4TO4A

Structure basis of cellular dntp regulation, samhd1-gtp-dgtp-dctp complex
Total Genus 171
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
171
sequence length
487
structure length
481
Chain Sequence
DTMKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASHNRFEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCRNLGHGPFSHMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPEEDICFIKEQIVGPLELWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFARDCHHLGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNSLHRRAYQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDDMEAYTKLTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKIKREDYESLPKEVASAKPKVLLDVKLKAEDFIVDVINMDYGMQEKNPIDHVSFYCKTAPNRAIRITKNQVSQLLPEKFAEQLIRVYCKKVDRKSLYAARQYFVQWCADRNFTKPQDGDVIAPLITPQKKEWN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase
source organism Homo sapiens
publication title Structural basis of cellular dNTP regulation by SAMHD1.
pubmed doi rcsb
molecule keywords Deoxynucleoside triphosphate triphosphohydrolase SAMHD1
total genus 171
structure length 481
sequence length 487
chains with identical sequence B, C, D
ec nomenclature ec 3.1.5.-:
pdb deposition date 2014-06-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01966 HD HD domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.3210.10 Mainly Alpha Orthogonal Bundle Hypothetical protein af1432 Hypothetical protein af1432 4to4A01
2PGSA 3MEMA 5TK7A 3KH1A 4L7EA 2PAUA 3RF0A 4TNXA 4MLNA 4MLMA 4N71A 4QG1A 5AO4A 3CCGA 5AO1A 4RXOA 2DQBA 4TNPA 4TNYA 1YNBA 3BG2A 4Q7HA 4L1JA 4MDZA 3M1TA 2PAQA 4TNRA 4L1JB 5TK6A 3HI0A 4R8ZA 5AO2A 1YOYA 3TMDA 4TO1A 4TO3A 4TNQA 4QFYA 2PQ7A 3TMCA 3U1NA 2FLOA 2CQZA 4TNZA 4ZWEA 5TK8A 2O08A 2PARA 4TO6A 5AO0A 4RXSA 4BZBA 4LRLA 4TO5A 4XDSA 2GZ4A 1U6ZA 4X9EA 2OGIA 4N6WA 4MZ7A 1XX7A 4TO0A 2O6IA 4QFZA 4BZCA 2Q14A 4ME4A 4ZWGA 1VQRA 4QG4A 4L7WA 4QFXA 3I7AA 3TM8A 4QG0A 3TMBA 4RXPA 5TKAA 5TK9A 3NQWA 3NR1A 4TO4A 4QG2A 4RXRA 1VJ7A 4MCWA 3IRHA 4TO2A 3P3QA 3LJXA 4DMBA 3MZOA 5AO3A 3HC1A 4RXQA 2HEKA
chains in the Genus database with same CATH superfamily
