4TNY | Genus

Total Genus 168

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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	168
sequence length	487
structure length	481
Chain Sequence	DTMKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASHNRFEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCRNLGHGPFSHMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPEEDICFIKEQIVGPLELWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFARDCHHLGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNSLHRRAYQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDDMEAYTKLTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKIKREDYESLPKEVASAKPKVLLDVKLKAEDFIVDVINMDYGMQEKNPIDHVSFYCKTAPNRAIRITKNQVSQLLPEKFAEQLIRVYCKKVDRKSLYAARQYFVQWCADRNFTKPQDGDVIAPLITPQKKEWN

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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

Chord Diagram

molecule tags	Hydrolase
source organism	Homo sapiens
publication title	Structural basis of cellular dNTP regulation by SAMHD1. pubmed doi rcsb
molecule keywords	Deoxynucleoside triphosphate triphosphohydrolase SAMHD1
total genus	168
structure length	481
sequence length	487
chains with identical sequence	B, C, D
ec nomenclature	ec 3.1.5.-:
pdb deposition date	2014-06-05

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF01966	HD	HD domain

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
1.10.3210.10	Mainly Alpha	Orthogonal Bundle	Hypothetical protein af1432	Hypothetical protein af1432	4tnyA01

1VJ7A 3U1NA 5TK9A 4TNYA 3KH1A 4RXQA 4N6WA 4TO6A 4ZWEA 4L1JB 5TK8A 4BZCA 3TMBA 2PGSA 4N71A 4L7EA 4TO0A 3M1TA 4LRLA 4BZBA 4TNZA 2PAUA 4TO4A 3TMCA 4L1JA 4MDZA 4RXRA 4TO5A 4RXSA 3HI0A 1XX7A 2O6IA 4ZWGA 3MZOA 1YNBA 2DQBA 5TK6A 4MCWA 4QG0A 5AO1A 2Q14A 3TM8A 2FLOA 4RXOA 4TO3A 5TK7A 5AO2A 2PARA 4RXPA 3TMDA 3IRHA 4MLMA 3NR1A 4TNXA 4TNQA 1VQRA 2O08A 3MEMA 5AO3A 3NQWA 3P3QA 4L7WA 1YOYA 4QG4A 2CQZA 4QFYA 2OGIA 5AO4A 3I7AA 1U6ZA 4MZ7A 4QG1A 4TO2A 4DMBA 5TKAA 3HC1A 4TNRA 3CCGA 4Q7HA 4R8ZA 2PQ7A 3RF0A 4QFZA 5AO0A 2PAQA 4QFXA 3BG2A 4MLNA 2HEKA 4XDSA 2GZ4A 4QG2A 3LJXA 4X9EA 4TNPA 4TO1A 4ME4A
chains in the Genus database with same CATH superfamily

1VJ7A 3U1NA 5TK9A 4TNYA 3KH1A 4RXQA 4N6WA 4TO6A 4ZWEA 4L1JB 5TK8A 4BZCA 3TMBA 3KQ5A 2PGSA 4N71A 4L7EA 4TO0A 3M1TA 3GW7A 4LRLA 4BZBA 4TNZA 2PAUA 4TO4A 3TMCA 4L1JA 4Q2DA 4MDZA 4RXRA 4TO5A 3S4LA 4RXSA 3HI0A 3SK9A 1XX7A 2O6IA 4ZWGA 3MZOA 1YNBA 2DQBA 5TK6A 4QQZA 4MCWA 4QG0A 5AO1A 2Q14A 3TM8A 4QQYA 2FLOA 4RXOA 4TO3A 5TK7A 5AO2A 2PARA 4RXPA 3TMDA 3IRHA 4MLMA 3NR1A 4TNXA 4TNQA 1VQRA 2O08A 3MEMA 5AO3A 4Q2CA 3NQWA 3P3QA 4L7WA 1YOYA 4QG4A 2CQZA 4QFYA 2OGIA 5AO4A 3I7AA 1U6ZA 4MZ7A 4QG1A 4TO2A 4DMBA 5TKAA 3HC1A 4TNRA 3CCGA 4Q7HA 4R8ZA 2PQ7A 3RF0A 4QFZA 5AO0A 2PAQA 4QFXA 3BG2A 4MLNA 2HEKA 4XDSA 2GZ4A 4QG2A 4QQWA 4QQXA 3LJXA 3SKDA 4X9EA 4TNPA 4TO1A 4ME4A
chains in the Genus database with same CATH topology

