4RXS | Genus

Total Genus 162

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	162
sequence length	487
structure length	481
Chain Sequence	DTMKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASHNRFEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCHDLGHGPFSHMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPEEDIYFIKEQIVGPLELWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFARDCHHLGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNSLHRRAYQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDDMEAYTKLTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKIKREDYESLPKEVASAKPKVLLDVKLKAEDFIVDVINMDYGMQEKNPIDHVSFYCKTAPNRAIRITKNQVSQLLPEKFAEQLIRVYCKKVDRKSLYAARQYFVQWCADRNFTKPQDGDVIAPLITPQKKEWN

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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

Chord Diagram

molecule tags	Hydrolase
source organism	Homo sapiens
publication title	The mechanism of substrate-controlled allosteric regulation of SAMHD1 activated by GTP. pubmed doi rcsb
molecule keywords	Deoxynucleoside triphosphate triphosphohydrolase SAMHD1
total genus	162
structure length	481
sequence length	487
chains with identical sequence	B
ec nomenclature	ec 3.1.5.-:
pdb deposition date	2014-12-11

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF01966	HD	HD domain

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
1.10.3210.10	Mainly Alpha	Orthogonal Bundle	Hypothetical protein af1432	Hypothetical protein af1432	4rxsA01

4MZ7A 5AO1A 4MLMA 2O6IA 4TNRA 2PAUA 4ZWGA 4QFZA 4QG1A 1XX7A 3I7AA 4BZBA 1U6ZA 1VQRA 5AO4A 2PAQA 4TNPA 4N71A 4TNZA 1YNBA 5TK7A 3TM8A 5TK8A 4ME4A 4RXSA 4L7WA 2DQBA 5TKAA 3BG2A 1VJ7A 3TMDA 3NQWA 4TO5A 5TK9A 3HI0A 4RXPA 4RXRA 2HEKA 4QG4A 3P3QA 2PGSA 3RF0A 3TMBA 3NR1A 2GZ4A 4MCWA 3M1TA 2PQ7A 4MLNA 4TNQA 4TO6A 4QFXA 2FLOA 4TO2A 4XDSA 4TO4A 1YOYA 2CQZA 2O08A 3TMCA 3U1NA 4MDZA 4QFYA 2PARA 4QG2A 4DMBA 4Q7HA 5AO0A 5TK6A 3IRHA 3KH1A 4BZCA 4L1JB 5AO3A 4L1JA 5AO2A 4X9EA 4R8ZA 4QG0A 4LRLA 3CCGA 3LJXA 3MZOA 4RXOA 4L7EA 4TNXA 2Q14A 4TO0A 3MEMA 2OGIA 4TNYA 4TO3A 4N6WA 4TO1A 3HC1A 4RXQA 4ZWEA
chains in the Genus database with same CATH superfamily

4MZ7A 5AO1A 4MLMA 2O6IA 4TNRA 2PAUA 4Q2CA 4ZWGA 4QFZA 4QG1A 1XX7A 3I7AA 4BZBA 1U6ZA 1VQRA 5AO4A 2PAQA 4TNPA 4N71A 4TNZA 1YNBA 5TK7A 3TM8A 5TK8A 3GW7A 4ME4A 4RXSA 4L7WA 2DQBA 5TKAA 3BG2A 1VJ7A 3TMDA 3NQWA 4TO5A 5TK9A 3HI0A 3SKDA 4RXPA 4RXRA 2HEKA 4QG4A 3P3QA 2PGSA 3RF0A 3TMBA 3NR1A 2GZ4A 4QQYA 4MCWA 3M1TA 4QQWA 2PQ7A 4MLNA 4TNQA 4TO6A 4QFXA 2FLOA 4TO2A 4XDSA 4TO4A 1YOYA 2CQZA 2O08A 3TMCA 3U1NA 3KQ5A 4MDZA 4QQZA 4QFYA 2PARA 4QG2A 4DMBA 4Q7HA 5AO0A 3S4LA 5TK6A 3IRHA 3KH1A 4BZCA 4L1JB 5AO3A 4L1JA 5AO2A 4X9EA 4R8ZA 4QG0A 4LRLA 4QQXA 3CCGA 3LJXA 3MZOA 4RXOA 4L7EA 4TNXA 2Q14A 4Q2DA 4TO0A 3MEMA 3SK9A 2OGIA 4TNYA 4TO3A 4N6WA 4TO1A 3HC1A 4RXQA 4ZWEA
chains in the Genus database with same CATH topology