2PGSA 3MEMA 5TK7A 3KH1A 4L7EA 2PAUA 3RF0A 3SKDA 4TNXA 4MLNA 4MLMA 4N71A 4QG1A 5AO4A 3KQ5A 3SK9A 3CCGA 4QQZA 5AO1A 4QQXA 4RXOA 2DQBA 4TNPA 4TNYA 1YNBA 3BG2A 4Q7HA 4L1JA 4MDZA 3M1TA 2PAQA 4TNRA 4L1JB 5TK6A 4QQYA 3HI0A 4R8ZA 5AO2A 1YOYA 3TMDA 4TO1A 4TO3A 4Q2CA 4TNQA 4Q2DA 4QFYA 3GW7A 2PQ7A 3TMCA 3U1NA 2FLOA 2CQZA 4TNZA 4ZWEA 5TK8A 2O08A 2PARA 4TO6A 5AO0A 4RXSA 4BZBA 4LRLA 4TO5A 4XDSA 2GZ4A 1U6ZA 4QQWA 4X9EA 2OGIA 4N6WA 4MZ7A 1XX7A 4TO0A 2O6IA 4QFZA 4BZCA 2Q14A 4ME4A 4ZWGA 1VQRA 4QG4A 4L7WA 4QFXA 3I7AA 3TM8A 4QG0A 3TMBA 4RXPA 5TKAA 5TK9A 3NQWA 3NR1A 4TO4A 4QG2A 4RXRA 1VJ7A 4MCWA 3IRHA 4TO2A 3P3QA 3LJXA 3S4LA 4DMBA 3MZOA 5AO3A 3HC1A 4RXQA 2HEKA
chains in the Genus database with same CATH topology
2PGSA 3MEMA 5TK7A 3KH1A 4L7EA 2PAUA 3RF0A 3SKDA 4TNXA 4MLNA 4MLMA 4N71A 4QG1A 5AO4A 3KQ5A 3SK9A 3CCGA 4QQZA 5AO1A 4QQXA 4RXOA 2DQBA 4TNPA 4TNYA 1YNBA 3BG2A 4Q7HA 4L1JA 4MDZA 3M1TA 2PAQA 4TNRA 4L1JB 5TK6A 4QQYA 3HI0A 4R8ZA 5AO2A 1YOYA 3TMDA 4TO1A 4TO3A 4Q2CA 4TNQA 4Q2DA 4QFYA 3GW7A 2PQ7A 3TMCA 3U1NA 2FLOA 2CQZA 4TNZA 4ZWEA 5TK8A 2O08A 2PARA 4TO6A 5AO0A 4RXSA 4BZBA 4LRLA 4TO5A 4XDSA 2GZ4A 1U6ZA 4QQWA 4X9EA 2OGIA 4N6WA 4MZ7A 1XX7A 4TO0A 2O6IA 4QFZA 4BZCA 2Q14A 4ME4A 4ZWGA 1VQRA 4QG4A 4L7WA 4QFXA 3I7AA 3TM8A 4QG0A 3TMBA 4RXPA 5TKAA 5TK9A 3NQWA 3NR1A 4TO4A 4QG2A 4RXRA 1VJ7A 4MCWA 3IRHA 4TO2A 3P3QA 3LJXA 3S4LA 4DMBA 3MZOA 5AO3A 3HC1A 4RXQA 2HEKA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2PGS A;  3MEM A;  5TK7 A;  3KH1 A;  4L7E A;  2PAU A;  3RF0 A;  4TNX A;  4MLN A;  4MLM A;  4N71 A;  4QG1 A;  5AO4 A;  3CCG A;  5AO1 A;  4RXO A;  2DQB A;  4TNP A;  4TNY A;  1YNB A;  3BG2 A;  4Q7H A;  4L1J A;  4MDZ A;  3M1T A;  2PAQ A;  4TNR A;  4L1J B;  5TK6 A;  3HI0 A;  4R8Z A;  5AO2 A;  1YOY A;  3TMD A;  4TO1 A;  4TO3 A;  4TNQ A;  4QFY A;  2PQ7 A;  3TMC A;  3U1N A;  2FLO A;  2CQZ A;  4TNZ A;  4ZWE A;  5TK8 A;  2O08 A;  2PAR A;  4TO6 A;  5AO0 A;  4RXS A;  4BZB A;  4LRL A;  4TO5 A;  4XDS A;  2GZ4 A;  1U6Z A;  4X9E A;  2OGI A;  4N6W A;  4MZ7 A;  1XX7 A;  4TO0 A;  2O6I A;  4QFZ A;  4BZC A;  2Q14 A;  4ME4 A;  4ZWG A;  1VQR A;  4QG4 A;  4L7W A;  4QFX A;  3I7A A;  3TM8 A;  4QG0 A;  3TMB A;  4RXP A;  5TKA A;  5TK9 A;  3NQW A;  3NR1 A;  4TO4 A;  4QG2 A;  4RXR A;  1VJ7 A;  4MCW A;  3IRH A;  4TO2 A;  3P3Q A;  3LJX A;  4DMB A;  3MZO A;  5AO3 A;  3HC1 A;  4RXQ A;  2HEK A; 
