4RXQA

The structure of gtp-dutp-bound samhd1
Total Genus 168
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
168
sequence length
486
structure length
481
Chain Sequence
TMKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASHNRFEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCHDLGHGPFSHMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPEEDIYFIKEQIVGPLESLWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFARDCHHLGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNSLHRRAYQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDDMEAYTKLTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKIKREDYESLPKEVASAKPKVLLDVKLKAEDFIVDVINMDYGMQEKNPIDHVSFYCKTAPNRAIRITKNQVSQLLPEKFAEQLIRVYCKKVDRKSLYAARQYFVQWCADRNFTKPQDGDVIAPLITPQKKEWN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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publication title The mechanism of substrate-controlled allosteric regulation of SAMHD1 activated by GTP.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords Deoxynucleoside triphosphate triphosphohydrolase SAMHD1
total genus 168
structure length 481
sequence length 486
chains with identical sequence B
ec nomenclature ec 3.1.5.-:
pdb deposition date 2014-12-11

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01966 HD HD domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.3210.10 Mainly Alpha Orthogonal Bundle Hypothetical protein af1432 Hypothetical protein af1432 4rxqA01
4QG1A 4RXPA 4DMBA 1XX7A 4Q7HA 4BZCA 4TNPA 1YNBA 3NQWA 4TO6A 3RF0A 4QFYA 4L1JB 4ME4A 3P3QA 3BG2A 4N6WA 2O08A 3U1NA 1VQRA 5TK9A 4MDZA 4BZBA 4L7WA 4QG0A 2DQBA 4TO0A 3CCGA 3LJXA 4RXRA 4RXSA 2HEKA 2PAUA 4QG4A 4TO4A 4R8ZA 4ZWGA 3MEMA 4TNQA 4XDSA 3TMDA 2PQ7A 4N71A 4MCWA 5AO2A 4MZ7A 4TO2A 4QFZA 4TO1A 4TNZA 3TMCA 4RXQA 2PARA 3TM8A 1YOYA 5AO3A 2O6IA 4MLNA 1VJ7A 3IRHA 2Q14A 3KH1A 4MLMA 4TNXA 5TK8A 5AO0A 4TO3A 4RXOA 3I7AA 5AO4A 4TO5A 4QG2A 4X9EA 5AO1A 2PAQA 4L1JA 5TKAA 4TNRA 4LRLA 2FLOA 3TMBA 1U6ZA 2CQZA 4ZWEA 3HI0A 2GZ4A 4TNYA 3NR1A 4L7EA 4QFXA 3HC1A 5TK6A 2OGIA 5TK7A 2PGSA 3M1TA 3MZOA
chains in the Genus database with same CATH superfamily
