4RXP | Genus

Total Genus 168

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	168
sequence length	486
structure length	481
Chain Sequence	TMKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASHNRFEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCHDLGHGPFSHMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPEEDIYFIKEQIVGPLESLWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFARDCHHLGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNSLHRRAYQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDDMEAYTKLTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKIKREDYESLPKEVASAKPKVLLDVKLKAEDFIVDVINMDYGMQEKNPIDHVSFYCKTAPNRAIRITKNQVSQLLPEKFAEQLIRVYCKKVDRKSLYAARQYFVQWCADRNFTKPQDGDVIAPLITPQKKEWN

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

Chord Diagram

molecule tags	Hydrolase
source organism	Homo sapiens
publication title	The mechanism of substrate-controlled allosteric regulation of SAMHD1 activated by GTP. pubmed doi rcsb
molecule keywords	Deoxynucleoside triphosphate triphosphohydrolase SAMHD1
total genus	168
structure length	481
sequence length	486
chains with identical sequence	B
ec nomenclature	ec 3.1.5.-:
pdb deposition date	2014-12-11

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF01966	HD	HD domain

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
1.10.3210.10	Mainly Alpha	Orthogonal Bundle	Hypothetical protein af1432	Hypothetical protein af1432	4rxpA01

5TK8A 3P3QA 4QG0A 3IRHA 5TK7A 4MCWA 1YOYA 3MEMA 5TKAA 3NQWA 3TM8A 4RXSA 3HI0A 4RXQA 3TMCA 4Q7HA 5TK6A 4QFXA 2PAUA 4QFZA 4TO4A 3TMDA 3KH1A 3LJXA 4TNXA 5AO4A 5AO1A 3NR1A 4TNPA 1XX7A 4X9EA 5AO0A 5AO3A 3CCGA 4L1JB 4XDSA 3U1NA 4N6WA 4QG2A 4TO5A 3HC1A 1YNBA 4L7WA 4RXOA 2PARA 4RXRA 4DMBA 5TK9A 1VQRA 5AO2A 2Q14A 2PQ7A 4TNQA 2HEKA 2CQZA 2GZ4A 4TO0A 3MZOA 3M1TA 3RF0A 1VJ7A 4MLNA 4TNZA 3I7AA 2DQBA 4TO1A 4RXPA 4TNRA 4N71A 4ZWEA 4L7EA 4TO6A 4TO2A 4QG4A 4R8ZA 4TO3A 4L1JA 4MLMA 4LRLA 1U6ZA 4QG1A 4BZCA 4ME4A 2OGIA 3BG2A 4TNYA 3TMBA 4MZ7A 2FLOA 4QFYA 2O6IA 4BZBA 4MDZA 4ZWGA 2PAQA 2PGSA 2O08A
chains in the Genus database with same CATH superfamily

5TK8A 3P3QA 4QG0A 3IRHA 5TK7A 3GW7A 4MCWA 1YOYA 3MEMA 5TKAA 3NQWA 3TM8A 4RXSA 3HI0A 4QQWA 4RXQA 3TMCA 4Q7HA 4QQZA 5TK6A 4QFXA 2PAUA 4QFZA 4TO4A 3TMDA 3KH1A 3LJXA 4TNXA 5AO4A 5AO1A 3NR1A 4TNPA 1XX7A 4X9EA 5AO0A 5AO3A 3CCGA 4L1JB 4XDSA 3U1NA 4N6WA 4QG2A 4TO5A 3HC1A 1YNBA 4L7WA 4RXOA 2PARA 4RXRA 4DMBA 5TK9A 1VQRA 5AO2A 2Q14A 2PQ7A 4TNQA 4QQXA 2HEKA 2CQZA 2GZ4A 4TO0A 3MZOA 3SKDA 3KQ5A 3M1TA 3RF0A 1VJ7A 4MLNA 4TNZA 4QQYA 3I7AA 2DQBA 4TO1A 4RXPA 4TNRA 4N71A 4ZWEA 4L7EA 4TO6A 4TO2A 4QG4A 4R8ZA 4TO3A 4L1JA 4MLMA 4LRLA 1U6ZA 4QG1A 4BZCA 4ME4A 2OGIA 3BG2A 3S4LA 4TNYA 3TMBA 4MZ7A 2FLOA 4QFYA 2O6IA 4BZBA 4MDZA 3SK9A 4Q2CA 4ZWGA 4Q2DA 2PAQA 2PGSA 2O08A
chains in the Genus database with same CATH topology