#chains in the Genus database with same CATH superfamily
 1VJ7 A;  3U1N A;  5TK9 A;  4TNY A;  3KH1 A;  4RXQ A;  4N6W A;  4TO6 A;  4ZWE A;  4L1J B;  5TK8 A;  4BZC A;  3TMB A;  2PGS A;  4N71 A;  4L7E A;  4TO0 A;  3M1T A;  4LRL A;  4BZB A;  4TNZ A;  2PAU A;  4TO4 A;  3TMC A;  4L1J A;  4MDZ A;  4RXR A;  4TO5 A;  4RXS A;  3HI0 A;  1XX7 A;  2O6I A;  4ZWG A;  3MZO A;  1YNB A;  2DQB A;  5TK6 A;  4MCW A;  4QG0 A;  5AO1 A;  2Q14 A;  3TM8 A;  2FLO A;  4RXO A;  4TO3 A;  5TK7 A;  5AO2 A;  2PAR A;  4RXP A;  3TMD A;  3IRH A;  4MLM A;  3NR1 A;  4TNX A;  4TNQ A;  1VQR A;  2O08 A;  3MEM A;  5AO3 A;  3NQW A;  3P3Q A;  4L7W A;  1YOY A;  4QG4 A;  2CQZ A;  4QFY A;  2OGI A;  5AO4 A;  3I7A A;  1U6Z A;  4MZ7 A;  4QG1 A;  4TO2 A;  4DMB A;  5TKA A;  3HC1 A;  4TNR A;  3CCG A;  4Q7H A;  4R8Z A;  2PQ7 A;  3RF0 A;  4QFZ A;  5AO0 A;  2PAQ A;  4QFX A;  3BG2 A;  4MLN A;  2HEK A;  4XDS A;  2GZ4 A;  4QG2 A;  3LJX A;  4X9E A;  4TNP A;  4TO1 A;  4ME4 A; 
#chains in the Genus database with same CATH topology
 1VJ7 A;  3U1N A;  5TK9 A;  4TNY A;  3KH1 A;  4RXQ A;  4N6W A;  4TO6 A;  4ZWE A;  4L1J B;  5TK8 A;  4BZC A;  3TMB A;  3KQ5 A;  2PGS A;  4N71 A;  4L7E A;  4TO0 A;  3M1T A;  3GW7 A;  4LRL A;  4BZB A;  4TNZ A;  2PAU A;  4TO4 A;  3TMC A;  4L1J A;  4Q2D A;  4MDZ A;  4RXR A;  4TO5 A;  3S4L A;  4RXS A;  3HI0 A;  3SK9 A;  1XX7 A;  2O6I A;  4ZWG A;  3MZO A;  1YNB A;  2DQB A;  5TK6 A;  4QQZ A;  4MCW A;  4QG0 A;  5AO1 A;  2Q14 A;  3TM8 A;  4QQY A;  2FLO A;  4RXO A;  4TO3 A;  5TK7 A;  5AO2 A;  2PAR A;  4RXP A;  3TMD A;  3IRH A;  4MLM A;  3NR1 A;  4TNX A;  4TNQ A;  1VQR A;  2O08 A;  3MEM A;  5AO3 A;  4Q2C A;  3NQW A;  3P3Q A;  4L7W A;  1YOY A;  4QG4 A;  2CQZ A;  4QFY A;  2OGI A;  5AO4 A;  3I7A A;  1U6Z A;  4MZ7 A;  4QG1 A;  4TO2 A;  4DMB A;  5TKA A;  3HC1 A;  4TNR A;  3CCG A;  4Q7H A;  4R8Z A;  2PQ7 A;  3RF0 A;  4QFZ A;  5AO0 A;  2PAQ A;  4QFX A;  3BG2 A;  4MLN A;  2HEK A;  4XDS A;  2GZ4 A;  4QG2 A;  4QQW A;  4QQX A;  3LJX A;  3SKD A;  4X9E A;  4TNP A;  4TO1 A;  4ME4 A; 
#chains in the Genus database with same CATH homology
 1VJ7 A;  3U1N A;  5TK9 A;  4TNY A;  3KH1 A;  4RXQ A;  4N6W A;  4TO6 A;  4ZWE A;  4L1J B;  5TK8 A;  4BZC A;  3TMB A;  3KQ5 A;  2PGS A;  4N71 A;  4L7E A;  4TO0 A;  3M1T A;  3GW7 A;  4LRL A;  4BZB A;  4TNZ A;  2PAU A;  4TO4 A;  3TMC A;  4L1J A;  4Q2D A;  4MDZ A;  4RXR A;  4TO5 A;  3S4L A;  4RXS A;  3HI0 A;  3SK9 A;  1XX7 A;  2O6I A;  4ZWG A;  3MZO A;  1YNB A;  2DQB A;  5TK6 A;  4QQZ A;  4MCW A;  4QG0 A;  5AO1 A;  2Q14 A;  3TM8 A;  4QQY A;  2FLO A;  4RXO A;  4TO3 A;  5TK7 A;  5AO2 A;  2PAR A;  4RXP A;  3TMD A;  3IRH A;  4MLM A;  3NR1 A;  4TNX A;  4TNQ A;  1VQR A;  2O08 A;  3MEM A;  5AO3 A;  4Q2C A;  3NQW A;  3P3Q A;  4L7W A;  1YOY A;  4QG4 A;  2CQZ A;  4QFY A;  2OGI A;  5AO4 A;  3I7A A;  1U6Z A;  4MZ7 A;  4QG1 A;  4TO2 A;  4DMB A;  5TKA A;  3HC1 A;  4TNR A;  3CCG A;  4Q7H A;  4R8Z A;  2PQ7 A;  3RF0 A;  4QFZ A;  5AO0 A;  2PAQ A;  4QFX A;  3BG2 A;  4MLN A;  2HEK A;  4XDS A;  2GZ4 A;  4QG2 A;  4QQW A;  4QQX A;  3LJX A;  3SKD A;  4X9E A;  4TNP A;  4TO1 A;  4ME4 A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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4TNYA

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

Chord Diagram

connected with : NaN

pfam database annotations