 5AO4A 4TNQA 3IRHA 4QQZA 3KQ5A 4BZCA 4RXQA 4Q7HA 3I7AA 4L7WA 4TO5A 4TNZA 3SKDA 2O08A 2PARA 4QFXA 4MZ7A 5AO3A 2HEKA 4TNYA 3LJXA 5TK6A 3NR1A 2PGSA 1YNBA 3U1NA 4MLNA 3TM8A 3SK9A 4QFYA 1VQRA 3GW7A 4R8ZA 4ZWEA 4QQXA 4Q2CA 4TO0A 4TNRA 4N71A 4BZBA 2O6IA 2PAQA 1U6ZA 4RXOA 3NQWA 4MCWA 4RXRA 4QG1A 3KH1A 4QQWA 4TO4A 3MZOA 4TNPA 5AO0A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3MEM A;  2DQB A;  2GZ4 A;  3RF0 A;  4RXS A;  3TMB A;  2PQ7 A;  4L1J B;  1YOY A;  5TK9 A;  1XX7 A;  5TK7 A;  2FLO A;  4MDZ A;  4QG2 A;  3P3Q A;  5AO1 A;  4X9E A;  4RXP A;  1VJ7 A;  4N6W A;  3M1T A;  5AO2 A;  4LRL A;  3CCG A;  3TMD A;  5TK8 A;  2Q14 A;  4TO2 A;  4QFZ A;  4TNX A;  2CQZ A;  2PAU A;  3HC1 A;  4QG4 A;  4DMB A;  4MLM A;  3BG2 A;  4ME4 A;  2OGI A;  4L7E A;  4XDS A;  5TKA A;  3HI0 A;  3TMC A;  4TO1 A;  4ZWG A;  4L1J A;  4QG0 A;  4TO3 A;  4TO6 A;  5AO4 A;  4TNQ A;  3IRH A;  4BZC A;  4RXQ A;  4Q7H A;  3I7A A;  4L7W A;  4TO5 A;  4TNZ A;  2O08 A;  2PAR A;  4QFX A;  4MZ7 A;  5AO3 A;  2HEK A;  4TNY A;  3LJX A;  5TK6 A;  3NR1 A;  2PGS A;  1YNB A;  3U1N A;  4MLN A;  3TM8 A;  4QFY A;  1VQR A;  4R8Z A;  4ZWE A;  4TO0 A;  4TNR A;  4N71 A;  4BZB A;  2O6I A;  2PAQ A;  1U6Z A;  4RXO A;  3NQW A;  4MCW A;  4RXR A;  4QG1 A;  3KH1 A;  4TO4 A;  3MZO A;  4TNP A;  5AO0 A; 
#chains in the Genus database with same CATH topology
 3MEM A;  2DQB A;  2GZ4 A;  3RF0 A;  4RXS A;  3TMB A;  2PQ7 A;  4L1J B;  1YOY A;  5TK9 A;  1XX7 A;  5TK7 A;  2FLO A;  4MDZ A;  4QG2 A;  3P3Q A;  5AO1 A;  4X9E A;  4RXP A;  1VJ7 A;  4N6W A;  3M1T A;  5AO2 A;  4LRL A;  3CCG A;  3TMD A;  5TK8 A;  2Q14 A;  3S4L A;  4TO2 A;  4QFZ A;  4TNX A;  2CQZ A;  2PAU A;  3HC1 A;  4QG4 A;  4DMB A;  4MLM A;  3BG2 A;  4ME4 A;  2OGI A;  4L7E A;  4XDS A;  5TKA A;  3HI0 A;  3TMC A;  4Q2D A;  4TO1 A;  4ZWG A;  4L1J A;  4QQY A;  4QG0 A;  4TO3 A;  4TO6 A;  5AO4 A;  4TNQ A;  3IRH A;  4QQZ A;  3KQ5 A;  4BZC A;  4RXQ A;  4Q7H A;  3I7A A;  4L7W A;  4TO5 A;  4TNZ A;  3SKD A;  2O08 A;  2PAR A;  4QFX A;  4MZ7 A;  5AO3 A;  2HEK A;  4TNY A;  3LJX A;  5TK6 A;  3NR1 A;  2PGS A;  1YNB A;  3U1N A;  4MLN A;  3TM8 A;  3SK9 A;  4QFY A;  1VQR A;  3GW7 A;  4R8Z A;  4ZWE A;  4QQX A;  4Q2C A;  4TO0 A;  4TNR A;  4N71 A;  4BZB A;  2O6I A;  2PAQ A;  1U6Z A;  4RXO A;  3NQW A;  4MCW A;  4RXR A;  4QG1 A;  3KH1 A;  4QQW A;  4TO4 A;  3MZO A;  4TNP A;  5AO0 A; 
#chains in the Genus database with same CATH homology
 3MEM A;  2DQB A;  2GZ4 A;  3RF0 A;  4RXS A;  3TMB A;  2PQ7 A;  4L1J B;  1YOY A;  5TK9 A;  1XX7 A;  5TK7 A;  2FLO A;  4MDZ A;  4QG2 A;  3P3Q A;  5AO1 A;  4X9E A;  4RXP A;  1VJ7 A;  4N6W A;  3M1T A;  5AO2 A;  4LRL A;  3CCG A;  3TMD A;  5TK8 A;  2Q14 A;  3S4L A;  4TO2 A;  4QFZ A;  4TNX A;  2CQZ A;  2PAU A;  3HC1 A;  4QG4 A;  4DMB A;  4MLM A;  3BG2 A;  4ME4 A;  2OGI A;  4L7E A;  4XDS A;  5TKA A;  3HI0 A;  3TMC A;  4Q2D A;  4TO1 A;  4ZWG A;  4L1J A;  4QQY A;  4QG0 A;  4TO3 A;  4TO6 A;  5AO4 A;  4TNQ A;  3IRH A;  4QQZ A;  3KQ5 A;  4BZC A;  4RXQ A;  4Q7H A;  3I7A A;  4L7W A;  4TO5 A;  4TNZ A;  3SKD A;  2O08 A;  2PAR A;  4QFX A;  4MZ7 A;  5AO3 A;  2HEK A;  4TNY A;  3LJX A;  5TK6 A;  3NR1 A;  2PGS A;  1YNB A;  3U1N A;  4MLN A;  3TM8 A;  3SK9 A;  4QFY A;  1VQR A;  3GW7 A;  4R8Z A;  4ZWE A;  4QQX A;  4Q2C A;  4TO0 A;  4TNR A;  4N71 A;  4BZB A;  2O6I A;  2PAQ A;  1U6Z A;  4RXO A;  3NQW A;  4MCW A;  4RXR A;  4QG1 A;  3KH1 A;  4QQW A;  4TO4 A;  3MZO A;  4TNP A;  5AO0 A; 
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