4RXQA

The structure of gtp-dutp-bound samhd1
Total Genus 168
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
168
sequence length
486
structure length
481
Chain Sequence
TMKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASHNRFEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCHDLGHGPFSHMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPEEDIYFIKEQIVGPLESLWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFARDCHHLGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNSLHRRAYQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDDMEAYTKLTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKIKREDYESLPKEVASAKPKVLLDVKLKAEDFIVDVINMDYGMQEKNPIDHVSFYCKTAPNRAIRITKNQVSQLLPEKFAEQLIRVYCKKVDRKSLYAARQYFVQWCADRNFTKPQDGDVIAPLITPQKKEWN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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publication title The mechanism of substrate-controlled allosteric regulation of SAMHD1 activated by GTP.
pubmed doi rcsb
molecule keywords Deoxynucleoside triphosphate triphosphohydrolase SAMHD1
molecule tags Hydrolase
source organism Homo sapiens
total genus 168
structure length 481
sequence length 486
chains with identical sequence B
ec nomenclature ec 3.1.5.-:
pdb deposition date 2014-12-11

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01966 HD HD domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.3210.10 Mainly Alpha Orthogonal Bundle Hypothetical protein af1432 Hypothetical protein af1432 4rxqA01
3HI0A 4X9EA 4TO2A 4TNPA 4L7WA 4TO6A 4TNZA 4BZCA 4QG2A 4N6WA 5AO4A 5TKAA 5AO2A 4MDZA 4L1JA 4MZ7A 4QFYA 4TO1A 3I7AA 4LRLA 3IRHA 1YNBA 2FLOA 5TK6A 4ZWGA 4XDSA 3M1TA 2O6IA 2PAUA 2CQZA 3CCGA 3HC1A 4DMBA 2OGIA 4RXOA 4TO3A 3KH1A 4TO5A 3NR1A 2GZ4A 3LJXA 1VQRA 4R8ZA 1YOYA 2PQ7A 5TK8A 4TO4A 4MCWA 5AO0A 4MLNA 1U6ZA 4QG0A 2O08A 3TMCA 2Q14A 1XX7A 4QFXA 4BZBA 4L1JB 3TMBA 3NQWA 5AO3A 3TM8A 2PGSA 4L7EA 3TMDA 4MLMA 2PARA 5AO1A 2PAQA 4TNXA 3P3QA 4RXPA 4Q7HA 1VJ7A 4TNRA 3U1NA 2HEKA 3MEMA 4RXRA 5TK7A 4N71A 5TK9A 4QFZA 3MZOA 4TO0A 4TNQA 4ME4A 4TNYA 4QG1A 4ZWEA 4RXQA 3RF0A 3BG2A 4QG4A 2DQBA 4RXSA
chains in the Genus database with same CATH superfamily
