4RXPA

The structure of gtp-datp-bound samhd1
Total Genus 168
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
168
sequence length
486
structure length
481
Chain Sequence
TMKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASHNRFEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCHDLGHGPFSHMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPEEDIYFIKEQIVGPLESLWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFARDCHHLGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNSLHRRAYQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDDMEAYTKLTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKIKREDYESLPKEVASAKPKVLLDVKLKAEDFIVDVINMDYGMQEKNPIDHVSFYCKTAPNRAIRITKNQVSQLLPEKFAEQLIRVYCKKVDRKSLYAARQYFVQWCADRNFTKPQDGDVIAPLITPQKKEWN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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publication title The mechanism of substrate-controlled allosteric regulation of SAMHD1 activated by GTP.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords Deoxynucleoside triphosphate triphosphohydrolase SAMHD1
total genus 168
structure length 481
sequence length 486
chains with identical sequence B
ec nomenclature ec 3.1.5.-:
pdb deposition date 2014-12-11

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01966 HD HD domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.3210.10 Mainly Alpha Orthogonal Bundle Hypothetical protein af1432 Hypothetical protein af1432 4rxpA01
3I7AA 4ZWEA 5AO2A 3TMBA 1VJ7A 4RXRA 4TO5A 5TK9A 4TNXA 4TO4A 1YNBA 2HEKA 4QG4A 3TMCA 2PQ7A 5TK6A 4ME4A 3KH1A 4TO6A 3NQWA 4QFYA 4QG1A 3BG2A 5AO0A 2PARA 3MEMA 2PAQA 3U1NA 4DMBA 4TO2A 1YOYA 4RXPA 4X9EA 3MZOA 4BZBA 1XX7A 4TO3A 4BZCA 4N71A 4TO1A 4QG2A 4N6WA 4L1JA 5AO1A 4MCWA 5AO4A 3CCGA 4QFXA 4ZWGA 4TNPA 2CQZA 4RXQA 4Q7HA 2OGIA 4R8ZA 4TNZA 1U6ZA 3LJXA 5TKAA 3P3QA 3RF0A 3HI0A 4LRLA 4TNRA 4QFZA 3TM8A 3TMDA 3IRHA 2O6IA 2Q14A 4MLMA 4MZ7A 4TNYA 2FLOA 5TK7A 2PGSA 4RXOA 3HC1A 2PAUA 5AO3A 4L7EA 1VQRA 4QG0A 4TNQA 2DQBA 4MDZA 3NR1A 4MLNA 4TO0A 4XDSA 4L7WA 4RXSA 2GZ4A 5TK8A 2O08A 4L1JB 3M1TA
chains in the Genus database with same CATH superfamily