#chains in the Genus database with same CATH topology
 2PGS A;  3MEM A;  5TK7 A;  3KH1 A;  4L7E A;  2PAU A;  3RF0 A;  3SKD A;  4TNX A;  4MLN A;  4MLM A;  4N71 A;  4QG1 A;  5AO4 A;  3KQ5 A;  3SK9 A;  3CCG A;  4QQZ A;  5AO1 A;  4QQX A;  4RXO A;  2DQB A;  4TNP A;  4TNY A;  1YNB A;  3BG2 A;  4Q7H A;  4L1J A;  4MDZ A;  3M1T A;  2PAQ A;  4TNR A;  4L1J B;  5TK6 A;  4QQY A;  3HI0 A;  4R8Z A;  5AO2 A;  1YOY A;  3TMD A;  4TO1 A;  4TO3 A;  4Q2C A;  4TNQ A;  4Q2D A;  4QFY A;  3GW7 A;  2PQ7 A;  3TMC A;  3U1N A;  2FLO A;  2CQZ A;  4TNZ A;  4ZWE A;  5TK8 A;  2O08 A;  2PAR A;  4TO6 A;  5AO0 A;  4RXS A;  4BZB A;  4LRL A;  4TO5 A;  4XDS A;  2GZ4 A;  1U6Z A;  4QQW A;  4X9E A;  2OGI A;  4N6W A;  4MZ7 A;  1XX7 A;  4TO0 A;  2O6I A;  4QFZ A;  4BZC A;  2Q14 A;  4ME4 A;  4ZWG A;  1VQR A;  4QG4 A;  4L7W A;  4QFX A;  3I7A A;  3TM8 A;  4QG0 A;  3TMB A;  4RXP A;  5TKA A;  5TK9 A;  3NQW A;  3NR1 A;  4TO4 A;  4QG2 A;  4RXR A;  1VJ7 A;  4MCW A;  3IRH A;  4TO2 A;  3P3Q A;  3LJX A;  3S4L A;  4DMB A;  3MZO A;  5AO3 A;  3HC1 A;  4RXQ A;  2HEK A; 
#chains in the Genus database with same CATH homology
 2PGS A;  3MEM A;  5TK7 A;  3KH1 A;  4L7E A;  2PAU A;  3RF0 A;  3SKD A;  4TNX A;  4MLN A;  4MLM A;  4N71 A;  4QG1 A;  5AO4 A;  3KQ5 A;  3SK9 A;  3CCG A;  4QQZ A;  5AO1 A;  4QQX A;  4RXO A;  2DQB A;  4TNP A;  4TNY A;  1YNB A;  3BG2 A;  4Q7H A;  4L1J A;  4MDZ A;  3M1T A;  2PAQ A;  4TNR A;  4L1J B;  5TK6 A;  4QQY A;  3HI0 A;  4R8Z A;  5AO2 A;  1YOY A;  3TMD A;  4TO1 A;  4TO3 A;  4Q2C A;  4TNQ A;  4Q2D A;  4QFY A;  3GW7 A;  2PQ7 A;  3TMC A;  3U1N A;  2FLO A;  2CQZ A;  4TNZ A;  4ZWE A;  5TK8 A;  2O08 A;  2PAR A;  4TO6 A;  5AO0 A;  4RXS A;  4BZB A;  4LRL A;  4TO5 A;  4XDS A;  2GZ4 A;  1U6Z A;  4QQW A;  4X9E A;  2OGI A;  4N6W A;  4MZ7 A;  1XX7 A;  4TO0 A;  2O6I A;  4QFZ A;  4BZC A;  2Q14 A;  4ME4 A;  4ZWG A;  1VQR A;  4QG4 A;  4L7W A;  4QFX A;  3I7A A;  3TM8 A;  4QG0 A;  3TMB A;  4RXP A;  5TKA A;  5TK9 A;  3NQW A;  3NR1 A;  4TO4 A;  4QG2 A;  4RXR A;  1VJ7 A;  4MCW A;  3IRH A;  4TO2 A;  3P3Q A;  3LJX A;  3S4L A;  4DMB A;  3MZO A;  5AO3 A;  3HC1 A;  4RXQ A;  2HEK A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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