4R8ZA

Crystal structure of pa4781 hd-gyp domain from pseudomonas aeruginosa at 2.2a resolution showing a bi-metallic ni ion center
Total Genus 85
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
85
sequence length
218
structure length
218
Chain Sequence
RTRQLQQLQDAVIEALATLGDLRDNPRSRHLPRIERYVRLLAEHLAAQRAFADELTPEAVDLLSKSALLHDIGKVAVPDRVLLNPGQLDAADTALLQGHTRAGRDALASAERRLGQPSGFLRFARQIAYSHHERWDGRGFPEGLAGERIPLAARIVALADRYDELTSRHAYRPPLAHAEAVLLIQAGAGSEFDPRLVEAFVAVADAFAEVARRYADSA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural basis of functional diversification of the HD-GYP domain revealed by the Pseudomonas aeruginosa PA4781 protein, which displays an unselective bimetallic binding site.
pubmed doi rcsb
molecule tags Hydrolase
source organism Pseudomonas aeruginosa pao1
molecule keywords Cyclic di-GMP phosphodiesterase
total genus 85
structure length 218
sequence length 218
chains with identical sequence B
ec nomenclature ec 3.1.4.1: Phosphodiesterase I.
pdb deposition date 2014-09-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF13487 HD_5 HD domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.3210.10 Mainly Alpha Orthogonal Bundle Hypothetical protein af1432 Hypothetical protein af1432 4r8zA00
2PQ7A 4DMBA 2O08A 4L7WA 1VQRA 3TM8A 4QFYA 1YNBA 3NQWA 4ZWEA 4TO5A 3CCGA 3TMDA 4MLNA 4RXPA 4LRLA 4TO4A 3P3QA 5AO0A 4TNYA 2O6IA 4TNQA 4ME4A 4QFZA 3LJXA 4TO3A 4BZCA 2PAQA 1VJ7A 1XX7A 4XDSA 4MLMA 4RXOA 4TNRA 3TMCA 3KH1A 4BZBA 4QG1A 3TMBA 5TK7A 3HC1A 4N6WA 3RF0A 5AO3A 2OGIA 2FLOA 5AO1A 3U1NA 4RXQA 3IRHA 4TNXA 5AO4A 4MZ7A 3NR1A 4MCWA 5TK8A 2DQBA 3MEMA 2Q14A 4QG0A 4TNZA 2HEKA 3I7AA 4QG2A 4TO1A 4RXRA 4N71A 4TNPA 2CQZA 4QFXA 5TK6A 1U6ZA 4R8ZA 2PGSA 3MZOA 4TO0A 2GZ4A 5TK9A 4ZWGA 4QG4A 4TO2A 3HI0A 4TO6A 4MDZA 1YOYA 2PAUA 4X9EA 5TKAA 5AO2A 4L1JB 3BG2A 3M1TA 4L7EA 4RXSA 4L1JA 4Q7HA 2PARA
chains in the Genus database with same CATH superfamily
