4TO3A

Structural basis of cellular dntp regulation, samhd1-dgtp-dgtp-dctp complex
Total Genus 167
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
167
sequence length
487
structure length
481
Chain Sequence
DTMKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASHNRFEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCRNLGHGPFSHMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPEEDICFIKEQIVGPLELWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFARDCHHLGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNSLHRRAYQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDDMEAYTKLTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKIKREDYESLPKEVASAKPKVLLDVKLKAEDFIVDVINMDYGMQEKNPIDHVSFYCKTAPNRAIRITKNQVSQLLPEKFAEQLIRVYCKKVDRKSLYAARQYFVQWCADRNFTKPQDGDVIAPLITPQKKEWN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural basis of cellular dNTP regulation by SAMHD1.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords Deoxynucleoside triphosphate triphosphohydrolase SAMHD1
total genus 167
structure length 481
sequence length 487
chains with identical sequence B, C, D
ec nomenclature ec 3.1.5.-:
pdb deposition date 2014-06-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01966 HD HD domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.3210.10 Mainly Alpha Orthogonal Bundle Hypothetical protein af1432 Hypothetical protein af1432 4to3A01
2PAQA 4TNZA 2Q14A 3MZOA 5TK7A 4TO6A 4MDZA 4BZCA 4RXOA 2PAUA 1U6ZA 3NR1A 3HC1A 1XX7A 3TMBA 3LJXA 4TO1A 2PGSA 3KH1A 2CQZA 4MLNA 5AO4A 4RXQA 4QG2A 2HEKA 4Q7HA 4QG4A 4QFYA 4ZWGA 4R8ZA 2O6IA 4L1JB 1VQRA 2OGIA 4QFZA 2GZ4A 3NQWA 4RXPA 5TK6A 4N6WA 4LRLA 1VJ7A 4TNRA 5AO1A 1YOYA 5TK9A 5AO2A 4TNYA 4MLMA 4TO4A 2PARA 4RXSA 3I7AA 3RF0A 4L7EA 3TMCA 4ME4A 3BG2A 5AO0A 4TNPA 5TK8A 3MEMA 1YNBA 4X9EA 2PQ7A 4BZBA 4XDSA 2O08A 4RXRA 4N71A 4TO0A 3TMDA 4TNXA 2FLOA 4ZWEA 3IRHA 5TKAA 3HI0A 3M1TA 4QG0A 4DMBA 4TNQA 3P3QA 4TO2A 5AO3A 4L7WA 4TO5A 2DQBA 3CCGA 4MCWA 4TO3A 4L1JA 4QFXA 4QG1A 3U1NA 3TM8A 4MZ7A
chains in the Genus database with same CATH superfamily
