4ZWGA

Crystal structure of the gtp-datp-bound catalytic core of samhd1 phosphomimetic t592e mutant
Total Genus 164
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
164
sequence length
468
structure length
461
Chain Sequence
TMKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASHNRFEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCRNLGHGPFSHMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPEEDICFIKEQIVGPLEEDSLWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFARDCHHLGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNSLHRRAYQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDDMEAYTKLTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKIKREDYESLPKEVASAKPKVKLKAEDFIVDVINMDYGMQEKNPIDHVSFYCKTAPNRAIRITKNQVSQLLPEKFAEQLIRVYCKKVDRKSLYAARQYFVQWCADRNFTKP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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publication title Impaired dNTPase Activity of SAMHD1 by Phosphomimetic Mutation of Thr-592.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords Deoxynucleoside triphosphate triphosphohydrolase SAMHD1
total genus 164
structure length 461
sequence length 468
chains with identical sequence B, C, D
ec nomenclature ec 3.1.5.-:
pdb deposition date 2015-05-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01966 HD HD domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.3210.10 Mainly Alpha Orthogonal Bundle Hypothetical protein af1432 Hypothetical protein af1432 4zwgA01
5AO4A 4TNYA 4QFZA 1YOYA 4BZBA 1VJ7A 3TM8A 4TNPA 4RXPA 4QG1A 4TO5A 2HEKA 5AO3A 5AO0A 3HC1A 1YNBA 5AO2A 4MZ7A 3MEMA 3U1NA 4BZCA 2OGIA 2DQBA 3TMBA 4QG2A 4L7WA 4TNRA 3I7AA 3HI0A 2PAQA 4QG4A 4DMBA 2PQ7A 3TMDA 4ME4A 3MZOA 1XX7A 4L7EA 2PGSA 4N6WA 4RXOA 1U6ZA 4TO2A 4RXRA 4TO4A 4TNXA 4X9EA 4TNZA 4RXSA 4QFYA 3LJXA 3IRHA 2O6IA 2PARA 4MDZA 4Q7HA 3NR1A 5AO1A 5TK7A 4TNQA 4TO6A 3CCGA 4L1JB 4TO0A 4ZWGA 4R8ZA 4LRLA 1VQRA 2O08A 3NQWA 4N71A 4MLNA 2FLOA 4QFXA 4RXQA 5TK8A 3P3QA 2CQZA 4MCWA 5TKAA 3KH1A 2PAUA 3TMCA 4XDSA 5TK6A 3M1TA 4TO3A 3RF0A 2Q14A 4ZWEA 4L1JA 4TO1A 4MLMA 4QG0A 5TK9A 2GZ4A 3BG2A
chains in the Genus database with same CATH superfamily