2PQ7A 3GW7A 4DMBA 2O08A 4L7WA 1VQRA 3TM8A 4QFYA 1YNBA 3NQWA 3S4LA 4ZWEA 4TO5A 3CCGA 3TMDA 3SKDA 3KQ5A 4MLNA 4RXPA 4LRLA 4TO4A 3P3QA 5AO0A 4TNYA 2O6IA 4TNQA 4ME4A 4QFZA 3LJXA 4TO3A 4BZCA 4QQWA 4QQYA 2PAQA 1VJ7A 4QQXA 1XX7A 4XDSA 4MLMA 4RXOA 4TNRA 3TMCA 3KH1A 4BZBA 4QG1A 3TMBA 5TK7A 3HC1A 4N6WA 3RF0A 5AO3A 2OGIA 2FLOA 5AO1A 3U1NA 4RXQA 3IRHA 4TNXA 5AO4A 4MZ7A 3NR1A 4MCWA 5TK8A 2DQBA 3MEMA 2Q14A 4QG0A 4TNZA 2HEKA 3I7AA 4QG2A 4TO1A 4RXRA 4N71A 4QQZA 4TNPA 2CQZA 4Q2CA 4Q2DA 4QFXA 5TK6A 1U6ZA 4R8ZA 2PGSA 3MZOA 4TO0A 2GZ4A 5TK9A 4ZWGA 4QG4A 4TO2A 3HI0A 4TO6A 4MDZA 1YOYA 2PAUA 4X9EA 5TKAA 5AO2A 4L1JB 3BG2A 3M1TA 4L7EA 4RXSA 4L1JA 4Q7HA 2PARA 3SK9A
chains in the Genus database with same CATH topology
2PQ7A 3GW7A 4DMBA 2O08A 4L7WA 1VQRA 3TM8A 4QFYA 1YNBA 3NQWA 3S4LA 4ZWEA 4TO5A 3CCGA 3TMDA 3SKDA 3KQ5A 4MLNA 4RXPA 4LRLA 4TO4A 3P3QA 5AO0A 4TNYA 2O6IA 4TNQA 4ME4A 4QFZA 3LJXA 4TO3A 4BZCA 4QQWA 4QQYA 2PAQA 1VJ7A 4QQXA 1XX7A 4XDSA 4MLMA 4RXOA 4TNRA 3TMCA 3KH1A 4BZBA 4QG1A 3TMBA 5TK7A 3HC1A 4N6WA 3RF0A 5AO3A 2OGIA 2FLOA 5AO1A 3U1NA 4RXQA 3IRHA 4TNXA 5AO4A 4MZ7A 3NR1A 4MCWA 5TK8A 2DQBA 3MEMA 2Q14A 4QG0A 4TNZA 2HEKA 3I7AA 4QG2A 4TO1A 4RXRA 4N71A 4QQZA 4TNPA 2CQZA 4Q2CA 4Q2DA 4QFXA 5TK6A 1U6ZA 4R8ZA 2PGSA 3MZOA 4TO0A 2GZ4A 5TK9A 4ZWGA 4QG4A 4TO2A 3HI0A 4TO6A 4MDZA 1YOYA 2PAUA 4X9EA 5TKAA 5AO2A 4L1JB 3BG2A 3M1TA 4L7EA 4RXSA 4L1JA 4Q7HA 2PARA 3SK9A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2PQ7 A;  4DMB A;  2O08 A;  4L7W A;  1VQR A;  3TM8 A;  4QFY A;  1YNB A;  3NQW A;  4ZWE A;  4TO5 A;  3CCG A;  3TMD A;  4MLN A;  4RXP A;  4LRL A;  4TO4 A;  3P3Q A;  5AO0 A;  4TNY A;  2O6I A;  4TNQ A;  4ME4 A;  4QFZ A;  3LJX A;  4TO3 A;  4BZC A;  2PAQ A;  1VJ7 A;  1XX7 A;  4XDS A;  4MLM A;  4RXO A;  4TNR A;  3TMC A;  3KH1 A;  4BZB A;  4QG1 A;  3TMB A;  5TK7 A;  3HC1 A;  4N6W A;  3RF0 A;  5AO3 A;  2OGI A;  2FLO A;  5AO1 A;  3U1N A;  4RXQ A;  3IRH A;  4TNX A;  5AO4 A;  4MZ7 A;  3NR1 A;  4MCW A;  5TK8 A;  2DQB A;  3MEM A;  2Q14 A;  4QG0 A;  4TNZ A;  2HEK A;  3I7A A;  4QG2 A;  4TO1 A;  4RXR A;  4N71 A;  4TNP A;  2CQZ A;  4QFX A;  5TK6 A;  1U6Z A;  4R8Z A;  2PGS A;  3MZO A;  4TO0 A;  2GZ4 A;  5TK9 A;  4ZWG A;  4QG4 A;  4TO2 A;  3HI0 A;  4TO6 A;  4MDZ A;  1YOY A;  2PAU A;  4X9E A;  5TKA A;  5AO2 A;  4L1J B;  3BG2 A;  3M1T A;  4L7E A;  4RXS A;  4L1J A;  4Q7H A;  2PAR A; 
#chains in the Genus database with same CATH topology