2PAQA 4TNZA 4Q2CA 2Q14A 3KQ5A 3MZOA 5TK7A 4TO6A 4MDZA 4BZCA 4RXOA 4Q2DA 3S4LA 2PAUA 1U6ZA 3NR1A 3HC1A 1XX7A 3TMBA 3LJXA 4TO1A 2PGSA 3KH1A 2CQZA 4MLNA 5AO4A 4RXQA 4QG2A 2HEKA 4Q7HA 4QG4A 4QFYA 4ZWGA 4R8ZA 2O6IA 4L1JB 1VQRA 2OGIA 4QFZA 2GZ4A 3GW7A 3NQWA 4RXPA 5TK6A 4N6WA 4LRLA 1VJ7A 4TNRA 5AO1A 1YOYA 5TK9A 5AO2A 4TNYA 4MLMA 4QQXA 4TO4A 2PARA 4RXSA 3I7AA 3RF0A 4L7EA 3TMCA 4ME4A 3SK9A 3BG2A 5AO0A 4TNPA 5TK8A 3MEMA 1YNBA 4X9EA 2PQ7A 4BZBA 4XDSA 2O08A 4RXRA 4N71A 4TO0A 3TMDA 4TNXA 2FLOA 4ZWEA 3IRHA 5TKAA 4QQZA 3HI0A 3M1TA 4QG0A 4DMBA 4TNQA 3P3QA 4TO2A 5AO3A 4L7WA 4TO5A 2DQBA 3CCGA 4MCWA 4TO3A 4L1JA 4QFXA 4QG1A 3U1NA 3TM8A 3SKDA 4MZ7A 4QQYA 4QQWA
chains in the Genus database with same CATH topology
2PAQA 4TNZA 4Q2CA 2Q14A 3KQ5A 3MZOA 5TK7A 4TO6A 4MDZA 4BZCA 4RXOA 4Q2DA 3S4LA 2PAUA 1U6ZA 3NR1A 3HC1A 1XX7A 3TMBA 3LJXA 4TO1A 2PGSA 3KH1A 2CQZA 4MLNA 5AO4A 4RXQA 4QG2A 2HEKA 4Q7HA 4QG4A 4QFYA 4ZWGA 4R8ZA 2O6IA 4L1JB 1VQRA 2OGIA 4QFZA 2GZ4A 3GW7A 3NQWA 4RXPA 5TK6A 4N6WA 4LRLA 1VJ7A 4TNRA 5AO1A 1YOYA 5TK9A 5AO2A 4TNYA 4MLMA 4QQXA 4TO4A 2PARA 4RXSA 3I7AA 3RF0A 4L7EA 3TMCA 4ME4A 3SK9A 3BG2A 5AO0A 4TNPA 5TK8A 3MEMA 1YNBA 4X9EA 2PQ7A 4BZBA 4XDSA 2O08A 4RXRA 4N71A 4TO0A 3TMDA 4TNXA 2FLOA 4ZWEA 3IRHA 5TKAA 4QQZA 3HI0A 3M1TA 4QG0A 4DMBA 4TNQA 3P3QA 4TO2A 5AO3A 4L7WA 4TO5A 2DQBA 3CCGA 4MCWA 4TO3A 4L1JA 4QFXA 4QG1A 3U1NA 3TM8A 3SKDA 4MZ7A 4QQYA 4QQWA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2PAQ A;  4TNZ A;  2Q14 A;  3MZO A;  5TK7 A;  4TO6 A;  4MDZ A;  4BZC A;  4RXO A;  2PAU A;  1U6Z A;  3NR1 A;  3HC1 A;  1XX7 A;  3TMB A;  3LJX A;  4TO1 A;  2PGS A;  3KH1 A;  2CQZ A;  4MLN A;  5AO4 A;  4RXQ A;  4QG2 A;  2HEK A;  4Q7H A;  4QG4 A;  4QFY A;  4ZWG A;  4R8Z A;  2O6I A;  4L1J B;  1VQR A;  2OGI A;  4QFZ A;  2GZ4 A;  3NQW A;  4RXP A;  5TK6 A;  4N6W A;  4LRL A;  1VJ7 A;  4TNR A;  5AO1 A;  1YOY A;  5TK9 A;  5AO2 A;  4TNY A;  4MLM A;  4TO4 A;  2PAR A;  4RXS A;  3I7A A;  3RF0 A;  4L7E A;  3TMC A;  4ME4 A;  3BG2 A;  5AO0 A;  4TNP A;  5TK8 A;  3MEM A;  1YNB A;  4X9E A;  2PQ7 A;  4BZB A;  4XDS A;  2O08 A;  4RXR A;  4N71 A;  4TO0 A;  3TMD A;  4TNX A;  2FLO A;  4ZWE A;  3IRH A;  5TKA A;  3HI0 A;  3M1T A;  4QG0 A;  4DMB A;  4TNQ A;  3P3Q A;  4TO2 A;  5AO3 A;  4L7W A;  4TO5 A;  2DQB A;  3CCG A;  4MCW A;  4TO3 A;  4L1J A;  4QFX A;  4QG1 A;  3U1N A;  3TM8 A;  4MZ7 A; 