3HI0A 4X9EA 4TO2A 4TNPA 4L7WA 4TO6A 4TNZA 4BZCA 4QG2A 4N6WA 5AO4A 5TKAA 5AO2A 4MDZA 4L1JA 4Q2DA 4MZ7A 4QFYA 4TO1A 3I7AA 4LRLA 3IRHA 1YNBA 2FLOA 3S4LA 5TK6A 4QQYA 4ZWGA 4XDSA 3M1TA 2O6IA 2PAUA 2CQZA 3CCGA 3HC1A 4DMBA 2OGIA 4RXOA 4TO3A 3KH1A 4TO5A 3NR1A 2GZ4A 3LJXA 1VQRA 4R8ZA 3SKDA 1YOYA 4Q2CA 2PQ7A 5TK8A 4TO4A 4MCWA 4QQWA 5AO0A 4MLNA 1U6ZA 4QG0A 2O08A 3TMCA 2Q14A 1XX7A 4QFXA 4BZBA 4L1JB 3TMBA 3GW7A 4QQXA 3NQWA 5AO3A 3TM8A 2PGSA 4L7EA 3TMDA 4MLMA 3SK9A 2PARA 5AO1A 2PAQA 4TNXA 3P3QA 4RXPA 4Q7HA 1VJ7A 4TNRA 3U1NA 2HEKA 3MEMA 4RXRA 5TK7A 4N71A 5TK9A 4QQZA 4QFZA 3MZOA 4TO0A 4TNQA 4ME4A 4TNYA 4QG1A 4ZWEA 4RXQA 3RF0A 3BG2A 4QG4A 2DQBA 3KQ5A 4RXSA
chains in the Genus database with same CATH topology
3HI0A 4X9EA 4TO2A 4TNPA 4L7WA 4TO6A 4TNZA 4BZCA 4QG2A 4N6WA 5AO4A 5TKAA 5AO2A 4MDZA 4L1JA 4Q2DA 4MZ7A 4QFYA 4TO1A 3I7AA 4LRLA 3IRHA 1YNBA 2FLOA 3S4LA 5TK6A 4QQYA 4ZWGA 4XDSA 3M1TA 2O6IA 2PAUA 2CQZA 3CCGA 3HC1A 4DMBA 2OGIA 4RXOA 4TO3A 3KH1A 4TO5A 3NR1A 2GZ4A 3LJXA 1VQRA 4R8ZA 3SKDA 1YOYA 4Q2CA 2PQ7A 5TK8A 4TO4A 4MCWA 4QQWA 5AO0A 4MLNA 1U6ZA 4QG0A 2O08A 3TMCA 2Q14A 1XX7A 4QFXA 4BZBA 4L1JB 3TMBA 3GW7A 4QQXA 3NQWA 5AO3A 3TM8A 2PGSA 4L7EA 3TMDA 4MLMA 3SK9A 2PARA 5AO1A 2PAQA 4TNXA 3P3QA 4RXPA 4Q7HA 1VJ7A 4TNRA 3U1NA 2HEKA 3MEMA 4RXRA 5TK7A 4N71A 5TK9A 4QQZA 4QFZA 3MZOA 4TO0A 4TNQA 4ME4A 4TNYA 4QG1A 4ZWEA 4RXQA 3RF0A 3BG2A 4QG4A 2DQBA 3KQ5A 4RXSA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 3HI0 A;  4X9E A;  4TO2 A;  4TNP A;  4L7W A;  4TO6 A;  4TNZ A;  4BZC A;  4QG2 A;  4N6W A;  5AO4 A;  5TKA A;  5AO2 A;  4MDZ A;  4L1J A;  4MZ7 A;  4QFY A;  4TO1 A;  3I7A A;  4LRL A;  3IRH A;  1YNB A;  2FLO A;  5TK6 A;  4ZWG A;  4XDS A;  3M1T A;  2O6I A;  2PAU A;  2CQZ A;  3CCG A;  3HC1 A;  4DMB A;  2OGI A;  4RXO A;  4TO3 A;  3KH1 A;  4TO5 A;  3NR1 A;  2GZ4 A;  3LJX A;  1VQR A;  4R8Z A;  1YOY A;  2PQ7 A;  5TK8 A;  4TO4 A;  4MCW A;  5AO0 A;  4MLN A;  1U6Z A;  4QG0 A;  2O08 A;  3TMC A;  2Q14 A;  1XX7 A;  4QFX A;  4BZB A;  4L1J B;  3TMB A;  3NQW A;  5AO3 A;  3TM8 A;  2PGS A;  4L7E A;  3TMD A;  4MLM A;  2PAR A;  5AO1 A;  2PAQ A;  4TNX A;  3P3Q A;  4RXP A;  4Q7H A;  1VJ7 A;  4TNR A;  3U1N A;  2HEK A;  3MEM A;  4RXR A;  5TK7 A;  4N71 A;  5TK9 A;  4QFZ A;  3MZO A;  4TO0 A;  4TNQ A;  4ME4 A;  4TNY A;  4QG1 A;  4ZWE A;  4RXQ A;  3RF0 A;  3BG2 A;  4QG4 A;  2DQB A;  4RXS A; 