5AO4A 4TNYA 4QFZA 1YOYA 4BZBA 1VJ7A 3TM8A 4TNPA 4RXPA 4QG1A 4TO5A 2HEKA 5AO3A 5AO0A 3HC1A 4Q2DA 1YNBA 5AO2A 4MZ7A 3MEMA 3U1NA 4BZCA 2OGIA 2DQBA 3TMBA 3GW7A 4QG2A 4L7WA 4TNRA 3I7AA 3HI0A 2PAQA 3KQ5A 4QG4A 4DMBA 2PQ7A 3TMDA 4ME4A 3MZOA 1XX7A 4L7EA 2PGSA 4N6WA 4RXOA 1U6ZA 4QQYA 4TO2A 4RXRA 4TO4A 4TNXA 4X9EA 4TNZA 4RXSA 4QFYA 3LJXA 3IRHA 2O6IA 2PARA 4MDZA 4Q7HA 3NR1A 5AO1A 5TK7A 4TNQA 4TO6A 3CCGA 4L1JB 4Q2CA 4TO0A 4ZWGA 4R8ZA 4LRLA 1VQRA 2O08A 3NQWA 4N71A 4MLNA 2FLOA 4QFXA 4RXQA 5TK8A 3P3QA 4QQZA 2CQZA 4MCWA 3SKDA 5TKAA 4QQWA 3SK9A 3KH1A 2PAUA 3TMCA 4XDSA 5TK6A 3M1TA 4TO3A 3RF0A 2Q14A 4ZWEA 4L1JA 3S4LA 4TO1A 4MLMA 4QQXA 4QG0A 5TK9A 2GZ4A 3BG2A
chains in the Genus database with same CATH topology
5AO4A 4TNYA 4QFZA 1YOYA 4BZBA 1VJ7A 3TM8A 4TNPA 4RXPA 4QG1A 4TO5A 2HEKA 5AO3A 5AO0A 3HC1A 4Q2DA 1YNBA 5AO2A 4MZ7A 3MEMA 3U1NA 4BZCA 2OGIA 2DQBA 3TMBA 3GW7A 4QG2A 4L7WA 4TNRA 3I7AA 3HI0A 2PAQA 3KQ5A 4QG4A 4DMBA 2PQ7A 3TMDA 4ME4A 3MZOA 1XX7A 4L7EA 2PGSA 4N6WA 4RXOA 1U6ZA 4QQYA 4TO2A 4RXRA 4TO4A 4TNXA 4X9EA 4TNZA 4RXSA 4QFYA 3LJXA 3IRHA 2O6IA 2PARA 4MDZA 4Q7HA 3NR1A 5AO1A 5TK7A 4TNQA 4TO6A 3CCGA 4L1JB 4Q2CA 4TO0A 4ZWGA 4R8ZA 4LRLA 1VQRA 2O08A 3NQWA 4N71A 4MLNA 2FLOA 4QFXA 4RXQA 5TK8A 3P3QA 4QQZA 2CQZA 4MCWA 3SKDA 5TKAA 4QQWA 3SK9A 3KH1A 2PAUA 3TMCA 4XDSA 5TK6A 3M1TA 4TO3A 3RF0A 2Q14A 4ZWEA 4L1JA 3S4LA 4TO1A 4MLMA 4QQXA 4QG0A 5TK9A 2GZ4A 3BG2A
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 5AO4 A;  4TNY A;  4QFZ A;  1YOY A;  4BZB A;  1VJ7 A;  3TM8 A;  4TNP A;  4RXP A;  4QG1 A;  4TO5 A;  2HEK A;  5AO3 A;  5AO0 A;  3HC1 A;  1YNB A;  5AO2 A;  4MZ7 A;  3MEM A;  3U1N A;  4BZC A;  2OGI A;  2DQB A;  3TMB A;  4QG2 A;  4L7W A;  4TNR A;  3I7A A;  3HI0 A;  2PAQ A;  4QG4 A;  4DMB A;  2PQ7 A;  3TMD A;  4ME4 A;  3MZO A;  1XX7 A;  4L7E A;  2PGS A;  4N6W A;  4RXO A;  1U6Z A;  4TO2 A;  4RXR A;  4TO4 A;  4TNX A;  4X9E A;  4TNZ A;  4RXS A;  4QFY A;  3LJX A;  3IRH A;  2O6I A;  2PAR A;  4MDZ A;  4Q7H A;  3NR1 A;  5AO1 A;  5TK7 A;  4TNQ A;  4TO6 A;  3CCG A;  4L1J B;  4TO0 A;  4ZWG A;  4R8Z A;  4LRL A;  1VQR A;  2O08 A;  3NQW A;  4N71 A;  4MLN A;  2FLO A;  4QFX A;  4RXQ A;  5TK8 A;  3P3Q A;  2CQZ A;  4MCW A;  5TKA A;  3KH1 A;  2PAU A;  3TMC A;  4XDS A;  5TK6 A;  3M1T A;  4TO3 A;  3RF0 A;  2Q14 A;  4ZWE A;  4L1J A;  4TO1 A;  4MLM A;  4QG0 A;  5TK9 A;  2GZ4 A;  3BG2 A; 
