4TNQA

Structural basis of cellular dntp regulation, samhd1-gtp-dttp-dttp complex
Total Genus 165
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
165
sequence length
485
structure length
480
Chain Sequence
TMKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASHNRFEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCRNLGHGPFSHMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPEEDICFIKEQIVGPLESLWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFARDCHHLGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNSLHRRAYQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDDMEAYTKLTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKIKREDYESLPKEVASAKPKVLLDVKLKAEDFIVDVINMDYGMQEKNPIDHVSFYCKTAPNRAIRITKNQVSQLLPEKFAEQLIRVYCKKVDRKSLYAARQYFVQWCADRNFTKPQDGDVIAPLITPQKKEW
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
publication title Structural basis of cellular dNTP regulation by SAMHD1.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords Deoxynucleoside triphosphate triphosphohydrolase SAMHD1
total genus 165
structure length 480
sequence length 485
chains with identical sequence B, C, D
ec nomenclature ec 3.1.5.-:
pdb deposition date 2014-06-04

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01966 HD HD domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.3210.10 Mainly Alpha Orthogonal Bundle Hypothetical protein af1432 Hypothetical protein af1432 4tnqA01
3CCGA 4L1JA 3NQWA 4N71A 3I7AA 4RXSA 4TO0A 4X9EA 2Q14A 4TNXA 4DMBA 2PGSA 2CQZA 4N6WA 1VQRA 4XDSA 4RXQA 3RF0A 3TMDA 4QG2A 4RXRA 3BG2A 5TK7A 1U6ZA 3P3QA 4L1JB 4MLMA 4L7EA 4TO6A 2O08A 2PQ7A 1YNBA 4TO1A 3IRHA 4TNZA 3HI0A 5AO2A 4TNQA 2GZ4A 2HEKA 4BZBA 4QG4A 5AO4A 4QFXA 4TNYA 3MEMA 3TM8A 4TNRA 4ZWEA 2PAUA 4MCWA 4ZWGA 1VJ7A 4L7WA 4MLNA 4QFYA 4R8ZA 4TNPA 4RXOA 2FLOA 4TO5A 2PARA 3TMCA 5TK9A 4TO3A 3KH1A 4MDZA 4QG1A 4QG0A 5AO1A 1XX7A 3MZOA 2O6IA 5TK6A 5TK8A 2PAQA 4RXPA 3M1TA 5TKAA 4Q7HA 4MZ7A 3TMBA 4QFZA 5AO3A 4LRLA 3NR1A 1YOYA 4BZCA 3HC1A 2DQBA 3U1NA 4TO4A 3LJXA 2OGIA 4ME4A 4TO2A 5AO0A
chains in the Genus database with same CATH superfamily