4QG1A 4RXPA 4DMBA 1XX7A 4Q7HA 4BZCA 4TNPA 1YNBA 3NQWA 4TO6A 3RF0A 4QQZA 4QFYA 4L1JB 4ME4A 3P3QA 3BG2A 4N6WA 2O08A 3U1NA 1VQRA 5TK9A 4MDZA 4BZBA 3KQ5A 4L7WA 4QG0A 2DQBA 4TO0A 3CCGA 3LJXA 4QQYA 4RXRA 4RXSA 2HEKA 2PAUA 4QG4A 4TO4A 4R8ZA 4ZWGA 3MEMA 4TNQA 4XDSA 3TMDA 2PQ7A 4N71A 4MCWA 5AO2A 4MZ7A 4TO2A 4QFZA 4TO1A 4TNZA 3TMCA 4RXQA 2PARA 3TM8A 1YOYA 5AO3A 2O6IA 4MLNA 1VJ7A 3IRHA 2Q14A 3KH1A 4Q2DA 3GW7A 4MLMA 4TNXA 5TK8A 5AO0A 3SKDA 4QQXA 4TO3A 4RXOA 3I7AA 5AO4A 4TO5A 4QG2A 4X9EA 5AO1A 2PAQA 4L1JA 5TKAA 4TNRA 4LRLA 3SK9A 2FLOA 3TMBA 1U6ZA 2CQZA 4ZWEA 3HI0A 2GZ4A 4TNYA 3NR1A 4L7EA 4QFXA 3HC1A 4QQWA 5TK6A 2OGIA 5TK7A 3S4LA 2PGSA 4Q2CA 3M1TA 3MZOA
chains in the Genus database with same CATH topology
4QG1A 4RXPA 4DMBA 1XX7A 4Q7HA 4BZCA 4TNPA 1YNBA 3NQWA 4TO6A 3RF0A 4QQZA 4QFYA 4L1JB 4ME4A 3P3QA 3BG2A 4N6WA 2O08A 3U1NA 1VQRA 5TK9A 4MDZA 4BZBA 3KQ5A 4L7WA 4QG0A 2DQBA 4TO0A 3CCGA 3LJXA 4QQYA 4RXRA 4RXSA 2HEKA 2PAUA 4QG4A 4TO4A 4R8ZA 4ZWGA 3MEMA 4TNQA 4XDSA 3TMDA 2PQ7A 4N71A 4MCWA 5AO2A 4MZ7A 4TO2A 4QFZA 4TO1A 4TNZA 3TMCA 4RXQA 2PARA 3TM8A 1YOYA 5AO3A 2O6IA 4MLNA 1VJ7A 3IRHA 2Q14A 3KH1A 4Q2DA 3GW7A 4MLMA 4TNXA 5TK8A 5AO0A 3SKDA 4QQXA 4TO3A 4RXOA 3I7AA 5AO4A 4TO5A 4QG2A 4X9EA 5AO1A 2PAQA 4L1JA 5TKAA 4TNRA 4LRLA 3SK9A 2FLOA 3TMBA 1U6ZA 2CQZA 4ZWEA 3HI0A 2GZ4A 4TNYA 3NR1A 4L7EA 4QFXA 3HC1A 4QQWA 5TK6A 2OGIA 5TK7A 3S4LA 2PGSA 4Q2CA 3M1TA 3MZOA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 4QG1 A;  4RXP A;  4DMB A;  1XX7 A;  4Q7H A;  4BZC A;  4TNP A;  1YNB A;  3NQW A;  4TO6 A;  3RF0 A;  4QFY A;  4L1J B;  4ME4 A;  3P3Q A;  3BG2 A;  4N6W A;  2O08 A;  3U1N A;  1VQR A;  5TK9 A;  4MDZ A;  4BZB A;  4L7W A;  4QG0 A;  2DQB A;  4TO0 A;  3CCG A;  3LJX A;  4RXR A;  4RXS A;  2HEK A;  2PAU A;  4QG4 A;  4TO4 A;  4R8Z A;  4ZWG A;  3MEM A;  4TNQ A;  4XDS A;  3TMD A;  2PQ7 A;  4N71 A;  4MCW A;  5AO2 A;  4MZ7 A;  4TO2 A;  4QFZ A;  4TO1 A;  4TNZ A;  3TMC A;  4RXQ A;  2PAR A;  3TM8 A;  1YOY A;  5AO3 A;  2O6I A;  4MLN A;  1VJ7 A;  3IRH A;  2Q14 A;  3KH1 A;  4MLM A;  4TNX A;  5TK8 A;  5AO0 A;  4TO3 A;  4RXO A;  3I7A A;  5AO4 A;  4TO5 A;  4QG2 A;  4X9E A;  5AO1 A;  2PAQ A;  4L1J A;  5TKA A;  4TNR A;  4LRL A;  2FLO A;  3TMB A;  1U6Z A;  2CQZ A;  4ZWE A;  3HI0 A;  2GZ4 A;  4TNY A;  3NR1 A;  4L7E A;  4QFX A;  3HC1 A;  5TK6 A;  2OGI A;  5TK7 A;  2PGS A;  3M1T A;  3MZO A; 
