4TNQ | Genus

Total Genus 165

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	165
sequence length	485
structure length	480
Chain Sequence	TMKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASHNRFEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCRNLGHGPFSHMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPEEDICFIKEQIVGPLESLWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFARDCHHLGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNSLHRRAYQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDDMEAYTKLTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKIKREDYESLPKEVASAKPKVLLDVKLKAEDFIVDVINMDYGMQEKNPIDHVSFYCKTAPNRAIRITKNQVSQLLPEKFAEQLIRVYCKKVDRKSLYAARQYFVQWCADRNFTKPQDGDVIAPLITPQKKEW

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

Chord Diagram

molecule tags	Hydrolase
source organism	Homo sapiens
publication title	Structural basis of cellular dNTP regulation by SAMHD1. pubmed doi rcsb
molecule keywords	Deoxynucleoside triphosphate triphosphohydrolase SAMHD1
total genus	165
structure length	480
sequence length	485
chains with identical sequence	B, C, D
ec nomenclature	ec 3.1.5.-:
pdb deposition date	2014-06-04

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF01966	HD	HD domain

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
1.10.3210.10	Mainly Alpha	Orthogonal Bundle	Hypothetical protein af1432	Hypothetical protein af1432	4tnqA01

2PGSA 1YOYA 4ZWEA 3HI0A 4RXRA 4TNQA 4QG2A 2DQBA 4TO5A 4TNZA 3MZOA 4L1JB 1YNBA 4N71A 4QFZA 2O08A 2O6IA 1XX7A 5TK7A 5AO3A 4MLMA 3NR1A 4L7WA 4TNYA 5AO0A 2GZ4A 5AO2A 4RXPA 5TK6A 4TO3A 3U1NA 4TO6A 2OGIA 3CCGA 4LRLA 4MDZA 4QG0A 4Q7HA 4R8ZA 5TK9A 4X9EA 5AO1A 3P3QA 4MZ7A 2HEKA 4TO1A 3TMCA 4QFYA 4L1JA 4RXOA 3M1TA 4QG1A 4XDSA 4TO0A 4L7EA 4BZCA 4ZWGA 3MEMA 4MCWA 4QFXA 4TO4A 2FLOA 5TK8A 3BG2A 4ME4A 1VQRA 4BZBA 4TO2A 3TMBA 3I7AA 3IRHA 3TMDA 3RF0A 4TNRA 3LJXA 2CQZA 2PAQA 4RXQA 2PARA 4QG4A 5TKAA 3TM8A 1VJ7A 2Q14A 2PQ7A 3NQWA 4TNPA 5AO4A 2PAUA 4N6WA 4RXSA 4DMBA 4MLNA 4TNXA 3HC1A 3KH1A 1U6ZA
chains in the Genus database with same CATH superfamily

2PGSA 1YOYA 4ZWEA 3HI0A 3SKDA 4QQZA 4RXRA 4TNQA 4QG2A 2DQBA 4TO5A 4TNZA 3MZOA 4L1JB 1YNBA 4N71A 4QFZA 4Q2CA 2O08A 2O6IA 1XX7A 5TK7A 5AO3A 4MLMA 3NR1A 4L7WA 4QQYA 4TNYA 5AO0A 2GZ4A 5AO2A 4QQWA 4RXPA 5TK6A 4TO3A 3U1NA 3S4LA 4TO6A 2OGIA 3CCGA 4LRLA 4MDZA 4QG0A 4Q7HA 4R8ZA 5TK9A 4X9EA 5AO1A 3P3QA 4MZ7A 2HEKA 4TO1A 3TMCA 4QFYA 4L1JA 4RXOA 3M1TA 4QG1A 4XDSA 4TO0A 4L7EA 4QQXA 4BZCA 4ZWGA 3MEMA 4MCWA 4QFXA 4TO4A 2FLOA 5TK8A 3KQ5A 3BG2A 4ME4A 1VQRA 4BZBA 4TO2A 3TMBA 3I7AA 3IRHA 3TMDA 3RF0A 4TNRA 3LJXA 3SK9A 2CQZA 2PAQA 4RXQA 3GW7A 2PARA 4QG4A 5TKAA 3TM8A 1VJ7A 2Q14A 2PQ7A 3NQWA 4TNPA 5AO4A 2PAUA 4N6WA 4RXSA 4DMBA 4MLNA 4TNXA 3HC1A 4Q2DA 3KH1A 1U6ZA
chains in the Genus database with same CATH topology