#chains in the Genus database with same CATH topology
 5AO4 A;  4TNY A;  4QFZ A;  1YOY A;  4BZB A;  1VJ7 A;  3TM8 A;  4TNP A;  4RXP A;  4QG1 A;  4TO5 A;  2HEK A;  5AO3 A;  5AO0 A;  3HC1 A;  4Q2D A;  1YNB A;  5AO2 A;  4MZ7 A;  3MEM A;  3U1N A;  4BZC A;  2OGI A;  2DQB A;  3TMB A;  3GW7 A;  4QG2 A;  4L7W A;  4TNR A;  3I7A A;  3HI0 A;  2PAQ A;  3KQ5 A;  4QG4 A;  4DMB A;  2PQ7 A;  3TMD A;  4ME4 A;  3MZO A;  1XX7 A;  4L7E A;  2PGS A;  4N6W A;  4RXO A;  1U6Z A;  4QQY A;  4TO2 A;  4RXR A;  4TO4 A;  4TNX A;  4X9E A;  4TNZ A;  4RXS A;  4QFY A;  3LJX A;  3IRH A;  2O6I A;  2PAR A;  4MDZ A;  4Q7H A;  3NR1 A;  5AO1 A;  5TK7 A;  4TNQ A;  4TO6 A;  3CCG A;  4L1J B;  4Q2C A;  4TO0 A;  4ZWG A;  4R8Z A;  4LRL A;  1VQR A;  2O08 A;  3NQW A;  4N71 A;  4MLN A;  2FLO A;  4QFX A;  4RXQ A;  5TK8 A;  3P3Q A;  4QQZ A;  2CQZ A;  4MCW A;  3SKD A;  5TKA A;  4QQW A;  3SK9 A;  3KH1 A;  2PAU A;  3TMC A;  4XDS A;  5TK6 A;  3M1T A;  4TO3 A;  3RF0 A;  2Q14 A;  4ZWE A;  4L1J A;  3S4L A;  4TO1 A;  4MLM A;  4QQX A;  4QG0 A;  5TK9 A;  2GZ4 A;  3BG2 A; 
#chains in the Genus database with same CATH homology
 5AO4 A;  4TNY A;  4QFZ A;  1YOY A;  4BZB A;  1VJ7 A;  3TM8 A;  4TNP A;  4RXP A;  4QG1 A;  4TO5 A;  2HEK A;  5AO3 A;  5AO0 A;  3HC1 A;  4Q2D A;  1YNB A;  5AO2 A;  4MZ7 A;  3MEM A;  3U1N A;  4BZC A;  2OGI A;  2DQB A;  3TMB A;  3GW7 A;  4QG2 A;  4L7W A;  4TNR A;  3I7A A;  3HI0 A;  2PAQ A;  3KQ5 A;  4QG4 A;  4DMB A;  2PQ7 A;  3TMD A;  4ME4 A;  3MZO A;  1XX7 A;  4L7E A;  2PGS A;  4N6W A;  4RXO A;  1U6Z A;  4QQY A;  4TO2 A;  4RXR A;  4TO4 A;  4TNX A;  4X9E A;  4TNZ A;  4RXS A;  4QFY A;  3LJX A;  3IRH A;  2O6I A;  2PAR A;  4MDZ A;  4Q7H A;  3NR1 A;  5AO1 A;  5TK7 A;  4TNQ A;  4TO6 A;  3CCG A;  4L1J B;  4Q2C A;  4TO0 A;  4ZWG A;  4R8Z A;  4LRL A;  1VQR A;  2O08 A;  3NQW A;  4N71 A;  4MLN A;  2FLO A;  4QFX A;  4RXQ A;  5TK8 A;  3P3Q A;  4QQZ A;  2CQZ A;  4MCW A;  3SKD A;  5TKA A;  4QQW A;  3SK9 A;  3KH1 A;  2PAU A;  3TMC A;  4XDS A;  5TK6 A;  3M1T A;  4TO3 A;  3RF0 A;  2Q14 A;  4ZWE A;  4L1J A;  3S4L A;  4TO1 A;  4MLM A;  4QQX A;  4QG0 A;  5TK9 A;  2GZ4 A;  3BG2 A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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