#chains in the Genus database with same CATH superfamily
 5TK8 A;  3P3Q A;  4QG0 A;  3IRH A;  5TK7 A;  4MCW A;  1YOY A;  3MEM A;  5TKA A;  3NQW A;  3TM8 A;  4RXS A;  3HI0 A;  4RXQ A;  3TMC A;  4Q7H A;  5TK6 A;  4QFX A;  2PAU A;  4QFZ A;  4TO4 A;  3TMD A;  3KH1 A;  3LJX A;  4TNX A;  5AO4 A;  5AO1 A;  3NR1 A;  4TNP A;  1XX7 A;  4X9E A;  5AO0 A;  5AO3 A;  3CCG A;  4L1J B;  4XDS A;  3U1N A;  4N6W A;  4QG2 A;  4TO5 A;  3HC1 A;  1YNB A;  4L7W A;  4RXO A;  2PAR A;  4RXR A;  4DMB A;  5TK9 A;  1VQR A;  5AO2 A;  2Q14 A;  2PQ7 A;  4TNQ A;  2HEK A;  2CQZ A;  2GZ4 A;  4TO0 A;  3MZO A;  3M1T A;  3RF0 A;  1VJ7 A;  4MLN A;  4TNZ A;  3I7A A;  2DQB A;  4TO1 A;  4RXP A;  4TNR A;  4N71 A;  4ZWE A;  4L7E A;  4TO6 A;  4TO2 A;  4QG4 A;  4R8Z A;  4TO3 A;  4L1J A;  4MLM A;  4LRL A;  1U6Z A;  4QG1 A;  4BZC A;  4ME4 A;  2OGI A;  3BG2 A;  4TNY A;  3TMB A;  4MZ7 A;  2FLO A;  4QFY A;  2O6I A;  4BZB A;  4MDZ A;  4ZWG A;  2PAQ A;  2PGS A;  2O08 A; 
#chains in the Genus database with same CATH topology
 5TK8 A;  3P3Q A;  4QG0 A;  3IRH A;  5TK7 A;  3GW7 A;  4MCW A;  1YOY A;  3MEM A;  5TKA A;  3NQW A;  3TM8 A;  4RXS A;  3HI0 A;  4QQW A;  4RXQ A;  3TMC A;  4Q7H A;  4QQZ A;  5TK6 A;  4QFX A;  2PAU A;  4QFZ A;  4TO4 A;  3TMD A;  3KH1 A;  3LJX A;  4TNX A;  5AO4 A;  5AO1 A;  3NR1 A;  4TNP A;  1XX7 A;  4X9E A;  5AO0 A;  5AO3 A;  3CCG A;  4L1J B;  4XDS A;  3U1N A;  4N6W A;  4QG2 A;  4TO5 A;  3HC1 A;  1YNB A;  4L7W A;  4RXO A;  2PAR A;  4RXR A;  4DMB A;  5TK9 A;  1VQR A;  5AO2 A;  2Q14 A;  2PQ7 A;  4TNQ A;  4QQX A;  2HEK A;  2CQZ A;  2GZ4 A;  4TO0 A;  3MZO A;  3SKD A;  3KQ5 A;  3M1T A;  3RF0 A;  1VJ7 A;  4MLN A;  4TNZ A;  4QQY A;  3I7A A;  2DQB A;  4TO1 A;  4RXP A;  4TNR A;  4N71 A;  4ZWE A;  4L7E A;  4TO6 A;  4TO2 A;  4QG4 A;  4R8Z A;  4TO3 A;  4L1J A;  4MLM A;  4LRL A;  1U6Z A;  4QG1 A;  4BZC A;  4ME4 A;  2OGI A;  3BG2 A;  3S4L A;  4TNY A;  3TMB A;  4MZ7 A;  2FLO A;  4QFY A;  2O6I A;  4BZB A;  4MDZ A;  3SK9 A;  4Q2C A;  4ZWG A;  4Q2D A;  2PAQ A;  2PGS A;  2O08 A; 
#chains in the Genus database with same CATH homology
 5TK8 A;  3P3Q A;  4QG0 A;  3IRH A;  5TK7 A;  3GW7 A;  4MCW A;  1YOY A;  3MEM A;  5TKA A;  3NQW A;  3TM8 A;  4RXS A;  3HI0 A;  4QQW A;  4RXQ A;  3TMC A;  4Q7H A;  4QQZ A;  5TK6 A;  4QFX A;  2PAU A;  4QFZ A;  4TO4 A;  3TMD A;  3KH1 A;  3LJX A;  4TNX A;  5AO4 A;  5AO1 A;  3NR1 A;  4TNP A;  1XX7 A;  4X9E A;  5AO0 A;  5AO3 A;  3CCG A;  4L1J B;  4XDS A;  3U1N A;  4N6W A;  4QG2 A;  4TO5 A;  3HC1 A;  1YNB A;  4L7W A;  4RXO A;  2PAR A;  4RXR A;  4DMB A;  5TK9 A;  1VQR A;  5AO2 A;  2Q14 A;  2PQ7 A;  4TNQ A;  4QQX A;  2HEK A;  2CQZ A;  2GZ4 A;  4TO0 A;  3MZO A;  3SKD A;  3KQ5 A;  3M1T A;  3RF0 A;  1VJ7 A;  4MLN A;  4TNZ A;  4QQY A;  3I7A A;  2DQB A;  4TO1 A;  4RXP A;  4TNR A;  4N71 A;  4ZWE A;  4L7E A;  4TO6 A;  4TO2 A;  4QG4 A;  4R8Z A;  4TO3 A;  4L1J A;  4MLM A;  4LRL A;  1U6Z A;  4QG1 A;  4BZC A;  4ME4 A;  2OGI A;  3BG2 A;  3S4L A;  4TNY A;  3TMB A;  4MZ7 A;  2FLO A;  4QFY A;  2O6I A;  4BZB A;  4MDZ A;  3SK9 A;  4Q2C A;  4ZWG A;  4Q2D A;  2PAQ A;  2PGS A;  2O08 A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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4RXPA

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

Chord Diagram

connected with : NaN

pfam database annotations