 2PQ7 A;  3GW7 A;  4DMB A;  2O08 A;  4L7W A;  1VQR A;  3TM8 A;  4QFY A;  1YNB A;  3NQW A;  3S4L A;  4ZWE A;  4TO5 A;  3CCG A;  3TMD A;  3SKD A;  3KQ5 A;  4MLN A;  4RXP A;  4LRL A;  4TO4 A;  3P3Q A;  5AO0 A;  4TNY A;  2O6I A;  4TNQ A;  4ME4 A;  4QFZ A;  3LJX A;  4TO3 A;  4BZC A;  4QQW A;  4QQY A;  2PAQ A;  1VJ7 A;  4QQX A;  1XX7 A;  4XDS A;  4MLM A;  4RXO A;  4TNR A;  3TMC A;  3KH1 A;  4BZB A;  4QG1 A;  3TMB A;  5TK7 A;  3HC1 A;  4N6W A;  3RF0 A;  5AO3 A;  2OGI A;  2FLO A;  5AO1 A;  3U1N A;  4RXQ A;  3IRH A;  4TNX A;  5AO4 A;  4MZ7 A;  3NR1 A;  4MCW A;  5TK8 A;  2DQB A;  3MEM A;  2Q14 A;  4QG0 A;  4TNZ A;  2HEK A;  3I7A A;  4QG2 A;  4TO1 A;  4RXR A;  4N71 A;  4QQZ A;  4TNP A;  2CQZ A;  4Q2C A;  4Q2D A;  4QFX A;  5TK6 A;  1U6Z A;  4R8Z A;  2PGS A;  3MZO A;  4TO0 A;  2GZ4 A;  5TK9 A;  4ZWG A;  4QG4 A;  4TO2 A;  3HI0 A;  4TO6 A;  4MDZ A;  1YOY A;  2PAU A;  4X9E A;  5TKA A;  5AO2 A;  4L1J B;  3BG2 A;  3M1T A;  4L7E A;  4RXS A;  4L1J A;  4Q7H A;  2PAR A;  3SK9 A; 
#chains in the Genus database with same CATH homology
 2PQ7 A;  3GW7 A;  4DMB A;  2O08 A;  4L7W A;  1VQR A;  3TM8 A;  4QFY A;  1YNB A;  3NQW A;  3S4L A;  4ZWE A;  4TO5 A;  3CCG A;  3TMD A;  3SKD A;  3KQ5 A;  4MLN A;  4RXP A;  4LRL A;  4TO4 A;  3P3Q A;  5AO0 A;  4TNY A;  2O6I A;  4TNQ A;  4ME4 A;  4QFZ A;  3LJX A;  4TO3 A;  4BZC A;  4QQW A;  4QQY A;  2PAQ A;  1VJ7 A;  4QQX A;  1XX7 A;  4XDS A;  4MLM A;  4RXO A;  4TNR A;  3TMC A;  3KH1 A;  4BZB A;  4QG1 A;  3TMB A;  5TK7 A;  3HC1 A;  4N6W A;  3RF0 A;  5AO3 A;  2OGI A;  2FLO A;  5AO1 A;  3U1N A;  4RXQ A;  3IRH A;  4TNX A;  5AO4 A;  4MZ7 A;  3NR1 A;  4MCW A;  5TK8 A;  2DQB A;  3MEM A;  2Q14 A;  4QG0 A;  4TNZ A;  2HEK A;  3I7A A;  4QG2 A;  4TO1 A;  4RXR A;  4N71 A;  4QQZ A;  4TNP A;  2CQZ A;  4Q2C A;  4Q2D A;  4QFX A;  5TK6 A;  1U6Z A;  4R8Z A;  2PGS A;  3MZO A;  4TO0 A;  2GZ4 A;  5TK9 A;  4ZWG A;  4QG4 A;  4TO2 A;  3HI0 A;  4TO6 A;  4MDZ A;  1YOY A;  2PAU A;  4X9E A;  5TKA A;  5AO2 A;  4L1J B;  3BG2 A;  3M1T A;  4L7E A;  4RXS A;  4L1J A;  4Q7H A;  2PAR A;  3SK9 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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