3CCGA 3S4LA 4L1JA 3NQWA 4Q2DA 4N71A 3I7AA 4RXSA 4TO0A 4X9EA 2Q14A 4TNXA 4DMBA 2PGSA 2CQZA 4N6WA 1VQRA 4XDSA 4RXQA 3RF0A 3TMDA 4QG2A 4RXRA 3BG2A 5TK7A 4QQZA 1U6ZA 3P3QA 4L1JB 4MLMA 4L7EA 4TO6A 2O08A 2PQ7A 1YNBA 4TO1A 3IRHA 4TNZA 3HI0A 5AO2A 4TNQA 2GZ4A 4QQYA 2HEKA 4BZBA 4QQWA 4QG4A 5AO4A 4QFXA 4TNYA 3MEMA 3TM8A 4TNRA 4ZWEA 2PAUA 4MCWA 4ZWGA 1VJ7A 4L7WA 4MLNA 4QFYA 4R8ZA 4TNPA 4RXOA 2FLOA 4TO5A 2PARA 3TMCA 5TK9A 4TO3A 3KH1A 4MDZA 4QG1A 4QG0A 5AO1A 1XX7A 3MZOA 2O6IA 4Q2CA 5TK6A 5TK8A 4QQXA 2PAQA 4RXPA 3M1TA 5TKAA 3KQ5A 4Q7HA 3SK9A 4MZ7A 3TMBA 3GW7A 4QFZA 5AO3A 4LRLA 3NR1A 1YOYA 4BZCA 3HC1A 2DQBA 3U1NA 4TO4A 3LJXA 2OGIA 4ME4A 4TO2A 3SKDA 5AO0A
chains in the Genus database with same CATH topology
3CCGA 3S4LA 4L1JA 3NQWA 4Q2DA 4N71A 3I7AA 4RXSA 4TO0A 4X9EA 2Q14A 4TNXA 4DMBA 2PGSA 2CQZA 4N6WA 1VQRA 4XDSA 4RXQA 3RF0A 3TMDA 4QG2A 4RXRA 3BG2A 5TK7A 4QQZA 1U6ZA 3P3QA 4L1JB 4MLMA 4L7EA 4TO6A 2O08A 2PQ7A 1YNBA 4TO1A 3IRHA 4TNZA 3HI0A 5AO2A 4TNQA 2GZ4A 4QQYA 2HEKA 4BZBA 4QQWA 4QG4A 5AO4A 4QFXA 4TNYA 3MEMA 3TM8A 4TNRA 4ZWEA 2PAUA 4MCWA 4ZWGA 1VJ7A 4L7WA 4MLNA 4QFYA 4R8ZA 4TNPA 4RXOA 2FLOA 4TO5A 2PARA 3TMCA 5TK9A 4TO3A 3KH1A 4MDZA 4QG1A 4QG0A 5AO1A 1XX7A 3MZOA 2O6IA 4Q2CA 5TK6A 5TK8A 4QQXA 2PAQA 4RXPA 3M1TA 5TKAA 3KQ5A 4Q7HA 3SK9A 4MZ7A 3TMBA 3GW7A 4QFZA 5AO3A 4LRLA 3NR1A 1YOYA 4BZCA 3HC1A 2DQBA 3U1NA 4TO4A 3LJXA 2OGIA 4ME4A 4TO2A 3SKDA 5AO0A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3CCG A;  4L1J A;  3NQW A;  4N71 A;  3I7A A;  4RXS A;  4TO0 A;  4X9E A;  2Q14 A;  4TNX A;  4DMB A;  2PGS A;  2CQZ A;  4N6W A;  1VQR A;  4XDS A;  4RXQ A;  3RF0 A;  3TMD A;  4QG2 A;  4RXR A;  3BG2 A;  5TK7 A;  1U6Z A;  3P3Q A;  4L1J B;  4MLM A;  4L7E A;  4TO6 A;  2O08 A;  2PQ7 A;  1YNB A;  4TO1 A;  3IRH A;  4TNZ A;  3HI0 A;  5AO2 A;  4TNQ A;  2GZ4 A;  2HEK A;  4BZB A;  4QG4 A;  5AO4 A;  4QFX A;  4TNY A;  3MEM A;  3TM8 A;  4TNR A;  4ZWE A;  2PAU A;  4MCW A;  4ZWG A;  1VJ7 A;  4L7W A;  4MLN A;  4QFY A;  4R8Z A;  4TNP A;  4RXO A;  2FLO A;  4TO5 A;  2PAR A;  3TMC A;  5TK9 A;  4TO3 A;  3KH1 A;  4MDZ A;  4QG1 A;  4QG0 A;  5AO1 A;  1XX7 A;  3MZO A;  2O6I A;  5TK6 A;  5TK8 A;  2PAQ A;  4RXP A;  3M1T A;  5TKA A;  4Q7H A;  4MZ7 A;  3TMB A;  4QFZ A;  5AO3 A;  4LRL A;  3NR1 A;  1YOY A;  4BZC A;  3HC1 A;  2DQB A;  3U1N A;  4TO4 A;  3LJX A;  2OGI A;  4ME4 A;  4TO2 A;  5AO0 A; 