#chains in the Genus database with same CATH topology
 4QG1 A;  4RXP A;  4DMB A;  1XX7 A;  4Q7H A;  4BZC A;  4TNP A;  1YNB A;  3NQW A;  4TO6 A;  3RF0 A;  4QQZ A;  4QFY A;  4L1J B;  4ME4 A;  3P3Q A;  3BG2 A;  4N6W A;  2O08 A;  3U1N A;  1VQR A;  5TK9 A;  4MDZ A;  4BZB A;  3KQ5 A;  4L7W A;  4QG0 A;  2DQB A;  4TO0 A;  3CCG A;  3LJX A;  4QQY A;  4RXR A;  4RXS A;  2HEK A;  2PAU A;  4QG4 A;  4TO4 A;  4R8Z A;  4ZWG A;  3MEM A;  4TNQ A;  4XDS A;  3TMD A;  2PQ7 A;  4N71 A;  4MCW A;  5AO2 A;  4MZ7 A;  4TO2 A;  4QFZ A;  4TO1 A;  4TNZ A;  3TMC A;  4RXQ A;  2PAR A;  3TM8 A;  1YOY A;  5AO3 A;  2O6I A;  4MLN A;  1VJ7 A;  3IRH A;  2Q14 A;  3KH1 A;  4Q2D A;  3GW7 A;  4MLM A;  4TNX A;  5TK8 A;  5AO0 A;  3SKD A;  4QQX A;  4TO3 A;  4RXO A;  3I7A A;  5AO4 A;  4TO5 A;  4QG2 A;  4X9E A;  5AO1 A;  2PAQ A;  4L1J A;  5TKA A;  4TNR A;  4LRL A;  3SK9 A;  2FLO A;  3TMB A;  1U6Z A;  2CQZ A;  4ZWE A;  3HI0 A;  2GZ4 A;  4TNY A;  3NR1 A;  4L7E A;  4QFX A;  3HC1 A;  4QQW A;  5TK6 A;  2OGI A;  5TK7 A;  3S4L A;  2PGS A;  4Q2C A;  3M1T A;  3MZO A; 
#chains in the Genus database with same CATH homology
 4QG1 A;  4RXP A;  4DMB A;  1XX7 A;  4Q7H A;  4BZC A;  4TNP A;  1YNB A;  3NQW A;  4TO6 A;  3RF0 A;  4QQZ A;  4QFY A;  4L1J B;  4ME4 A;  3P3Q A;  3BG2 A;  4N6W A;  2O08 A;  3U1N A;  1VQR A;  5TK9 A;  4MDZ A;  4BZB A;  3KQ5 A;  4L7W A;  4QG0 A;  2DQB A;  4TO0 A;  3CCG A;  3LJX A;  4QQY A;  4RXR A;  4RXS A;  2HEK A;  2PAU A;  4QG4 A;  4TO4 A;  4R8Z A;  4ZWG A;  3MEM A;  4TNQ A;  4XDS A;  3TMD A;  2PQ7 A;  4N71 A;  4MCW A;  5AO2 A;  4MZ7 A;  4TO2 A;  4QFZ A;  4TO1 A;  4TNZ A;  3TMC A;  4RXQ A;  2PAR A;  3TM8 A;  1YOY A;  5AO3 A;  2O6I A;  4MLN A;  1VJ7 A;  3IRH A;  2Q14 A;  3KH1 A;  4Q2D A;  3GW7 A;  4MLM A;  4TNX A;  5TK8 A;  5AO0 A;  3SKD A;  4QQX A;  4TO3 A;  4RXO A;  3I7A A;  5AO4 A;  4TO5 A;  4QG2 A;  4X9E A;  5AO1 A;  2PAQ A;  4L1J A;  5TKA A;  4TNR A;  4LRL A;  3SK9 A;  2FLO A;  3TMB A;  1U6Z A;  2CQZ A;  4ZWE A;  3HI0 A;  2GZ4 A;  4TNY A;  3NR1 A;  4L7E A;  4QFX A;  3HC1 A;  4QQW A;  5TK6 A;  2OGI A;  5TK7 A;  3S4L A;  2PGS A;  4Q2C A;  3M1T A;  3MZO A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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