3I7AA 4ZWEA 5AO2A 3SK9A 3TMBA 1VJ7A 4RXRA 4TO5A 5TK9A 4TNXA 4TO4A 3S4LA 4Q2DA 1YNBA 2HEKA 4QG4A 3TMCA 2PQ7A 5TK6A 4QQZA 4ME4A 3KH1A 4TO6A 3NQWA 4QFYA 4QG1A 3BG2A 5AO0A 2PARA 3MEMA 2PAQA 3U1NA 4DMBA 3SKDA 4TO2A 1YOYA 4RXPA 4X9EA 3MZOA 4BZBA 1XX7A 3GW7A 4QQYA 4TO3A 4BZCA 4N71A 4TO1A 4QG2A 4N6WA 4L1JA 5AO1A 4MCWA 5AO4A 3CCGA 4QFXA 4ZWGA 4TNPA 2CQZA 4QQXA 4RXQA 4QQWA 4Q7HA 2OGIA 4R8ZA 4TNZA 1U6ZA 3LJXA 5TKAA 3P3QA 3RF0A 3HI0A 4LRLA 4TNRA 4QFZA 3TM8A 3TMDA 3IRHA 2O6IA 2Q14A 4MLMA 4MZ7A 4TNYA 2FLOA 5TK7A 2PGSA 4RXOA 3HC1A 2PAUA 5AO3A 4L7EA 1VQRA 4QG0A 4TNQA 2DQBA 4MDZA 3NR1A 4MLNA 4Q2CA 4TO0A 4XDSA 3KQ5A 4L7WA 4RXSA 2GZ4A 5TK8A 2O08A 4L1JB 3M1TA
chains in the Genus database with same CATH topology
3I7AA 4ZWEA 5AO2A 3SK9A 3TMBA 1VJ7A 4RXRA 4TO5A 5TK9A 4TNXA 4TO4A 3S4LA 4Q2DA 1YNBA 2HEKA 4QG4A 3TMCA 2PQ7A 5TK6A 4QQZA 4ME4A 3KH1A 4TO6A 3NQWA 4QFYA 4QG1A 3BG2A 5AO0A 2PARA 3MEMA 2PAQA 3U1NA 4DMBA 3SKDA 4TO2A 1YOYA 4RXPA 4X9EA 3MZOA 4BZBA 1XX7A 3GW7A 4QQYA 4TO3A 4BZCA 4N71A 4TO1A 4QG2A 4N6WA 4L1JA 5AO1A 4MCWA 5AO4A 3CCGA 4QFXA 4ZWGA 4TNPA 2CQZA 4QQXA 4RXQA 4QQWA 4Q7HA 2OGIA 4R8ZA 4TNZA 1U6ZA 3LJXA 5TKAA 3P3QA 3RF0A 3HI0A 4LRLA 4TNRA 4QFZA 3TM8A 3TMDA 3IRHA 2O6IA 2Q14A 4MLMA 4MZ7A 4TNYA 2FLOA 5TK7A 2PGSA 4RXOA 3HC1A 2PAUA 5AO3A 4L7EA 1VQRA 4QG0A 4TNQA 2DQBA 4MDZA 3NR1A 4MLNA 4Q2CA 4TO0A 4XDSA 3KQ5A 4L7WA 4RXSA 2GZ4A 5TK8A 2O08A 4L1JB 3M1TA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 3I7A A;  4ZWE A;  5AO2 A;  3TMB A;  1VJ7 A;  4RXR A;  4TO5 A;  5TK9 A;  4TNX A;  4TO4 A;  1YNB A;  2HEK A;  4QG4 A;  3TMC A;  2PQ7 A;  5TK6 A;  4ME4 A;  3KH1 A;  4TO6 A;  3NQW A;  4QFY A;  4QG1 A;  3BG2 A;  5AO0 A;  2PAR A;  3MEM A;  2PAQ A;  3U1N A;  4DMB A;  4TO2 A;  1YOY A;  4RXP A;  4X9E A;  3MZO A;  4BZB A;  1XX7 A;  4TO3 A;  4BZC A;  4N71 A;  4TO1 A;  4QG2 A;  4N6W A;  4L1J A;  5AO1 A;  4MCW A;  5AO4 A;  3CCG A;  4QFX A;  4ZWG A;  4TNP A;  2CQZ A;  4RXQ A;  4Q7H A;  2OGI A;  4R8Z A;  4TNZ A;  1U6Z A;  3LJX A;  5TKA A;  3P3Q A;  3RF0 A;  3HI0 A;  4LRL A;  4TNR A;  4QFZ A;  3TM8 A;  3TMD A;  3IRH A;  2O6I A;  2Q14 A;  4MLM A;  4MZ7 A;  4TNY A;  2FLO A;  5TK7 A;  2PGS A;  4RXO A;  3HC1 A;  2PAU A;  5AO3 A;  4L7E A;  1VQR A;  4QG0 A;  4TNQ A;  2DQB A;  4MDZ A;  3NR1 A;  4MLN A;  4TO0 A;  4XDS A;  4L7W A;  4RXS A;  2GZ4 A;  5TK8 A;  2O08 A;  4L1J B;  3M1T A; 