#chains in the Genus database with same CATH superfamily
 4MZ7 A;  5AO1 A;  4MLM A;  2O6I A;  4TNR A;  2PAU A;  4ZWG A;  4QFZ A;  4QG1 A;  1XX7 A;  3I7A A;  4BZB A;  1U6Z A;  1VQR A;  5AO4 A;  2PAQ A;  4TNP A;  4N71 A;  4TNZ A;  1YNB A;  5TK7 A;  3TM8 A;  5TK8 A;  4ME4 A;  4RXS A;  4L7W A;  2DQB A;  5TKA A;  3BG2 A;  1VJ7 A;  3TMD A;  3NQW A;  4TO5 A;  5TK9 A;  3HI0 A;  4RXP A;  4RXR A;  2HEK A;  4QG4 A;  3P3Q A;  2PGS A;  3RF0 A;  3TMB A;  3NR1 A;  2GZ4 A;  4MCW A;  3M1T A;  2PQ7 A;  4MLN A;  4TNQ A;  4TO6 A;  4QFX A;  2FLO A;  4TO2 A;  4XDS A;  4TO4 A;  1YOY A;  2CQZ A;  2O08 A;  3TMC A;  3U1N A;  4MDZ A;  4QFY A;  2PAR A;  4QG2 A;  4DMB A;  4Q7H A;  5AO0 A;  5TK6 A;  3IRH A;  3KH1 A;  4BZC A;  4L1J B;  5AO3 A;  4L1J A;  5AO2 A;  4X9E A;  4R8Z A;  4QG0 A;  4LRL A;  3CCG A;  3LJX A;  3MZO A;  4RXO A;  4L7E A;  4TNX A;  2Q14 A;  4TO0 A;  3MEM A;  2OGI A;  4TNY A;  4TO3 A;  4N6W A;  4TO1 A;  3HC1 A;  4RXQ A;  4ZWE A; 
#chains in the Genus database with same CATH topology
 4MZ7 A;  5AO1 A;  4MLM A;  2O6I A;  4TNR A;  2PAU A;  4Q2C A;  4ZWG A;  4QFZ A;  4QG1 A;  1XX7 A;  3I7A A;  4BZB A;  1U6Z A;  1VQR A;  5AO4 A;  2PAQ A;  4TNP A;  4N71 A;  4TNZ A;  1YNB A;  5TK7 A;  3TM8 A;  5TK8 A;  3GW7 A;  4ME4 A;  4RXS A;  4L7W A;  2DQB A;  5TKA A;  3BG2 A;  1VJ7 A;  3TMD A;  3NQW A;  4TO5 A;  5TK9 A;  3HI0 A;  3SKD A;  4RXP A;  4RXR A;  2HEK A;  4QG4 A;  3P3Q A;  2PGS A;  3RF0 A;  3TMB A;  3NR1 A;  2GZ4 A;  4QQY A;  4MCW A;  3M1T A;  4QQW A;  2PQ7 A;  4MLN A;  4TNQ A;  4TO6 A;  4QFX A;  2FLO A;  4TO2 A;  4XDS A;  4TO4 A;  1YOY A;  2CQZ A;  2O08 A;  3TMC A;  3U1N A;  3KQ5 A;  4MDZ A;  4QQZ A;  4QFY A;  2PAR A;  4QG2 A;  4DMB A;  4Q7H A;  5AO0 A;  3S4L A;  5TK6 A;  3IRH A;  3KH1 A;  4BZC A;  4L1J B;  5AO3 A;  4L1J A;  5AO2 A;  4X9E A;  4R8Z A;  4QG0 A;  4LRL A;  4QQX A;  3CCG A;  3LJX A;  3MZO A;  4RXO A;  4L7E A;  4TNX A;  2Q14 A;  4Q2D A;  4TO0 A;  3MEM A;  3SK9 A;  2OGI A;  4TNY A;  4TO3 A;  4N6W A;  4TO1 A;  3HC1 A;  4RXQ A;  4ZWE A; 
#chains in the Genus database with same CATH homology
 4MZ7 A;  5AO1 A;  4MLM A;  2O6I A;  4TNR A;  2PAU A;  4Q2C A;  4ZWG A;  4QFZ A;  4QG1 A;  1XX7 A;  3I7A A;  4BZB A;  1U6Z A;  1VQR A;  5AO4 A;  2PAQ A;  4TNP A;  4N71 A;  4TNZ A;  1YNB A;  5TK7 A;  3TM8 A;  5TK8 A;  3GW7 A;  4ME4 A;  4RXS A;  4L7W A;  2DQB A;  5TKA A;  3BG2 A;  1VJ7 A;  3TMD A;  3NQW A;  4TO5 A;  5TK9 A;  3HI0 A;  3SKD A;  4RXP A;  4RXR A;  2HEK A;  4QG4 A;  3P3Q A;  2PGS A;  3RF0 A;  3TMB A;  3NR1 A;  2GZ4 A;  4QQY A;  4MCW A;  3M1T A;  4QQW A;  2PQ7 A;  4MLN A;  4TNQ A;  4TO6 A;  4QFX A;  2FLO A;  4TO2 A;  4XDS A;  4TO4 A;  1YOY A;  2CQZ A;  2O08 A;  3TMC A;  3U1N A;  3KQ5 A;  4MDZ A;  4QQZ A;  4QFY A;  2PAR A;  4QG2 A;  4DMB A;  4Q7H A;  5AO0 A;  3S4L A;  5TK6 A;  3IRH A;  3KH1 A;  4BZC A;  4L1J B;  5AO3 A;  4L1J A;  5AO2 A;  4X9E A;  4R8Z A;  4QG0 A;  4LRL A;  4QQX A;  3CCG A;  3LJX A;  3MZO A;  4RXO A;  4L7E A;  4TNX A;  2Q14 A;  4Q2D A;  4TO0 A;  3MEM A;  3SK9 A;  2OGI A;  4TNY A;  4TO3 A;  4N6W A;  4TO1 A;  3HC1 A;  4RXQ A;  4ZWE A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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4RXSA

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

Chord Diagram

connected with : NaN

pfam database annotations