4TO1A

Structure basis of cellular dntp regulation, samhd1-gtp-datp/dctp-dctp complex
Total Genus 172
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
172
sequence length
486
structure length
479
Chain Sequence
TMKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASHNRFEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCRNLGHGPFSHMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPEEDICFIKEQIVGPLLWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFARDCHHLGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNSLHRRAYQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDDMEAYTKLTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKIKREDYESLPKEVASAKPKVLLDVKLKAEDFIVDVINMDYGMQEKNPIDHVSFYCKTAPNRAIRITKNQVSQLLPEKFAEQLIRVYCKKVDRKSLYAARQYFVQWCADRNFTKPQDGDVIAPLITPQKKEWN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural basis of cellular dNTP regulation by SAMHD1.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords Deoxynucleoside triphosphate triphosphohydrolase SAMHD1
total genus 172
structure length 479
sequence length 486
chains with identical sequence B, C, D
ec nomenclature ec 3.1.5.-:
pdb deposition date 2014-06-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01966 HD HD domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.3210.10 Mainly Alpha Orthogonal Bundle Hypothetical protein af1432 Hypothetical protein af1432 4to1A01
4TO1A 3NR1A 3IRHA 3RF0A 2PGSA 3TMDA 3KH1A 2FLOA 4MLMA 4L1JB 4QG1A 4TO6A 4TO5A 1VQRA 4QFXA 4QG2A 4RXQA 4TO3A 4TNZA 4Q7HA 4N6WA 1VJ7A 4RXRA 5AO0A 4MLNA 5AO3A 4TO2A 4MZ7A 4QG4A 3MZOA 4TO4A 4QG0A 3BG2A 2HEKA 4BZBA 3HI0A 5TK7A 4DMBA 2DQBA 2PQ7A 4TNXA 1YNBA 4L7EA 2O08A 3CCGA 4TNYA 2Q14A 4ME4A 4MDZA 3LJXA 4QFYA 4TNPA 4ZWGA 4RXOA 3TMBA 4BZCA 2CQZA 3HC1A 5TK9A 4RXSA 5TKAA 1YOYA 4XDSA 3P3QA 4ZWEA 3U1NA 2PAUA 3I7AA 3TMCA 1U6ZA 5AO4A 3TM8A 4L1JA 4L7WA 4TNRA 4LRLA 4N71A 4TNQA 2PAQA 3M1TA 3MEMA 4MCWA 5TK6A 1XX7A 2O6IA 4R8ZA 4X9EA 5TK8A 5AO1A 2PARA 4RXPA 4QFZA 5AO2A 2OGIA 2GZ4A 4TO0A 3NQWA
chains in the Genus database with same CATH superfamily