#chains in the Genus database with same CATH topology
 3I7A A;  4ZWE A;  5AO2 A;  3SK9 A;  3TMB A;  1VJ7 A;  4RXR A;  4TO5 A;  5TK9 A;  4TNX A;  4TO4 A;  3S4L A;  4Q2D A;  1YNB A;  2HEK A;  4QG4 A;  3TMC A;  2PQ7 A;  5TK6 A;  4QQZ A;  4ME4 A;  3KH1 A;  4TO6 A;  3NQW A;  4QFY A;  4QG1 A;  3BG2 A;  5AO0 A;  2PAR A;  3MEM A;  2PAQ A;  3U1N A;  4DMB A;  3SKD A;  4TO2 A;  1YOY A;  4RXP A;  4X9E A;  3MZO A;  4BZB A;  1XX7 A;  3GW7 A;  4QQY A;  4TO3 A;  4BZC A;  4N71 A;  4TO1 A;  4QG2 A;  4N6W A;  4L1J A;  5AO1 A;  4MCW A;  5AO4 A;  3CCG A;  4QFX A;  4ZWG A;  4TNP A;  2CQZ A;  4QQX A;  4RXQ A;  4QQW A;  4Q7H A;  2OGI A;  4R8Z A;  4TNZ A;  1U6Z A;  3LJX A;  5TKA A;  3P3Q A;  3RF0 A;  3HI0 A;  4LRL A;  4TNR A;  4QFZ A;  3TM8 A;  3TMD A;  3IRH A;  2O6I A;  2Q14 A;  4MLM A;  4MZ7 A;  4TNY A;  2FLO A;  5TK7 A;  2PGS A;  4RXO A;  3HC1 A;  2PAU A;  5AO3 A;  4L7E A;  1VQR A;  4QG0 A;  4TNQ A;  2DQB A;  4MDZ A;  3NR1 A;  4MLN A;  4Q2C A;  4TO0 A;  4XDS A;  3KQ5 A;  4L7W A;  4RXS A;  2GZ4 A;  5TK8 A;  2O08 A;  4L1J B;  3M1T A; 
#chains in the Genus database with same CATH homology
 3I7A A;  4ZWE A;  5AO2 A;  3SK9 A;  3TMB A;  1VJ7 A;  4RXR A;  4TO5 A;  5TK9 A;  4TNX A;  4TO4 A;  3S4L A;  4Q2D A;  1YNB A;  2HEK A;  4QG4 A;  3TMC A;  2PQ7 A;  5TK6 A;  4QQZ A;  4ME4 A;  3KH1 A;  4TO6 A;  3NQW A;  4QFY A;  4QG1 A;  3BG2 A;  5AO0 A;  2PAR A;  3MEM A;  2PAQ A;  3U1N A;  4DMB A;  3SKD A;  4TO2 A;  1YOY A;  4RXP A;  4X9E A;  3MZO A;  4BZB A;  1XX7 A;  3GW7 A;  4QQY A;  4TO3 A;  4BZC A;  4N71 A;  4TO1 A;  4QG2 A;  4N6W A;  4L1J A;  5AO1 A;  4MCW A;  5AO4 A;  3CCG A;  4QFX A;  4ZWG A;  4TNP A;  2CQZ A;  4QQX A;  4RXQ A;  4QQW A;  4Q7H A;  2OGI A;  4R8Z A;  4TNZ A;  1U6Z A;  3LJX A;  5TKA A;  3P3Q A;  3RF0 A;  3HI0 A;  4LRL A;  4TNR A;  4QFZ A;  3TM8 A;  3TMD A;  3IRH A;  2O6I A;  2Q14 A;  4MLM A;  4MZ7 A;  4TNY A;  2FLO A;  5TK7 A;  2PGS A;  4RXO A;  3HC1 A;  2PAU A;  5AO3 A;  4L7E A;  1VQR A;  4QG0 A;  4TNQ A;  2DQB A;  4MDZ A;  3NR1 A;  4MLN A;  4Q2C A;  4TO0 A;  4XDS A;  3KQ5 A;  4L7W A;  4RXS A;  2GZ4 A;  5TK8 A;  2O08 A;  4L1J B;  3M1T A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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