#chains in the Genus database with same CATH topology
 2PAQ A;  4TNZ A;  4Q2C A;  2Q14 A;  3KQ5 A;  3MZO A;  5TK7 A;  4TO6 A;  4MDZ A;  4BZC A;  4RXO A;  4Q2D A;  3S4L A;  2PAU A;  1U6Z A;  3NR1 A;  3HC1 A;  1XX7 A;  3TMB A;  3LJX A;  4TO1 A;  2PGS A;  3KH1 A;  2CQZ A;  4MLN A;  5AO4 A;  4RXQ A;  4QG2 A;  2HEK A;  4Q7H A;  4QG4 A;  4QFY A;  4ZWG A;  4R8Z A;  2O6I A;  4L1J B;  1VQR A;  2OGI A;  4QFZ A;  2GZ4 A;  3GW7 A;  3NQW A;  4RXP A;  5TK6 A;  4N6W A;  4LRL A;  1VJ7 A;  4TNR A;  5AO1 A;  1YOY A;  5TK9 A;  5AO2 A;  4TNY A;  4MLM A;  4QQX A;  4TO4 A;  2PAR A;  4RXS A;  3I7A A;  3RF0 A;  4L7E A;  3TMC A;  4ME4 A;  3SK9 A;  3BG2 A;  5AO0 A;  4TNP A;  5TK8 A;  3MEM A;  1YNB A;  4X9E A;  2PQ7 A;  4BZB A;  4XDS A;  2O08 A;  4RXR A;  4N71 A;  4TO0 A;  3TMD A;  4TNX A;  2FLO A;  4ZWE A;  3IRH A;  5TKA A;  4QQZ A;  3HI0 A;  3M1T A;  4QG0 A;  4DMB A;  4TNQ A;  3P3Q A;  4TO2 A;  5AO3 A;  4L7W A;  4TO5 A;  2DQB A;  3CCG A;  4MCW A;  4TO3 A;  4L1J A;  4QFX A;  4QG1 A;  3U1N A;  3TM8 A;  3SKD A;  4MZ7 A;  4QQY A;  4QQW A; 
#chains in the Genus database with same CATH homology
 2PAQ A;  4TNZ A;  4Q2C A;  2Q14 A;  3KQ5 A;  3MZO A;  5TK7 A;  4TO6 A;  4MDZ A;  4BZC A;  4RXO A;  4Q2D A;  3S4L A;  2PAU A;  1U6Z A;  3NR1 A;  3HC1 A;  1XX7 A;  3TMB A;  3LJX A;  4TO1 A;  2PGS A;  3KH1 A;  2CQZ A;  4MLN A;  5AO4 A;  4RXQ A;  4QG2 A;  2HEK A;  4Q7H A;  4QG4 A;  4QFY A;  4ZWG A;  4R8Z A;  2O6I A;  4L1J B;  1VQR A;  2OGI A;  4QFZ A;  2GZ4 A;  3GW7 A;  3NQW A;  4RXP A;  5TK6 A;  4N6W A;  4LRL A;  1VJ7 A;  4TNR A;  5AO1 A;  1YOY A;  5TK9 A;  5AO2 A;  4TNY A;  4MLM A;  4QQX A;  4TO4 A;  2PAR A;  4RXS A;  3I7A A;  3RF0 A;  4L7E A;  3TMC A;  4ME4 A;  3SK9 A;  3BG2 A;  5AO0 A;  4TNP A;  5TK8 A;  3MEM A;  1YNB A;  4X9E A;  2PQ7 A;  4BZB A;  4XDS A;  2O08 A;  4RXR A;  4N71 A;  4TO0 A;  3TMD A;  4TNX A;  2FLO A;  4ZWE A;  3IRH A;  5TKA A;  4QQZ A;  3HI0 A;  3M1T A;  4QG0 A;  4DMB A;  4TNQ A;  3P3Q A;  4TO2 A;  5AO3 A;  4L7W A;  4TO5 A;  2DQB A;  3CCG A;  4MCW A;  4TO3 A;  4L1J A;  4QFX A;  4QG1 A;  3U1N A;  3TM8 A;  3SKD A;  4MZ7 A;  4QQY A;  4QQW A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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