4TO1A 3NR1A 3IRHA 3RF0A 2PGSA 3TMDA 3KH1A 2FLOA 4MLMA 4L1JB 4QG1A 4TO6A 4TO5A 1VQRA 4QFXA 4QG2A 4RXQA 4TO3A 4TNZA 4Q7HA 4N6WA 1VJ7A 3GW7A 4RXRA 5AO0A 4QQXA 4MLNA 4QQWA 5AO3A 4TO2A 4MZ7A 4QG4A 3MZOA 4TO4A 4QG0A 3BG2A 2HEKA 4BZBA 3HI0A 5TK7A 4DMBA 2DQBA 2PQ7A 4TNXA 1YNBA 4L7EA 2O08A 3CCGA 4TNYA 2Q14A 4ME4A 4MDZA 3LJXA 4QQZA 4QFYA 4TNPA 4ZWGA 4Q2CA 4RXOA 3TMBA 4BZCA 2CQZA 4Q2DA 3HC1A 5TK9A 3SKDA 4RXSA 5TKAA 1YOYA 4XDSA 3P3QA 4ZWEA 3S4LA 3U1NA 2PAUA 3I7AA 3TMCA 1U6ZA 5AO4A 3TM8A 4L1JA 4L7WA 3SK9A 4TNRA 4LRLA 3KQ5A 4N71A 4TNQA 2PAQA 3M1TA 3MEMA 4MCWA 5TK6A 1XX7A 2O6IA 4R8ZA 4X9EA 4QQYA 5TK8A 5AO1A 2PARA 4RXPA 4QFZA 5AO2A 2OGIA 2GZ4A 4TO0A 3NQWA
chains in the Genus database with same CATH topology
4TO1A 3NR1A 3IRHA 3RF0A 2PGSA 3TMDA 3KH1A 2FLOA 4MLMA 4L1JB 4QG1A 4TO6A 4TO5A 1VQRA 4QFXA 4QG2A 4RXQA 4TO3A 4TNZA 4Q7HA 4N6WA 1VJ7A 3GW7A 4RXRA 5AO0A 4QQXA 4MLNA 4QQWA 5AO3A 4TO2A 4MZ7A 4QG4A 3MZOA 4TO4A 4QG0A 3BG2A 2HEKA 4BZBA 3HI0A 5TK7A 4DMBA 2DQBA 2PQ7A 4TNXA 1YNBA 4L7EA 2O08A 3CCGA 4TNYA 2Q14A 4ME4A 4MDZA 3LJXA 4QQZA 4QFYA 4TNPA 4ZWGA 4Q2CA 4RXOA 3TMBA 4BZCA 2CQZA 4Q2DA 3HC1A 5TK9A 3SKDA 4RXSA 5TKAA 1YOYA 4XDSA 3P3QA 4ZWEA 3S4LA 3U1NA 2PAUA 3I7AA 3TMCA 1U6ZA 5AO4A 3TM8A 4L1JA 4L7WA 3SK9A 4TNRA 4LRLA 3KQ5A 4N71A 4TNQA 2PAQA 3M1TA 3MEMA 4MCWA 5TK6A 1XX7A 2O6IA 4R8ZA 4X9EA 4QQYA 5TK8A 5AO1A 2PARA 4RXPA 4QFZA 5AO2A 2OGIA 2GZ4A 4TO0A 3NQWA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4TO1 A;  3NR1 A;  3IRH A;  3RF0 A;  2PGS A;  3TMD A;  3KH1 A;  2FLO A;  4MLM A;  4L1J B;  4QG1 A;  4TO6 A;  4TO5 A;  1VQR A;  4QFX A;  4QG2 A;  4RXQ A;  4TO3 A;  4TNZ A;  4Q7H A;  4N6W A;  1VJ7 A;  4RXR A;  5AO0 A;  4MLN A;  5AO3 A;  4TO2 A;  4MZ7 A;  4QG4 A;  3MZO A;  4TO4 A;  4QG0 A;  3BG2 A;  2HEK A;  4BZB A;  3HI0 A;  5TK7 A;  4DMB A;  2DQB A;  2PQ7 A;  4TNX A;  1YNB A;  4L7E A;  2O08 A;  3CCG A;  4TNY A;  2Q14 A;  4ME4 A;  4MDZ A;  3LJX A;  4QFY A;  4TNP A;  4ZWG A;  4RXO A;  3TMB A;  4BZC A;  2CQZ A;  3HC1 A;  5TK9 A;  4RXS A;  5TKA A;  1YOY A;  4XDS A;  3P3Q A;  4ZWE A;  3U1N A;  2PAU A;  3I7A A;  3TMC A;  1U6Z A;  5AO4 A;  3TM8 A;  4L1J A;  4L7W A;  4TNR A;  4LRL A;  4N71 A;  4TNQ A;  2PAQ A;  3M1T A;  3MEM A;  4MCW A;  5TK6 A;  1XX7 A;  2O6I A;  4R8Z A;  4X9E A;  5TK8 A;  5AO1 A;  2PAR A;  4RXP A;  4QFZ A;  5AO2 A;  2OGI A;  2GZ4 A;  4TO0 A;  3NQW A; 