#chains in the Genus database with same CATH topology
 3CCG A;  3S4L A;  4L1J A;  3NQW A;  4Q2D A;  4N71 A;  3I7A A;  4RXS A;  4TO0 A;  4X9E A;  2Q14 A;  4TNX A;  4DMB A;  2PGS A;  2CQZ A;  4N6W A;  1VQR A;  4XDS A;  4RXQ A;  3RF0 A;  3TMD A;  4QG2 A;  4RXR A;  3BG2 A;  5TK7 A;  4QQZ A;  1U6Z A;  3P3Q A;  4L1J B;  4MLM A;  4L7E A;  4TO6 A;  2O08 A;  2PQ7 A;  1YNB A;  4TO1 A;  3IRH A;  4TNZ A;  3HI0 A;  5AO2 A;  4TNQ A;  2GZ4 A;  4QQY A;  2HEK A;  4BZB A;  4QQW A;  4QG4 A;  5AO4 A;  4QFX A;  4TNY A;  3MEM A;  3TM8 A;  4TNR A;  4ZWE A;  2PAU A;  4MCW A;  4ZWG A;  1VJ7 A;  4L7W A;  4MLN A;  4QFY A;  4R8Z A;  4TNP A;  4RXO A;  2FLO A;  4TO5 A;  2PAR A;  3TMC A;  5TK9 A;  4TO3 A;  3KH1 A;  4MDZ A;  4QG1 A;  4QG0 A;  5AO1 A;  1XX7 A;  3MZO A;  2O6I A;  4Q2C A;  5TK6 A;  5TK8 A;  4QQX A;  2PAQ A;  4RXP A;  3M1T A;  5TKA A;  3KQ5 A;  4Q7H A;  3SK9 A;  4MZ7 A;  3TMB A;  3GW7 A;  4QFZ A;  5AO3 A;  4LRL A;  3NR1 A;  1YOY A;  4BZC A;  3HC1 A;  2DQB A;  3U1N A;  4TO4 A;  3LJX A;  2OGI A;  4ME4 A;  4TO2 A;  3SKD A;  5AO0 A; 
#chains in the Genus database with same CATH homology
 3CCG A;  3S4L A;  4L1J A;  3NQW A;  4Q2D A;  4N71 A;  3I7A A;  4RXS A;  4TO0 A;  4X9E A;  2Q14 A;  4TNX A;  4DMB A;  2PGS A;  2CQZ A;  4N6W A;  1VQR A;  4XDS A;  4RXQ A;  3RF0 A;  3TMD A;  4QG2 A;  4RXR A;  3BG2 A;  5TK7 A;  4QQZ A;  1U6Z A;  3P3Q A;  4L1J B;  4MLM A;  4L7E A;  4TO6 A;  2O08 A;  2PQ7 A;  1YNB A;  4TO1 A;  3IRH A;  4TNZ A;  3HI0 A;  5AO2 A;  4TNQ A;  2GZ4 A;  4QQY A;  2HEK A;  4BZB A;  4QQW A;  4QG4 A;  5AO4 A;  4QFX A;  4TNY A;  3MEM A;  3TM8 A;  4TNR A;  4ZWE A;  2PAU A;  4MCW A;  4ZWG A;  1VJ7 A;  4L7W A;  4MLN A;  4QFY A;  4R8Z A;  4TNP A;  4RXO A;  2FLO A;  4TO5 A;  2PAR A;  3TMC A;  5TK9 A;  4TO3 A;  3KH1 A;  4MDZ A;  4QG1 A;  4QG0 A;  5AO1 A;  1XX7 A;  3MZO A;  2O6I A;  4Q2C A;  5TK6 A;  5TK8 A;  4QQX A;  2PAQ A;  4RXP A;  3M1T A;  5TKA A;  3KQ5 A;  4Q7H A;  3SK9 A;  4MZ7 A;  3TMB A;  3GW7 A;  4QFZ A;  5AO3 A;  4LRL A;  3NR1 A;  1YOY A;  4BZC A;  3HC1 A;  2DQB A;  3U1N A;  4TO4 A;  3LJX A;  2OGI A;  4ME4 A;  4TO2 A;  3SKD A;  5AO0 A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...