#chains in the Genus database with same CATH superfamily
 2PGS A;  1YOY A;  4ZWE A;  3HI0 A;  4RXR A;  4TNQ A;  4QG2 A;  2DQB A;  4TO5 A;  4TNZ A;  3MZO A;  4L1J B;  1YNB A;  4N71 A;  4QFZ A;  2O08 A;  2O6I A;  1XX7 A;  5TK7 A;  5AO3 A;  4MLM A;  3NR1 A;  4L7W A;  4TNY A;  5AO0 A;  2GZ4 A;  5AO2 A;  4RXP A;  5TK6 A;  4TO3 A;  3U1N A;  4TO6 A;  2OGI A;  3CCG A;  4LRL A;  4MDZ A;  4QG0 A;  4Q7H A;  4R8Z A;  5TK9 A;  4X9E A;  5AO1 A;  3P3Q A;  4MZ7 A;  2HEK A;  4TO1 A;  3TMC A;  4QFY A;  4L1J A;  4RXO A;  3M1T A;  4QG1 A;  4XDS A;  4TO0 A;  4L7E A;  4BZC A;  4ZWG A;  3MEM A;  4MCW A;  4QFX A;  4TO4 A;  2FLO A;  5TK8 A;  3BG2 A;  4ME4 A;  1VQR A;  4BZB A;  4TO2 A;  3TMB A;  3I7A A;  3IRH A;  3TMD A;  3RF0 A;  4TNR A;  3LJX A;  2CQZ A;  2PAQ A;  4RXQ A;  2PAR A;  4QG4 A;  5TKA A;  3TM8 A;  1VJ7 A;  2Q14 A;  2PQ7 A;  3NQW A;  4TNP A;  5AO4 A;  2PAU A;  4N6W A;  4RXS A;  4DMB A;  4MLN A;  4TNX A;  3HC1 A;  3KH1 A;  1U6Z A; 
#chains in the Genus database with same CATH topology
 2PGS A;  1YOY A;  4ZWE A;  3HI0 A;  3SKD A;  4QQZ A;  4RXR A;  4TNQ A;  4QG2 A;  2DQB A;  4TO5 A;  4TNZ A;  3MZO A;  4L1J B;  1YNB A;  4N71 A;  4QFZ A;  4Q2C A;  2O08 A;  2O6I A;  1XX7 A;  5TK7 A;  5AO3 A;  4MLM A;  3NR1 A;  4L7W A;  4QQY A;  4TNY A;  5AO0 A;  2GZ4 A;  5AO2 A;  4QQW A;  4RXP A;  5TK6 A;  4TO3 A;  3U1N A;  3S4L A;  4TO6 A;  2OGI A;  3CCG A;  4LRL A;  4MDZ A;  4QG0 A;  4Q7H A;  4R8Z A;  5TK9 A;  4X9E A;  5AO1 A;  3P3Q A;  4MZ7 A;  2HEK A;  4TO1 A;  3TMC A;  4QFY A;  4L1J A;  4RXO A;  3M1T A;  4QG1 A;  4XDS A;  4TO0 A;  4L7E A;  4QQX A;  4BZC A;  4ZWG A;  3MEM A;  4MCW A;  4QFX A;  4TO4 A;  2FLO A;  5TK8 A;  3KQ5 A;  3BG2 A;  4ME4 A;  1VQR A;  4BZB A;  4TO2 A;  3TMB A;  3I7A A;  3IRH A;  3TMD A;  3RF0 A;  4TNR A;  3LJX A;  3SK9 A;  2CQZ A;  2PAQ A;  4RXQ A;  3GW7 A;  2PAR A;  4QG4 A;  5TKA A;  3TM8 A;  1VJ7 A;  2Q14 A;  2PQ7 A;  3NQW A;  4TNP A;  5AO4 A;  2PAU A;  4N6W A;  4RXS A;  4DMB A;  4MLN A;  4TNX A;  3HC1 A;  4Q2D A;  3KH1 A;  1U6Z A; 
#chains in the Genus database with same CATH homology
 2PGS A;  1YOY A;  4ZWE A;  3HI0 A;  3SKD A;  4QQZ A;  4RXR A;  4TNQ A;  4QG2 A;  2DQB A;  4TO5 A;  4TNZ A;  3MZO A;  4L1J B;  1YNB A;  4N71 A;  4QFZ A;  4Q2C A;  2O08 A;  2O6I A;  1XX7 A;  5TK7 A;  5AO3 A;  4MLM A;  3NR1 A;  4L7W A;  4QQY A;  4TNY A;  5AO0 A;  2GZ4 A;  5AO2 A;  4QQW A;  4RXP A;  5TK6 A;  4TO3 A;  3U1N A;  3S4L A;  4TO6 A;  2OGI A;  3CCG A;  4LRL A;  4MDZ A;  4QG0 A;  4Q7H A;  4R8Z A;  5TK9 A;  4X9E A;  5AO1 A;  3P3Q A;  4MZ7 A;  2HEK A;  4TO1 A;  3TMC A;  4QFY A;  4L1J A;  4RXO A;  3M1T A;  4QG1 A;  4XDS A;  4TO0 A;  4L7E A;  4QQX A;  4BZC A;  4ZWG A;  3MEM A;  4MCW A;  4QFX A;  4TO4 A;  2FLO A;  5TK8 A;  3KQ5 A;  3BG2 A;  4ME4 A;  1VQR A;  4BZB A;  4TO2 A;  3TMB A;  3I7A A;  3IRH A;  3TMD A;  3RF0 A;  4TNR A;  3LJX A;  3SK9 A;  2CQZ A;  2PAQ A;  4RXQ A;  3GW7 A;  2PAR A;  4QG4 A;  5TKA A;  3TM8 A;  1VJ7 A;  2Q14 A;  2PQ7 A;  3NQW A;  4TNP A;  5AO4 A;  2PAU A;  4N6W A;  4RXS A;  4DMB A;  4MLN A;  4TNX A;  3HC1 A;  4Q2D A;  3KH1 A;  1U6Z A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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4TNQA

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

Chord Diagram

connected with : NaN

pfam database annotations