#chains in the Genus database with same CATH topology
 3HI0 A;  4X9E A;  4TO2 A;  4TNP A;  4L7W A;  4TO6 A;  4TNZ A;  4BZC A;  4QG2 A;  4N6W A;  5AO4 A;  5TKA A;  5AO2 A;  4MDZ A;  4L1J A;  4Q2D A;  4MZ7 A;  4QFY A;  4TO1 A;  3I7A A;  4LRL A;  3IRH A;  1YNB A;  2FLO A;  3S4L A;  5TK6 A;  4QQY A;  4ZWG A;  4XDS A;  3M1T A;  2O6I A;  2PAU A;  2CQZ A;  3CCG A;  3HC1 A;  4DMB A;  2OGI A;  4RXO A;  4TO3 A;  3KH1 A;  4TO5 A;  3NR1 A;  2GZ4 A;  3LJX A;  1VQR A;  4R8Z A;  3SKD A;  1YOY A;  4Q2C A;  2PQ7 A;  5TK8 A;  4TO4 A;  4MCW A;  4QQW A;  5AO0 A;  4MLN A;  1U6Z A;  4QG0 A;  2O08 A;  3TMC A;  2Q14 A;  1XX7 A;  4QFX A;  4BZB A;  4L1J B;  3TMB A;  3GW7 A;  4QQX A;  3NQW A;  5AO3 A;  3TM8 A;  2PGS A;  4L7E A;  3TMD A;  4MLM A;  3SK9 A;  2PAR A;  5AO1 A;  2PAQ A;  4TNX A;  3P3Q A;  4RXP A;  4Q7H A;  1VJ7 A;  4TNR A;  3U1N A;  2HEK A;  3MEM A;  4RXR A;  5TK7 A;  4N71 A;  5TK9 A;  4QQZ A;  4QFZ A;  3MZO A;  4TO0 A;  4TNQ A;  4ME4 A;  4TNY A;  4QG1 A;  4ZWE A;  4RXQ A;  3RF0 A;  3BG2 A;  4QG4 A;  2DQB A;  3KQ5 A;  4RXS A; 
#chains in the Genus database with same CATH homology
 3HI0 A;  4X9E A;  4TO2 A;  4TNP A;  4L7W A;  4TO6 A;  4TNZ A;  4BZC A;  4QG2 A;  4N6W A;  5AO4 A;  5TKA A;  5AO2 A;  4MDZ A;  4L1J A;  4Q2D A;  4MZ7 A;  4QFY A;  4TO1 A;  3I7A A;  4LRL A;  3IRH A;  1YNB A;  2FLO A;  3S4L A;  5TK6 A;  4QQY A;  4ZWG A;  4XDS A;  3M1T A;  2O6I A;  2PAU A;  2CQZ A;  3CCG A;  3HC1 A;  4DMB A;  2OGI A;  4RXO A;  4TO3 A;  3KH1 A;  4TO5 A;  3NR1 A;  2GZ4 A;  3LJX A;  1VQR A;  4R8Z A;  3SKD A;  1YOY A;  4Q2C A;  2PQ7 A;  5TK8 A;  4TO4 A;  4MCW A;  4QQW A;  5AO0 A;  4MLN A;  1U6Z A;  4QG0 A;  2O08 A;  3TMC A;  2Q14 A;  1XX7 A;  4QFX A;  4BZB A;  4L1J B;  3TMB A;  3GW7 A;  4QQX A;  3NQW A;  5AO3 A;  3TM8 A;  2PGS A;  4L7E A;  3TMD A;  4MLM A;  3SK9 A;  2PAR A;  5AO1 A;  2PAQ A;  4TNX A;  3P3Q A;  4RXP A;  4Q7H A;  1VJ7 A;  4TNR A;  3U1N A;  2HEK A;  3MEM A;  4RXR A;  5TK7 A;  4N71 A;  5TK9 A;  4QQZ A;  4QFZ A;  3MZO A;  4TO0 A;  4TNQ A;  4ME4 A;  4TNY A;  4QG1 A;  4ZWE A;  4RXQ A;  3RF0 A;  3BG2 A;  4QG4 A;  2DQB A;  3KQ5 A;  4RXS A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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