#chains in the Genus database with same CATH topology
 4TO1 A;  3NR1 A;  3IRH A;  3RF0 A;  2PGS A;  3TMD A;  3KH1 A;  2FLO A;  4MLM A;  4L1J B;  4QG1 A;  4TO6 A;  4TO5 A;  1VQR A;  4QFX A;  4QG2 A;  4RXQ A;  4TO3 A;  4TNZ A;  4Q7H A;  4N6W A;  1VJ7 A;  3GW7 A;  4RXR A;  5AO0 A;  4QQX A;  4MLN A;  4QQW A;  5AO3 A;  4TO2 A;  4MZ7 A;  4QG4 A;  3MZO A;  4TO4 A;  4QG0 A;  3BG2 A;  2HEK A;  4BZB A;  3HI0 A;  5TK7 A;  4DMB A;  2DQB A;  2PQ7 A;  4TNX A;  1YNB A;  4L7E A;  2O08 A;  3CCG A;  4TNY A;  2Q14 A;  4ME4 A;  4MDZ A;  3LJX A;  4QQZ A;  4QFY A;  4TNP A;  4ZWG A;  4Q2C A;  4RXO A;  3TMB A;  4BZC A;  2CQZ A;  4Q2D A;  3HC1 A;  5TK9 A;  3SKD A;  4RXS A;  5TKA A;  1YOY A;  4XDS A;  3P3Q A;  4ZWE A;  3S4L A;  3U1N A;  2PAU A;  3I7A A;  3TMC A;  1U6Z A;  5AO4 A;  3TM8 A;  4L1J A;  4L7W A;  3SK9 A;  4TNR A;  4LRL A;  3KQ5 A;  4N71 A;  4TNQ A;  2PAQ A;  3M1T A;  3MEM A;  4MCW A;  5TK6 A;  1XX7 A;  2O6I A;  4R8Z A;  4X9E A;  4QQY A;  5TK8 A;  5AO1 A;  2PAR A;  4RXP A;  4QFZ A;  5AO2 A;  2OGI A;  2GZ4 A;  4TO0 A;  3NQW A; 
#chains in the Genus database with same CATH homology
 4TO1 A;  3NR1 A;  3IRH A;  3RF0 A;  2PGS A;  3TMD A;  3KH1 A;  2FLO A;  4MLM A;  4L1J B;  4QG1 A;  4TO6 A;  4TO5 A;  1VQR A;  4QFX A;  4QG2 A;  4RXQ A;  4TO3 A;  4TNZ A;  4Q7H A;  4N6W A;  1VJ7 A;  3GW7 A;  4RXR A;  5AO0 A;  4QQX A;  4MLN A;  4QQW A;  5AO3 A;  4TO2 A;  4MZ7 A;  4QG4 A;  3MZO A;  4TO4 A;  4QG0 A;  3BG2 A;  2HEK A;  4BZB A;  3HI0 A;  5TK7 A;  4DMB A;  2DQB A;  2PQ7 A;  4TNX A;  1YNB A;  4L7E A;  2O08 A;  3CCG A;  4TNY A;  2Q14 A;  4ME4 A;  4MDZ A;  3LJX A;  4QQZ A;  4QFY A;  4TNP A;  4ZWG A;  4Q2C A;  4RXO A;  3TMB A;  4BZC A;  2CQZ A;  4Q2D A;  3HC1 A;  5TK9 A;  3SKD A;  4RXS A;  5TKA A;  1YOY A;  4XDS A;  3P3Q A;  4ZWE A;  3S4L A;  3U1N A;  2PAU A;  3I7A A;  3TMC A;  1U6Z A;  5AO4 A;  3TM8 A;  4L1J A;  4L7W A;  3SK9 A;  4TNR A;  4LRL A;  3KQ5 A;  4N71 A;  4TNQ A;  2PAQ A;  3M1T A;  3MEM A;  4MCW A;  5TK6 A;  1XX7 A;  2O6I A;  4R8Z A;  4X9E A;  4QQY A;  5TK8 A;  5AO1 A;  2PAR A;  4RXP A;  4QFZ A;  5AO2 A;  2OGI A;  2GZ4 A;  4TO0 A;  3NQW A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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